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Alzheimer's disease is a common central neurodegenerative disease， mainly manifested by cognitive impairment and non-cognitive neuropsychiatric symptoms that severely affect patients' daily life and behavioral functioning. The pathogenesis of Alzheimer's disease is still unclear， and the western medicine currently used to treat Alzheimer's disease is only symptomatic， with a single pathway， limited efficacy， and many side effects. In recent years， with the deepening of research on Alzheimer's disease， the study and application of traditional Chinese medicine （TCM） in the treatment of Alzheimer's disease have gradually increased. Several studies have shown that TCM and its effective components can exert anti-Alzheimer's disease effects by regulating molecular mechanisms such as pathological protein production and aggregation， oxidative stress， neuroinflammation， ferroptosis， mitochondrial dysfunction， neurogenesis and neurotransmission， and brain-gut axis. This paper summarized the research progress of TCM in the treatment of Alzheimer's disease in recent years， so as to provide a reference for further study of the specific mechanism of TCM in the prevention and treatment of Alzheimer's disease and the discovery of effective components of TCM.
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Objective@#To investigate the epidemiological characteristics of overseas imported dengue fever and malaria cases in Yunnan Province from 2015 to 2021, so as to provide insights into the prevention and control of overseas imported arthropod-borne infectious diseases.@*Methods@#The data pertaining to imported dengue fever and malaria cases in Yunnan Province from 2015 to 2021 were collected from the Chinese Disease Prevention and Control Information System, and the temporal distribution, regional distribution, population distribution, sources, diagnosis and treatment of imported dengue fever and malaria cases were descriptively analyzed.@*Results@#Totally 4 332 overseas imported dengue fever cases and 2 011 overseas imported malaria cases were reported in Yunnan Province form 2015 to 2021, which accounted for 30.09% of all reported dengue fever cases and 98.53% of all reported malaria cases. The number of overseas imported dengue fever and malaria cases peaked from August to November (83.13% of all imported dengue fever cases) and from April to July (59.08% of all imported malaria cases), and the cases were predominantly reported in Dehong Prefecture (50.99% and 58.88%), with farmers as the predominant occupation (40.21% and 67.93%). The dengue fever and malaria cases were mainly imported from Southeast Asia (99.04% and 88.21%), and the proportions of definitive diagnosis of dengue fever and malaria were 88.33% and 97.80% at township hospitals, respectively.@*Conclusions@#The number of overseas imported dengue fever and malaria cases peaked from August to November and from April to July in Yunnan Province from 2015 to 2021, and the cases were predominantly reported in Dehong Prefecture and imported from Southeast Asia, with farmers as the predominant occupation.
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Objective:To understand the correlation between urinary iodine, salt iodine and thyroid nodules in children aged 8 - 10 years and pregnant women in different regions of Fujian Province, and to explore the influencing factors of thyroid diseases.Methods:A cross-sectional study was conducted in Dongshan County and Pingtan County of Fujian Province from September to November 2019. According to the inclusion criteria, 140 pregnant women and 270 children aged 8 - 10 years were selected in Dongshan County, and 189 pregnant women and 368 children aged 8 - 10 years were selected in Pingtan County. Random urine and edible salt samples were collected to determine iodine content, and iodine nutrition was evaluated in each population. Thyroid was examined by B ultrasound and questionnaire survey of thyroid diseases was carried out. The correlation between urinary iodine, salt iodine and thyroid nodules in children aged 8 - 10 years and pregnant women in different regions was analyzed.Results:There were statistically significant differences in the median urinary iodine among children in different genders (male: 151.30 μg/L, female: 130.30 μg/L) and regions (Dongshan County: 160.30 μg/L, Pingtan County: 129.70 μg/L, P < 0.05); there was no significant difference in the median urinary iodine among children of different ages (8, 9, 10 years old: 141.60, 128.05, 150.30 μg/L, P > 0.05). The median urinary iodine among pregnant women was 119.30 μg/L, and there was no significant difference in median urinary iodine among pregnant women in different stages and regions ( P > 0.05). The medians of salt iodine from children and pregnant women were 20.30 and 23.65 mg/kg, respectively. Urinary iodine in children was positively correlated with salt iodine ( r = 0.13, P < 0.05). However, there was no correlation between urinary iodine and salt iodine in pregnant women ( P > 0.05). The detection rate of thyroid nodules in children was 21.79% (139/638). There was significant difference in the detection rate of thyroid nodules in children of different ages ( P < 0.05). The detection rate of thyroid nodules in pregnant women was 4.26% (14/329). There was no correlation between detection rate of thyroid nodules and urinary iodine or salt iodine in children and pregnant women ( P > 0.05). Thyroid volume of children in the two counties was within the normal range, and there was no correlation between thyroid volume and urinary iodine or salt iodine ( P > 0.05). Conclusions:The iodine nutrition of children in Dongshan County and Pingtan County is suitable (100 - 199 μg/L), while iodine deficiency (< 150 μg/L) exists in pregnant women. Urinary iodine in children is related to salt iodine, and urinary iodine increased with increase of salt iodine. The prevalence of thyroid nodules in children of different ages is different, which requires further study. The detection rate of thyroid nodules in children and pregnant women is not correlated with urinary iodine and salt iodine.
