Sesgos cognitivos en el dolor crónico no oncológico / Cognitive biases in chronic non-cancer pain

Los sesgos cognitivos son un constructo que acuñaron Kahneman & Tveysky (1972) en su Enfoque de Sesgos dentro de la Psicología Cognitiva. Estos son atajos intelectuales que realizan siempre las personas, desde un razonamiento probabilístico intuitivo. El presente trabajo es una primera aproximación que intenta aplicar y describir algunos sesgos cognitivos en el complejo mundo de las representaciones mentales en la experiencia dolorosa, como la ilusión de control; del presente; la confirmación; representatividad; disponibilidad, entre otros. Los sesgos en dolor nos permiten comprender el procesamiento de información frente al dolor y utilizar estrategias comunicacionales más efectivas para su abordaje.

Cognitive biases are a construct coined by Kahneman & Tveysky (1972) in their Approach to Biases in Cognitive Psychology. These are intellectual shortcuts that people always carry out, from an intuitive probabilistic reasoning. An attempt is made to apply and describe some cognitive biases in the complex world of mental representations in the painful experience, like the illusion of control; of the present; the confirmation; representativeness; availability among others. Biases in pain allow us to understand the processing of information in the face of pain and use more effective communication strategies to address it.

Atajos heurísticos en las decisiones políticas

R E S U M E N Las ciencias cognitivas, en especial la psicología y la neurociencia social en los últimos años han ofrecido gracias a los avances investigativos del cerebro y a las técnicas no invasivas de neuroimagen métodos novedosos para comprender los mecanismos neurobiológicos subyacentes a la toma de decisiones. Por tanto, en este documento, se busca entender y comprender en qué medida los atajos heurísticos contribuyen a la toma de decisiones políticas, al contrastar los diferentes atajos mentales y sesgos cognitivos que asumen lo votantes a la hora de elegir candidatos o partidos políticos.

R E S U M O As ciências cognitivas, especialmente a psicologia e as neurociências sociais, têm nos últimos anos oferecido novos métodos para a compreensão dos mecanismos neurobiológicos subjacentes à tomada de decisões graças aos avanços na investigação cerebral e às técnicas de neuroimagem não invasivas. Portanto, este artigo procura compreender até que ponto os atalhos heurísticos contribuem para a tomada de decisões políticas, contrastando os diferentes atalhos mentais e os preconceitos cognitivos que os eleitores assumem quando escolhem candidatos ou partidos políticos.

A B S T R A C T Cognitive sciences, especially psychology and social neuroscience, have offered in recent years, thanks to advances in brain research and non-invasive neuroimaging techniques, novel methods to understand the neurobiological mechanisms underlying decision making. Therefore, this paper seeks to understand the extent to which heuristic shortcuts contribute to political decision making, by contrasting the different mental shortcuts and cognitive biases assumed by voters when choosing candidates or political parties.

Estudios de corte transversal: un diseño de investigación a considerar en ciencias morfológicas / Cross section studies: a research design to consider in morphological sciences

Los estudios de corte transversal (ECT) inician en la década de los 40 en países Europeos. Los ECT corresponden a investigaciones de tipo observacional que permiten estudiar prevalencia de enfermedad, determinar asociación entre variables y el desarrollo de un efecto de interés, conocer propiedades de una prueba diagnóstica, y censar poblaciones; describiendo las características de una población en un momento y lugar determinado. Esto implica, que no se requieren periodos de seguimiento, que no son prospectivos ni retrospectivos; características que permiten que sean más baratos y fáciles de realizar en relación a los estudios longitudinales. Por otro lado, al ser de carácter descriptivo sirven como insumo y evidencia preliminar para estudios de mayor complejidad metodológica, como estudios de cohortes. Sin embargo, tienen limitantes y sesgos que deben ser considerados por los investigadores. El objetivo de este manuscrito fue generar un documento de estudio para revisar características esenciales, fortalezas y debilidades; discutir cuestiones metodológicas de los ECT en ciencias de la salud; y proporcionar algunos ejemplos obtenidos de la literatura, para mejor comprensión del diseño.

SUMMARY: Cross-sectional studies (CSS) began European countries in the 1940s in. The CSSs correspond to observational-type investigations that allow studying the prevalence of disease, determining the association between variables and the development of an effect of interest, discovering the properties of a diagnostic test, and censusing populations, describing the characteristics of a population at a given time and place. This implies that follow-up periods are not required, and that they are neither prospective nor retrospective. These characteristics allow them to be cheaper and easier to perform in relation to longitudinal studies. On the other hand, being descriptive in nature, they serve as input and preliminary evidence for studies of greater methodological complexity, such as cohort studies. However, they have limitations and biases that must be considered by researchers. The aim of this manuscript was to generate a study document to review essential characteristics, strengths and weaknesses; discuss methodological issues of ECT in health sciences; and provide some examples obtained from the literature, for a better understanding of the design.

