The treatment of 3D-printed metal prostheses on bone defect of malignant bone tumors in lower limbs / 中华骨科杂志

Objective:To investigate the early and middle term clinical efficacies of 3D-printed metal prostheses in the reconstruction of bone defects after osteotomy in malignant bone tumors.Methods:A total of 34 patients with malignant bone tumors of lower extremity femur and tibia who underwent 3D printing individualized metal prosthesis replacement surgery in the Department of Bone and Soft Tissue of Affiliated Cancer Hospital of Zhengzhou University from March 2019 to March 2022 were retrospectively analyzed. There were 23 males and 11 females, with an average age of 19.1±15.2 years (range, 7-80 years). There were 22 children and adolescents younger than 18 years old. There were 3 cases in the proximal femur, 15 cases in the middle and distal femur, 10 cases in the proximal tibia and 6 cases in the distal tibia. According to the final pathological diagnosis, 24 cases of osteosarcoma, 6 cases of Ewing's sarcoma, 2 cases of undifferentiated sarcoma, 1 case of osteosarcoma, and 1 case of malignant giant cell tumor of bone were enrolled in this study. Postoperative complications, wound healing, periprosthetic fracture and aseptic loosening, tumor outcome (evaluated by tumor control evaluation criteria), and length difference of lower limbs were recorded. Response evaluation criteria in solid tumor (RECIST) was used to evaluate tumor outcomes. Prosthetic-bone interface healing was evaluated postoperatively, and the function was evaluated based on Musculoskeletal Oncology Society (MSTS) 93.Results:The length of lesions was 70-240 mm in 34 patients, with an average of 125.5±35.4 mm. The length of osteotomy was 80-275 mm, with an average of 160.2±33.9 mm. No tumor was found on the osteotomy surface. The customized prosthesis was firmly installed and closely matched with the side of the preserved articular surface. There were 2 patients with local incision fat liquefaction and 4 patients with superficial wound infection, which healed after debridement and antibiotic treatment. One distal tibia osteosarcoma case developed severe periprosthetic infection 2 months after surgery, resulting in prosthesis implantation failure, limb movement pain and poor ankle function. After removal of the prosthesis, infection control and osteogenesis with the Ilizarov technique, the infection was completely controlled and local osteogenesis was possible. The remaining 33 patients had a good prosthetic-bone interface union. One case was found to have localized bone resorption on the contact surface of the prosthesis 7 months after operation, but the metal prosthesis and screws were not loose. The incisions healed well in other patients, without infection, prosthesis loosening, fracture or other complications. All patients survived and were followed up for 13.8±5.6 months (range, 7-27 months). During the follow-up, there was no recurrence of tumor at the osteotomy end in all patients, but 5 patients developed lung metastasis. At the end of the last follow-up, all patients survived. Among them, 16 patients had unequal length of lower limbs, including 10 cases within 2 cm, 3 cases between 2-5 cm, and 3 cases over 5 cm. With the exception of one patient whose prosthesis was removed due to infection, the MSTS 93 of the other patients was 24.9±2.2 (range, 19-28), and were rated as excellent in 26 cases and good in 7 cases. According to the RECIST evaluation criteria, 26 of 34 patients had complete response, 5 had disease progression, and 3 had stable disease.Conclusion:3D printed metal prosthesis is one of the effective methods for the treatment of bone defects after resection of malignant bone tumors in lower limbs, which is safe, reliable and has satisfactory early curative effect.

Mid-term follow-up of reconstruction with liquid nitrogen-inactivated autologous bone graft in patients with diaphyseal malignant tumours / 中华骨科杂志

Objective:To explore the mid-term efficacy of liquid nitrogen-inactivated autologous tumor segment bone replantation for repairing bone defects after resection of malignant tumors in the long bone shaft.Methods:A retrospective analysis was performed on the clinical data of 16 patients treated with liquid nitrogen-inactivated autologous bone graft at Beijing Jishuitan Hospital from July 2015 to June 2017 to repair defects caused by malignant tumour resection of the diaphysis. There were 10 males and 6 females with a mean age of 23.4±11.6 years (range, 8-44 years), including 8 classic osteosarcoma, 2 high-grade surface osteosarcoma, 4 Ewing's sarcoma, 1 periosteal osteosarcoma, and 1 undifferentiated pleomorphic sarcoma. Tumors were located in the humerus in 2 cases, in the femur in 8 cases and in the tibia in 6 cases. The mean length of tumor was 12.4±4.8 cm (range, 5.5-26 cm). Postoperative imaging examination was performed every 6 months, and the healing status of the transplanted bone-host bone was evaluated based on the imaging assessment method of the International Society of Limb Salvage (ISOLS) imaging assessment after allogeneic bone transplantation, and the complications were assessed using the Henderson classification. The five-year survival rate for patients and grafted bone was calculated using the Kaplan-Meier survival curve.Results:The median follow-up was 64 (60.3, 69.8) months. At the end of follow-up, 13 patients were tumour free and 3 patients died of multiple metastases at 19, 20 and 33 months after surgery. There were 32 osteotomy ends in 16 patients, of which 30 healed, including 11 metaphyseal osteotomy ends, and the healing time was 9 (6, 12) months after replantation of the tumour segment with liquid nitrogen-inactivated autologous bone; 19 osteotomy ends in the diaphysis took 13 (9, 21) months to heal, with a statistically significant difference in healing time between different sites ( Z=-2.25, P=0.025). Sixteen patients had six complications, including two cases of non-union at the diaphyseal site, one case of failure of internal fixation due to non-union, three cases of recurrence, and no soft tissue complications or infections. One patient with failed internal fixation was treated with a vascularized tip iliac bone graft that healed 6 months after surgery. Another patient died of multiple metastases with 1 unhealed diaphysis left. Three cases of recurrence were all located in the extracranial soft tissue of the autologous tumor segment inactivated by liquid nitrogen. Among them, one case underwent reoperation and local radiotherapy, and there was still no tumor survival after 65 months of surgery, and two cases died due to multiple metastases. The five-year survival rate of patients was 81% as calculated using the Kaplan-Meier survival curve, and the graft survival rate was 100%. There was no amputation and the limb salvage rate was 100%. Conclusion:The use of liquid nitrogen-inactivated autologous tumor segment bone replantation for reconstruction of bone defects after resection of malignant tumors in the shaft has advantages of higher healing rate, shorter healing time at the metaphyseal end compared to the osteotomy end, fewer complications, and higher survival rate of the replanted bone.

