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An experiment was conducted on urdbean during kharif 2021 at Instructional Farm, College of Agriculture, Ummedganj, Kota (Rajasthan). The experiment comprised of 10 treatments viz. (Control, 75% RDF, 100% RDF, 75% RDF + Rhizobium @ 600 g ha-1 seed inoculation, 75% RDF + PSB @ 600 g ha-1 seed inoculation, 75% RDF + Rhizobium @ 600 g ha-1 + PSB @ 600 g ha-1, 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage, 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage + Rhizobium @ 600 g ha-1, 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage + PSB @ 600 g ha-1, 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage + Rhizobium 600 g ha-1+ PSB @ 600 g ha-1) was carried out in randomized block design with three replications. Significantly higher plant height at 60 DAS (25.28 cm) and at harvest (34.43 cm), nodules plant-1 (29.22) at 45 DAS, nodule fresh weight (86.31 mg plant-1) at 45 DAS, chlorophyll content (3.19 mg g-1) at 45 DAS and dry matter accumulation (2.71, 5.94 and 9.99 g plant-1) at 30, 60 DAS and at harvest were recorded with application of 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage + Rhizobium 600 g ha-1+ PSB @ 600 g ha-1 in urdbean over rest of the treatments. Among these treatments, application of 75% RDF + 0.1% FeSO4 + 0.5% ZnSO4 at pre flowering and pod formation stage + Rhizobium 600 g ha-1+ PSB @ 600 g ha-1 produced maximum seed yield (1269.30 kg ha-1) of urdbean.
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An experiment was conducted on mungbean (Vigna radiata L.) during three consecutive years of zaid (2016 to 2018) at Agricultural Research Station, Ummedganj, Kota (Rajasthan). The experiment consisted of 12 treatment combinations including three irrigation regimes (IW/CPE ratio 0.8, 1.0 and 1.2) and four fertility amendments along with foliar spray of bio-regulator (100 % RDF, 100 % RDF + salicylic acid 100 ppm, 125 % RDF + salicylic acid 100 ppm and 150% RDF + salicylic acid 100 ppm) were under taken in split plot design with four replications. The maximum grain yield (930 kg ha-1) was recorded under application of IW/CPE ratio 1.2 over IW/CPE ratio 1.0 and 0.8. Significantly higher WUE (2.04 and 2.03 kg ha-mm-1) and WP (0.204 and 0.203 kg m-3) were recorded under irrigation regime of IW/CPE ratio 1.2 and 1.0 in comparison to IW/CPE ratio 0.8. Significantly higher net return (Rs. 37409/- ha-1) and B:C ratio (1.89) were recorded under irrigation regime of IW/CPE ratio 1.2 over irrigation regimes of IW/CPE ratio 1.0 and 0.8. The maximum grain yield (830 and 840 kg ha-1) was recorded with the application of 125 % RDF + foliar spray of salicylic acid 100 ppm remained on par with 150 % RDF + foliar spray of salicylic acid 100 ppm, but it was found significantly superior over application of over application of 100 % RDF + foliar spray of salicylic acid 100 ppm and 100 % RDF. Significantly higher water use efficiency (2.06 kg ha-mm-1) and water productivity (0.206 kg m-3) were recorded in mungbean with the application of 125 % RDF + foliar spray of salicylic acid 100 ppm over application of 100% RDF + foliar spray of salicylic acid 100 ppm and 100 % RDF in mungbean. Application of 125 % RDF + foliar spray of salicylic acid 100 ppm gave maximum net return (Rs. 31272/- ha-1) and B:C ratio (1.59) over application of 100% RDF + foliar spray of salicylic acid 100 ppm and 100 % RDF.
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Persistent poststernotomy pain (PSP) is a well?known entity following cardiac surgery done with midline strenotomy. The severity of pain is usually mild to moderate in the majority of the patients. However, a small percentage of patients develop severe and persistent pain and need aggressive treatment. Our patient, a 63?year?old lady developed chronic severe parasternal pain following coronary artery bypass graft surgery. As multiple medications did not relieve her pain effectively, we did an ultrasound?guided pectoral?intercostal fascial plane block to which she responded with excellent and long?lasting pain relief. This is the first such case report of the use of this novel block technique for treating PSP.