Stoichioproteomics study of differentially expressed proteins and pathways in head and neck cancer / Estudo estequioproteômico de proteínas e vias expressas diferencialmente no câncer de cabeça e pescoço

Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project. Then compared the oxygen and carbon element contents between proteomes of head and neck cancer and normal oral mucosa-squamous epithelial cells, genome locations, pathways, and functional dissection associated with head and neck cancer were also studied. A total of 902 differentially expressed proteins were observed where the average oxygen content is higher than that of the lowly expressed proteins in head and neck cancer proteins. Further, the average oxygen content of the up regulated proteins was 2.54% higher than other. None of their coding genes were distributed on the Y chromosome. The up regulated proteins were enriched in endocytosis, apoptosis and regulation of actin cytoskeleton. The increased oxygen contents of the highly expressed and the up regulated proteins might be caused by frequent activity of cytoskeleton and adapted to the rapid growth and fast division of the head and neck cancer cells. The oxygen usage bias and key proteins may help us to understand the mechanisms behind head and neck cancer in targeted therapy, which lays a foundation for the application of stoichioproteomics in targeted therapy and provides promise for potential treatments for head and neck cancer.

A hipóxia é uma característica proeminente do câncer de cabeça e pescoço. No entanto, as características do elemento oxigênio das proteínas e como elas se adaptam aos microambientes de hipóxia do câncer de cabeça e pescoço ainda são desconhecidas. Sequências do genoma humano e dados expressos de proteínas de câncer de cabeça e pescoço foram recuperados do atlas de patologia do projeto Human Protein Atlas. Em seguida, comparou o conteúdo do elemento de oxigênio e carbono entre proteomas de câncer de cabeça e pescoço, e células epiteliais escamosas da mucosa oral normal, localizações do genoma, vias e dissecção funcional associada ao câncer de cabeça e pescoço também foram estudadas. Um total de 902 proteínas expressas diferencialmente foi observado onde o conteúdo médio de oxigênio é maior do que as proteínas expressas de forma humilde em proteínas de câncer de cabeça e pescoço. Além disso, o conteúdo médio de oxigênio das proteínas reguladas positivamente foi 2,54% maior do que das outras. Nenhum de seus genes codificadores foi distribuído no cromossomo Y. As proteínas reguladas positivamente foram enriquecidas em endocitose, apoptose e regulação do citoesqueleto de actina. O conteúdo aumentado de oxigênio das proteínas altamente expressas e reguladas pode ser causado pela atividade frequente do citoesqueleto e adaptado ao rápido crescimento e divisão das células cancerosas de cabeça e pescoço. O viés do uso de oxigênio e as proteínas-chave podem nos ajudar a entender os mecanismos por trás do câncer de cabeça e pescoço na terapia direcionada, o que estabelece uma base para a aplicação da estequioproteômica na terapia direcionada e oferece uma promessa para potenciais tratamentos para o câncer de cabeça e pescoço.

Stoichioproteomics study of differentially expressed proteins and pathways in head and neck cancer

Abstract Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project. Then compared the oxygen and carbon element contents between proteomes of head and neck cancer and normal oral mucosa-squamous epithelial cells, genome locations, pathways, and functional dissection associated with head and neck cancer were also studied. A total of 902 differentially expressed proteins were observed where the average oxygen content is higher than that of the lowly expressed proteins in head and neck cancer proteins. Further, the average oxygen content of the up regulated proteins was 2.54% higher than other. None of their coding genes were distributed on the Y chromosome. The up regulated proteins were enriched in endocytosis, apoptosis and regulation of actin cytoskeleton. The increased oxygen contents of the highly expressed and the up regulated proteins might be caused by frequent activity of cytoskeleton and adapted to the rapid growth and fast division of the head and neck cancer cells. The oxygen usage bias and key proteins may help us to understand the mechanisms behind head and neck cancer in targeted therapy, which lays a foundation for the application of stoichioproteomics in targeted therapy and provides promise for potential treatments for head and neck cancer.

Resumo A hipóxia é uma característica proeminente do câncer de cabeça e pescoço. No entanto, as características do elemento oxigênio das proteínas e como elas se adaptam aos microambientes de hipóxia do câncer de cabeça e pescoço ainda são desconhecidas. Sequências do genoma humano e dados expressos de proteínas de câncer de cabeça e pescoço foram recuperados do atlas de patologia do projeto Human Protein Atlas. Em seguida, comparou o conteúdo do elemento de oxigênio e carbono entre proteomas de câncer de cabeça e pescoço, e células epiteliais escamosas da mucosa oral normal, localizações do genoma, vias e dissecção funcional associada ao câncer de cabeça e pescoço também foram estudadas. Um total de 902 proteínas expressas diferencialmente foi observado onde o conteúdo médio de oxigênio é maior do que as proteínas expressas de forma humilde em proteínas de câncer de cabeça e pescoço. Além disso, o conteúdo médio de oxigênio das proteínas reguladas positivamente foi 2,54% maior do que das outras. Nenhum de seus genes codificadores foi distribuído no cromossomo Y. As proteínas reguladas positivamente foram enriquecidas em endocitose, apoptose e regulação do citoesqueleto de actina. O conteúdo aumentado de oxigênio das proteínas altamente expressas e reguladas pode ser causado pela atividade frequente do citoesqueleto e adaptado ao rápido crescimento e divisão das células cancerosas de cabeça e pescoço. O viés do uso de oxigênio e as proteínas-chave podem nos ajudar a entender os mecanismos por trás do câncer de cabeça e pescoço na terapia direcionada, o que estabelece uma base para a aplicação da estequioproteômica na terapia direcionada e oferece uma promessa para potenciais tratamentos para o câncer de cabeça e pescoço.