Comportamiento de fracturas diafisarias del fémur en el niño

Introducción: Las fracturas de la diáfisis del fémur en las edades pediátricas representan un problema de salud que necesita de la intervención del ortopedista, quien aplica una de las distintas modalidades de tratamiento, que van desde la conservadora a la quirúrgica. Objetivo: Describir las características epidemiológicas de un grupo de pacientes pediátricos diagnosticados y tratados con esta enfermedad traumática. Métodos: Se realizó un estudio observacional descriptivo en 54 pacientes atendidos en el Hospital Pediátrico Provincial Dr. Eduardo Agramonte Piña de la provincia Camagüey desde el primero de enero de 2018 al 31 de diciembre del año 2022 con un total de 60 meses. Resultados: La razón sexo masculino-femenino de los 54 pacientes fue de 2,8 a 1, fémur izquierdo-derecho de 1,2 a 1. El promedio de edades en general fue de 8,1 años. La estadía hospitalaria promedio fue de seis días. El tercio medio estuvo afectado en el 57,4 % de los casos. Los meses de julio y diciembre en conjunto con los días del martes y domingo fueron los que presentaron la mayor cantidad de pacientes. El tratamiento más empleado fue la colocación de espica de yeso en 28 pacientes para un 51,8 %, los clavos rígidos fueron utilizados en 16 enfermos y representó el 29,6 %. Por su parte, los clavos flexibles fueron colocados en 10 casos para un 18,5 %. Conclusiones: Las fracturas de la diáfisis femoral en las edades pediátricas son más frecuentes en el sexo masculino, lado izquierdo, en el tercio medio, con patrón transversal. Los meses del año con mayor incidencia fueron julio y diciembre y los días martes y domingo. El tratamiento depende de la edad, peso y configuración de la fractura.

Introduction: Fractures of the diaphysis of the femur in children, represent a health problem that requires the intervention of an orthopedist who applies various treatment modalities ranging from conservative to surgical. Objective: To describe the epidemiological characteristics of a group of pediatric patients with this traumatic entity. Methods: A descriptive observational study was carried out in 54 patients treated at the Dr. Eduardo Agramonte Piña Provincial Pediatric Hospital in the city of Camagüey from January 1st, 2018 to December 31st, 2022 with a total of 60 months. Results: The male-female sex ratio of the 54 patients was 2.8 to 1, left-right femur 1.2 to 1. The average age in general was 8.1 years. The average hospital stay was 6 days. The middle third was affected in 57.4 % of the cases. The months of July and December together with the days of Tuesday and Sunday were the ones that presented the largest number of patients. The most used treatment was the placement of a plaster spike in 28 patients for 51.8%, rigid intramedullary nails were used in 16 patients and represented 29.6 %. On the other hand, flexible intramedullary nails were placed in 10 cases for 18.5%. Conclusions: Femoral diaphysis fractures in children are more frequent in males, left side, in the middle third, with a transversal pattern. The months of the year with the highest incidence were July and December and on Tuesdays and Sundays. Treatment depends on age, weight, and configuration of the fracture.

An unusual case of adamantinoma of long bone

Adamantinoma of the long bones is an exceedingly rare and slow-growing tumor that affects the diaphysis of long bones, particularly the tibia. Based on the pattern of the epithelial cell component and the presence or absence of the osteofibrous dysplasia-like element, several histological variants have been described, such as (i) tubular (the most frequent), (ii) basaloid, (iii) squamous, (iv) spindle variant, (v) osteofibrous dysplasia -like variant, and (vi) Ewing's sarcoma - like adamantinoma (the least frequent). The diagnosis may be challenging since this tumor may be mistakenly interpreted as carcinoma, myoepithelial tumor, osteofibrous dysplasia, and vascular tumor. We report the case of a 41-year-old male who presented with swelling over the right leg associated with pain. The X-ray showed a lytic lesion of the right-sided tibia. The diagnosis of adamantinoma was made based on the clinico-radiological, histomorphology, and immunohistochemical findings. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components in varying proportions and differentiating patterns. The diagnosis can be confirmed by immunohistochemistry for demonstrating sparse epithelial cell nests when the radiological features are strongly consistent with adamantinoma. This case is highlighted because the epithelial component can lead to a misdiagnosis, particularly when the clinico-radiological features are overlooked. Adamantinoma of long bones has the potential for local recurrence and may metastasize to the lungs, lymph nodes, or other bones. The prognosis is good if early intervention is taken.

Efficacy of Masquelet membrane induction technique for traumatic long bone defects / 中华创伤杂志