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Objective:To establish a medical reference range of serum iodine in adults with normal thyroid function in Fujian Province.Methods:Permanent residents aged 16 - 60 years old and living in the local area for 5 years and more were selected as survey subjects in three areas with appropriate iodine nutrition in Fujian Province from September 2019 to January 2020. Urine and blood samples were collected to detect urinary iodine, serum iodine and thyroid function indexes [thyroid stimulating hormone (TSH), thyroglobulin (Tg), free triiodothyronine (FT 3), free thyroxine (FT 4), total triiodothyronine (TT 3), total thyroxine (TT 4), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] levels. The percentile method was used to establish the 95% medical reference range of serum iodine in adults with normal thyroid function, and Pearson correlation analysis was used to analyze the correlation between serum iodine and thyroid function indexes in adults with normal thyroid function. Results:A total of 149 adults with normal thyroid function were examined, and the median urinary iodine was 119.45 μg/L, which was at the appropriate level (100 - 199 μg/L); serum iodine was (61.35 ± 16.20) μg/L, and the 95% medical reference range of serum iodine in adults with normal thyroid function was preliminarily formulated as 34.36 - 97.17 μg/L. Correlation analysis showed that serum iodine was positively correlated with FT 4 level ( r = 0.17, P = 0.035), but was not correlated with other thyroid function indexes ( P > 0.05). Conclusion:The medical reference range of serum iodine in adults with normal thyroid function in Fujian Province is successfully established, which provides a basis for judgment of individual iodine nutrition in adults.
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Objective:To evaluate the clinical effect of Guanxin Tongmai plaster combined with conventional western medicine in the treatment of phlegm and blood stasis syndrome of coronary heart disease and angina pectoris.Methods:A total of 60 patients in the Department of Cardiology of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (TCM) from February to August 2020 who met the inclusion criteria were randomly divided into two groups with 30 in each group. Both groups were treated with conventional western medicine. On this basis, Guanxin Tongmai plaster was applied at the acupoints in the treatment group and placebo plaster was applied in the control group. TCM syndrome score was performed before and after treatment, angina score was evaluated from three aspects of angina attack frequency, duration and pain degree, and blood lipid TG, TC, LDL-C and HDL-C were detected by enzyme quantitative method. The blood homocysteine (Hcy) was detected by enzyme circulation method, the ECG and the nitroglycerin reduction rate were recorded, and the safety index was detected according to the ECG changes.Results:In the treatment period, 2 patients in the treatment group fell off, 3 in the control group. A total of 28 patients in the treatment group and 27 in the control group were analyzed. The total effective rate of ECG efficacy in the treatment group was 67.9% (19/28) and the control group was 48.1% (13/27). There was significant difference between the two groups ( χ2=4.46, P=0.040). After treatment, the TCM syndrome score and angina score in the treatment group were significantly lower than those in the control group ( t values were 9.12 and 4.45, P values were 0.004 and 0.042, respectively). The reduction rate of nitroglycerin in the treatment group was 82.1% (23/28) and 55.6% (15/27) in the control group. There was significant difference between the two groups ( χ 2=4.72, P=0.030). After treatment, the plasma TG, TC, LDL-C in the treatment group were significantly lower than those in the control group ( t values were 4.17, 6.57 and 6.52, P<0.05 or P<0.01), the level of HDL-C was significantly higher than that of the control group ( t=7.07, P=0.010), and the level of plasma Hcy was significantly lower than that in the control group ( t=6.70, P=0.012). There was no significant difference in liver, kidney and coagulation function between the two groups. Conclusion:Guanxin Tongmai plaster combined with conventional western medicine can improve the clinical symptoms of patients with coronary heart disease and angina pectoris, reduce the level of blood lipid and Hcy, and improve the clinical curative effect.
