The therapeutic efficacy of compound lidocaine cream on psoriasis / 药学学报

Psoriasis is a non-infectious chronic inflammatory skin disease. It′s acknowledged that interleukin (IL)-17 signaling pathway dominantly drives the development of psoriasis. Recently, the role of neuro-immune axis in psoriasis has attracted widespread attention. Lidocaine, a local anesthetic, has ability to block the conduction of nerve impulses, while its therapeutic efficacy on psoriasis remains to be confirmed. Here, we evaluated the therapeutic efficacy of topical application of compound lidocaine cream (LIDO) on imiquimod (IMQ)-induced mouse psoriasis model. Animal welfare and experimental procedures follow the regulations of the Ethics Committee of China Pharmaceutical University. The psoriasis area and severity index (PASI) scoring was used to evaluate the severity of psoriasis-like symptoms. Hematoxylin-eosin staining was used to examine histopathological changes and epidermal thickness was measured. Ki67 immunofluorescence staining was used to evaluate the proliferation of keratinocytes. The relative mRNA expression of inflammatory cytokines (including Il17, Il22, Il23 and Il36) in skin was measured by real-time quantitative PCR. Results show that IMQ-induced increases in the PASI score, epidermal thickness, number of Ki67+ cells and the mRNA expression of inflammatory cytokines are significantly alleviated by topical application of LIDO, whose therapeutic efficacy is also better than that of the positive control drug calcipotriol. Our study suggests that LIDO could be used for psoriasis treatment.

Utilization and Satisfaction of Beneficiaries Regarding Take Home Ration Provided At Urban Anganwadis of Ahmedabad, Gujarat

Introduction: Nutrition is fundamental to human health and development. The Take Home Ration (THR) program provides fortified rations for 6 months to 3 years normal children and severely underweight children up to 6 years, adolescent girls, pregnant women, lactating women through Anganwadis (AW). The National Nutrition Missions have targeted to decrease under nutrition by 3% each year. oObjective : T assess the utilization and satisfaction level of beneficiaries regarding THR and to identify challenges faced by AWW related to THR. Method: A cross-sectional study was conducted at 40Aanganwadi Workers ( ) Aanganwadis situated in the urban field practice area of the institute. Interview of all the (40) Anganwadi workers were conducted regarding implementation of THR Program. For assessing the utilization and satisfaction regarding THR, total 200 beneficiaries were selected from five different groups viz; 6 months to 3-year children, severely underweight children up to 6 years, Adolescent girls, Pregnant women and lactating women. Purposive sampling was used for selection of beneficiaries considering availability of beneficiaries at the time of study. Knowledge of AWW regarding THR scheme was good. Out of 200Results: beneficiaries, 97.5% beneficiaries were obtaining THR packets from anganwadis, out of which 66% beneficiaries were using them regularly. Around 36% of beneficiaries weren't satisfied with THR provided to them. Major challenges faced by beneficiaries were: Lack of variety, not possible to make separate food items from THR due to time constraints and lack of knowledge. Utilization of THR amongConclusion: beneficiaries was not satisfactory. Most of the beneficiaries were disappointed with taste of the THR. Beneficiaries strongly recommended for improvement in taste and flavour. Awareness regarding THR scheme was satisfactory among AWW. Biggest challenge faced by AWW was to convince beneficiaries regarding intended benefits of THR and regular usage of the same.

Estimated Deficits in Nutrient Intake of ICDS Beneficiaries Who Receive Take Home Ration at Two Districts in Karnataka

Background: The current estimates of energy and protein to bridge nutrient gap in the beneficiaries of the Integrated Child Development Services (ICDS) supplementary nutrition program use sub-optimal methodology for deficit calculation. Objective: To estimate the nutrient deficit and the risk of inadequate nutrient intake in beneficiaries of the ICDS, aged 6-36 months, using individual 24-hour diet recalls, from districts of Chitradurga and Davanagere in Karnataka. Study design: Cross-sectional design. Participants: Children (aged 6 to 36 months) registered as beneficiaries of the ICDS in these districts. Methods: Data were collected on socio-demographic factors, child feeding patterns, perception and usage of take home ration (THR), between August to October, 2019. Three non-consecutive days’ 24-hour diet recall data of children were obtained from mothers, and anthropometric measurements were taken. The proportion of children at risk of inadequate nutrient intakes was estimated using the probability approach. Assuming that 50% of a healthy population will be at risk of nutrient inadequacy such that intake and requirement distributions overlap, the proportion at actual risk of nutrient inadequacy (?50%) was calculated. Results: A combined district analysis showed a median energy deficit of 109 kcal and 161 kcal in children belonging to the age groups of 6-12 month and 13-36 month, respectively. The actual risk of inadequate intake for both age groups ranged between 12- 47% for fat and other micronutrient (iron, calcium, zinc, folate, vitamin B12 and vitamin A), despite breastfeeding, complementary feeding and reported THR use. Conclusion: Children who receive supplementary nutrition as part of the national program fail to meet their nutrient requirements that are essential for growth and development. The study results may help in strengthening the IYCF counselling and in modification of the existing THR, with quality and cost implications.

