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Objective:According to the analysis of the research field of tumor genetics and epigenetics from 2015 to 2019 funded by National Natural Science Foundation of China (NSFC), which covered the General Program, Young Science Fund project and Fund for Less Developed Regions, to provide possible references for researchers′ research content selection, and also for the administration of research performance.Methods:Searching the project information of H1603 tumor genetics and epigenetics funded during 2015 to 2019 from the management information system.Results:During the five-year period time, the total number of General Program and Young Science Fund project funded annually by NSFC in the field of tumor genetics and epigenetics had fluctuated to a certain extent, and the funded projects of Youth Science Fund project were firstly greater than General Program in the year 2019. The projects in tumor epigenetics were more than tumor genetics in general, and gene methylation, histone modification and non-coding RNA were the main research fields in the projects funded by NSFC in tumor epigenetics.Conclusions:The research in the tumor genetics and epigenetics funded by NSFC increased rapidly, the content of the research was more diversified and the research hotspot also gradually converted, however, the research based on high-level technology and experiment platform was still need to be improved.
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Objective:To evaluate the scientific research development trend of young talents in Cancer Hospital of Peking University.Methods:The papers published by the young talents in the hospital as first or corresponding author from 2010 to 2019 were retrieved and analyzed, bibliometric method was used to evaluate the scientific and technological output of young talents in the hospital.Results:In the past 10 years, the number of papers increased from 149 to 402, and the quality of papers also improved significantly. SCI papers contributed a lot to the growth of the number, and its impact factors increased year by year.Conclusions:In recent years, the scientific research ability of young talents in hospital has been significantly improved, and some advantageous disciplines have been formed. At the hospital level, we should strengthen the combination of basic science and clinical medicine, strengthen the discipline construction, and attach importance to the strategy of young talents training. The management department should pay more attention to the significance of scientific and technological evaluation, making appropriate considerations of paper publication, and promote the development of young talents.
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Objective:By analyzing National Natural Science Foundation of China′s (NSFC′s) application and funding situations of the key program in the field of oncology from 2014 to 2018, taking into considerations of the Project areas funded each year, to explore the development trends of oncology research, from which might inform the selection of research areas and content for both researchers and research administrative personnel.Methods:Searching the key program information funded by Division VII of Health Sciences (Oncology Division) from the management information system during the period of 2014 and 2018.Results:During the five years, a total number of 472 key program applications were received by the Oncology Division, among which 74 were funded with total funding of 217.32 million RMB. Twenty-one Project areas were approved with concentration on the occurrence, development of tumors, as well as the tumor therapies.The funded number of different project areas varied a lot.Conclusions:The key scientific problems and the focus areas of oncology research that need to be solved urgently in China were revealed by the Project areas of key program. Although the high-level basic and applied basic research were evolving fast, some research areas that not well studied yet still need to pay more attention, more combination of basic and applied basic research should be developed, to further improve the transformation effectiveness of basic research.
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Objective:To analyze some problems identified in the transformation of scientific and technological achievements in hospitals and put forward corresponding strategies in order to provide reference for other hospitals.Methods:This paper analyzes some problems identified in the transformation of scientific and technological achievements in hospitals.Results:The common problems identified in the research include: too many steps in the transformation of scientific and technological achievements, market information is asymmetry, there is also risks of leakage and infringement, lack of professional institutions and specialized talents. Several strategies to solve these problems were proposed.Conclusions:The management department needs to create a good external environment to adapt to the transformation of achievements. That is to integrate the intellectual property layout and the transformation of achievements; optimize the transformation model; implement the whole process of security supervision to protect the confidentiality; improve the construction of transformation platform; strengthen the construction of professional talent team. This can promote the "bench-to-bed" transition of medical scientific research, as well as assure the long-term development of scientific and technological innovation.
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Objective:To establish a performance evaluation index system and evaluation method for young scientists in hospitals, and to provide reliable evidence for management departments in evaluating, selecting outstanding young scientists and formulating tailored training programs.Methods:Literature analysis, expert consultation, analytic hierarchy process and data envelopment analysis were adopted in this article to evaluate the scientific research performance of young scientists in hospitals.Results:The scientific research data of young scientists under 45 years of age in Peking University Cancer Hospital from 2015 to 2019 were collected, and their scale efficiency and technical efficiency were analyzed by using index system and its weight and propose the improvement measures to achieve the purpose of evaluation and reform.Conclusions:This method is useful for the effective evaluation of the young scientists in the hospital, and is helpful to improve the level of scientific research management, as well as realize the virtuous circle of matching the input and output of scientific and technological innovation.
