ABSTRACT
Objective: Previous studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index [BMI] in patients with normal TSH levels [2.5-4.2 microIU/mL], patients diagnosed with subclinical hypothyroidism, and healthy control subjects
Methods: The study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 [high-normal], TSH levels were 2.5-4.2 microIU/mL [n=33]; Group 2 [subclinical hypothyroidism], TSH levels were 4.2-10 microIU/mL [n=42]; and Group 3 [healthy control], TSH levels were 0.27-2.5 microIU/mL [n=29].The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance [HOMA-IR] was used to estimate insulin resistance
Results: HOMA-IR and BMI were not significantly different among groups [p>0.05]. A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH [p>0.059] and subclinical hypothyroidism [p>0.05] groups
Conclusions: HOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups
Subject(s)
Humans , Female , Male , Adult , Middle Aged , Insulin Resistance , Body Mass Index , Obesity , Tertiary HealthcareABSTRACT
The etiology of functional dyspepsia is not known. The objective of the present study was to determine the characteristics of functional dyspepsia in Western Turkey. We divided 900 patients with functional dyspepsia into three subgroups according to symptoms: ulcer-like (UL), 321 (35.6 percent), motility disorder-like (ML), 281 (31.2 percent), and the combination (C) of these symptoms, 298 (33.1 percent). All patients were submitted to endoscopic evaluation, with two biopsies taken from the cardia and corpus, and four from the antrum of the stomach. All biopsy samples were studied for Helicobacter pylori (Hp) density, chronic inflammation, activity, intestinal metaplasia, atrophy, and the presence of lymphoid aggregates by histological examination. One antral biopsy was used for the rapid urease test. Tissue cagA status was determined by PCR from an antral biopsy specimen by a random sampling method. We also determined the serum levels of tumor necrosis factor-alpha (TNF-alpha) and gastrin by the same method. Data were analyzed statistically by the Kolmogorov-Smirnov test and by analysis of variance. Hp and cagA positivity was significantly higher in the UL subgroup than in the others. The patients in the ML subgroup had the lowest Hp and cagA positivity and Hp density. The ML subgroup also showed the lowest level of Hp-induced inflammation among all subgroups. The serum levels of TNF-alpha and gastrin did not reveal any difference between groups. Our findings show a poor association of Hp with the ML subgroup of functional dyspepsia, but a stronger association with the UL and C subgroups