Objective To investigate the early clinical efficacy of Masquelet membrane induction technique in the treatment of traumatic long bone defects.Methods A retrospective case series study was conducted to analyze the clinical data of 41 patients with traumatic long bone defects admitted to the General Hospital of the Northern Theater Command from January 2012 to April 2017.There were 36 males and five females,aged 15-70 years,with an average of 38.2 years.There were 20 patients with bone defect at the femur,19 at the tibia,one at the fibula,and one at the ulna.All patients received staged treatment using the Masquelet membrane induction technique.In stage Ⅰ surgery,thorough debridement was first performed,and the secretions were taken for bacterial culture.The average bone defect length after debridement was 6.9 cm (2.0-18.5 cm).The bone defect was filled with antibiotic bone cement to induce the biofilm formation.If the postoperative bacterial culture showed positive results,debridement surgery was performed again.Stage Ⅱ surgery was performed after 6-12 weeks.The white blood cell count,C-reactive protein (CRP),procalcitonin (PCT),erythrocyte sedimentation rate (ESR) were measured before the operation.During the operation,bone biopsy was performed,and the bone cement placeholder was completely removed.The autologous cancellous bone and artificial bone were implanted in the bone defect areas,and the induced membrane was sutured.The healing time of bone defects was recorded,and the Paley fracture healing scoring criteria were used to evaluate the limb function.The complications were observed.The inflammatory markers were reviewed at the last follow-up.Results All patients were followed up for 7-36 months with an average of 13.6 months.A total of 37 patients obtained bone healing.The fracture healing rate of stage Ⅰ was 90％,and the healing time was 6-13 months,with an average of 9 months.According to the Paley fracture healing scoring criteria,the results were excellent in 25 patients,good in 10,and fair in two patients,with the excellent and good rate of 85％.In terms of complications,one patient with superficial infection recovered after dressing change,three patients had deep infection,of which one patient was treated with amputation and two received other treatments,and three patients were treated with membrane induction again because of bone resorption.At the last follow-up,there were significant differences between preoperative and postoperative White blood cell count,CRP,PCT and ESR(P ＜ 0.05).Conclusion For traumatic long bone defects,Masquelet membrane induction technique can promote fracture healing,restore limb function and reduce complications.

Clinical application of segmental prosthesis in reconstruction of diaphyseal tumors / 中华骨科杂志

Objective To investigate the clinical value of segmental prosthesis in the repair of diaphyseal defect.Methods The clinical data and follow-up information of 40 patients who accepted segmental prosthesis reconstruction of long bone defects in limbs were collected from June 2010 to June 2017 in General Hospital of Jinan Military Commanding and Tianjin Hospital.The parameters for outcome evaluation including general information,surgical complications,Musculoskeletal Tumor Society (MSTS) functional score,survival and prostheses status were analyzed.Results Forty patients were underwent segmental prosthesis surgery,including 18 males and 22 females,with a median age of 64 years and the age range of 13-83 years.The surgery was performed on 28 cases of femur,8 cases of humerus,3 cases of tibia,and 1 cases of ulna.There were 5 cases of primary tumor,3 cases of multiple myeloma and 32 cases of metastatic tumor of bone,in which lung cancer,breast cancer,kidney cancer,liver cancer and colorectal cancer are common.Pathological fracture of surgical site occurred in 32 cases.The average osteotomy length was 93.5 mm.The shortest osteotomy was 60 mm and the longest osteotomy was 190 mm.The average operation time was 104.6 minutes.The median bleeding volume was 600 ml.The least bleeding was 200 ml and the most bleeding was 2 800 ml.The patients median survival time was 8.5 months from 3 to 79 months.The prosthesis median survival time was 8 months from 3 to 79 months.According to the Henderson tumor prosthesis complications classification,there were 3 cases of type Ⅰ including 2 cases of incision delayed healing and 1 case of radial nerve paralysis.There was 1 case of type Ⅱ with humeral prosthesis aseptic loosening.There was 1 case of type Ⅲ with angulation deformity between femoral prosthesis force line and biological force line.There were 2 cases of type Ⅴ with tumor recurrence followed by amputation.The limb function score of MSTS was 20.4±4.1 points.Except for two patients with tumor recurrence and amputation,38 patients got stable prosthesis function until the death or follow-up cut-off.The similar tendency of patients survival curve and prosthesis survival curve indicated that survival was the main factor affecting postoperative prosthesis survivorship.Although the use rate of humeral plate (4/8,50.0％) was higher than that of femoral plate (5/28,17.9％),the difference was not statistically significant (F=3.426,P=0.064).The results of statistical analysis of complications showed that the type of tumor was an independent risk factor for complications (x2=7.446,P=0.024).The postoperative complications rate of primary tumor was significantly higher than that of multiple myeloma and bone metastasis.Patients with no complications have better limb function after surgery (F=9.709,P=0.003).Multivariate linear regression analysis showed that age,tumor type,preoperative pathologic fracture,surgery,osteotomy length did not affect limb functions after operation.The longer survival time mean better limb function (t=4.228,P=0.000).Conclusion Segmental prosthesis is a reliable method for the repair of bone metastases with defects.Combined with bone plate fixation,it can effectively reduce the occurrence of prosthetic complications.

Causes and strategies for postoperative bone nonunion after bone transport of lower limb bone of chronic osteomyelitis with bone defect / 中国骨伤

<p><b>OBJECTIVE</b>To explore causes and strategies for postoperative bone nonunion after bone transport of lower limb bone of chronic osteomyelitis with bone defect.</p><p><b>METHODS</b>From June 2012 to December 2015, clinical data of 38 patients with lower limb bone of chronic osteomyelitis with bone defect were retrospectively analyzed, including 23 males and 15 females aged from 20 to 56 years old with an average of 36.5 years old; 5 cases occurred on 5 femoral osteomyelitis and 33 cases were tibial;the time from injury to bone transport ranged from 2 to 19 months with an average of 7.4 months; the distance of bone defect ranged from 4 to 12 cm with an average of 7.3 cm. Bone transport were performed at 1 week later after operations, and transport directions were from near-end to far-end for 30 cases, from far-end to near-end for 3 cases and bidirectional transport for another 5 cases. The alignment and transport speed were adjusted and weight-bearing was encouraged. Regular follow-up was performed and X-ray films were taken to observe complications such as poor mineralization in transport gaps, nonunion of docking sites, and recurrent fracture. Paley scoring was used to evaluate clinical effects.</p><p><b>RESULTS</b>All patients were followed up for 12 to 36 months with an average of 23.1 months. No recurrence of osteomyelitis, but multiple complications associated with poor bony healing occurred. In the process of bone transport, 3 cases occurred poor mineralization in transport gaps, 17 cases occurred ununion of docking sites, 5 cases suffered fracture gap, 1 case occurred fracture without remove of external fixation, and 4 cases occurred facture after remove of external fixation. The time of taken fixation ranged from 9 to 27 months with an average of 16.3 months; index of external fixation ranged from 1.7 to 2.7 months/cm with an average of 2.24 months/cm. According to Paley's scoring, bony results showed 12 cases excellent, 16 good, 3 moderate and 7 poor;and functional results showed 14 cases excellent, 18 good, 3 moderate and 3 poor.</p><p><b>CONCLUSIONS</b>Bone transport technique could effectively solve clinical problems of long bone osteomyelitis with bone defect. However, long treatment period influence prognosis. Therefore, indications should be chosen strict, and operations should be precise and accurate, also monitored across whole process and followed up in time. Doctors should be actively guide corresponding prevention strategies.</p>

