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Objective To evaluate the therapeutic effect and safety of Kangai injection combined with Chemotherapy in treating Colorectal cancer. Methods The CNKI, Wanfang, CBM, VIP, Medline and Cochrane Library from inception to the August 17th 2017 were searched, and all the relevant journals, and the literature of RCTs were enrolled. The quality of RCTs was assessed by Jadad scores, meta-analyses were performed by Review Manager 5.3 software. Results 21 Chinese articles were enrolled, including three high quality article, and the Jadad average score is 2.7. 1 879 patients were included. The result of Meta-analyses showed that intervention could improve the quality of life [OR=3.29, 95% CI (2.53-4.27), P＜0.01]; improve the short-term effects [OR=1.79, 95% CI (1.36-2.37),P＜0.001]; reduce the gastrointestinal reactions [OR=0.36,95% CI (0.29-0.45), P＜0.01], reduce bone marrow suppression reaction [OR=0.35, 95% CI (0.27-0.44),P＜0.01]. reduce the peripheral neurotoxicity [OR=0.57, 95% CI (0.41-0.78), P＜0.01], improve the abnormal liver function [OR=0.0.41,95% CI (0.26-0.65), P＜0.01], and improve the abnormal renal function [OR=0.55,95% CI (0.31-0.98), P=0.04]. Conclusions The combination of Kangai injection and Chemotherapy in treating Colorectal cancer is better than only using chemotherapy. However, we need more high-quality RCTs to improve the research.
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Objective To explore the clinical effects of flurbiprofen axetl injection on the treatment of postoperative pain in patients with laparoscopic appendectomy and on the platelet aggregation function.Methods From April 2013 to October 2015,100 laparoscopic appendectomy patients were randomly divided into observation and control groups,50 cases in each group.Observation group was injected flurbiprofen axetl injection 1 mg/kg,the control group was injected normal saline 5 ml.Analgesic effect,platelet aggregation function,and side effect were observed for two groups.Results Activities and resting visual analogue scale (VAS) score were significantly lower after flurbiprofen axetl injection in observation group (P ＜ 0.01),while activities and resting VAS score were not significantly decreased after normal saline used (P ＞ 0.05).Compared to those in control group,activities and resting VAS score at 30 min,1 h,2 h,4 h,and 6 h after flurbiprofen axetl injection in observation group were significantly lower (P ＜0.01).Platelet aggregation level before and after medication in two groups were no significant change (P ＞ 0.05).Drug side effects in two groups were no difference (P ＞ 0.05).Conclusions Patients with laparoscopic appendectomy do well with flurbiprofen axetl injection,and no obvious side effects.It is worthy of clinical application.
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Objective To investigate the efficacy and safety of compound kushen injection (CKI)in the treatment for patients with advanced liver cancers.Methods Relevantly randomized controlled trials from China National Knowledge Infrastructure (CNKI),Chinese Science and Technology Journal Database (VIP),Wanfang Data,and Pubmed were searched until November,2014.Randomized controlled trials (RCTs) of supportive care compared with combined therapy of CKI in the treatment for patients with advanced liver cancers were included.The methodological quality of RCTs was assessed independently with bias risk according to the Cochrane collaboration.All data were analyzed with the Review Manager 5.3.Results Eight RCTs involving 472 patients were included.The meta-analysis results suggested that the shortterm efficacy of the treatment group be higher (P =0.008) and that the pain relief be a significant benefit in the treatment group (P ＜0.01).Adverse reactions were not observed.Conclusions CKI is an effective and safe adjuvant drug for advanced liver cancers.
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Objective To evaluate the effectiveness and safety of tanreqing injection to children bronchial pneumonia.Methods PubMed,Ovid,CNKI,and data retrieval system of all places were searched to identify relevant studies from 2003 to November of 2014.The final documents were examined with inclusive and exclusive criteria.Results were pooled with meta-analysis on RevMan software to assess the efficacy of tanreqing injection to children bronchial pneumonia.Results The database was derived from 13 qualified studies that included a total of 1479 patients.Meta analysis showed that,compared to the control group,tanreqing injection treatment group resulted in higher effective rate [OR =2.96,95％ CI (2.22,3.96),P ＜0.01],shorter time of recovering the normal temperature [MD----0.53,95％ CI (-0.77,-0.29),P ＜ 0.01],shorter time of disappearance of cough [MD =-1.25,95％ CI (-2.14,-0.37),P ＜0.01],shorter time of lungrale [MD=-1.00,95％ CI(-1.4,-0.6),P ＜0.01],and shorter time of hospitalization time [MD =-1.35,95％ CI (-1.83,-0.86),P ＜ 0.01].Significant difference was observed between control and treatment groups.Conclusions This study showed that tanreqing injection appeared to be more effective for children bronchial pneumonia.However,methodology showed low quality.The efficacy needs high-quality clinical trials to verify.