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Objective:To understand the assessment results of external quality control of iodine deficiency disorders laboratories of centers for disease control and prevention at the three levels of province, city and county, so as to promote the improvement of testing ability of laboratories at all the three levels in Fujian Province.Methods:In 2019, iodine deficiency disorders laboratories of one provincial and nine municipal centers for disease control and prevention in Fujian Province participated in the external quality control blind sample examination of urinary iodine, salt iodine and water iodine; iodine deficiency disorders laboratories of 84 county-level centers for disease control and prevention participated in the blind sample examination of external quality control of urinary iodine and salt iodine. The external quality control assessment results were collected and analyzed by descriptive statistics.Results:The qualified rates of urinary iodine, salt iodine and water iodine in provincial and municipal iodine deficiency disorders laboratories all reached 100.0% (10/10); the qualified rate of urinary iodine in county-level iodine deficiency disorders laboratories was 96.4% (81/84), and the qualified rate of salt iodine was 100.0% (84/84).Conclusion:The overall detection capacity of provincial, municipal and county-level iodine deficiency disorders laboratories in Fujian Province remains at a high level, and the urinary iodine detection capacity of some county-level iodine deficiency disorders laboratories still needs to be improved.
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Iodine is an essential trace element for growth and development of fetus. More and more surveys currently show that the urinary iodine level of pregnant women is between 100 - 149 μg/L, which is lower than the level recommended by the World Health Organization (WHO). Under this level of iodine nutrition, different investigations have shown different effects on thyroid function of pregnant women, and the impact on growth and development of the fetus requires long-term objective evaluation. At present, there are three aspects: development, intelligence quotient (IQ), and psychological behavior. There are not many studies on comprehensive evaluation. This article combs the related published research to provide a reference for further clarifying the influence of iodine nutrition level during pregnancy on thyroid function of pregnant women and the growth and development of their offspring.
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Objective:The iodine excretion of adult individuals was calculated by two creatinine correction methods of urinary iodine, and the significance and value of the methods to measure individual iodine nutrition levels were assessed to provide a reference basis for further epidemiological investigation and study of iodine deficiency disorders.Methods:Healthy adults aged 18 - 59 years from Fujian Province were recruited and their 24 h urine, fasting urine, and morning spot urine (8:00 - 12:30) were collected and the corresponding urinary iodine and creatinine concentrations were measured. The estimated 24 h urinary iodine excretion was calculated using two different creatinine correction and creatinine estimation formulas were compared with the measured 24 h urinary iodine excretion.Results:There were no significant differences in measured 24 h urinary iodine excretion value, estimated 24 h urinary iodine excretion value 1 of fasting urine and morning spot urine, and estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine between genders (μg/d: 195.5 vs 190.9, 190.0 vs 181.7, 160.2 vs 144.2, 174.8 vs 179.2, 148.3 vs 131.5); there were no significant differences in measured 24 h urinary iodine excretion and fasting urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P > 0.05), and there were significant differences in measured 24 h urinary iodine excretion and morning spot urinary estimated 24 h urinary iodine excretion 1, estimated 24 h urinary iodine excretion 2 ( P < 0.01). And there were significant linear correlations between measured 24 h urinary iodine excretion and estimated 24 h urinary iodine excretion 1 of fasting urine and morning spot urine, estimated 24 h urinary iodine excretion 2 of fasting urine and morning spot urine ( r = 0.772, 0.266, 0.828, 0.391, P < 0.01). Conclusions:It is feasible to estimate 24 h urinary iodine excretion in adults with creatinine-corrected fasting urinary iodine concentration. Creatinine-corrected fasting urinary iodine concentration can be used as an individual iodine nutrition level evaluation index, but whether it is applicable to children and pregnant women remains to be further studied.
