study of histopathologic changes in soft tissues associated with asymptomatic impacted mandibular third molar

Forty eight patients participated in the present study. They were divided according to the width of non-pathological radiographic pericoronal radiolucency into group one with pericoronal radiolucencies having width of less than 1mm, and group two with pericoronal radiolucency less than 2.5 mm but more than 1 mm. The present study was designed to find out firstly; the possible incidence of histopathological changes in the soft tissues adjacent to impacted mandibular third molar that were asymptomatic and not associated with pathological pericoronal radiographic radiolucency. Secondly, to examine if the pathological changes, in the soft tissue around the asymptomatic impacted third molars; parallel those noted in the radiographic radiolucency. The pericoronal soft tissue were removed after the extraction of teeth, fixed in 10% formaline. and processed to be submitted for the histological study. The examination revealed firstly; mild variable tissue changes in the different tissue specimens which dose not encourage the prophylactic removal of impacted third molars because the histological changes were not conclusive for cystic degeneration. Secondly; no significant histopathological differences had been recorded between the two groups of different radiolucencies

influence of cortisone administration on the histology and carbohydrate histochemistry of the rat salivary glands

The effect of administration of excessive dose of cortisone for 4 successivedays on the histology and carbohydrate histochemistry of the rat salivaryglands was investigated. An atrophy of some acini in the posterior lingualand palatine glands and unalteration in size of the submandibular andsublingual acini occurred. However, the prevailing cortisone influence led tohypertrophy of the posterior lingual and palatine acini and the proliferationof ducts and associated vessels and the prominence of basal striation. Inmajor glands, the secretory tubules became hypertrophic, though the peripheralones were most frequently seen absolutely degranulated, so appeared closelyresembling mucous units. The carbohydrate content was generally increased inthe submandibular and sublingual acini, while the neutral mucin was reducedand the acidic one was increased in the posterior lingual and palatine acini. The study has generally evidenced the stimulatory influence of cortisone on theinvestigated glands, irrespective of which glandular component has beenresponded to cortisone administration

influence of testosterone administration on the histology and carbohydrate histochemistry of the rat salivary glands

The influence of intramuscular administration of 25 mg/100 g body weighttestosterone propionate, for four successive days, on the rat salivary glandswas examined. A predominating acinar hypertrophy of the posterior lingual andpalatine glands occurred though some other acine showed atrophic changes. This was in contradistinction to the morphological unalteration of thesubmandibular and sublingual glands, except the marked hypertrophy of thegranular convoluted tubules [GCT] and the proliferation of intercalated ducts. Histochemically, the periodate reactive materials were generally reduced,except in the submandibular gland where they were increased. However, thealcianophilic materials were increased in all mucous acini of theexamined glands

response of dentin-pulp complex of the rat to thyroxin administrations for two different periods

The histological and carbohydrate histochemical studies of the response of the rat dental pulp to the subcutaneous administration of 50 mug/100 g body weight thyroxine for 5 or 10 consequent days were performed. Deeply seated alterations in the dentin-pulp complex were noted including changes in dentinogenesis evidenced by the most frequent localized increase in predentine formation in a regular or irregular pattern. Also, localized hyalinization of the accumulated collagen fibers and ground substance, proliferation of cellular and fibrillar elements and the development of osseous structures in the pulp stroma were noted. The vascular alterations were striking, as manifested by the proliferation of blood vessels and capillaries associated with the appearance of localized or diffused hyaline materials rich with neutral mucopolysaccharides intra- and extravascularity. Whereas, these alterations helped for the dentin-pulp complex after thyroxine injections for 5 days; however they became more dramatically accentuated after thyroxine injections for 10 days and in females than males. It was concluded that hormonization causes predominant stimulation of dentin matrix genesis, but dentin matrix mineralization is impaired. It also leads to alterations in the physical consistency of the ground substance, thus inducing stromal hyalinization and increased vascular permeability. However, the changes in the vessel walls and in the perivascular stroma may be reminiscent to those occurring in acute inflammation

Evaluation of the effect of estrogen and progesterone at different doses on the major salivary glands of rat

An evaluative study of the effect of different doses of estrogen andprogesterone, either singly or in combination, for 21 days was undertaken on the major salivary glands of female rats. Variable degrees of acinar atrophy in submandibular and parotid glands occurred whether estrogen and progesterone were administered individually or in combination. The most severe acinar atrophy occurred when the low doses of both hormones were combined. Conversely, sublingual acini became hypertrophic individually or in combination at the same individually given doses. While, an eventual degeneration of tubules was associated more with estrogen than with progesterone; it was most extensive when 2.1 mg progesterone was combined with a moderate dose of 0.021 mg estrogen. However, the tubules showed hormonally induced initial proliferation. The content of the acidic mucins was unchanged in parotid and submandibular glands. Conversely, this content in sublingual gland was increased with estrogen and decreased with progesterone administration

Histological changes of the dental pulp of rat after estrogen and progesterone administration

In response to the parental administration of estrogen and/or progesterone, atdifferent doses, the pulp showed dramatic regressive alterations which couldbe categorized into; edematous vacuolization of the odontoblastema associatedwith the displacement of odontoblasts and their nuclei, and the elaboration ofnodular or diffused vascularized tissue hyperplasia. The individualadministration of estrogen produced more generous pulp regression than thatshowed with progesterone. The regressive effects of the individualadministration of either of these hormones were more or less dramaticallyreversed when both of them were simultaneously administered. Theantiestrogenic potentiality of progesterone to control the unrestrainedpernicious influences of estrogen on the pulp tissue was highly determinedwhen administered in combination with estrogen only at a properproportional measures. However, it seems that the presence of both hormonesin a symbiotic condition would be essential for the maintenance and integrityof the normal structure of the dentin-pulp complex

study of the histology and carbohydrate histochemistry of the posterior lingual and palatine salivary glands of rat after estrogen and progesterone administration

An investigation of the effect of daily intramuscular administration ofestrogen and/or progesterone, for 21 days at different doses, has beenperformed on female rats to study the histological and histochemicalparticulars of the posterior lingual and palatine glands after hormonization. On the other hand, the increase in acidic mucin when 2.1 mg progesterone iscombined with high estrogen dose, indicates that the antiestrogenic effect ofprogesterone is highly blocked with the increase of estrogen dose

Histological and histochemical evaluation of the effect of povidone iodine versus sodium hypochlorite on the rat connective tissue

Betadine was used in different concentrations ranging from 1% to 10% to study its histological and histochemicol effect on the connective tissue of the adult rat skin. Also a comparison was performed between the effect of betadine and 5% sodium hypochlorite on the some tissue. The lower concentrations of betadine up to 4% gave no injurious action, while 6% betadine was of a relatively lesser tissues reaction than 5% sodium hypochlorite. However, the tissue reaction resulted from 8% betadine was approximately similar to that reported with 5% sodium hypochlorite, Severe tissue reaction was demonstrated with 8% and 10% betadine, which makes the use of this high concentration in root canal disinfection contraindicated