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Background & objectives: RHD gene typing is highly complex due to homology with RHCE genes. Molecular polymorphism of the RHCE and RHD genes have been characterized among various populations, but no studies have been undertaken among Indians. This study was undertaken to assess the genetic basis of RHD-negative phenotype in Indian blood donor population. Methods: Sample from a total of 200 phenotypically RhD-negative blood donors were analyzed for presence of RHD gene using polymerase chain reaction (PCR). RHD genotyping was done using three primer sets designed for exons 4 and 10 and one set for identification of pseudo (RHD?) gene between introns (int) 3 and 4. Amplified PCR products were analyzed by gel-electrophoresis (XY Loper, Uvitech, Cambridge) and confirmed by nucleotide sequencing (ABI 3730 xl 96 capillary system). Results: No PCR product was found in 195/200 (97.5%) of study samples indicating homozygous gene deletion. Of the 5/200 (2.5%) showing RHD gene polymorphisms, 4/200 (2%) were positive for presence of exon 10 only (RHD-CE-D hybrid). RHD? gene was not detected in any of the samples tested. One sample showed presence of all three tested regions and was negative for RHD? gene. Interpretation & conclusions: RHD gene deletion was found to be the most common cause of an RHD-negative phenotype while RHD? gene was, reported to be present in up to 39 per cent of various ethnic populations, but was not detected. RHD-CE-D hybrid gene (found in 2.5% individuals) is important for predicting the requirement of Rh prophylaxis during the antenatal period.
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Objectives:The primary objective of the present study was to review the demographics of infants and children operated upon for Meckel's diverticulum. The secondary objectives were to review the clinical characteristics, surgical procedures performed, postoperative complications, and the outcome. Materials and Methods?This study is a single-institutional, retrospective study and descriptive in nature. It consisted of infants and children below 12 years who were operated upon for Meckel's diverticulum at the author's institute and included data from January 1, 2000 to December 31, 2020. Results?Eighty-four children below 12 years were operated upon for Meckel's diverticulum during the study period. The ratio for males to females was 3:1. This study consisted of infants, (n?=?22, 26.19%), children of 1 to 5 years of age (n =19, 22.61%), and children of 6 to 12 years of age (n?=?43, 51.19%). Clinically, children with Meckel's diverticulum presented in the following order of frequency: (1) intestinal obstruction (n?=?59, 70.23%), (2) perforation peritonitis (n?=?17, 20.23%), (3) lower gastrointestinal bleeding (n?=?4, 4.76%), and (4) incidental finding (n?=?4, 4.76%). In 35 (41.66%) children, bowel gangrene was detected. One-fifth (n?=?17) of Meckel's diverticulum was responsible for the secondary intussusception. The surgical procedures were performed in the following order of frequency: (1) resection of Meckel's diverticulum, an adjacent segment of ileum and ileoileal anastomosis (n?=?36, 42.85%); (2) Meckel's diverticulectomy (n?=?32, 38.09%); (3) resection of Meckel's diverticulum, an adjacent segment of ileum with or without cecum and an ileostomy (n?=?12, 14.28%); and (4) resection of Meckel's diverticulum, an adjacent segment of ileum, cecum, part of the colon, and ileocolic anastomosis (n?=?4, 4.76%). In 8 (9.52%) children, complications were documented during the postoperative period. The present study observed three (3.57%) deaths during the postoperative period. Conclusion?Meckel's diverticulum was one of the common causes of acute intestinal obstruction in infants and older children. Ninety percent of children with Meckel's diverticulum presented with features of an acute abdomen. Forty percent of children evidenced bowel gangrene during the surgical procedures. In these children, early diagnosis, timely referral, and institution of surgical therapy for acute abdomen/intestinal obstruction may prevent the development of bowel gangrene and the requirement of bowel resections to some extent.