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Objective:To understand the epidemic situation of drinking-water-borne endemic fluorosis in Fujian Province, and to provide more information for control and evaluation of the disease.Methods:In 2019, all villages in the 36 drinking-water-borne endemic fluorosis areas in Fujian Province were selected, in which the situation of water improvement was investigated, fluorine content of drinking water was tested and dental fluorosis of all the children aged 8 to 12 was examined. The urinary fluoride content and skeletal fluorosis of people over 25-year old was investigated in some of those villages.Results:A total of 153 disease affected villages were investigated, in which the water improvement projects were all completed. The fluoride content in each tap water sample of the water improvement project ranged from 0.00 to 1.05 mg/L, and the qualified rate was 100.00% (153/153). The normal operation rate of the water improvement projects was 95.42% (146/153). The detection rate of dental fluorosis in children aged 8 to 12 was 2.72% (76/2 789) with a dental fluorosis index 0.07. The detection rate of children's dental fluorosis was statistically different in different age groups, so was it in areas with different coverage rate of water improvement projects ( P < 0.05). The geometric mean of urinary fluorine level in adults was 0.80 mg/L ( n = 3 765), and the detection rate of skeletal fluorosis was 2.00% (6/300). Conclusion:Although some achievements have been made in the prevention and control of drinking-water-borne endemic fluorosis in Fujian Province, it is still necessary to further consolidate and enhance the water improvement projects.
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There are five-year transitional period for manufacturers after the issue of regulation(EU) 2017/746 on
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European Union , Marketing , Reagent Kits, DiagnosticABSTRACT
As a member of the tumor suppressor gene inhibitor of growth (ING) family, ING4 participates in tumor growth, invasion and metastasis by affecting various cell processes such as cell cycle and apoptosis. As the most common malignant tumor of head and neck and endocrine, thyroid cancer has increased dramatically year by year, and the pathogenesis is still unclear. Its development involves the up-regulation of oncogene expression and down-regulation of tumor suppressor gene expression. In this paper, we describe the research status of ING4 and thyroid cancer by combining relevant reports and data at home and abroad.
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The implementation of mandatory iodized salt in Taiwan made a great achievements by eliminated the widespread goiter in 1970s, which is earlier than mainland China. The policy of mandatory iodized salt lasting until 2003, on which Taiwan changed its policy in accordence with the request of WTO. Iodized salt policy changed from mandatory to optional, in the aftermath of the change, the urine iodine level of citizens drop significantly that may be produce negative impact, and finally adjustments have to made. As what have happened in Taiwan, in 2017 a series of changes similar to Taiwan carried out in mailand China, but follow-up impact is lacking especially large-scale survey data. Therefore, this paper introduces Taiwan's experience in detail for reference.
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Objective:To analyze the disease burden of iodine deficiency disorders (IDD) and its changes in China in 1990 and 2016.Methods:Based on the data of Global Burden of Disease Study 2016 (GBD 2016), a descriptive statistical method was used to compare and analyze the changes of deaths number, mortality, disability adjusted life year [DALY, including years of life lost (YLL) and years lived with disability (YLD)], DALY rate and other disease burden indicators caused by IDD in China in 1990 and 2016.Results:The GBD 2016 data showed that the deaths number from IDD in China decreased from 259.31 in 1990 to 116.41 in 2016, the mortality decreased from 0.022 827/100 000 in 1990 to 0.008 515/100 000 in 2016; and the mortality in different age groups had decreased, the children mortality in the < 5 years old group had decreased from 0.088 639/100 000 to 0.009 875/100 000. The DALY and YLD due to IDD in China increased from 406.13 thousand person-years and 391.68 thousand person-years in 1990 to 455.05 thousand person-years and 451.95 thousand person-years in 2016, while YLL decreased from 14.45 thousand person-years to 3.10 thousand person-years; the DALY rate, YLL rate, and YLD rate decreased from 35.75 person-years per 100 000, 1.27 person-years per 100 000 and 34.48 person-years per 100 000 in 1990 to 33.29 person-years per 100 000, 0.23 person-years per 100 000 and 33.06 person-years per 100 000 in 2016. The main component of DALY for IDD was YLD, and the proportion increased from 96.44% in 1990 to 99.32% in 2016.Conclusions:The mortality of IDD in China has decreased, and IDD in the younger age group has been effectively controlled; however, the disease burden, especially the burden caused by disability has increased, and the disability of the population due to IDD should be given special attention.