Stoichioproteomics study of differentially expressed proteins and pathways in head and neck cancer / Estudo estequioproteômico de proteínas e vias expressas diferencialmente no câncer de cabeça e pescoço

Abstract Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project. Then compared the oxygen and carbon element contents between proteomes of head and neck cancer and normal oral mucosa-squamous epithelial cells, genome locations, pathways, and functional dissection associated with head and neck cancer were also studied. A total of 902 differentially expressed proteins were observed where the average oxygen content is higher than that of the lowly expressed proteins in head and neck cancer proteins. Further, the average oxygen content of the up regulated proteins was 2.54% higher than other. None of their coding genes were distributed on the Y chromosome. The up regulated proteins were enriched in endocytosis, apoptosis and regulation of actin cytoskeleton. The increased oxygen contents of the highly expressed and the up regulated proteins might be caused by frequent activity of cytoskeleton and adapted to the rapid growth and fast division of the head and neck cancer cells. The oxygen usage bias and key proteins may help us to understand the mechanisms behind head and neck cancer in targeted therapy, which lays a foundation for the application of stoichioproteomics in targeted therapy and provides promise for potential treatments for head and neck cancer.

Resumo A hipóxia é uma característica proeminente do câncer de cabeça e pescoço. No entanto, as características do elemento oxigênio das proteínas e como elas se adaptam aos microambientes de hipóxia do câncer de cabeça e pescoço ainda são desconhecidas. Sequências do genoma humano e dados expressos de proteínas de câncer de cabeça e pescoço foram recuperados do atlas de patologia do projeto Human Protein Atlas. Em seguida, comparou o conteúdo do elemento de oxigênio e carbono entre proteomas de câncer de cabeça e pescoço, e células epiteliais escamosas da mucosa oral normal, localizações do genoma, vias e dissecção funcional associada ao câncer de cabeça e pescoço também foram estudadas. Um total de 902 proteínas expressas diferencialmente foi observado onde o conteúdo médio de oxigênio é maior do que as proteínas expressas de forma humilde em proteínas de câncer de cabeça e pescoço. Além disso, o conteúdo médio de oxigênio das proteínas reguladas positivamente foi 2,54% maior do que das outras. Nenhum de seus genes codificadores foi distribuído no cromossomo Y. As proteínas reguladas positivamente foram enriquecidas em endocitose, apoptose e regulação do citoesqueleto de actina. O conteúdo aumentado de oxigênio das proteínas altamente expressas e reguladas pode ser causado pela atividade frequente do citoesqueleto e adaptado ao rápido crescimento e divisão das células cancerosas de cabeça e pescoço. O viés do uso de oxigênio e as proteínas-chave podem nos ajudar a entender os mecanismos por trás do câncer de cabeça e pescoço na terapia direcionada, o que estabelece uma base para a aplicação da estequioproteômica na terapia direcionada e oferece uma promessa para potenciais tratamentos para o câncer de cabeça e pescoço.

Differences in decisions affected by cognitive biases: examining human values, need for cognition, and numeracy

Abstract A better understanding of factors that can affect preferences and choices may contribute to more accurate decision-making. Several studies have investigated the effects of cognitive biases on decision-making and their relationship with cognitive abilities and thinking dispositions. While studies on behaviour, attitude, personality, and health worries have examined their relationship with human values, research on cognitive bias has not investigated its relationship to individual differences in human values. The purpose of this study was to explore individual differences in biased choices, examining the relationships of the human values self-direction, conformity, power, and universalism with the anchoring effect, the framing effect, the certainty effect, and the outcome bias, as well as the mediation of need for cognition and the moderation of numeracy in these relationships. We measured individual differences and within-participant effects with an online questionnaire completed by 409 Brazilian participants, with an age range from 18 to 80 years, 56.7% female, and 43.3% male. The cognitive biases studied consistently influenced choices and preferences. However, the biases showed distinct relationships with the individual differences investigated, indicating the involvement of diverse psychological mechanisms. For example, people who value more self-direction were less affected only by anchoring. Hence, people more susceptible to one bias were not similarly susceptible to another. This can help in research on how to weaken or strengthen cognitive biases and heuristics.

Serie investigación cómo leer y generar publicaciones científicas sesgos cognitivos. Una trampa del pensamiento / Cognitive biases. A thought trap

Los sesgos cognitivos son fallas en el razonamiento que pueden alterar los resultados de la investigación. Se presenta brevemente la historia de éstos y ejemplos para facilitar la comprensión y la reflexión en torno a esta "trampa del pensamiento".

Cognitive biases are flaws in reasoning that can alter research outcomes. The history of these biases is briefly presented, along with examples to facilitate understanding and reflection on this 'thinking trap'."

