Optimal design and application of information management system of biobank in hospitals / 中华医学科研管理杂志

Objective:To establish a standardized information management system (IMS) for preserving, managing, querying, and performing statistics on biospecimens and their clinical data, which is conducive to improving the utilization of biobank.Methods:Under the premise of ensuring operating environment and data security, a database-based data logic relationship model is created and applied to the IMS to manage and analyze biospecimens and their supporting clinical information of patients enrolled in the biobank of our center.Results:To ensure the establishment of the follow-up cohort, biospecimens and clinical information of inpatients and outpatients were continuously collected in the biobank of our center. Since December 2014, more than 270 000 biospecimens from inpatient, outpatient, and scientific research have been preserved. The IMS optimized by this model efficiently completes the basic work of the biobank. At the same time, the data can be queried jointly and in batches, and then converted into a report format for statistical analysis.Conclusions:The IMS of our center is suitable for application and popularization as a construction and management model for the hospital-level biobank, which meets the daily work of the biobank and diverse research needs, and provides a convenient platform and rich resources for the development of precision medicine.

Carcinoma epidermoide de conjuntiva con invasión local / Squamous cell carcinoma of conjunctive with local invasion

Se presenta el caso clínico de una paciente de 62 años de edad, mestiza, de procedencia rural, quien había sido atendida 3 años atrás en consulta de oftalmología por un tumor de conjuntiva en el ojo izquierdo. Asistió nuevamente a consulta por dicha razón, pero esta vez además existía sangrado profuso y daño grave de las estructuras oculares. Se le realizaron varios exámenes, entre ellos rayos X de órbita, ecografía ocular, tomografías de órbita (con contraste) y cráneo, así como biopsia de la lesión exofítica y estudio inmunohistoquímico. El diagnóstico histológico definitivo fue carcinoma epidermoide de conjuntiva, por lo que se decidió realizar exéresis orbitaria, cirugía plástica reconstructiva y, posteriormente, radioterapia y quimioterapia. La paciente evolucionó favorablemente y fue controlada la diseminación de la neoplasia maligna, lo que además pudo evitarse si la atención médica inicial hubiese sido oportuna.

The case report of a 62 years mestiza patient of rural origin is presented, who had been assisted 3 years ago in the ophthalmology service due to a tumor of conjunctive in the left eye. She went again to the service for this reason, but this time it also existed profuse bleeding and serious damage of the ocular structures. Several exams were carried out, among them orbit X rays, ocular echography, orbit and skull tomographies (with contrast), as well as biopsy of the exofitic lesion and immunohistochemical study. The definitive histologic diagnosis was squamous cell carcinoma of conjunctive, reason why it was decided to carry out orbit exeresis, reconstructive cosmetic surgery and, later on, radiotherapy and chemotherapy. The patient had a favorable clinical course and the dissemination of the malignancies was controlled, what could also be avoided if initial medical care might have been opportune.

Complicaciones tardías de la radioterapia ocular / Late complications of the ocular radiotherapy

La radioterapia es uno de los pilares terapéuticos utilizados en la oncología, no exenta de producir daño ocular, lo que constituye un fenómeno bien establecido. La aparición de complicaciones continúa siendo la principal preocupación de la aplicación de la radioterapia, a pesar del empleo de nuevas estrategias que buscan reducir las complicaciones y mejorar el índice terapéutico. Se presenta una paciente femenina de 63 años con diagnóstico de carcinoma epidermoide de la conjuntiva, moderadamente diferenciado G-II, invasor (T3N0M0) en ojo izquierdo, que llevó tratamiento quirúrgico y radioterapia superficial complementaria. Como complicación tardía, la paciente presentó catarata radiógena, que recibió tratamiento quirúrgico, además de aneurismas conjuntivales en el área tratada(AU)

Radiotherapy is one of the therapeutic pillars used in oncology, but ocular damage may occur and this is a well-established phenomenon. The occurrence of complications remains the main concern for the application of radiotherapy, despite the use of new strategies to reduce complications and to improve the therapeutic rate. Here is a 63 years old female patient, who was diagnosed with epidermoid carcinoma of the conjunctiva, moderately differentiated G-II invader (T3N0M0) in the left eye. She was surgically treated and received supplementary superficial radiotherapy As a late complication, the patient presented with radiogenic cataract treated by surgery, in addition to conjunctival aneurysms in the treated area as well(AU)

Morphological changes of corneal and conjunctival epithelia in a rat model of dry eye / 中国比较医学杂志