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Objective:To investigate the iodine nutritional status among children aged from 8 - 10 and pregnant women in Xiamen City before and after adjustment of salt iodine concentration, and scientifically evaluate the suitability of the new standard iodized salt adjustment policy for Xiamen City.Methods:In the pre-adjustment period (2011) and the post-adjustment period (2018), cross-sectional research methods and stratified cluster sampling methods were adopted in six districts of Xiamen City. The salt samples of residents and pregnant women, urine samples of children aged from 8 - 10 and pregnant women were collected to determine the iodine level; thyroid of children aged from 8 - 10 was examined. Changes in salt iodine, urine iodine and goiter prevalence before and after adjusting iodine content of salt were compared.Results:The median of salt iodine in residents after the adjustment (23.5 mg/kg) was significantly lower than that of before (28.9 mg/kg, Z = - 10.512, P < 0.05), the median of salt iodine in pregnant women after the adjustment (23.7 mg/kg) was significantly lower than that of before (29.2 mg/kg, Z = - 12.622, P < 0.05); the consumption rate of qualified iodized salt in residents after the adjustment (95.7%, 1 196/1 250) was significantly lower than that of before (97.1%, 1 608/1 656; χ 2 = 4.250, P < 0.05); before and after adjustment of salt iodine concentration, the consumption rate of qualified iodized salt in pregnant women was 94.7% (124/131) and 95.9% (579/604), respectively. No significant difference was found when comparing the consumption rate of qualified iodized salt in pregnant women (χ 2 = 0.015, P > 0.05). There was significant difference in median urinary iodine (from 204.2 to 183.9 μg/L, detected in 652, 1 250 urine samples, respectively) of children aged 8 - 10 years ( Z = - 3.583, P < 0.05); the difference of iodine nutritional status in pregnant women before and after adjustment of salt iodine concentration(130.2, 130.8 μg/L, detected in 132, 604 urine samples, respectively) was not significant ( Z = - 1.715, P > 0.05). The thyroid goiter rate of children aged 8 - 10 years had reduced from 1.1% (14/1 239) to 0.2% (2/1 253), the difference was statistically significant (χ 2 = 9.195, P < 0.05). Conclusions:As a whole, the measure of control and prevention of iodine deficiency disorders through iodized salt is implemented well in Xiamen City. After adjustment of salt iodine concentration, the iodine status of children aged from 8 to 10 is adequate, but the pregnant women has showed iodine deficiency.
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Objective To analyze the iodine nutritional status among pregnant women,breasffeeding women,0-2 years old infants,8-10 years old children,18-45 years old women and men in both urban and rural areas of Xiamen 3 years after promotion of new standard iodized salt.Methods The Huli and Xiang'an were selected as the urban and rural study sites in Xiamen City,from March 2015 to March 2016.Each study site was further divided into five geographic locations (east,south,west,north and center).In each location,one township was randomly selected.In each town,2 tap water samples,60 salt samples of residents,and urine samples of 40 children aged from 8-10 years old,20 pregnant women,12 breastfeeding women,0-2 years old infants,18-45 years old women and men were collected to determine the iodine level.The water iodine and urinary iodine were detected by arsenic cerium catalytic spectrophotometry;salt iodine was detected by direct titration.Results The medians of salt iodine in urban and rural were 23.0 and 25.3 μg/L,respectively.The coverage rates of iodized salt in urban and rural area were 99.3％ (298/300) and 94.0％ (282/300),respectively.The consumption rates of qualified iodized salt were 93.7％ (281/300) and 90.7％ (272/300),respectively.The medians of tap water iodine in urban and rural were 4.1 and 4.4 μg/L,respectively.In urban and rural areas,the medians of urinary iodine of pregnant women were 167.6 and 119.6 μg/L,respectively.The medians of urinary iodine of breastfeeding women were 121.6 and 101.2 μg/L,respectively.The medians of urinary iodine of infants were 165.9 and 110.5 μg/L,respectively.The medians of urinary iodine of children were 208.9 and 167.2 μg/L,respectively.The medians of urinary iodine of women aged 18-45 were 132.5 and 154.5 μg/L,respectively.The medians of urinary iodine of men aged 18-45 were 131.7 and 154.5 μg/L,respectively.Conclusions After 3 year promotion of new standard iodized salt,the iodine status of pregnant women in urban,breastfeeding women,0-2 years old infants,children aged 8 to 10 and adults aged 18 to 45 is adequate,but the pregnant women in rural has showed iodine deficiency.So surveillance and health education should be continuously strengthened in the future.Scientific salt iodization should continue to ensure the amount of iodine intake.
