Novel pyidopyrimidinedione analogs as possible anticonvulsants

Novel pyrido [2,3-d] pyrimidine-2,4-dione derivatives were synthesized as anticonvulsant agents. The proposed compounds possess bio- isosteric relationships to quinazolinone analogs and to ethosuximide agent. Anti-MMS assays were conducted for six of the newly synthesized compounds [VIIIa, IX, XII, XV, XVII, XX] in relevance to ethosuximide as reference st and ard. The results revealed that compound VIIIa was the most effective and displayed 60% protection

Synthesis and characterization of some [t] 1- [substituted amino or piperidino] -1-phenylethanes: novel bioisosteric relatives of pcp

The fact that phencyclidine [PCP]-receptors have been involved in the binding interactions with other hallucinogens, such as sigmaopiates, initiated the idea of synthesizing some novel bioisosteric relatives of PCP. Such compounds would act as potential blockers for central PCP-receptors, and thus might be utilized in the discouraging drug abusers or the therapeutic treatment of the hallucinogenic symptoms of such abused agents. The suggested compounds are 1-[substituted amino or piperidino]-1-phenylethane derivatives

N-phenylaminosuccinimide derivatives: potential convulsants related to ethosuximide with lower ionization parameters

The synthesis of two series of N-phenylaminosuccinimide derivatives [II] and some of their C-Mannich bases [III] was described. The structure of the new products was substantiated by spectral as well as microanalytical data. The pKa values and evaluation of the anti-MMS potency, for some selected compounds, were reported. Ethosuximide was utilized as prototype