Identification of pulmonary nodule location in three dimensional images and its clinical significance / 中国胸心血管外科临床杂志

@#Objective    To analyze the difference of location identification of pulmonary nodules in two dimensional (2D) and three dimensional (3D) images, and to discuss the identification methods and clinical significance of pulmonary nodules location in 3D space. Methods    The clinical data of 105 patients undergoing sublobectomy in the Department of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University from December 2018 to December 2019 were analyzed retrospectively. There were 28 males and 77 females, with an average age of 57.21±13.19 years. The nodule location was determined by traditional 2D method and 3D depth ratio method respectively, and the differences were compared. Results    A total of 30 nodules had different position identification between the two methods, among which 25 nodules in the inner or middle zone of 2D image were located in the peripheral region of 3D image. The overall differences between the two methods were statistically significant (P<0.05). The diagnostic consistency rates of two methods were 66.67% in the right upper lung, 83.33% in the right middle lung, 73.68% in the right lower lung, 75.76% in the left upper lung, and 64.71% in the left lower lung. In each lung lobe, the difference between the two methods in the right upper lung (P=0.014) and the left upper lung (P=0.019) was statistically significant, while in the right middle lung (P=1.000), right lower lung (P=0.460) and left lower lung (P=0.162) were not statistically significant. Conclusion    The 3D position definition of lung nodules based on depth ratio is more accurate than the traditional 2D definition, which is helpful for preoperative planning of sublobectomy.

Effect of the infusion ration between frozen plasma and plasma substitutes on the prognosis of adult patients with major burn in shock stage / 中南大学学报(医学版)

OBJECTIVES@#In recent years, it has been reported that the anti-shock effect of plasma substitutes in adult patients with major burn in shock stage is not good. However, due to the shortage of clinical frozen plasma supply, it is impossible to guarantee that frozen plasma is used as colloidal solution for anti-shock treatment. The purpose of this study is to explore the effect of the infusion ration between frozen plasma and plasma substitutes on the prognosis of adult patients with major burn in shock stage.@*METHODS@#This study enrolled 586 adult patients with major burn by selecting the hospitalization burn patients, who had been hospitalized at the Jiangxi province burn center from September 2014 to April 2019. The patients with the infusion ratio of frozen plasma to plasma substitutes ≥2꞉1 at 48 hours after admission were included in the experimental group, otherwise they were included in the control group. The basic clinical data and clinical prognosis indicator in the 2 groups were compared. Logistic univariate regression analysis was used to screen the influential factors of 30-day mortality in adult patients with major burn, and logistic multivariate regression analysis was used to obtain independent risk and protective factors; Kaplan-Meier method was used to draw the survival curve of the 2 groups, and log-rank test was used to compare the 30-day survival rate of the 2 groups.@*RESULTS@#There were significant differences in the infusion volume of frozen plasma and plasma substitutes between the 2 groups at 48 hours after admission (both @*CONCLUSIONS@#Infusion ration between frozen plasma to plasma substitutes at 48 hours after admission is an independent protective factor for 30-day mortality of adult patients with major burn. In the early stage of adult patients with major burn, frozen plasma should be used as the anti-shock therapy as far as possible (frozen plasma꞉plasma substitute ≥2꞉1) to improve the prognosis and reduce the of 30-day mortality.