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The health-related quality of life (HRQoL) is the individual subjective evaluation of disease and treatment on their physical, mental and social health status, and is an important part of health and medical services.Chronic kidney disease (CKD) is a kind of diseases that has lasted for more than 3 months of abnormal renal structure or function.It is one of the diseases that seriously affect children′s HRQoL.This article reviews the emergence, development, evaluation tools of children′s HRQoL and its application in the field of nephrology.
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Objective To understand the iodine nutritional status of children aged 8 to 10 years old and pregnant women in the new standard iodized salt pilot areas of Fujian Province,and to analyze the rationality of urine specific gravity correction for urinary iodine.Methods In the 3rd,6th,9th,12th,15th and 21th months after supplying of new standard iodized salt in March 2012,the first to sixth phases' assessment were conducted in Xindian Town of Xiang'an District,Xiamen City and Yongfu Town,Xinqiao Town of Zhangping City,Longyan City.Totally 200 children aged 8 to 10 years old and 50 pregnant women were selected from each town,home salt samples and urine samples were collected,salt iodine,urinary iodine and urine specific gravity were tested.Salt iodine was detected by "General Test Method in Salt Industry-Determination of Iodine" (GB/T 13025.7-2012);urinary iodine was detected by "Method for Determination of Iodine in Urine by As3+-Ce4+ Catalytic Spectrophotometry" (WS/T 107-2006);urine specific gravity was detected by digital refractometer.Results From the first to sixth phases' assessment,the iodized salt coverage rates of children aged 8 to 10 years old and pregnant women were ＞ 95％,the edible rates of qualified iodized salt were ＞ 90％.The measured medians of urinary iodine of children aged 8 to 10 years old were 216.7,219.5,188.1,206.7,209.2,and 201.0 μg/L,respectively;except the third phase's assessment,which was in the iodine appropriate level (100-199 μg/L),the other five phases/ assessment were all higher than the iodine appropriate level (200-299 μg/L);the medians of urinary iodine of children aged 8 to 10 yearsold after urine specific gravity correction were 215.0,213.6,197.3,202.9,204.3,and 197.7 μg/L,respectively;there were no significant differences in urinary iodine between the measured and urine specific gravity correction (Z =-0.131,-0.183,-1.052,-1.180,-0.311,-0.368,P ＞ 0.05).The measured medians of urinary iodine of pregnant women were 134.0,132.2,120.9,115.6,113.3,and 123.3 μg/L,respectively,which were in the iodine deficiency level (＜ 150 μg/L);the medians of urinary iodine of pregnant women after urine specific gravity correction were 207.3,197.1,168.8,158.3,171.8,and 181.7 μg/L,respectively;there were significant differences in urinary iodine between the measured and urine specific gravity correction (Z =-6.419,-6.406,-5.990,-6.648,-7.008,-8.034,P ＜ 0.01).Conclusions The iodine nutrition of children aged 8 to 10 years old is appropriate in the new standard iodized salt pilot areas of Fujian Province,while that of pregnant women is mild iodine deficiency.Further research is needed to use urine specific gravity to calibrate the concentration of urinary iodine to assess the iodine nutritional level of the focused populations in the regions.