Trastorno límite de la personalidad (TLP), experiencias adversas tempranas y sesgos cognitivos: una revisión sistemática

Introducción: La investigación actual y los artículos rastreados sobre adversidad temprana y sesgos cognitivos en pacientes con trastorno límite de la personalidad (TLP) evidencian la relación entre estas variables y la gravedad de los síntomas clínicos de este trastorno. Objetivo: Revisar sistemáticamente la evidencia de la relación entre adversidad temprana, sesgos cognitivos y agudización de los síntomas del TLP. El vacío investigativo tiene que ver con el tipo específico de adversidad temprana y su relación con el tipo específico de sesgos cognitivos y el curso del TLP de pacientes con este diagnóstico. Metodología: Se realizó una revisión sistemática de la literatura y para reportar la evidencia se utilizó la versión 2020 de la declaración Prisma. Las bases de datos consultadas fueron Scopus, Pubmed, Web of Science y PsycInfo. En la búsqueda también se incluyeron bases de datos de literatura gris como Google Académico, Open Gray y WorldCat. Resultados: En total se incluyeron en el estudio 13 artículos que satisficieron criterios de originalidad, temática estudiada (adversidad temprana, funcionamiento cognitivo y sintomatología límite) y población indicada (pacientes con diagnóstico de TLP). Conclusiones: Si bien existe evidencia de que la adversidad temprana en general es un factor de riesgo para el TLP, se necesita más investigación para comprender los tipos específicos de adversidad que pueden estar más fuertemente relacionados con el desarrollo del TLP. Si bien algunos estudios han identificado sesgos cognitivos en individuos con TLP, poco se conoce sobre el modo en que estos sesgos se desarrollan y cambian con el tiempo, o según la etapa de exposición del paciente a la adversidad temprana.

Introduction: Current research and articles on early adversity and cognitive biases in patients with borderline personality disorder (BPD) demonstrate the relationship between these variables and the severity of the clinical symptoms of this disorder. Objective: The aim was to systematically review the evidence of the relationship between early adversity, cognitive biases, and exacerbation of symptoms of borderline personality disorder. The research gap concerns the particular type of early adversity and its relationship with the specific type of cognitive biases and the course of BPD in patients with this diagnosis. Methodology: We conducted a systematic literature review, and the Prisma statement version 2020 was used to report the evidence. The databases consulted were Scopus, Pubmed, Web of Science, and PsycInfo. Gray literature databases, such as Google Scholar, Open Gray, and WorldCat, were also included in the search. Results: We included 13 articles in the study that met the criteria for originality, studied theme (early adversity, cognitive functioning, and borderline symptomatology), and target population (patients diagnosed with a personality disorder). Conclusions: We found that while there is evidence that early adversity, in general, is a risk factor for BPD, further research is needed to understand the specific types of adversity that may be more strongly related to the development of BPD. In addition, although some studies have identified cognitive biases in individuals with BPD, little is known about how these biases develop and change over time or according to the stage of the patient's exposure to early adversity.

Principales sesgos en la investigación epidemiológica en salud ocupacional / Main biases in epidemiological research in occupational health

El objetivo de este documento es mostrar una síntesis de los principales sesgos que pueden aparecer en el estudio de la salud del trabajo, sus orígenes y consecuencias. Para ello, se realizó una revisión documental de libros y artículos publicados en los últimos 10 años en inglés y español. Se dejó fuera aquellos documentos que no estuvieran publicados en revistas con comité editorial y en caso de los libros, que no tuvieran registro ISBN. Se incluyeron 7 libros y 14 artículos. Un sesgo es un error sistemático, que sucede en el proceso de investigación y que pueden darse durante la planeación, recolección y procesamiento de datos. Se revisarán dos tipos principales de sesgos: 1) Selección y 2) Información y/o medición, en cada caso se describe la definición, potencial impacto en los resultados y se plantean una serie de ejemplos que ayudan a su compresión. Uno de los efectos principales de la presencia de sesgos en investigación es que ocasiona un error de clasificación en los participantes, que puede ser diferencial o no, esto impacta los resultados al sobre o subestimarlos, en otras palabras, se encuentran efectos mayores a los reales o peor, no los encontramos cuando si existen. Para ilustrar el impacto de los sesgos, se revisan distintos escenarios que ejemplifican los casos de sobreestimación y subestimación que originan resultados poco confiables(AU)

This document aims to show a synthesis of the main biases that can be present in occupational health studies, their origins and their consequences. For this purpose, a documentary review was conducted of books and articles published in the last 10 years in English and Spanish. Excluding those documents that were not published in journals with an editorial board and, in the case of books, that did not have an ISBN registry. A total of 7 books and 14 articles were included. A bias is a systematic error that occurs in the research process and can occur during the data planning, collection, and processing. Two main types of biases will be reviewed: 1) Selection and 2) Information and/or measurement biases, in each case their definition and, their possible impact on the results are described, a series of examples that may help to understand them are provided. One of the main effects of the presence of biases in research is that they cause an error in the classification of participants, which can be differential or not, and this has an impact on the results by overestimating or underestimating them, i.e., finding stronger effects than the real ones, or worse, not finding them when they exist. To illustrate the impact of biases, different scenarios were reviewed that provide examples of cases of overestimation and underestimation that lead to unreliable results(AU)

Serie de Redacción Científica: Estudio de Casos y Controles / Scientific Writing Series: Case-Control studies

Introducción: Un estudio de casos y controles es un estudio en el que se compara individuos que tuvieron un desenlace de interés o outcome (casos) versus individuos que no tuvieron dicho resultado (controles) con respecto a la exposición de interés, potencialmente un "factor de riesgo" o "factor de protección". El objetivo de un estudio de casos y controles es primariamente determinar si existe asociación entre una exposición (o varias) y un desenlace de interés. Esta asociación debe ser cuantificada y reportada como un odds ratio o razón de momios teniendo en cuenta sus fortalezas y limitaciones. En general, este tipo de estudios ofrece como ventajas su relativo bajo costo y rapidez con la que es posible realizarlos. Sin embargo, no son idóneos si lo que se quiere investigar son desenlaces de interés frecuente o con periodos de latencia largos. En el presente artículo se han revisado las principales consideraciones metodológicas del diseño de los estudios de casos y controles esperando con ello contribuir objeto de promover su correcta utilización e interpretación.

