Subject(s)
Animals , Antidepressive Agents/pharmacology , Bupropion , Catalepsy/prevention & control , Female , Haloperidol , Male , Morphine , Propiophenones/pharmacology , RatsABSTRACT
The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
Subject(s)
Acute Disease , Animals , Anti-Inflammatory Agents , Arthritis/drug therapy , Arthritis, Experimental/drug therapy , Carrageenan , Chronic Disease , Female , Granuloma/drug therapy , Inflammation/drug therapy , Male , Peritonitis/drug therapy , Ranitidine/therapeutic use , Rats , Rats, Inbred Strains , TurpentineSubject(s)
Animals , Cataract/physiopathology , Goats , Humans , Lens, Crystalline/physiopathology , Organ Preservation/methods , Rabbits , Rats , Time FactorsABSTRACT
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.