Hematological picture and some histopathological changes of albino rats experimentally treated with propofol [diprivan]

Forty adult albino rats were divided into two groups each of twenty. The first group was used as control. The second group was injected intraperitoneally with 2 mg propofol daily for 2 months. At the end of experiment blood was collected on EDTA for investigation and specimens from liver and kidneys were processed for histopathological examination. There were a significant reduction in the amount of haemoglobin, PCV and number of erythrocytes and insignificant increase in the total leukocytic count. The histopathological examination revealed congested hepatic central veins, vacuolar degeneration and leukocytic infiltration in the portal areas in liver while kidneys there were leukocytic infiltration in cortex and medulla

Some biochemical investigations and histopathological changes of liver in albino rats experimentally treated with nalbuphine [Nubain]

Forty adult albino rats were used in this investigation. They were divided into four groups each of ten. The first group was used as control. The second, third and fourth group were injected with Nalbuphine [Nubain] for 30, 60 and 90 days respectively. The injection was done intramuscularly and daily with 1 mg/lg B.W. At the end of experiment blood samples were collected from each group and the sera were obtained for immediate determination of aspartate amino transferase [ASAT], alanine aminotransferase [ALAT], alkaline phosphatase [ALP], seruloplasmin, total proteins and its fractions. Specimens from liver were processed for histopathological examination. There was a significant decrease in the amount of total proteins and albumins with a significant increase in beta and gamma globulins in all treated group, while the alpha 1 globulins were significantly decreased in the last two groups. A significant increase in ASAT, ALAT and ALP were detected in the sera of rats treated for 60 and 90 days i.e. the third and fourth groups. The ceruloplasmin was significantly decreased in the sera of all treated rats. The histopathological changes of liver revealed congested central veins, leucoytic infiltration and hydropic degeneration in rats treated for 30 days while those treated for 60 and 90 days showed coagulative necrosis

Some aspects of drug interaction

One hundred and twenty adult rats were used in this study. They were divided into 6 groups each of twenty. The first group was used as control, the second group was treated with 5 fluoro uracil for 4 weeks, the third group was treated with 5 fluoro uracil then exposed to sub anaesthetic doses of halothane for the last 3 weeks. The fourth group was treated with 5-fluoro uracil and exposed to sub-anaesthetic doses of isoflurane, the fifth group and the sixth groups were exposed to sub anaesthetic doses of halothane and isoflurane sub-sequently. There was a reduction in the antibody titres in the sera of rats belonging to groups 2, 3 and 5, while those rats belonging to groups 4 and 6 their titres resemble the normal at the 7[th] day post injection with bovine serum albumin [BSA]. There was anaemia in rats belonging to groups 2, 3 and 4. Leucopenia with lymphopenia was seen in rats belonging to groups 2, 3 and 5 and slight leucocytosis with lympho-cytosis was demonstrated in the blood of rats belonging to group 6. The histopathological changes of lungs, spleen and foot pads of all group were investigated and discussed