Introduction: A case-control study is a study comparing individuals who had an outcome of interest (cases) versus individuals who had no such outcome (controls) with respect to the exposure of interest, potentially a "risk factor "or" protection factor." The objective of a case-control study is primarily to determine if there is an association between one exposure (or several) and an outcome of interest. This association must be quantified and reported as an odds ratio or odds ratio taking into account its strengths and limitations. In general, this type of study offers as advantages its relatively low cost and speed with which it is possible to carry them out. However, they are not ideal if what you want to investigate are frequent outcomes or with long latency periods. In this article, the primary methodological considerations of the design of case-control studies have been reviewed, hoping thereby to contribute to promoting their correct use and interpretation.

Effect of personality on compound reasoning / Efecto de la personalidad en el razonamiento compuesto

Abstract Objective :This study aims to describe the relationship between personality and propositional reasoning regarding compound negations by using, in particular, De Morgan's laws. Method :To evaluate personality traits, we used the Adjective Checklist for Personality Assessment, an instrument based on the Big Five theory and developed for the Argentine context. To assess reasoning, we used a task implemented in previous studies, according to which subjects had to find the logical equivalent of a compound negation. Four response options were offered: one was correct and the other three were linked to specific biases. Both the research study and the paradigm were developed on the basis of the Mental Models Theory of Negation. The study had a correlational design and included 150 university students. Results :We found that factors such as neuroticism, extraversion, and agreeableness were linked to specific response patterns. Difficulty and context were considered mediators of the process. Discussion :The evidence was compatible with the Mental Models Theory but inconsistent with theories based on formal rules.

Resumen Objetivo: el propósito de este estudio es describir la relación entre personalidad y razonamiento proposicional sobre negaciones compuestas, de forma particular aplicado a las leyes De Morgan. Método :para evaluar los rasgos de personalidad se utilizó el Listado de Adjetivos para Evaluar Personalidad, un instrumento basado en la Teoría de los Cinco Factores desarrollado para el medio Argentino. En el caso del razonamiento, se aplicó una tarea utilizada en estudios previos, en la cual el sujeto debía encontrar el equivalente lógico de una negación compuesta. Se ofrecieron cuatro opciones de respuesta, una correcta y tres ligadas a sesgos específicos. Tanto la investigación como el paradigma, fueron diseñados desde la Teoría de Modelos Mentales propuesta para la negación. El estudio fue de tipo correlacional, y participaron del mismo 150 estudiantes universitarios. Resultados :se encontró que los factores de Neuroticismo, Extraversión y Amabilidad estaban ligados a patrones de respuestas específicos. La dificultad y el contexto fueron considerados mediadores del proceso. Discusión :la evidencia resultó compatible con la Teoría de Modelos Mentales pero inconsistente respecto de las teorías basadas en reglas formales.

Sesgo Cognitivo de Optimismo y Percepción de Bienestar en una Muestra de Universitarios Ecuatorianos / Cognitive Bias of Optimism and Perception of Wellbeing in a Sample of Ecuadorian University Students / Viés Cognitivo de Otimismo e Percepção de Bem-Estar em uma Amostra de Universitários Equatorianos

Resumen El propósito de esta investigación fue determinar la relación del sesgo cognitivo de optimismo en el bienestar subjetivo y psicológico en una muestra de universitarios del Ecuador. Para ello, se implementó un estudio descriptivo, correlacional y de corte transversal, a través de la aplicación de cuestionarios de satisfacción con la vida, afectos positivos y negativos, bienestar psicológico, orientación de vida y visión del futuro, en una muestra de 400 participantes (67% mujeres y 33% hombres), con edad media de 21,3 años, estudiantes de una universidad pública (66.5%) y una cofinanciada (37.5%) de la ciudad de Ambato, Ecuador. Según los resultados, el optimismo disposicional se correlaciona con la satisfacción con la vida (r=.378), los afectos positivos (r =.357) y los negativos (r =-.413), y el bienestar psicológico (r=.616), mientras que los sesgos de optimismo ilusorio (r=.221) e ilusión de invulnerabilidad (r=-.235) lo hacen únicamente con el bienestar psicológico. Como conclusión se adelanta que existe evidencia de racionalidad limitada a través de los sesgos que estimulan el bienestar.