Recurrence of a Unicameral Bone Cyst in the Femoral Diaphysis

Diaphyseal unicameral bone cysts of the long bone are generally known to originate near the growth plate and migrate from the metaphysis to the diaphysis during skeletal growth. In the case of unicameral bone cysts of diaphyseal origin, recurrence at the same location is extremely rare. We report a case of recurrence of a unicameral bone cyst in the diaphysis of the femur that developed 8 years after treatment with curettage and bone grafting. We performed bone grafting and lengthening of the affected femur with an application of the Ilizarov apparatus over an intramedullary nail to treat the cystic lesion and limb length discrepancy simultaneously.

Fracturas segmentarias de tibia / Segmental tibial fractures

Fundamento: las fracturas segmentarias de la diáfisis tibial (FSDT) son afecciones causadas por trauma de alta energía y están por lo general, asociadas a otras lesiones de partes blandas y óseas, que empeoran su pronóstico y hacen más difícil el tratamiento. Objetivo: profundizar en los elementos esenciales y características de pacientes que sufren de fracturas segmentarias de la diáfisis tibial. Métodos: se realizó una revisión bibliográfica de un total de 400 artículos publicados en Pubmed, Hinari y Medline, mediante el localizador de información Endnote, de ellos se utilizaron 51 citas seleccionadas para realizar la revisión, 47 de ellas de los últimos cinco años, además se incluyeron cuatro libros. Desarrollo: se describen los mecanismos de producción más frecuentes, así como las principales diferencias entre las fracturas segmentarias y no segmentarias. En relación a la clasificación, se describió la propuesta por el grupo de Asociación para la Osteosíntesis (AO) en especial la del tipo C y la aplicación de la clasificación de Winquist R y Hansen S. Se hace referencia a los traumas asociados y las complicaciones reportadas en la literatura. Los tipos de tratamientos son por lo general quirúrgicos y pueden ser mediante enclavijado intramedular, uso de fijadores externos y placas subcutáneas. Conclusiones: las fracturas segmentarias de la diáfisis tibial son lesiones graves, que necesitan de acciones inmediatas, para prevenir o aminorar las complicaciones inmediatas y tardías características de esta lesión.

Background: segmental tibial shaft fractures are affections caused by high energy traumatisms and are generally associated to other lesions of soft and osseous parts that make worse the prognosis and more difficult the treatment. Objective: to deepen in the essential elements and characteristics of patients who suffer from segmental tibial shaft fractures. Methods: a bibliographic review of 400 articles published in Pubmed, Hinari and Medline was made by means of the reference management software Endnote. Fifty-one references were selected for making the review, 47 of them were from the last five years and four books were included. Development: the most frequent mechanisms of production are described, as well as the main differences between segmental and non-segmental fractures. Regarding the classification, the proposal described by the Osteosynthesis Association, especially type C was described, as well as the application of the classification by Winquist R and Hansen S. The traumas associated and the complications reported in the literature are mentioned. The types of treatment are generally surgical and can be conducted by means of intramedullar nailing, external fixators and subcutaneous plates. Conclusions: segmental tibial shaft fractures are serious lesions that need to be treated immediately to prevent or reduce the instant complications and the belated characteristics of this lesion.

Tratamiento quirúrgico de pacientes con fractura diafisaria del húmero / Surgical treatment of patients with diaphysary fracture of the humerus

FUNDAMENTO: las fracturas de la diáfisis humeral son por lo general tratadas de forma conservadora, pero existe un pequeño porcentaje de pacientes que necesitan de tratamiento quirúrgico basado en indicaciones muy específicas. OBJETIVO: profundizar en los elementos necesarios para el tratamiento quirúrgico de pacientes con fractura de diáfisis humeral. Métodos: se realizó una revisión bibliográfica de un total de 400 artículos publicados en Pubmed, Hinari y Medline mediante el localizador de información Endnote, de ellos se utilizaron 50 citas seleccionadas para realizar la revisión, 47 de ellas de los últimos cinco años donde se incluyeron tres libros. DESARROLLO: se discuten los aspectos relacionados con el diagnóstico clínico e imaginológico. Se abordan las indicaciones quirúrgicas según los criterios del McKee MD basados en propias de la fractura, traumas asociados y propios del enfermo. En relación a los métodos de osteosíntesis se plasman sus indicaciones en cada caso, así como sus ventajas y desventajas. En relación a las complicaciones se describen las más importantes y el accionar médico, se propone un algoritmo para pacientes con lesión del nervio radial. CONCLUSIONES: el tratamiento quirúrgico de pacientes con fracturas de la diáfisis humeral está basado en indicaciones quirúrgicas muy específicas. El método de osteosíntesis a emplear depende de las ventajas de cada uno y de las condiciones del paciente y el cirujano. Los resultados por lo general son favorables con un mínimo de complicaciones.

BACKGROUND: generally speaking, fractures of the humeral diaphysis are treated in a conservative way, but there is a little percentage of patients that need surgical treatment based on very specific indications. OBJECTIVE: to study in depth the necessary elements for the surgical treatment of patients with fracture of the humeral diaphysis. Methods: a bibliographic review of 400 articles published in Pubmed, Hinari and Medline by means of the reference management software Endnote, was made. Fifty references were selected for making the review, 47 of them were from the last five years and three books were included. DEVELOPMENT: aspects related to the clinical and imaging diagnosis are discussed. Surgical indications according to Mckee criteria based on the indications of the fracture, on associated traumas and on own traumas of the patient, are tackled. Regarding the osteosynthesis methods, its indications step by step, as well as its advantages and disadvantages, are presented. Concerning the complications, the most important ones are described; the medical procedure is also described. An algorithm for patients with lesion of the radial nerve is proposed. CONCLUSIONS: the surgical treatment of patients with humeral diaphysis is based on very specific surgical indications. The osteosynthesis method to use depends on the advantages of each of them and on the conditions of the patient and the surgeon. In general, the results are favourable with a minimum of complications.