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Objective:According to the characteristics of basic science research in the field of cancer during the 14 th five-year plan period, the scientific construction pattern which is available for the development of basic research in a cancer hospital is explored. Methods:A series of policy adjustments and the directions of research and development promulgated by the National Natural Science Foundation of China (NSFC) which supports basic and applied basic research in various scientific fields during the middle and late period of the 13 th five-year plan and the beginning year of the 14 th five-year plan is expounded and analyzed. Results:The cancer basic research will be more systematic, interdisciplinary and clinical fusion, and the clinical application of basic research achievements will be the key purposes under the new research pattern.Conclusions:The construction of basic research in the hospital should be combined with the characteristics of the new research pattern. The overall scientific and systematic layout of the research should be strengthened, the interdisciplinary research model should be established, and the clinical applied basic research should also be encouraged and supported, as well as the efficiency of transformation of basic research achievements needs to be further improved.
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Objective:To establish a scientific, directional and operable evaluation index system for clinical disciplines, which can meet the needs of discipline construction and is suitable for the evaluation and selection of various disciplines in oncology hospitals, so as to provide decision-making basis for discipline construction.Methods:Literature analysis and in-depth interview were used to draw up the preliminary evaluation index system. The index frame of subject evaluation was compiled, and the expert inquiry paper was compiled, and the index was added, subtracted and modified by Delphi method through two rounds of expert consultation. The index weight was determined by Analytic hierarchy process. Each index was given a specific scoring standard. The evaluation index system was used to test and analyze 22 clinical medical disciplines in the hospital. The total score of each discipline was calculated by weighted summation method. The validity of evaluation was judged by Spearman grade correlation analysis.Results:The clinical discipline evaluation index system consisted of 4 first-class indexes, 10 second-class indexes and 34 third-class indexes. The weights and scoring criteria of each index were determined. 22 disciplines were evaluated by the index system, which was divided into three grades: excellent, medium and poor.Conclusions:The evaluation index system of clinical discipline constructed in this study has high authoritative coefficient of experts, and the P value is less than 0.01.The evaluation results of 22 disciplines are highly correlated with those of experts, and the P value is less than 0.01. It has strong scientific validity and feasibility, and lays a foundation for the widespread application of clinical evaluation.
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Objective To analyze the research achievements and their outcome influence factors of the National Natural Science Foundation of China (NSFC) funding projects in Peking University Cancer Hospital during the "Twelfth Five-Year Plan".Methods Based on project data and outcomes of 68 projects supported by NSFC from 2011 to 2015,this paper studies the number of SCI papers,Chinese Journal papers and conference papers published,the citations per paper and talent cultivation of different subcategories of projects,as well as different professional titles,academic degrees,genders,ages,occupations of the principle investigator,and component of project team members.Results 90％ of the 68 projects published SCI papers,basically completed the intended research objectives set in the application.41.7％ of the SCI papers were published in the 1-5 year after the project closure.Research team collaborated between clinical and scientific research staff has higher output.Conclusions Scientific research management department should strengthen the process management and the tracking of project achievements,and should promote the combination of basic and clinical research to achieve mutually complementary.
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Colorectal Cancer (CRC) is a kind of molecular diversified neoplasm.For nonmetastatic early CRC patients who received surgery based systemic treatment,the 5 years survival rate is as high as 50％-80％.However,only chemotherapy is available for majority of metastatic advanced CRC patients.The effect of chemotherapy is disappointing.Numerous studies have demonstrated that some patients with metastatic advanced CRC can benefit from anti-EGFR and anti-VEGF monoclonal antibodies.Here,we give a brief overview about the clinical research of the detection of KRAS,BRAF,MSI and HER2in guiding treatment with targeted drugs in metastatic advanced CRC
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Rhesus monkey (Macaca mulatta)ABO blood typing was carried out by agglutination test with anti human sera, and monoclonal antibodies against A and B blood group antigcus Blood Samples of 113 monkeys were tested. The results showed that there wete no human like A and B agglutinins and anti-A and anti-B agglutnins on the surface of the red blood cells and in the sera of monkeys. How ever human like blood group substances were found in monkey's galiva lemonsliated by agglutination inhibition test. The ABO phenotype frequoncies of Rhesus monkey were as follows: A-17. 70 %;B-52,21 %;AW-20, 36% and O-9. 73 % which of ther from foreign reports.