Abstract The purpose of our research was to determine the relation between the cognitive bias of optimism and subjective and psychological wellbeing in a sample of Ecuadorian university students. To that effect, a cross-cutting, correlational, descriptive study was implemented. Questionnaires regarding life satisfaction, positive and negative affects, psychological wellbeing, life orientation, and vision for the future were applied in sample of 400 participants (67% women and 33% men), average age 21.3, studying in a public university (66.5%) and a co-financed university (37.5%) in the city of Ambato, Ecuador. According to the results, dispositional optimism is correlated with life satisfaction (r=.378), positive affects (r=.357) and negative affects (r=-.413), and psychological wellbeing (r=.616), while the illusory optimism (r=.221) and the illusion of invulnerability biases (r=-.235) are correlated only with psychological wellbeing. We conclude that there is evidence of bounded rationality as a result of biases that promote wellbeing.

Resumo Esta pesquisa tem o objetivo de determinar a relação do viés cognitivo de otimismo no bem-estar subjetivo e psicológico em uma amostra de universitários do Equador. Para isso, foi realizado um estudo descritivo, correlacional e de corte transversal, por meio da aplicação de questionários de satisfação com a vida, afetos positivos e negativos, bem-estar psicológico, orientação de vida e visão do futuro, em uma amostra de 400 participantes (67% mulheres e 33% homens), com idade média de 21,3 anos, estudantes de uma universidade pública (66.5%) e uma cofinanciada (37.5%) da cidade de Ambato, Equador. Segundo os resultados, o otimismo disposicional se correlaciona com a satisfação com a vida (r=.378), com os afetos positivos (r=.357) e os negativos (r=-.413), e com o bem-estar psicológico (r=.616), enquanto os vieses de otimismo ilusório (r=.221) e ilusão de invulnerabilidade (r=-.235) acontecem unicamente com o bem-estar psicológico. Como conclusão, existe evidência de racionalidade limitada por meio dos vieses que estimulam o bem-estar.

Atitudes de enfermeiros de equipe da Saúde da Família em relação à obesidade / Attitudes of nurses from the Family Health Team (eSF) towards obesity

Introdução: A obesidade é uma doença multifatorial, crônica e um grande problema de saúde pública. Há muitos estigmas e estereótipos empregados à essa patologia e os pacientes obesos são, muitas vezes, considerados preguiçosos, incompetentes e responsáveis pelo seu ganho de peso. Os profissionais de saúde são relatados pelos pacientes como uma das principais fontes de aplicação desse estigma. Objetivo: Avaliar as atitudes dos enfermeiros em relação aos indivíduos obesos. Método: Foram convidados todos os enfermeiros das 66 equipes de Saúde da Família de Blumenau ­ SC para a participação na pesquisa. A coleta de dados incluiu a aplicação da Escala de Atitudes Antiobesidade com 34 questões, além de um questionário de entrevista estruturada elaborado pelos autores e auto preenchido com dados sociodemográficos e de saúde, com 14 questões, dentre elas peso e altura relatados pelos participantes para cálculo do Índice de Massa Corporal. Resultados: Participaram 42 enfermeiros, com predomínio do sexo feminino, estado nutricional prevalente de sobrepeso e a maioria relatou histórico de sobrepeso ou obesidade. Na Escala de Atitudes Antiobesidade, a maior média foi da subescala 'controle de peso e culpa', havendo associação estatisticamente significativa à afirmação 'a maioria dos gordos compram muita besteira ('junkfood')' com o fato de os participantes se considerarem com excesso de peso atualmente (p<0,05). Conclusão: Os resultados sugerem que os profissionais apresentam algumas atitudes antiobesidade frente a obesidade. (AU)

Introduction: Obesity is a multifactorial, chronic disease and a major public health problem. There are many stigmas and stereotypes used in this pathology and obese patients are often considered lazy, incompetent and responsible for their weight gain. Health professionals are reported by patients as one of the main sources of application of this stigma. Objective: To evaluate nurses' attitudes towards obese individuals. Method: All nurses from the 66 Family Health teams in Blumenau - SC were invited to participate in the research. Data collection included the application of the Antifat Attitude Test with 34 questions, in addition to a structured interview questionnaire prepared by the authors and self-completed with sociodemographic and health data, with 14 questions, including weight and height reported by the participants for calculation of the Body Mass Index. Results: 42 nurses participated, with a predominance of females, prevalent nutritional status of overweight and most reported a history of overweight or obesity. In the Antifat Attitude Test, the highest average was from the subscale 'Weight Control/Blame' associated with the statement 'most fat people buy too much junk food' with the fact that the participants consider themselves to be overweight (p <0.05). Conclusion: The results suggest that professionals have some anti-obesity attitudes towards obesity. (AU)

De vuelta a la clínica. Métodos I. Diseños de investigación. Mayor calidad de información, mayor certeza a la respuesta / Back to the clinic. Methods I. Research designs. Higher quality of information, greater certainty to the answer

Resumen Los diseños de investigación se refieren a la forma como se obtiene la información y están limitados por viabilidad ética, económica y temporal. Son estrategias estandarizadas para disminuir los sesgos que en el modelo arquitectónico de la investigación se identifican en el estado basal, maniobra y desenlace; de ahí que no hay diseños específicos para cada pregunta. El diseño con menor probabilidad de sesgos es el ensayo clínico, seguido de la cohorte, el estudio de casos y controles y, finalmente, la encuesta transversal. Entre las principales características que dan mérito a los diseños están las siguientes: la pesquisa de la población, que se refiere a la ubicación de la población en relación con el curso clínico o historia natural de la enfermedad; la maniobra, o acción que se espera modifique la condición basal, que puede ser observacional o experimental; el seguimiento, o monitoreo documentado que se le da a cada sujeto, que puede ser longitudinal o transversal; y la direccionalidad, prolectiva o retrolectiva, que alude al tiempo de recopilación de la información con fines de investigación. Siempre será mejor tener una pregunta valiosa, incluso cuando se responda con un diseño con mayor riesgo de sesgos, que una pregunta irrelevante o sin aplicabilidad.

