Anti-inflammatory terpenoids from Cyperus rotundus rhizomes

Phytochemical investigation of the methanolic extract of Cyperus rotundus L. [Cyperaceae] rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A [1] and sugetriol triacetate [2]. Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D [[1]H and [13]C], 2D [[1]H-[1]H COSY, HSQC, HMBC, and NOESY]] NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC[50s] 0.22, 1.03, and 1.37 MuM, respectively compared to indomethacin [IC50s 0.15, 0.69, and 0.81 MuM, respectively]. Moreover, 2 demonstrated significant activity with IC[50s] 0.57 [PGE2], 1.74 [COX-2] and 2.03 [LOX-5] MuM

Single versus two layer suturing for closing the uterine incision at ceasarean section

To evaluate the impact of a single versus two-layer closure of low transverse cesarean section [LTCS] on operative and postoperative outcome, this randomized trial was done at Sohag Teaching Hospital. It included 400 women randomized into two groups, each included 200 cases: Group A underwent a routine cesarean section [CS] with double layer closure of the uterine incision and closure of the visceral and parietal peritoneum and group B underwent CS with single layer closure of the uterine incision and leaving the peritoneum unsutured. The results showed a significant shorter operating time, less suture material use, less antibiotic and analgesic use in group B than group A. The follow up showed no differences in scar integrity with less adhesion formation in group B. It was concluded that single layer closure of the uterine incision and leaving the peritoneum unsutured are associated with shorter operating time, less suture material use, faster recovery and shorter hospital stay. Subsequent scar integrity and adhesion formation are also more favorable

Screening policy for cervical cancer and CIN among Egyptian women

Based on our previous epidemiologic studies on the risk factors for cervical cancer and its precursor lesions [Cervical Intraepithelial Neoplasia] among Egyptian women, recommendations for cytologic screening policy are given. Patient grouping into high risk and low risk was also specified suing a simple scoring system. The optimum screening interval to be adopted and the age for starting screening was also suggested