Shaft Fractures of Both Forearm Bones: The Outcomes of Surgical Treatment with Plating Only and Combined Plating and Intramedullary Nailing

BACKGROUND: Plate fixation is the most commonly used technique for the treatment of shaft fractures of both forearm bones (SFBFBs). However, all fractures are difficult to treat with plate fixation because of soft tissue injuries, fracture patterns, or the patient's condition. The purpose of this study is to compare the functional results of plate fixation only and combined plate and intramedullary (IM) nail fixation in SFBFBs. METHODS: Fifty-nine cases of SFBFBs that were surgically treated from June 2007 to July 2012 were retrospectively reviewed. In this study, 47 cases that were followed up for more than 12 months were included. All SFBFBs were divided into two groups according to the methods used for internal fixation: plate fixation only (group A) and combined plate and IM nail fixation (group B). The fixation methods were determined intraoperatively. Plate fixation was considered as the first option in all cases, but combined plate and IM nail fixation was selected as the second option if it was difficult to be fixed with plate only. Groups A and B comprised of 31 and 16 cases, respectively. The functional results were evaluated by the Grace and Eversmann rating system and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. RESULTS: In groups A and B, a radiologic union was achieved in 30/31 and 14/16 cases and average union time was 11.1 and 17.8 weeks, respectively. According to the Grace and Eversmann rating system, group A had excellent results in 15 cases, good in 14, acceptable in one, and unacceptable in one. Group B had excellent results in three cases, good in nine, acceptable in two, and unacceptable in two. The average DASH score was 7.1 points (range, 0 to 19.2 points) in group A and 15.1 points (range, 0 to 29.6 points) in group B. Three cases of nonunion with unacceptable results achieved a bony union by additional procedures and the functional results of these cases improved to good or excellent. CONCLUSIONS: The functional results and the average union time were superior in group A than in group B. However, we think that combined fixation is a useful method for SFBFBs that cannot be treated with plate fixation only.

Fracture of distal humerus: MIPO technique with visualization of the radial nerve

Avaliar os resultados de pacientes submetidos à osteossíntesede fraturas do terço distal do úmero, com técnica MIPO evisualização direta do nervo radial por via acessória, em pacientessem déficit neurológico pré-operatório. Métodos: Os pacientes foramsubmetidos à osteossíntese através da técnica MIPO. A visualizaçãoe isolamento do nervo radial foram realizados por abordagem entreo braquial e o braquiorradial, com incisão oblíqua, na face lateral dobraço. A avaliação funcional do cotovelo foi realizada por meio doescore de MEPS. Resultados: Sete pacientes foram avaliados, comidade media de 29,8 anos. O tempo de seguimento médio foi 29,85meses. A neuropraxia pós-operatória ocorreu em três pacientes.Houve recuperação sensitiva do nervo radial (M=3,16 meses) etambém motora (M=5,33 meses) em todos os pacientes. Observamosconsolidação da fratura em todos pacientes (M=4,22 meses).As médias de flexo-extensão e prono-supinação foram 112,85° e145°, respectivamente. A média do escore MEPS foi de 86,42. Nãohouve nenhum caso de infecção pós-operatória. Conclusão: Essaabordagem permitiu excluir a interposição do nervo radial no focode fratura e/ou na placa, apresentando alto índice de consolidaçãoda fratura e boa evolução do arco de movimento do cotovelo. Nívelde Evidência IV, Série de Casos...

To evaluate the outcomes in patients treated for humerusdistal third fractures with MIPO technique and visualizationof the radial nerve by an accessory approach, in those withoutradial palsy before surgery. Methods: The patients were treatedwith MIPO technique. The visualization and isolation of the radialnerve was done by an approach between the brachialis and thebrachiorradialis, with an oblique incision, in the lateral side of thearm. MEPS was used to evaluate the elbow function. Results: Sevenpatients were evaluated with a mean age of 29.8 years old. Theaverage follow up was 29.85 months. The radial neuropraxis aftersurgery occurred in three patients. The sensorial recovery occurredafter 3.16 months on average and also of the motor function,after 5.33 months on average, in all patients. We achieved fractureconsolidation in all patients (M=4.22 months). The averages forflexion-extension and prono-supination were 112.85° and 145°,respectively. The MEPS average score was 86.42. There was nocase of infection. Conclusion: This approach allowed excludinga radial nerve interposition on site of the fracture and/or under theplate, showing a high level of consolidation of the fracture and agood evolution of the range of movement of the elbow. Level ofEvidence IV, Case Series...

Seudoartrosis de la diáfisis humeral tratada mediante impactación intramedular. Presentación de un caso / Nonunion of the Humeral Shaft Treated by Intramedullary Impaction. A Case Report

La seudoartrosis de la diáfisis del húmero es una de las complicaciones más desafiantes para los ortopédicos. Se presenta el caso de una paciente de 39 años de edad, femenina, que sufrió un traumatismo el cual le causó fractura conminuta del tercio proximal de la diáfisis humeral derecha; recibió tratamiento conservador con órtesis enyesada durante seis meses sin signos de consolidación. Al año y seis meses de dicha fractura fue operada de una seudoartrosis, para lo cual se realizó impactación ósea intramedular, con resultados satisfactorios. Por esa razón se decidió la publicación del caso con el objetivo de mostrar que esta opción es válida para el manejo de la seudoartrosis de la diáfisis del húmero por su fácil aplicación y sus buenos resultados.