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Objective To observe curative effect of the rat nerve growth factor (NGF) treatment on anterior ischemic op?tic neuropathy(AION). Methods Patients with AION (n=78) were randomly divided into mouse NGF treatment group (treatment group):39 cases (39 eyes) and conventional treatment group (control group):37 cases (37 eyes). Patients in control group were given Actovegin 1.2 g intravenously, once a day while patients in treatment group were given 18μg mouse NGF once a day. Milton insurable were given orally at 0.5 mg, 3 times per day at both groups. Dexamethasone of 3 mg were given retrobulbarly once a day upon onset of symptoms and the extend of edema for 3 to 5 days. Rat nerve growth factor were given for consecutive14 days as a period of treatment, and the curative effect was observed after 28 days of treatment. Results In the treatment group:treatments were obviously effective in 28 eyes (71.79%), effective in 7 eyes (17.95%) and ineffective in 4 eyes (10.26%), so the total effective rate was 89.74%; In control group: treatments were obviously effective in 11 eyes (29.73%), effective in 15 eyes (40.54%) and ineffective in 11 eyes (29.73%), so the total effective rate was 70.27%. Curative effects in these 2 groups were of statistical significance (Z=3.552, P<0.05). Vision acuity and average light sensitivity in vi?sual field are better in treatment group than those control group (P<0.05). Conclusion Mouse NGF is effective in the treat?ment of AION and can improve vision acuity and visual field, therefore is worth promoting.
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Objective To investigate the effect of Reduning injection(RI)on international normalized ratio(INR) ,prothrombin time(PT)and activated partial thromboplastin time(APTT)levels in patients with Trimeresurus stejnegeri(TS)bite .Methods Three hundred cases of patients with TS bite in our hospital from July 2010 to July 2013 were randomly divided into 2 groups .The control group received the routine treatment while the observation group treated with RI besides ,and then compared the growth of symptoms ,effect and changes of INR ,PT and APTT of 2 groups .Results The observation group′s swelling time [(127 .8 ± 56 .2) h] ,analgesic time [(5 .3 ± 2 .7)h] ,hospitalization time [(3 .8 ± 2 .7)d] was lower than those of the control group[ (150 .3 ± 83 .4) h ,(11 .5 ± 6 .1)h ,(5 .8 ± 4 .4)d] .The INR ,PT and APTT of 2 groups after treatment were both extended .However ,the extended degree of observation group was much lower .The observation group′s cure rate [90 .00% (135/150)] ,markedly effective rate [98 .00% (147/150)]were higher than those of the control group [67 .33% (101/150) ,84 .67% (127/150)] ,which showed statisti‐cally significant difference(P<0 .05) .Conclusion RI shows good effect on curing TS bite patients and could effectively shorten the time for symptom improvement and inhibit the prolonged coagulation index .
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Objective To investigate the expression of C/EBP homology protein(CHOP) in rat brain tissue after focal cerebral ischemia-reperfusion,as well as to observe the influence of the shenxiong injection on the expression of CHOP.Methods One hundred forty four male rats were randomly divided into three groups:the sham-operation group,operation group,shenxiong group.Focal cerebral ischemia and reperfusion rat models were established by using suture.Zea Longa method was introduced to evaluate neurologic behavioral changes.The levels of mRNA and protein of CHOP were measured with methods of immunohistochemistry and reverse transcription polymerase chain reaction.The neuronal apoptosis was detected by the method of terminal deoxynucleotidy1 transferase-mediated dUTP-biotin nick end labeling.Results The expression of CHOP was up-regulated in per-infarction after cerebral ischemia-reperfusion in rats.CHOP mRNA and protein levels peaked at the 12th h and 24th h after reperfusion,respectively.The apoptosis cell counting increased gradually after cerebral ischemia-reperfusion and peaked at the 24th h after reperfusion.Compared with the saline control group,treatment with shenxiong injection could reduce the neuronal apoptosis at the 6th,12th,24th,and 72nd h after reperfusion (P ＜0.01).Compared with the saline control group,treatment with shenxiong injection could decrease CHOP mRNA and protein expression at the 6th,12th,24th,and 72nd h after reperfusion (P ＜0.01).Conclusions Shenxiong Injection may prevent neurocyte from apoptosis by inhibition of the expression of CHOP induced by endoplasmic reticulum stress.