Prediction of hepatic fibrosis by FibroScan and serum markers in chronic hepatitis B patients with mildly elevated alanine transaminase levels / 中华传染病杂志

Objective To assess the diagnostic performance of liver stiffness measurement(LSM)and serum markers on hepatic fibrosis in chronic hepatitis B(CHB)patients with alanine aminotransferase(ALT)less than or equal to two times the upper limit of normal(≤2×ULN).Methods A total of 284 CHB patients with ALT≤2×ULN who were treated in Department of Hepatobiliary Medicine,Public Health Clinical Center,Shanghai from October 2015 to December 2017 were analyzed.FibroScan,routine blood tests and serum fibrosis markers were conducted on the day or one day before liver biopsy.The Scheuer scoring system was used for liver histologic assessment.Aspartate aminotransferase to platelet ration index(APRI)and FIB-4 were calculated.Based on the results of liver pathology,the area under receiver operating characteristic curve(AUROC)was used to evaluate the value of LSM and serum markers in the diagnosis of liver fibrosis stage.Non-normal distribution variables were expressed as M(QR)as appropriate,and compared by analysis of Kruskal-Wallis test as appropriate.The correlation between two variables was analyzed by Spearman correlation analysis.Results Of 284 CHB patients,175 were male and 109 were female.For inflammatory grading,175 cases were G1 grade,88 cases were G2,and 21 cases were G3.For fibrosis grading,153 cases were S1,53 cases were S2,34 cases were S3,and 44 cases were S4.Spearman correlation analysis showed that LSM,APRI and FIB-4 were positively correlated with hepatic fibrosis stage(r=0.650,0.484,and 0.317,respectively,all P<0.01).The AUC of LSM for predicting fibrosis≥S2,≥S3,and S4 were 0.840,0.902,and 0.942,respectively.The cut-off of LSM values were 6.10,8.40,and 10.10 kPa,respectively.The values of AUC of APRI and FIB-4 for predicting fibrosis≥S2 were 0.755 and 0.638,respectively,those for predicting fibrosis≥S3 were 0.737 and 0.657,respectively,and those for S4 were 0.804 and 0.694,respectively.The AUCs of LSM for predicting fibrosis≥S2 in patients with ALT≤1×ULN and those with ALT>1 -≤2×ULN were 0.857 and 0.813,respectively,those for fibrosis≥S3 were 0.890 and 0.892,respectively,and those for S4 were 0.925 and 0.908,respectively.The cut-off of LSM were 5.90 and 7.80 kPa,8.10 and 9.50 kPa,8.40 and 10.40 kPa,respectively.Conclusions LSM could accurately assess the degree of liver fibrosis in CHB patients with ALT≤2×ULN,which is superior to serum markers for predicting liver fibrosis stage.

Study on medical technical support system in tent-form field medical system / 医疗卫生装备

Objective To develop a medical technical support module and box-type medical technical equipment so as to supply medical oxygen and water for the tent-form field medical system at field conditions.Methods The medical technical support module had its service orientation analyzed to determine its functional requirements and technical indexes, which involved in PSA oxygen generation technology with variable frequency,constant pressure and self-adaptability to altitudes as well as medical water preparation technology by integrated membrane separation. Box-type modules for medical oxygen generation and medial water preparation were trial-produced with the mode of integrated box and instruments as well as high-density polyethylene as the box material.Results The oxygen production was 1.3 Nm3/h,and the oxygen concentration was 92.7%.The flow volume of cleaning water and purified water was 433.7 and 37.2 L/h respectively at 25℃,and the water quality accorded with the relevant water quality indexes of GB 5749—2006 and the national pharmacopoeia(2010 edition). Conclusion This set of medical equipment can meet the design requirements and can effectively guarantee the medical oxygen and medical water needed for medical treatmentin field tent hospital under field conditions. [Chinese Medical Equipment Journal,2018,39(5):7-11]

Análisis de la relación entre la proporción áurea y el parámetro facial / Analysis of the relation between the golden ratio and the facial parameter