Objective To evaluate the rat model of dry eye induced by topical administration of benzalkonium chloride and compare the morphological characteristics of corneal and conjunctival tissues of the normal and model rats . Methods Topical administration of benzalkonium chloride (0.3%) twice per day for seven days to induce the rat model of dry eye.Pathology with HE and periodic acid-Schiff staining and transmission electron microscopy were performed to evaluate the corneal and conjunctival changes .Results The corneal and conjunctival epithelial cells were sloughed off , the number of goblet cells was decreased in the dry eye model .Microvilli were obviously lost in the surface epithelial cells of the dry eye rat cornea and conjunctiva compared with the normal rats , as indicated by the amount and size of microvilli . Conclusions The changes in the corneal and conjunctival epithelia of BAC-induced rat dry eye are similar to the changes in human dry eye .This rat model may play an essential role for dry eye studies in the future .

Pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation on recurrent pterygium / 国际眼科杂志(Guoji Yanke Zazhi)

To discuss the effective method of decreasing the postoperative recurrence rate of recurrent pterygium. ●METHODS:Totally 126 cases (126 eyes) with recurrent pterygium were randomly divided into A group (56 cases) and B group ( 70 cases ). Group A was treated by pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation, group B was treated by amniotic membrane transplantation. The followed-up time after surgery was 6-24mo. ●RESULTS:ln group A, postoperative 5-7d (average 5. 62± 1. 38d), cornea epithelium was repaired. ln group B, postoperative 7- 10d ( average 7. 38 ± 1. 12d), the corneal wound was healed. There was statistical significant difference between two groups (t = 4. 307,P ●CONCLUSlON: lt is suggested that pterygium conjunctive reverse transplantation combined with amniotic membrane transplantation is effective in the treatment of recurrent pterygium.

Potential and Merits of the Eigenvalues Method to Simulate the Conjunctive Use of Groundwater and Surface Water.

It is necessary predict the effect of aquifer stresses in surface water and wetlands and consider the mutual effects that are produced by the conjunctive use of surface water and groundwater. This was originally made with very simple idealized analytical methods. The next development was the application of finite differences or finite elements numerical models, but poses problems when the model has to be run many times to analyze different management alternatives. When aquifer behavior is linear, as in confined, semiconfined, or unconfined aquifers with not too large changes in its saturated thickness, it is possible to apply the superposition strategy through influence functions. That has simplified significantly modeling and improved the effectiveness of management models. However, for large models, long modeling periods and a large number of alternatives, it is needed to handle and store many influence functions and to consider and store all the previous stresses. In that case, the eigenvalue method can be a more appropriated option. This approach solves the spatially discretized flow equation explicitly and continuously in time, obtaining modal orthogonal components through very simple explicit state equations in function of time. To reduce the computational load, the simulation can be simplified with appropriate truncation using only dominant modes of the components at the expense of a small error. Efficient methods have been developed to get the modal components as well as to perform truncation with limited errors.

Carcinoma de células escamosas con invasión orbitaria / Squamous cll carrcinoma with orbital extension

El carcinoma de células escamosas (CE) es una patología rara, su incidencia es del 0,13 a 1.9 casos por 100.000 habitantes, que acontece con más frecuencia en varones entre la quinta y séptima década de la vida. Presentamos el caso de una paciente de 42 años con CE con invasión a orbita de ojo izquierdo que fue sometida a exenteraciòn.

The carcinoma ofscaly cells (CE) it is a strange pathology, their incidence it is from the 0,13 to 1.9 cases for 100.000 inhabitants that it happens with more frequency in males between the fifth and seventh decade of the life. We present the case of a 42 year-old patient with CE with invasion to it orbits from left eye that was subjected to exenteracion.

Elastose perfurante serpiginosa em portadora da síndrome de Down / Elastosis perforans serpiginosa in a patient with Down's syndrome

A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da síndrome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.

Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions.

Tratamento cirurgico do pterigio primario: comparação entre as tecnicas de rotação de retalho conjuntival e transplante de membrana amniotica / Surgical treatment of the primary pterrygium: comparison between rotation of conjunctival flap and amniotic membrane transplant