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PURPOSE@#The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement (Fraser's type Ⅱ). This study aims to evaluate and compare the functional outcomes among different Fraser's type Ⅱ floating knee injuries after surgical management.@*METHODS@#Twenty-seven patients with Fraser's type Ⅱ floating knee injuries (54 fractures) between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser's floating knee classification into three different groups as type ⅡA (ipsilateral femoral shaft and tibial intra-articular involvement, n = 11), type ⅡB (ipsilateral tibial shaft and femoral intra-articular involvement, n = 9) and type ⅡC (both femoral and tibial intra-articular involvement, n = 7). The differences among the groups were evaluated and compared. The functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score (KOOS) which covers 5 subscales of pain, other symptoms, activities of daily living, sports and recreation, and quality of life. The result was also compared with standardized age-sex matched healthy population using paired samples t-test.@*RESULTS@#All the patients were male, and the injury mechanism was solely roadside accident. The mean age was 29.8 years and injury severity score 17.9 (comparable in all the three groups). Most injuries were observed on the right side (20 cases, 74.1%). Based on paired samples t-test, the KOOS score of patients with Fraser's type ⅡA was found to be better than that of type ⅡB and type ⅡC. Compared with the reference age-sex matched control group, patients with Fraser's type ⅡB and ⅡC fractures had significantly lower mean score in all KOOS subscales (all p < 0.01). However, Fraser's type ⅡA only revealed significant difference regarding the subscales of activities of daily living (p < 0.0001), sports and recreation (p < 0.0001), and quality of life (p < 0.0001).@*CONCLUSION@#The results of this study show that patients with Fraser's type ⅡA fractures had a better functional outcome as compared to those with type ⅡB and ⅡC fractures. This might be due to the open intra-articular involvement of the distal femur of the latter two fracture types.
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Introduction: Normal hearing is very important for overalldevelopment of child. If a child is suffering from hearing loss,it affects his ability to acquire knowledge and skills. So thisstudy was done to estimate true prevalence in primary schoolsof Jodhpur region between ages 8 to 14 years.Material and Methods: Total 1200 students were includedin study from various schools of Jodhpur between ages 8 to14 years. Detailed otological examination done and hearingassessment done in silent room with 512 HZ turning fork test.All data with history obtained and analysed.Results: Total 146 students from 1200 students had hearingloss with most common type of hearing loss is conductive.Conclusion: Hearing loss specially in age group 8 to 14 yearsof school going children is preventable by simple measureslike paying attention to children regarding hearing by theirparents, teachers, Para-medical staff and conducting regularscreening programs.
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Introduction:Hearing impairment in pediatric population specially in early age could affect their learning abilities, skills and communication. Early diagnosis is utmost important in these cases to prevent this disability permanently. Aims:In this study, we evaluate the role of BERA in early diagnosis of hearing impairment specially in high risk pediatric population.Materials and methods:A total 65 high risk cases below 12 years of age are included in the study and BERA was obtained and data obtained and analysed.Results:In our study, 40.9 % cases showed hearing impairment on BERA investigation. Severe to modied hearing loss was found in 2 4 cases (88.9 %).Conclusion:In our study, BERA is very simple, useful, reliable, screening tool specially in high risk and un-cooperative pediatric population for early diagnose and management of hearing loss.
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INTRODUCTION:Otomycosis is the fungal infection of EAC (External Auditory Canal) that is very commonly seen in Ear , Nose and Throat clinics .Local debridement and antifungals , topical or systemic is the treatment of choice but recurrences are very common and resistant to treatment.METHODS:Total 220 patients, divided into two groups each 110 in 'A' and 'B' were subjected to betadine (povidone - iodine )10% solution and Clotrimazole (1 %) drops treatment and response of treatment assessed on 5th , 10th and 20th day and analyzed.RESULTS :Out of 110 patients in each group on 5th day 21.8 % patients in group 'A', and 23.6 % in group B' showed no response. 70.9 % in group 'A' and 72.7 % in group 'B' were showed good response at evaluation of 20th day of treatment.CONCLUSION :In our study, betadine (10% solution) and Clotrimazole (1 %) drops were equally effective in treatment of otomycosis. Betadine(10% solution) is low cost, non-ototoxic, nonresistant and equally effective in bacterial and fungal infection. That's why this study support betadine 10% solution as treatment of choice for otomycosis specially in developing countries
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Background: The prevalence of type 2 diabetes mellitus(T2DM) is growing worldwide, and these patients may beasymptomatic and present with complications at the time ofdiagnosis. Diabetic neuropathy is the most commoncomplication affecting the patients who may present with distalpolyneuropathy at the time of diagnosis and also poorglycaemic control. The Diabetic peripheral polyneuropathyaffects approximately 1 in every 10 newly diagnosed patients,whereas two third of patients with diabetes mellitus haveclinical or subclinical neuropathy.Objective: This study is designed to find prevalence of diabeticperipheral neuropathy in Newly Diagnosed Patients of T2DM ina tertiary care hospital.Materials and Methods: This observational study was carriedout in patients diagnosed with T2DM as per ADA criteria. Athorough clinical examination; Nerve conduction velocitytesting; evaluation of plasma glucose and glycosylatedhemoglobin and assessment of neuropathy by using theDiabetic neuropathy index and diabetic neuropathy score wasperformed on all patients.Results: 18% of patients had signs of peripheral neuropathyas shown by NCV testing at the time of diagnosis. Thesepatients had elevated levels of glycosylated hemoglobin,fasting plasma glucose and 2-hour plasma glucose and lowerscores of DNI and DNS which were statistically significant. Themost common type of neuropathy seen in these patients wassensorimotor involvement with demyelinating type ofneuropathy with more involvement of lower limbs. The NCVstudies showed reduced distal latency and prolongedamplitude as well as conduction velocity in patients withdiabetic neuropathy.Conclusion: Our study showed that approximately 1 in 5newly diagnosed patients with type 2 diabetes mellitus are atrisk of developing diabetic peripheral neuropathy.