The nonunion of the humeral shaft is one of the most challenging orthopedic complications. The case of a 39-year-old female patient who suffered a trauma resulting in a comminuted fracture of the proximal third of the right humeral shaft is presented; she received conservative treatment with a cast brace for six months without showing signs of bone consolidation. A year and six months after the fracture, the patient underwent an intramedullary impaction for repairing the nonunion with satisfactory results. This case is presented in order to show the validity of this option for the management of nonunions of the humeral shaft due to its easy application and favorable results.

Open tibial shaft fractures. Treatment with intramedullary nailing after provisional stabilization with non penetrating external fixator / Fratura exposta da diáfise da tíbia - tratamento com osteossíntese intramedular após estabilização provisória com fixador externo não transfixante

Objective: To evaluate the incidence of union, nonunion, deep infection and factors influencing the time of bone healing in the treatment of open tibial shaft fractures Gustilo and Anderson types I and II initially treated with a non penetrating external fixator (Pinless(r)) followed by an unreamed intramedullary locked nail (UTN(r)). Methods: It is a prospective study of 39 open tibial shaft fractures. According to the AO classification, 16 patients (41.0%) were type A, 17 (43.6%) were type B and six (15.4%) were type C. According to the Gustilo and Anderson classification, 14 patients (35.9%) were type I and 25 (64.1%) were type II. For the definitive stabilization of the fracture were used an unreamed intramedulary locked nail (UTN(r)). Results: Bone healing was achieved in 97.4% of the cases, with a mean time of 21.2 weeks, ranging from 12 to 104 weeks. Deep infection was seen in 2.6% patients and malunion were seen in 5.1%. Only the presence of complications were statistically significant to the time of bone healing, with a risk of faster healing in patients without complications of 4.29 times (CI 95%: 1.25 -14.71) comparing to patients with complications. Conclusion: The treatment of open tibial shaft fractures with unreamed intramedullary locked nail allows high rates of bone healing, low rates of nonunion and deep infection, and only the presence of complications is statistically significant to the time of bone healing. .

Objetivo: Avaliar as taxas de consolidação, não consolidação e infecção profunda e quais fatores podem influenciar o tempo de consolidação nos pacientes com fraturas expostas da diáfise da tíbia grausIeIIde Gustilo e Anderson, tratadas segundo um protocolo sequencial inicialmente com fixador externo não transfixante Pinless(r), seguido por osteossíntese com haste intramedular maciça bloqueada não fresada (UTN(r)). Métodos: Em estudo prospectivo, 39 fraturas expostas da diáfise da tíbia foram acompanhadas. Segundo a classificação AO, 16 pacientes (41%) sofreram fraturas do tipo A, 17 (43,6%) dotipoB e seis(15,4%) dotipoC. SegundoaclassificaçãodeGustiloeAnderson, 14pacientes (35,9%) sofreram fraturas expostas grau I e 25 (64,1%) fraturas grau II. Para fixação interna foi usada haste intramedular maciça bloqueada não fresada (UTN(r)). Resultados: Consolidação ocorreu em 97,4% dos casos com tempo médio de 21,2 semanas, variação de 12 até 104 semanas. Infecção profunda ocorreu em 2,6% dos casos e consolidação viciosa ocorreu em 5,1%. Da análise estatística observamos que apenas a presença de complicações é estatisticamente significativa para explicar o tempo de consolidação. O risco de consolidação mais rápida em pacientes sem complicações é de 4,29 vezes (IC 95%: 1,25-14,71) em relação a pacientes com complicações. Conclusão: O tratamento das fraturas expostas da diáfise da tíbia com osteossíntese intramedular maciça bloqueada não fresada apresenta taxa alta de consolidação, baixas taxas de não consolidação e de infecçãoprofunda eapenas a presençade complicações apresenta relação ...

Estudo transversal sobre os diferentes pontos de entrada na osteossíntese intramedular femoral anterógrada / Cross-sectional study on different entry points for anterograde femoral intramedullary osteosynthesis

OBJETIVO: Analisar o grau de conhecimento dos profissionais que tratam essas fraturas com a técnica preconizada relacionando a haste ao ponto de entrada considerado apropriado. MÉTODOS: Foi desenvolvido um questionário no qual constavam cinco tipos de hastes e simulada uma fratura diafisária do fêmur transversa. RESULTADOS: Os pontos de entrada correspondentes à escolha do tipo de haste foram respondidos por 370 médicos ortopedistas que participaram do 41º Congresso Brasileiro de Ortopedia e Traumatologia. Constatou-se que somente 20 por cento acertaram o ponto de entrada e que não houve diferença entre os profissionais que faziam a especialidade Traumatologia e os demais. CONCLUSÃO: Concluiu-se que a maioria dos médicos que frequentaram o congresso desconhece tal fato.

OBJECTIVE: To analyze the degree of knowledge among professionals who treat fractures using the recommended technique, with regard to correlating the nail with the entry point that is considered appropriate. METHODS: A questionnaire that presented five types of nail and simulated a transverse diaphyseal fracture of the femur was developed. RESULTS: Responses regarding the entry points corresponding to choosing the type of nail were obtained from 370 orthopedists who were participating in the 41st Brazilian Congress of Orthopedics and Traumatology. It was observed that only 20 percent correctly identified the entry point and that there was no difference between the professionals within the specialty of Traumatology and the others. CONCLUSION: It was concluded that the majority of the physicians attending the congress were unaware of the entry points.