Abstract Research designs refer to the way information is obtained and are limited by ethical, economic and temporal viability. Research designs are standardized strategies to reduce biases, which in the architectural model of research are identified in the baseline state, the maneuver and the outcome; hence, there are no specific designs for each question. The design with the lowest probability of bias is the clinical trial, followed by cohort and case-control studies and, finally, by cross-sectional surveys. Among the main characteristics that give merit to research designs are the following: population inquiry, which refers to the situation of the population in relation to the clinical course/natural history of the disease; the maneuver, or action that is expected to modify the baseline state, which can be observational or experimental; follow-up, or documented monitoring that is given to each subject, which can be longitudinal or cross-sectional; and directionality, which can prolective or retrolective and refers to the timing of data collection for research purposes. It will always be better having a valuable question, even when answered with a design with higher risk of bias, than a question that is irrelevant or has no applicability.

Sesgos de la evaluación docente y su relación con el desarrollo profesional en docentes de pregrado en enfermería / Bias of teacher evaluation and its relationship with professional development in undergraduate teaching in nursing

Objetivo: determinar qué sesgos están presentes en la evaluación de los docentes y cuáles son las consecuencias de sus resultados en el desarrollo profesional de los profesores de una facultad de enfermería de Bogotá. DC. Metodología: investigación de tipo cualitativo, con enfoque hermenéutico y diseño etmografico descriptivo, basado en el análisis discursivo de los docentes y estudiantes de una facultad de enfermería de Bogotá. Resultados:se identifico que los sesgos que mas afectan la objetividad de un estudiante en el proceso de evaluación de sus docentes son los que hacen referencia a la personalidad del docente y las relaciones interpersonales con sus estudiantes, y en segundo lugar la calificación recibida al finalizar el semestre o la rotación académica. Conclusiones: como conclusión se establece que la evaluación docente, realizado por estudiantes, presenta una serie de sesgos que influyen en sus resultados. Ademas la concepción de desarrollo profesional que tienen los docentes no es clara, por lo tanto, los resultados de esta evaluación no impactan de forma adecuada en el desarrollo profesional

Objective: To determine which biases are present in the evaluation of the teachers and what are the consequences of their results in the professional development of the teachers of a faculty of nursing in Bogotá. DC.Methods: Qualitative research, with a hermeneutic approach and descriptive ethnographic design, based on the discursive analysis of the teachers and students of a school of nursing in Bogotá.Results: Iprocess of evaluation of their teachers are those that refer to the personality of the teacher and interpersonal relationships with their students and secondly the grade received at the end of the semester or academic rotation.Conclusions: As a conclusion, it can be stated that teacher evaluation, performed by professional development that teachers have is unclear; therefore, the results of this assessment do not impact properly in professional development

NS1 codon usage adaptation to humans in pandemic Zika virus

BACKGROUND Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome. OBJECTIVES To better understand the recent and rapid expansion of ZIKV, as well as the presentation of novel complications, we compared the genetic differences between the African sylvatic lineage and the Asian epidemic lineage that caused the recent massive outbreaks. FINDINGS The epidemic lineages have significant codon adaptation in NS1 gene to translate these proteins in human and Aedes aegypti mosquito cells compared to the African zoonotic lineage. Accordingly, a Brazilian epidemic isolate (ZBR) produced more NS1 protein than the MR766 African lineage (ZAF) did, as indicated by proteomic data from infections of neuron progenitor cells-derived neurospheres. Although ZBR replicated more efficiently in these cells, the differences observed in the stoichiometry of ZIKV proteins were not exclusively explained by the differences in viral replication between the lineages. MAIN CONCLUSIONS Our findings suggest that natural, silent translational selection in the second half of 20th century could have improved the fitness of Asian ZIKV lineage in human and mosquito cells.

Exploring some biases in the ethical judgement of Managers: An empirical study / Explorando algunos sesgos en el juicio ético de los Directivos: Un estudio empírico / Explorando alguns preconceitos no julgamento ético dos Gerentes: um estudo empírico

Abstract One of the main and most challenging tasks of managers is to judge their own actions and, even more, the actions of others. There are different biases that might affect the accuracy of their ethical judgment. Two of the most common biases studied are the group affiliation bias and the want/should conflict. In the present study by empirical means, we analyzed these biases in the ethical judgment of managers. Examining answers of 153 effective respondents, we found significant differences in some of the four categories of ethical decision making studied, especially in the use of working time, money management and the use of corporate assets. We also explored some demographic characteristics of the managers, finding gender and level of study as the most relevant ones which play an important role on how they assess their own past and future behavior and the behavior of others. Although, we obtained somehow mixed results, they show that there seems to be a tendency within managers, to judge harder moral behavior of others compared to the judgment of their own ethical behavior Furthermore, managers judge others, contrary to expected, harder if they know them than if they do not.