Objetivo: Determinar se o transplante de membrana amniótica é um procedimento mais eficaz que a rotação de retalho conjuntival, no tratamento cirúrgico de pterígio primário, quanto à taxa de recidiva. Material e métodos: Foi realizado um estudo prospectivo, do tipo ensaio clínico randomizado, de 228 pacientes (228 olhos) com pterígio primário grau II. Os pacientes foram divididos em dois grupos: grupo teste (126 olhos) - exérese de pterígio seguida de transplante de membrana amniótica; grupo controle(102 olhos)- exérese de pterígio seguida de rotação de retalho conjuntival. Os procedimentos foram realizados no período de janeiro de 2001 a outubro de 2005 no bloco cirúrgico do Hospital Escola da Universidade Federal do Triângulo Mineiro. Os pacientes tiveram um seguimento de 1 ano e o critério de recidiva foi a invasão corneana por tecido fibrovascular. A análise estatística foi feita pelo teste de igualdade de duas proporções. Resultados: No grupo teste foram observados 8 quadros de recidiva (6,3%) sendo 6 em pacientes do sexo masculino e 2 no sexo feminino. A média de idade dos pacientes foi de 39,6 anos, sendo que a recidiva ocorreu em média 3.3 meses pós-operatório. No grupo controle foram observadas 17 recidivas (16,7%) sendo 11 no sexo masculino e 6 no feminino.A média de idade dos pacientes foi de 35,7 anos sendo que a recidiva ocorreu em média 3,1 meses pós operatório . O z calculado foi de 2,48 evidenciando significância estatística e validando a hipótese proposta. Conclusão: O transplante de membrana amniótica é um procedimento efetivo e seguro no tratamento cirúrgico do pterígio primário apresentando baixa taxa de recidiva.

Objective: Determine the best procedure for the treatment of the surgical primary pterygium according to the recurrence rate. Design: Randomized clinical trials. Material and Methods: 228 patients (228 eyes) carrying primary pterygium level II diagnosed with biomicroscopy, having the surgical treatment from January 2001 to October 2005 in the surgical room of the School Hospital of UFTM. Patients were divided into two groups:Test group (126 eyes): exeresis of the pterygium followed by a transplant of amnionic membrana;Control group (102 eyes): exeresis of the pterygium followed by rotation of the conjunctival flap. Criterion of recidivation considered was the corneal invasion by the fibrovascular tissue in a period of a year after the surgery. Statistics analysis was done using the significance test for equality of two proportions. Results: In the test group we observed 8 tables of recidivation, being 6 in male patients and 2 in female ones. Average age of these patients was 39.6 (ranging from 22 to 53). Recidivation occurred on an average of 3.3 months (ranging from the 2nd to the 7th month). In the control group we observed 17 recidivations of the pterygium being 11 in the male sex and 06 in the female one. The average age of these patients was 35.7 years old (ranging from 20 to 50 years). Recidivation occurred on an average of 3.1 months (ranging from the 1st to the 8th month). The calculated z (2.48) was higher than the table z. Conclusions: Amniotic membrane transplantation is an effective and safe procedure for primary pterygium surgery with a relatively low recurrence rate. However, we couldn't affirm that the amniotic membrane transplant has to be considered the first choice in the primary pterygium surgery treatment.

Clone: o inferno do si mesmo / Clon: el inferno de uno mismo / The clone: the torment of the same

A autora desenvolve formulações a respeito da clonagem como um mito revelador e em criação. Um mito que auxilia reflexões sobre uma forma específica de relação do sujeito com o outro, de sua relação com o real e de um modo peculiar de pensamento. Utilizando-se do mito e de fragmentos extraídos da clínica, discute-se um conjunto de operações mentais que auxiliam a compreensão de pacientes referidos na literatura psicanalítica como desvitalizados, desobjetalizados, de difícil acesso, borderline. Discute-se também as especificidades do processo transferencial e contratransferencial com esses pacientes.

La autora desarrolla formulaciones respecto a la clonación como un mito revelador y a la creación. Un mito que auxilia en la reflexión sobre una forma específica de relación de un sujeto con otro, de su relación con lo real y de un modo peculiar de pensamiento. Valiéndose del mito y de fragmentos extraídos de la clínica, se discute un conjunto de operaciones mentales que auxilian en la comprensión de pacientes referidos en la literatura psicoanalítica como desvitalizados, sin objeto, de difícil acceso, borderline. También se discuten las especificidades de los procesos transferenciales y contra-transferenciales con esos pacientes.

The author develops thoughts about cloning as a myth, in creation, which reveals interesting aspects of some patients. A myth which helps reflections about a specific type of relationship between the subject and the other, about his relationship with reality and about peculiar ways of thinking. The author uses the myth of the clone and some clinical experiences to discuss mental operations which help to understand those patients referred to in the psychoanalytical literature as devitalized, de-objectalized, of difficult access, borderline. Specificities of the transferencial and contratransferencial process with these patients are also discussed.