Imaging features of hemangioma in the long bone / 中华放射学杂志

Objective To explore the imaing features of hemangioma in the long bone and improve the diagnostic level of this disease. Methods The X-ray(14 cases), CT(9 cases) and MRI(6 cases)findings of 18 patientswith histologically proven hemangioma in the long bone after surgery were retrospectively reviewed. Results Ten tumors occurred in medullary cavity or bone end(medullary type),6 on the surface of bone (periosteal type) and 3 in cortex (intracortical type). X-ray findings: among 8 cases of medullary type, 3 showed honeycomb appearance, 3 lytic areas with sclerotic borders, one purely osteolyticchanges, and 1 frosted glass; 3 cases of periosteal type showed sclerosis and thickening of the underlying cortex; 3 cases of intracortical type showed well-defined osteolytic foci. CT findings: among 6 cases of medullary type, 5 appeared as expansile lytic lesion with uneven selerotic rim (3 cases)orhoneycomb appearance (2 cases), 1 cribriform appearance in the cortical bone, 2 periostealnew bone formation in vertical radiation pattern; 1 ground-glass appearance; among 2 cases of periosteal typeone showed regular cortical thickening, and the other irregular periosteal proliferation with marrowing of medullarycavity; 1 case of intracorticaltype showed density similar to that of soft tissue, with cortical thickening and expansion . MRI findings: 2 apeared as well-defined lesions with low signal intensity on T1WI and high signal intensity on T2WI; 1 appeared as ill-defined lesion with low to intermediate signal intensity on T1 WI and T2 WI. One showed breakthrogh of cortex and formation of soft tissue mass with low signal intensity on T1 WI and high signal on T2WI. Two showed thickening of periosteumwith intermediate signal intensity in one of them and very low signal intensity in the other. Two showed abnormal signal intensity in surrounding muscles, which was high on T2 WI and intermediate on T1 WI. Conclusions The soap-bubble or honeycomb appearance is the typical radiographic finding of hemangioma in long bone. CT and MRI can provide useful information for the diagnosis of hemangioma in long bone.

Correlación entre los índices radiológicos preoperatorios y la pérdida ósea periprotésica determinada por densitometría ósea en artroplastia de cadera no cementada IAHULA 2007-2009 / Correlation between radiologic index and perioprostethic bone loss determined by bone densiometry in cementless total hip arthroplasty IAHULA 2007-2009

Se realizó un estudio observacional descriptivo en 43 caderas intervenidas por artroplastia total no cementada en el Hospital Universitario de Los Andes entre Enero de 2007 y Agosto de 2009, para determinar la correlación existente entre los índices corticodiafisario (ICD), corticometafisario (ICM) y la relación canal-cálcar (CC) preoperatorios con la pérdida ósea periprotésica evaluada mediante densitometría ósea (DEXA) postoperatoria en las zonas de Gruen. Se incluyó igualmente como variable interviniente el uso del ácido zoledrónico en dosis de 5 mg postoperatorios en 24 de los casos para determinar su asociación al aumento de la densidad mineral ósea periprotésica. Se obtuvo correlación entre el índice corticometafisario y la densidad mineral ósea en las zonas 1 y 7 de Gruen, y entre la relación canal-cálcar y la densidad mineral ósea en la zona 2 de Gruen. Por otra parte, el uso del ácido zoledrónico mostró aumento de la densidad mineral ósea en la zona 1 de Gruen.

This is a descriptive observational study of 43 hips which underwent uncemented total arthroplasty at Los Andes University Hospital since January 2007 to August 2009, to determinate correlation among preoperatory corticodiaphysary index (CDI), corticometaphysary index (CMI) and canal to calcar ratio (CCR) with periprosthetic bone loss evaluated through postoperatory bone densitometry (DEXA) in the seven Gruen´s zones. Use of postoperatory 5 mg of zoledronic acid in 24 cases was included as intervening variant to determinate its association with increase in periprosthetic bone mineral density. Correlation was obtained between corticometaphysary index and bone mineral density in Gruen´s zones 1 and 7, and canal to calcar ratio and bone mineral density in Gruen´s zone 2. Besides, it was show increased bone mineral density in Gruen´s zone 1, in patients who received zoledronic acid.

Dispositivo de tração do membro superior para osteossínteses intramedulares bloqueadas anterógradas de fraturas diafisárias de úmero / Upper limb traction device for anterograde intramedullary locked nail of humeral shaft fractures

As fraturas diafisárias de fêmur e tíbia no adulto são, na sua maioria, tratadas cirurgicamente, geralmente através de osteossínteses intramedulares bloqueadas. Algumas fraturas diafisárias cominutivas e/ou muito desviadas podem representar um verdadeiro desafio técnico. As mesas de fraturas (ou ortopédicas), que permitem a estabilização instrumental vertical, horizontal e rotacional do membro, facilitam enormemente as manobras de redução e de colocação do implante e são amplamente utilizadas pelos cirurgiões ortopédicos. As fraturas diafisárias de úmero são, na sua maioria, tratadas não cirurgicamente. Entretanto, algumas requerem o tratamento cirúrgico, cujas indicações estão bem definidas na literatura. Podem ser fixadas através de placas ou de hastes intramedulares por via anterógrada ou retrógrada. No úmero, as manobras de redução da fratura e estabilização do membro para a implantação da haste intramedular são realizadas manualmente, geralmente por dois auxiliares e, por serem sujeitas à fadiga muscular, podem ser menos eficientes. O objetivo deste trabalho é apresentar um dispositivo externo de tração do membro superior para utilização em osteossínteses intramedulares bloqueadas anterógradas de fraturas diafisárias de úmero que permite a estabilização vertical, horizontal e rotacional do membro superior, de maneira similar àquela utilizada para os membros inferiores. O dispositivo é portátil, de construção simples, e pode ser instalado em qualquer mesa cirúrgica equipada com trilhos laterais. Foi utilizado no tratamento cirúrgico de 29 fraturas diafisárias de úmero com haste intramedular bloqueada anterógrada. Nossa experiência foi extremamente positiva. Não tivemos nenhuma complicação relacionada à sua utilização, que acreditamos ter facilitado, de maneira notável, os procedimentos cirúrgicos.