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Background: Leprosy is probably the oldest disease affl icting mankind and a public health problem for centuries. Many cases are hidden or undiagnosed, especially due to social stigma, and neglect of painless patches. Between years 2001 and 2005, during which time active surveillance for detection of leprosy was in practice, a steep fall in the prevalence rate (PR) of leprosy was observed. However, during later years, leprosy program discontinued active surveillance for detection of leprosy cases. Presently block level awareness campaign (BLAC) is a special measure undertaken in a campaign mode during September–November in priority areas, (PR > 1/10000 population), during which information, education and communication (IEC) activities and active surveillance of leprosy cases is done. Aims: To evaluate the effect of Block Level Awareness Campaign on performance indicators of national leprosy elimination program (NLEP) in Vadodara district. Methods: The campaign was carried out for 6 days in 12 talukas of Vadodara district by the district leprosy offi ce, Vadodara. Trained teams of health workers carried out information, education and communication (IEC) activity and active surveillance by undertaking house to house survey in each primary health centre (PHC) area. Suspected cases were identifi ed by the team and confi rmed clinically by medical offi cers in the primary health centre of the corresponding areas. A district nucleus team (DNT) validated these confi rmed cases. These data were compared with the district’s national leprosy eradication programme (NLEP) data for the same year, 2012 and the previous year, 2011. Results: A total of 1,574,586 persons, comprising 76%of the population surveyed, were screened for leprosy, which resulted in detection of 358 clinically confi rmed new cases of leprosy, out of which 225 (62.8%) were paucibacillary (PB) and 133 (37.2%) were multibacillary (MB) leprosy. Of these cases, 14 (4%) had deformities, and 37 (10.3%) were children. Limitations: Only 76% of the population could be covered. Histopathological confi rmation of the diagnosis was not undertaken. Because of the large number of health workers invovled, variations in their skills may have infl uenced the diagnosis of suspected cases. Conclusions: Active surveillance linked to focused block level campaigns can be useful tools to detect new hidden leprosy cases.
Subject(s)
Awareness , Female , Humans , India/epidemiology , Leprosy/epidemiology , Leprosy/prevention & control , Male , National Health Programs/organization & administration , Prevalence , Public Health Surveillance/methodsABSTRACT
PURPOSE: To identify and quantify the presence of extra-articular tibia vara that might influence the mechanical axis alignment after total knee arthroplasty (TKA). MATERIALS AND METHODS: A total of 48 TKAs in 30 osteoarthritic Indian patients were prospectively evaluated. The hip-knee-ankle angle (HKA), joint line convergence angle, and varus angulation at the femur and tibia were measured from the preoperative and postoperative standing hip-to-ankle radiographs. Four different methods were used to measure the varus angulation at the tibia: metaphyseo-diaphyseal angle (MDA), the angle between the anatomical axis and mechanical axis of the tibia, the angle between the proximal third and distal third of tibia and the angle between the proximal half and distal half of tibia. RESULTS: Extra-articular tibia vara quantified using MDA had the most positive correlation with HKA. Receiver operating characteristic plotting showed that MDA of >4degrees predicts abnormal postoperative HKA. Twenty-eight out of 48 knees had MDA of >4degrees, and 78.6% of these had postoperative HKA under-correction and 21.4% had less than ideal tibial component position. CONCLUSIONS: A significant inherent extra-articular varus angulation best measured using MDA exists in the proximal tibia in osteoarthritic Indian patients undergoing TKA. MDA of >4degrees is associated with abnormal postoperative HKA. Computer navigation may be useful for achieving ideal correction in such cases.