Introducción: la habilidad clínica para modificar la forma dentofacial a través del tratamiento ortodóntico, cirugía maxilofacial o cirugía plástica, requiere comprensión de la belleza facial, incluyendo la evaluación de la estética facial, proporciones y simetría. Objetivo: analizar la relación entre los componentes de la proporción áurea con el parámetro facial de estudiantes en la provincia Chiclayo. Métodos: la población de estudio fue representada por 88 estudiantes que cumplieron con los siguientes criterios de inclusión: edad entre 17-28 años, ambos sexos, sin tratamiento ortodóntico, con maloclusión clase I y dentición completa. Se diseñó una ficha de recolección de datos para medidas antropométricas craneofaciales. Se calibraron los examinadores, se evaluó la estabilidad de la concordancia intra e interexaminador mediante el coeficiente Kappa de Cohen. Para el contraste de la hipótesis se utilizó el coeficiente de correlación chi cuadrado. Para todas las pruebas estadísticas el nivel de significancia fue de 5 por ciento (p< 0,05). Resultados: se observó que el 65,91 por ciento del total de pacientes presentaban proporción divina en su dimensión externa, 48,86 por ciento son braquifaciales, 13,64 por ciento mesofaciales, 3,41 por ciento dolicofaciales, y el 57,95 por ciento del total presentaban proporción divina en su relación vertical, 42,05 por ciento son braquifaciales, 10,23 por ciento mesofaciales y 5,68 por ciento dolicofaciales. En cuanto al perfil armónico, el 70,45 por ciento del total de pacientes no presenta proporción divina, de los cuales el 53,41 por ciento son braquifaciales, 10,23 por ciento son mesofaciales y 6,82 por ciento son dolicofaciales. Conclusiones: solo existe relación entre la proporción áurea en su componente de dimensión externa con el parámetro facial. La proporción áurea se cumplió en todos sus componentes, en un mayor porcentaje en los individuos braquifaciales y hubo predominio de la proporción áurea en el sexo femenino(AU)

Introduction: the clinical ability to modify the dentofacial form through orthodontic treatment, maxillofacial surgery, or plastic surgery requires an understanding of facial beauty, including the evaluation of facial aesthetics, proportions, and symmetry. Objective: to analyze the relationship between the components of the golden ratio and the facial parameter of students in the province of Chiclayo. Methods: the study population was represented by 88 students who met the following inclusion criteria: age between 17 and 28 years, both sexes, without orthodontic treatment, with class I malocclusion and complete dentition. A data collection form for craniofacial anthropometric measurements was designed. The examiners were calibrated, the stability of the intra- and inter-rater concordance was evaluated using the Cohen's Kappa coefficient. For the contrast of the hypothesis, the correlation coefficient square chi was used. For all statistical tests, the level of significance was 5 percent (p< 0.05). Results: 65.91 percent of all the patients were observed to have a divine proportion in their external dimension: 48.86 percent are brachifacial, 13.64 percent mesofacial, and 3.41 percent dolichofacial. 57.95 percent of the total number of patients presented divine proportion in its vertical relation: 42.05 percent are brachifacial, 10.23 percent mesofacial, and 5.68 percent dolichofacial. Regarding the harmonic profile, 70.45 percent of the total number of patients did not present a divine proportion: 53.41 percent are brachifacial, 10.23 percent are mesofacial, and 6.82 percent are dolichofacial. Conclusions: there is only a relationship between the golden ratio in its external dimension component and the facial parameter. The golden ratio was fulfilled in all its components, in a greater percentage in the brachifacial individuals, and there was a predominance of the golden ratio in the female sex(AU)

Impacto do sistema de campo livre dinâmico na voz do professor: estudo de caso / Dynamic soundfield system impact on the teacher's voice: case report

RESUMO Este estudo teve como tema avaliar o efeito do sistema de campo livre dinâmico, em um período do dia, nos sintomas vocais e na qualidade vocal de uma professora em sala de aula. Relato de caso clínico de uma professora de 44 anos, que atuava na função há 23 anos, e lecionava na mesma sala no período matutino e vespertino. A professora utilizou um sistema de amplificação em campo livre dinâmico durante um dos períodos do dia por aproximadamente três meses. Foi realizada avaliação diária da ocorrência dos sintomas no trato vocal, e da intensidade deles antes e após a aula; análise perceptivo-auditiva e acústica da voz antes e após o período de observação, e aplicação de um questionário de autopercepção sobre o uso do sistema de campo livre dinâmico, ao final do período de observação. Os dados foram analisados descritivamente e por meio do teste de Wilcoxon (p=0,05). Observou-se diminuição da intensidade do sintoma "secura" ao final da aula, e menor ocorrência de sintomas vocais com a utilização do sistema de campo livre dinâmico, além de melhora em parâmetros perceptivo-auditivos e acústicos da voz após o período de observação, e do relato de pontos positivos pela professora quanto ao uso de sistema de campo livre dinâmico. No caso estudado, o uso do sistema de campo livre dinâmico, em um dos períodos do dia, foi efetivo na diminuição dos sintomas e na melhora na qualidade vocal perceptivo-auditiva e acústica.