Resumen Una de las principales y más exigentes obligaciones de un directivo es juzgar sus propias acciones y aún más, las acciones de los demás. Hay diferentes sesgos que pueden afectar la precisión del juicio ético. Dos de los sesgos más comúnmente estudiados son el sesgo por afiliación a grupos y el dilema del conflicto entre el deber y el querer En esta investigación, se analizan estos sesgos en el juicio ético de los directivos, por medio de un estudio empírico. Examinando respuestas de 153 encuestados, encontramos diferencias significativas en algunas de las cuatro categorías estudiadas de toma de decisiones éticas, específicamente, en el uso del tiempo laboral, manejo del dinero y el uso de activos corporativos. Igualmente, se exploraron algunas características demográficas de los directivos, encontrando que el género y el nivel educativo de los directivos, son las variables más explicativas de cómo éstos juzgan su propio pasado, su futuro y el comportamiento de los demás. A pesar de haber encontrado resultados variados, parece haber una tendencia general en los directivos a juzgar más duramente los actos de los demás que los suyos propios. Además, se encontró que, contrario a lo esperado, los directivos juzgan más duramente a las personas que conocen que a las que no conocen.

Resumo Uma das principais e mais exigentes obrigações de um gerente é julgar suas próprias ações e, ainda mais, as ações de outros. Existem diferentes tendências que podem afetar a precisão do julgamento ético. Dois dos viés mais comumente estudados são viés devido à afiliação grupal e ao dilema do conflito entre dever e vontade. Nesta pesquisa, esses preconceitos são analisados no julgamento ético dos gerentes, através de um estudo empírico. Examinando respostas de 153 entrevistados, encontramos diferenças significativas em algumas das quatro categorias de tomada de decisão ética estudadas, especificamente, no uso do tempo de trabalho, gerenciamento de dinheiro e uso de ativos corporativos. Do mesmo modo, foram exploradas algumas características demográficas dos gestores, encontrando que o gênero e o nível educacional dos gerentes são as variáveis mais explicativas de como eles julgam seu próprio passado, seu futuro e o comportamento de outros. Apesar de ter encontrado resultados mistos, parece haver uma tendência geral para que os gerentes julguem as ações dos outros mais severamente do que as suas. Além disso, descobriu-se que, contrariamente às expectativas, os gerentes julgam mais duramente as pessoas que conhecem do que aqueles que não conhecem.

Reaction time and attention bias characteristics of patients with first-episode depressive disorder / 中华行为医学与脑科学杂志

Objective To explore the reaction time and attention bias characteristics of patients with first-episode depressive disorder.MethodsTotally 32 patients with first-episode depressive disorder (MD group) and 24 non-depression control participants(NC group) matched with MD group on age,gender and education level were enrolled in the study.The clinical symptoms were assessed by Beck Depression Inventory(BDI).All participants completed a dot-probe task to assess attentional preference for facial stimuli with varying valence (happy,sad and neutral facial expressions).ResultsThe reaction times(RTs) of MD group was longer than that of NC group in the dot-probe task ((468.6±87.7)ms,(451.7±82.5)ms,P<0.01).The four-way ANOVA revealed a significant main effect of prime duration,indicating overall shorter RTs on primes with longer duration ((476.9±88.4)ms vs (456.2±82.7)ms vs (447.7±83.9)ms,P<0.01).Compared with NC group,the scores of attention bias for sad faces were decreased in MD group ((7.43±26.4)ms vs (-4.97±19.5)ms,P<0.05).With the longer duration of presentation,the score of attention maintenance of emotional facies for MD group were increased (happy faces: (-11.0±4.8)ms,(2.2±6.9)ms,(6.1±8.5)ms;angry faces:(-1.6±7.5)ms,(6.5±8.6)ms,(14.9±6.7)ms).The adherence score of attention to happy faces were decreased ((1.8±5.6)ms,(-8.2±6.7)ms,(-8.7±7.1)ms),while the score of adherence score towards sad faces were increased ((-7.6±7.2)ms,(-2.6±8.5)ms,(1.5±6.2)ms) with increasing prime duration.ConclusionPatients with first-episode depressive disorder have slower response to emotional faces and associated with attentional bias for sad faces.With the increasing prime duration,it is more and more obvious to attentional bias in the two aspects of allocation and adherence.

Information narrowing and perception of its users under the micro-dissemination environment / 中华医学图书情报杂志

Objective To study the association between users behaviors and information narrowing and the effect of in-formation narrowing on the access of information under the micro-dissemination environment.Methods The presence of in-formation narrowing and the reasons why it occurs were analyzed by literature analysis, the perception of its users was analyzed according to the questionnaire survey,and the data recorded during the questionnaire survey were ana-lyzed by ordinal logistic regression analysis using the SPSS 21.0.Results Five variables displayed in ordinal logistic regression analysis showed their significant effect on information narrowing.Conclusion Information narrowing can affect our understanding of information and lead to the spread of false information and rumors. Information users should thus expand their knowledge structure and information access channels,strengthen Internet management and take a lead in the healthy development of network information dissemination.