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Objective To validate a developing method for determination of iodine in serum by inductively coupled plasma mass spectrometry (ICP-MS).Methods Ammonium chloride,ethanolamine,ascorbic acid and water were mixed at a certain ratio,adding ethanol as sensitization,to dilute samples in the ratio of 1 ∶ 20,and then the diluted samples were analyzed by ICP-MS.Re was used as the internal standard.Serum samples were from 8 different individuals.After combining,they were divided into 4 groups,control group and low,medium and high iodine groups.Iodine groups were added with potassium iodide (100 mg/L),iodine standard solution 1.5,9.0,15.0 μl.The methodological evaluation of this method was done through standard curve linearity,sample detection limit,precision,recovery and accuracy in determining biological sample.And the results were compared with the current serum iodine arsenic cerium catalytic spectrophotometry standard method (WS/T 572-2017).Results The linear range of the calibration curve was 0-300 μg/L and the linear correlative coefficients of the standard curve were 0.999 8-1.000 0.The detection limit was 0.38 μg/L (the sample amount was 0.2 ml).The coefficients of variation (CV) were all below 2％ for 4 serum samples in precision.The recovery rate was in a range of 95.8％-108.5％.No significant difference was found between the results of the 15 serum samples determined by the standard method andthis new method (t =1.139,P ＞ 0.05).Conclusions The newly developed method in determination of iodine in serum by ICP-MS,has wide linear range,high sensitivity,good precision,and wide applicability.It is suitable for application in determining serum iodine.
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Objective To understand the effects of salt iodine content adjustment on iodine nutritional status of residents in Fujian Province.Methods In 2009 (before the adjustment) and 2014 (after the adjustment),cross-sectional research methods and stratified cluster sampling methods were adopted,17 and 19 survey sites (residential committees and villages) were selected,respectively.At each survey site,20 adults,30 pregnant women,30 lactating women and 50 children (8-10 years old) were selected in 2009;50 adults,50 pregnant women,50 lactating women and 100 children (8-10 years old) were selected in 2014.Random urine samples in one day were collected,and the urinary iodine content was measured by "the Arsenic and Cerium Catalyzed Spectrophotometric Method" (WS/T 107-2006).The results of before and after the adjustment were compared and iodine nutrition was evaluated.Results Before and after adjustment of salt iodine content,the urinary iodine median of children and adults was 208.7,202.8,163.0 and 157.6 μg/L,respectively,and after the adjustment,the iodine nutrition was at the appropriate level (100-199 μg/L).The urinary iodine median of lactating women was 128.9 and 107.4 μg/L before and after the adjustment,iodine nutrition was at an appropriate level (≥ 100 μg/L).The urinary iodine median of pregnant women was 149.2 and 124.0 μg/L before and after the adjustment,which were deficient (＜ 150 μg/L).Conclusion After down-regulating the iodized salt content,the iodine nutrition of the general residents in Fujian Province is basically at an appropriate level,and pregnant women have different levels of iodine deficiency.
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Objective To establish reference values for thyroid hormone in school-age children in iodineadequate nutrition areas.Methods Totally 128 8-10-year-old healthy children (male:62,female:66) were screened rigorously in iodine-adequate nutrition areas (median of urinary iodine:100-200 μg/L).The values of total triiodothyronine (TT3) total thyroxine (TT4) free triiodothyronine (FT3),free thyroxine (FT4),thyrotropin (TSH）,thyroglobulin (Tg),thyroid peroxidase antibody (TPOAb),and thyroglobulin antibody (TgA) in serum were determined through the Access 2 Immunoassay System (Beckman-Coulter,USA) using a chemiluminescence detection system.Results Normal reference ranges for thyroid function indicators in children (95％ confidence limit) of TT3,TT4,FT3,FT4,TSH,and Tg were 1.63-3.36 nmol/L,110.65-186.67 nmol/L,4.65-7.25 pmol/L,9.75-15.59 pmol/L,1.10-5.54 mU/L,and 3.75-36.27 μg/L,respectively.There was no significant difference in hormone levels between boys and girls (P ＞ 0.05).The thyroid function indices were substantially different between children and adults.Conclusions Normal reference range of thyroid function index of children is different from that of adults.It is necessary to establish the reference range of thyroid function indices for children in order to diagnose thyroid diseases and monitor iodine nutrition.