Subject(s)
Humans , Arthroplasty , Axis, Cervical Vertebra , Femur , Incidence , Joints , Knee , Osteoarthritis , Prospective Studies , ROC Curve , TibiaABSTRACT
N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems.
Subject(s)
Acyltransferases/metabolism , Animals , Calpain/metabolism , Caspases/metabolism , Gene Expression Regulation, Enzymologic/physiology , Humans , Lipid Metabolism/physiology , Models, Biological , Signal Transduction/physiologyABSTRACT
Disclosure of one’s human immunodeficiency virus (HIV)-positive serostatus to a spouse or sex partner is important, particularly to inform the partner of the need to take precautions to prevent HIV transmission. Thus, understanding the process of disclosure is important to facilitating it to occur more often. Such understanding can best be achieved through a qualitative study (in-depth-interview) that elicits and systematically explores individuals’ stories of what has happened to them after disclosure of HIV.
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The aim of this study is to find out the iodine nutrition and thyroid function status of the school age children of Sunsari and Dhankuta districts. A total of 386 urine and 142 blood samples were randomly collected from four schools of above districts to estimate urinary iodine and thyroid hormones, respectively. Median UIE of Dhankuta and Sunsari were 238.00 μg/L and 294.96 μg/L respectively. Relatively higher percentage (31.8%) of subclinical hypothyroid cases was found in Sunsari than Dhankuta (29.59%).
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In 2009, as a supplement to a National Institutes of Health (NIH) -funded collaboration between the Indian Council of Medical Research (ICMR) and the NIH, a formative study was conducted with 30 HIV-positive people and 18 HIV-related service providers to understand sexual risk-taking, HIV-related disclosure, and other behavioural patterns among HIV-positive individuals in Baroda, Gujarat. One goal of this research was to determine how to adapt a counselling intervention which had been tested in the United States, in order to make it culturally and linguistically relevant for PLWHA(People living with HIV/AIDS) here.
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Hypertrophic cardiomyopathy with or without left ventricular outflow tract obstruction is characterized by asymmetric hypertrophy of the interventricular septum causing intermittent obstruction of the left ventricular outflow tract. Because Hypertrophic cardiomyopathy is the most common genetic cardiovascular disease, it may present to the anesthesiologist more often than anticipated, sometimes in undiagnosed form during routine preoperative visit. Surgery and anesthesia often complicate the perioperative outcome if adequate monitoring and proper care are not taken. Therefore, a complete understanding of the pathophysiology, hemodynamic changes and anesthetic implications is needed for successful perioperative outcome. We hereby describe the perioperative management of three patients with Hypertrophic cardiomyopathy for different surgical procedures.
Subject(s)
Adult , Anesthesia, General , Cardiomyopathy, Hypertrophic/complications , Delivery, Obstetric , Female , Head and Neck Neoplasms/secondary , Head and Neck Neoplasms/surgery , Humans , Kidney Calculi/therapy , Lithotripsy , Male , Middle Aged , Monitoring, Intraoperative , Nephrostomy, Percutaneous , Neuromuscular Blockade , Perioperative Care/methods , Pregnancy , Surgical Procedures, Operative , Tonsillar Neoplasms/pathology , Tonsillar Neoplasms/surgerySubject(s)
Animal Husbandry , Animals , Biomedical Technology , Biotechnology , Food Technology , Genetic Engineering , Humans , India , Industrial Microbiology , Medicine , Patents as TopicABSTRACT
The results obtained in the present investigations point to a definite correlation between the onset of myocardial injury, electrocardiographic changes and biochemical changes. Changes in the electrocardiogram and elevated serum levels were paralleled by an increased excretion of magnesium in urine as early as one hour. Serum calcium and serum potassium levels did not show any significant result, but in coming days these ions including serum magnesium might help clinicians diagnose myocardial infarction. In this study, increased urinary magnesium excretion was found to coincide with elevated serum transaminases, and it is suggested that in addition to the other established diagnostic criteria, estimation of serum as well as urinary magnesium may be used as an additional index of myocardial infarction