Influence of natural wild honey on the cardiac muscle activity "an approach to mechanism of action". In vitro study

In this investigation, an in vitro study was performed to emphasize the mechanism of action of a natural wild honey on the heart function. The wild honey was obtained from the area of Saint Katherine Protectorate, Southern Sinai, Egypt. Isolated toad hearts were perfused with the wild honey [0.5 g/ml]. Electrocardiograms [ECGs] of the isolated toad hearts were recorded for 30 minutes. A chemical analysis of the wild honey was performed to clarify the complexity of the blend of components and to establish the relationship between the honey constituents and its mode of action. Significant bradycardia accompanied by negative dromotropism was obtained following the application of the wild honey. Neither atropine nor nicotine could abolish the previous noticed effects. A gradual and progressive increase in R-wave amplitude was also noticed, reflecting positive inotropism of the honey. The application of verapamil could abolish this effect. Substantial quantities of calcium, potassium, chlorine, sodium and magnesium were estimated in the wild honey

Cardiovascular effects of faba bean extract in mammals

Electrocardiograms [ECG] and blood pressure [BP] were recorded in both rats and rabbits to establish are effect of c crude extract of faba beans. The LD50 of the extract was found to be 5.2 gm/kg body weight in the rat and 2.7 gm/kg body weight in the rabbit. In young rats 1/2 LD50 of the extract induced brief bradycardia followed by severe tachycardia, while in adults rats, slight bradycardia was obtained. In rabbits, a negative chronotropic effect was noticed following the extract administration. This decrease in heart rate was accompanied by a significant prolongation of the QT interval and ST segment depression. Nonsignificant change in blood pressure values were obtained after the administration of the extract in both rats and rabbits. The present results suggest the myocardial ischemia mediated by a decrease in O2 concentration as a result from faba bean extract administration in rats and rabbits

Toxicity induced to perfused heart by two Cr[VI] compounds

Chromium is being used in industry for almost two decades. Since then, the adverse effects of its compounds on human health were reported. The effects of perfusion of isolated toad's heart with Potassium Mono [K2Cr2O7] were investigated. Electrocardigram [ECG] was recorded before and after application with 1ml of either solutions mM/L]. Perufsion with Monochromates resulted in server changes of the ECG parameters mainly in the heart rate [HR] which decseased significantly while conduction time [P-R], contlactile force [R] and repolarization [T] increased also significantly. Dichromate solution induced milder, nonsignificant changes. Several cases of cardiac disorders were noticed after perfusion with each of the two compounds. Monochromates had also more severe abnormalities than Dichromates. These cases were represented as different types of arrhythmias such as bradycardia, tachycardia and sinus arrhythmias. Different degrees of A-V block; 1s, 2nd and complete block were also noticed as well as S-T segment elevation or depression. The effects mentioned above indicate direct toxic effects on the heart as ischaemia and infarct. Potassium monochromate proved by have more toxic effects than dichromates on the heat