Diaphyseal fractures of the femur and tibia in adults are mostly treated surgically, usually by means of intramedullary locked nail. Some comminuted and/or very deviated shaft fractures can represent a real technical challenge. The fracture table, which allows for the vertical, horizontal and rotational instrumental stabilization of the limb, greatly facilitates reduction and implant placement maneuvers and are widely used by orthopedic surgeons. Humeral shaft fractures are mostly treated nonsurgically. However, some whose indications are well defined in literature require surgical treatment. They can be fixed by plates, or by anterograde or retrograde intramedullary nail. In the humerus, limb fracture reduction and stabilization maneuvers for implantation of intramedullary nails are done manually, usually by 2 assistants. Because they are subject to muscle fatigue, this option may be less efficient. The aim of this paper is to present an external traction device for use in anterograde intramedullary fixation of humerus shaft fractures that allows vertical, horizontal and rotational stabilization of the upper limb similarly to that used in the lower limbs. The device is portable, of simple construction, and can be installed on any operating table equipped with side rails. It was used in the surgical treatment of 29 humeral shaft fractures with anterograde locked intramedullary nail. Our experience was extremely positive. We had no complications related to its use and we believe it to have facilitated the surgical procedures in a remarkable way.

Salvataje de miembro superior en pacientes pediátrico con sarcoma de Ewing: a propósito de un caso / Upper limb salvage in pediatric patients with Ewing sarcoma: report of a case

El sarcoma de Ewing es un tumor maligno perteneciente al grupo de tumores neuroectodérmicos primitivos. Se conoce poco acerca de los factores etiológicos y generalmente afecta la diáfisis de hueso largo y la pelvis. Rara vez puede localizarse extraesqueléticamente. La tendencia es a presentarse en gente joven durante la fase de mayor crecimiento. Representa el 1 por ciento de los tumores en la infancia y es el segundo tumor maligno primario del hueso en la niñez y adolescencia, con un pico de edad entre 5 y 13 años. En el presente se reporta el caso de un paciente masculino de 10 años de edad, con diagnóstico de Sarcoma de Ewing Primario en Húmero Izquierdo Estadio III. Fue tratado con esquema de Quimioterapia y Radioterapia; en vista de su buena evolución se ofreció Cirugía Reconstructiva como medida de salvataje del miembro superior. Se realizó resección del húmero con márgenes quirúrgicos amplios y se colocó aloinjerto óseo de tibia, estabilizándose con material de osteosíntesis proximal y distalmente. Como resultado se observó remodelación ósea y osteointegración completa del injerto, así como rangos de movilidad aceptables en el primer año de evolución. Los procedimientos quirúrgicos para la reconstrucción de los miembros, después de la extirpación del Sarcoma de Ewing Primario, constituyen una alternativa en un intento por evitar la amputación.

The Sarcoma of Ewing is a malignant tumor pertaining to the gruop of primitive neuroectodermal tumors. Little is known about the etiologic factors and it generally affects the diaphysis of long bones and pelvis. Rarely it can be located extraskeletally. The tendency is to appear in young people during the phase of greater growth. It represents 1 percent of the tumors in the childhood and is the second primary malignant tumor of the bone in the childhood and adolescence, with a tip of age between 5 and 13 years. In the present work the case of a masculine patient of 10 years of age is resported, with diagnosis of Sarcoma of Primary Ewing in Left Chimney Stage III. It was dealed with schemes Chemotherapy and X-ray; in view of its good evolution Reconstructive Surgery was offered like measurement of salvataje of the member superior. Resection of the chimmey with ample surgical margins was realised and aloinjerto bony of tibia was placed distate, becoming stabilized with material of proximal osteosynthesisand as result were observed bony remodeling and complete osseointegration of the graft, as well as acceptable ranks of mobility in the first yeras of evolution. The surgical procedures for the reconstruction of the members, after the extirpation of the Sarcoma of Primary Ewing, constitute an alternative in an attempt to avoid the amputation.

Tratamiento de las fracturas del fémur con sistemas de enclavado endomedular Centro de Innovación Tecnológica de la Universidad de Los Andes (CITEC-ULA) estudio tipo serie clínica / Fractures of the femur after intramedullary nailing systems Technology Innvation Center at the University of The Andes (CITEC-ULA) clinical series study type

Actualmente las fracturas de huesos largos como fémur y tibia se han convertido en un problema de slaud pública. Por lo cual nos plantemos como objetivo evaluar el sistema de enclavado endomedular del Centro de Innovación Tecnológica de la Universidad de Los Andes (CITEC-ULA) en pacientes con fracturas diafiarias de fémur ingresados en el servicio de cirugía ortopédica y traumatología del Hospital Universitario de Los Andes (IAHULA) durante el periodo junio 2004 a mayo 2009. En un total de 27 pacientes sólo 23 cumplieron con el segumiento adecuado del protocolo de estudio. Obtuvimos 96 por ciento pacientes masculinos, con una edad promedio de 30 años, como causa de fractura predominaron los hechos vialrs con 72 por ciento, y sólo un 28 por ciento de los casos presentaron fracturas asociadas. El promedio de espera preoperatorio fue 10,35 días. Y el 60 por ciento de las fracturas según su tipo correspondió a trazos complejos tipo B según la AO; se logro la consolidación en 95 por ciento de los casos y se presentaron un 13 por ciento de complicacuones representadas en 3 casos por fatiga de los pernos. Podemos evidenciar que los resultados obtenidos son comparables con otros sistemas de enclavado ya conocidos con la ventaja de tener menor costo y mayor disponibilidad por ser de producción local.

Currently fractures of long bones as the femur and tibia have become a public health problem. Therefore we set the objetive of evaluating the system of intramedullary nailing of the Tecnological Innovation Center at the Universitary of The Andes (CITEC-ULA) in patients with femoral shaft fractures admitted to the service of Orthopedic Surgery, University Hospital of The Andes (IAHULA) during june 2004 in may 2009. In a total of 27 patients, only 23 met the fracture predominated facts vials with 72 percent and only 28 percent of cases had associated fractures. The average waiting time was 10.35 days preoperatively. And 60 percent of fractures according to type complex traits corresponded to type B as the AO, the consolidationwas achieved in 95 percent of cases and presentd a 13 percent complication represented by 100 percent due to fatigue of the bolts. We show that the results are comparable to other well-known embedded systems with the advantage of lower cost and greater availability to be locally produced.