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Objective To compare the differences of pharmacokinetic parameters of paclitaxel injections and liposome.Methods An high performance liquid chromatography (HPLC) assay method was established to estimate the blood concentrations of paclitaxel after caudal vein administration of 12 mg/kg weigh.The blood concentration-time curves as well as correlated pharmaciokinetic parameters were obtained.Moreover,the data were analyzed with t-test.Results In rats,the mean drug concentration in plasma of paclitaxel injection and paclitaxel liposome were (0.18 ± 0.07)C/(mg · L) and (50 ± 9.2)C/(mg · L),respectively,and there were significant differences between the two formulations (t =5.879,P ＜ 0.01) ;compared with paclitaxel injection,the area under concentration-time curve (AUC) was bigger (17.693 ±2.657 vs 10.812 ± 2.846,t =4.892,P ＜ 0.01),the apparent volume of distribution (Vc) was smaller [(1.629 ±4.91) × 10-3 L vs (5.268 ± 1.121) × 10-3 L,t =3.75,P ＜0.01],the clearance rate(Cl)was slower[(7.2 ± 1.0) × 10-4 L vs (1.2 ±2.7) × 10-4 L,t =4.25,P ＜ 0.01],in the paclitaxel liposome.Conclusions Paclitaxel liposome has higher efficacy,longer release time,higher target tissue concentration,and lower side effects than paclitaxel injection.
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Objective To study the protective effects of Ginkgo biloba injection on the renal in diabetic nephropathy rats. Methods The models of diabetic rats were induced by streptozotecin. SD rats (n=18) were randomly divided into three groups, including control group, diabetic group and treated group. After 6 weeks, blood glucose, serum cholesterol and urinary protein were measured respectively. The expression of MCP-1 in the glomerulus was determined by immunohistechemical staining. Results Xingding injection did not influence blood glucose and serum cholesterol, but significantly inhibited expression of MCP-1 and lowered urinary protein excretion. Conclusion Xingding injection has some protective effect, which may be through down-regulating MCP-1 expression.
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Objective To investigate the effectiveness of Xingding injection on glomeruloscerosis in rats treated with adriblastine.Methods Twenty-four rats were randomly divided into three groups.The rats in three groups were injected with normal saline(NS),NS associated with adriblastine,adriblastine associated with Xingding injection respectively.The content of protein in urine of 24 hours and total cholesterol(Chol),total protein(TP),albumin(Alb),creatinine(Cr) in serum were detected.Results In Xingding group,the contents of protein in urine of 24 hours and Cr in serum were significantly lower,and that of serum Alb was significantly higher compared with those of the control group(P
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Objective To investigate the prevalence of mite sensitivity in patients with urticaria or other skin rashes, and to observe the clinical efficacy of a specific immunotherapy(SIT) by the Injectio dermatophagoidei farinae for the patients.Methods In 7-year period(1998-2005), skin prick test(SPT) with a dust mite(Df) allergen was carried out to detect the prevalence of mite sensitivity in OPD patients suffering from skin rashes.Among the patients sensitive to mite with SPT ≥++ response, 3 groups were established.In group A, routine SIT with Injectio dermatophagoidei farinae was conducted.In 9-week increasing dose phase, three stepwise increasing volumes(0.3ml, 0.6 ml and 1.0 ml) each case was injected subcutaneously with mite concentration of 1 ∶ 100 000(w/v) , 1 ∶ 10 000(w/v) or 1 ∶ 5 000(w/v) respectively once a week, followed by a maintenance dose phase for an injection with 1 ∶ 5 000(w/v) 1.0 ml/wk for 6 weeks.Group B received rush SIT with mite injections.A total of 15 injections in a course of therapy with same concentration and volume was given as those for the routine ones except shortened intervals, namely, 9 initial injections completed in 3 days by three injections of each concentration per day with two 30 min intervals, maintenancedoses were then provided in 6 days with 1 ∶ 5 000(w/v) 1.0 ml/d.Thereafter, both groups A and B were maintained for one year with a dose of 1 ∶ 5 000(w/v) 1.0 ml every 2 wk.Group C received antihistamine treatment as control, the patients received daily oral Ebastine 10 mg in the morning and Cetirizine dihydrochloride 10 mg in the evening for one week course and pro re nata later.Levels of serum tIgE and serum mite sIgE were detected by ELISA in 20 urticaria cases before and after one year mite SIT.Results Altogether, 2 685 cases with skin rashes were detected by Df allergen SPT.The prevalence of urticaria cases sensitive to mite was 70.3%(1 754/2 496), which was higher than that of eczema 63.5%(54/85) and anaphylactoid purpura 60.6%(63/104)(P
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Purpose:To evaluate the thrombolytic effect of transcatheter intra-arterial infusion of urokinase injectio salviae miltiorrhizae and heparine.Materials and methods:A 5F catheter was delivered to the thrombotic site via femoral artery,then infused urokinase.Injectio salviae mihionrrhizae via catheter.During and after the procedure heparin was given for antico- agulation.Finally to evaluate the effect by femoral arteriograms.Results:Blood circulation of 10 eases were inproved with complete pateney.One case wasn't very fluent and the last one remained obstructed.Total effective rate was 92%.Conclusion:Transcatheter Intraarterial thrombolysis by combing urokinase,injeetio salviae miltiorrhizae and heparin was a effective and safe theraputic method.
