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1.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1960-1964, 2019.
Article in Chinese | WPRIM | ID: wpr-802817

ABSTRACT

Objective@#To investigate the diagnostic value of non-specific diagnostic indicators for bacterial neonatal late-onset sepsis.@*Methods@#A total of 55 children with bacterial neonatal late-onset sepsis in Langfang People's Hospital were selected as sepsis group.Another 67 cases of non-infected newborns were selected as control group.White blood cell, platelet and C-reactive protein were retrospectively analyzed for diagnostic value.Meanwhile, percentage of neutrophils and mean platelet volume were analyzed for diagnostic value.@*Results@#When the bacterial neonatal late-onset sepsis occurred, the sensitivity(41.8%), specificity(95.6%) and positive predictive value(92.0%) of C-reactive protein were high.The sensitivity(18.2%, 10.9%), positive predictive value(71.4%, 85.7%) of white blood cell and platelet were low, but specificity(94%, 98.5%) was high.The percentage of neutrophils [(62.01±22.16)] and mean platelet volume[(11.60±0.98)] were higher than those of the control group [(36.58±11.06), (10.88±0.95)], and the differences were statistically significant(all P<0.05).@*Conclusion@#C-reactive protein has greater diagnostic value for bacterial neonatal late-onset sepsis.The percentage of neutrophils and mean platelet volume have some diagnostic value.

2.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1960-1964, 2019.
Article in Chinese | WPRIM | ID: wpr-753721

ABSTRACT

Objective To investigate the diagnostic value of non -specific diagnostic indicators for bacterial neonatal late-onset sepsis.Methods A total of 55 children with bacterial neonatal late -onset sepsis in Langfang Peopleˊs Hospital were selected as sepsis group.Another 67 cases of non-infected newborns were selected as control group.White blood cell, platelet and C -reactive protein were retrospectively analyzed for diagnostic value. Meanwhile,percentage of neutrophils and mean platelet volume were analyzed for diagnostic value .Results When the bacterial neonatal late -onset sepsis occurred, the sensitivity ( 41.8%), specificity ( 95.6%) and positive predictive value(92.0%) of C -reactive protein were high.The sensitivity (18.2%,10.9%),positive predictive value(71.4%,85.7%) of white blood cell and platelet were low ,but specificity (94%,98.5%) was high.The percentage of neutrophils [(62.01 ±22.16)] and mean platelet volume [(11.60 ±0.98)] were higher than those of the control group [(36.58 ±11.06),(10.88 ±0.95)],and the differences were statistically significant ( all P<0.05).Conclusion C-reactive protein has greater diagnostic value for bacterial neonatal late -onset sepsis.The percentage of neutrophils and mean platelet volume have some diagnostic value .

3.
Journal of China Pharmaceutical University ; (6): 157-166, 2017.
Article in Chinese | WPRIM | ID: wpr-613409

ABSTRACT

A series of 5H-benzo[b] carbazole derivatives were synthesized to find new TopⅡ inhibitors.The substitution pattern at C-9 was discussed.All 16 compounds were tested for their antiproliferative activities against 4 tumor cell lines (SMMC-7721,S1,HCT116,and HeLa) by sulforhodamine B assay.Four compounds were found to inhibit the proliferation of all tested cell lines.And compound 10e displayed the best antiproliferative activity against all 4 tested cell lines with IC50 values of 5.06,4.50,5.29,and 6.32 μmol/L,respectively.

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