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Objective To observe the effect of Huangqi (Radix Astragali seu Hedysari) Injectio on the abnormal expression of aquaporin-1 (AQP-1) caused by glucose lactate peritoneal dialysis solution. Methods Different glucose concentration lactate peritoneal dialysis solutions and Huangqi Injectio given to the rats intraperitoneally. Eight weeks later, the ultrafiltration of peritoneal dialysis, peritoneum clearance, peritoneal structure, AQP-1 and its gene expression were observed. Results Compared with the control group, in the glucose and Huangqi groups, the ultrafiltration of peritoneal dialysis was remarkably decreased (P
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Objective:To observe clinical therapeutic effect of Xintong Injectio on angina pectoris of coronary heart disease.Methods:The patients of treatment group were treated by intravenous dipping of Xintong Injectio,and the control group by Isosorbide mononitrate,and changes of their clinical symptoms,signs,ECG,dynamic ECG,hemorheological indexes,blood lipids and other indexes were investigated.Results:The total effective rate was 95% in the treatment group and 65% in the control group,and the total effective rate for ECG was 76.67% in the treatment group and 48.33% in the control group,with significant differences between the two groups(both P
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AIM: To compare the chemical constituents of Injectio erigerontis and breviscapine. METHODS: High performance liquid chromatography and diotron array detection (HPLC-DAD) was adopled with Hypersil ODS2 Column (250 mm?4.6 mm,5 ?m), and mobile phase was acetonitrile-H 2O-H 3PO 4(18∶82∶0.2),detection wavelength was at 286 nm, temperature was at 40 ?C. RESULTS: Weak peaks of Seutellarin and caffeic acid were resembling between injetio erigerontis and breviscapine in UV spectra. but Injectio eriperontis possibly contained 10 catteic acid derivatives. CONCLUSION: Injectio erigerontis and breviscapine are completely different in chemical constituents,though their clinic application and curative effect are equal.
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OBJECTIVE:To approach the feasibility of replacing pyrogen test by bacterial endotoxin test(BET)in assaying the injectio puerarin.METHODS:Kinetic turbimetric assay(KTA)was used to determine the bacterial endotoxin,and an inhi?bition and strengthen test by using the EDS-99bacterial endotoxin systems was adopted for assaying injectio puerarin.RES_ ULTS:The regression equation of standard curve was logT=2.7957—0.2422logC,r=—0.9973;Injectio puerarin did not interfere with limulus test agent in1∶60dilution.CONCLUSION:This method is slight in interference and accurate in de?tection result,and can be used in routine assay.
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AIM To study the antiperoxide damage of injectio tanshin during dissolving thrombus to cure the acute myocardial infarction(AMI). METHODS AMI model formatted by electricity to irritate the left ventricular branch of coronary artery of open-chest rabbit,and observation aspects including electrocardiogram(ECG),cardiac output and contractility,serumal enzymatic activities and biochemistry and pathology of lipid peroxide extent of myocardial infarction zone. RESULTS By urinate kinase(UK) combining with injection tanshin,abnormal changes of ECG, descending of cardiac contractiles and cardiac output,going up of serum cardiac damage enzyme(CPK-MB and LDH),and the malondialdehyde(MDA)of serum and myocardial infarction zone could be remarkably reduced or avoided during UK dissolving the thrombus to cure AMI rabbits. CONCLUSION Injection tanshin can clearly reduce or avoid lipid peroxidation damage during UK dissolving the thrombus to cure the acute myocardial infarction.