ABSTRACT The theme of this study was to evaluate the effect of the dynamic soundfield system in one period of the day, the teacher's vocal symptoms and voice quality in the classroom. A case relate of a teacher of 44 years who served in the role for 23 years, and taught in the same room in the morning and afternoon. The teacher used the dynamic soundfield system during one of the periods of the day for about three months. Daily evaluation was carried out of the occurrence of symptoms in the vocal tract, and their intensity before and after school; perceptual and acoustic analysis of voice before and after the observation period, and applying a self-perception questionnaire about the use of dynamic open field system, the end of the observation period. The data were analyzed descriptive and by the Wilcoxon test (p=0.05). There was a decrease in the intensity of the symptom "dryness" to the end of class, and lower incidence of vocal symptoms with the use of dynamic soundfield system, as well as improvement in perceptual and acoustic parameters of the voice after a period of observation and reporting of positives by the teacher on the use of dynamic soundfield system. In the case study, the use of dynamic soundfield system, one of the periods of the day, was effective in reducing symptoms and improvement in perceptual voice quality and acoustics.

Uso de aminas bioativas na dieta de aves de corte: uma revisão / Use of bioactive amines in the cutting bird diet: a review

Aminas bioativas vêm, ao longo dos anos, despertando o interesse dos pesquisadores no que se refere aos benefícios e aos prejuízos da sua presença ou mesmo do seu uso intencional, principalmente na alimentação de aves de corte, refletindo posteriormente na qualidade da carne produzida pelas mesmas. A presença de determinadas aminas em rações de aves de corte pode beneficiar e acelerar o desenvolvimento das mesmas, no entanto, quando presente em níveis elevados pode retardar o crescimento, causar disfunções metabólicas ou mesmo a morte dos animais. Estudos vêm sendo realizados a fim de definir quantidades ideais e tipos de aminas a ser adicionada à dieta a fim de propiciar um desenvolvimento adequado às aves sem, no entanto, apresentar resíduos na carne das mesmas.

Role of platelet-derived growth factor after hemorrhagic shock in rats / 局解手术学杂志

Objective To investigate platelet-derived growth factor ( PDGF ) protection on blood flow and mitochondrial function of hemorrhagic shock rats. Methods Ninety-six SD rats were randomly divided into six groups including shock group, lactated ringer's solution (LR) resuscitation group,PDGF treatment groups(1,3. 5,7,15μg/kg). Laster-Doppler and oxygen concentration determination method were applied to observe the protective effect of PDGF treatment on animal survival,blood flow and mitochondrial function in liver and kidney. Re-sults As compared with LR resuscitation group,PDGF treatment increased animal survival rate and also improved blood fiow of liver and kindy,mitochondrial respiration control ration(RCR),of which the group with 3. 5μg/kg had the best result. Conclusion This finding sug-gests that PDGF may be a potential agent to treat acute critical such as hemorrhagic shock.

Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats.

Introduction: Melatonin has been considered a potent antioxidant that detoxifi es a variety of reactive oxygen species in many pathophysiological states of eye. The present study was designed to determine the eff ects of Wi-Fi exposure on the lens oxidant, antioxidant redox systems, as well as the possible protective effects of melatonin on the lens injury induced by electromagnetic radiation (EMR). Materials and Methods: Thirty-two rats were used in the current study and they were randomly divided into four equal groups as follows: First and second groups were cage-control and sham-control rats. Rats in third group were exposed to Wi-Fi (2.45 GHz) for duration of 60 min/day for 30 days. As in the third group, the fourth group was treated with melatonin. The one-hour exposure to irradiation in second, third and fourth took place at noon each day. Results: Lipid peroxidation levels in the lens were slightly higher in third (Wi-Fi) group than in cage and sham control groups although their concentrations were signifi cantly (P < 0.05) decreased by melatonin supplementation. Glutathione peroxidase (GSH-Px) activity was signifi cantly (P < 0.05) lower in Wi-Fi group than in cage and sham control groups although GSH-Px (P < 0.01) and reduced glutathione (P < 0.05) values were signifi cantly higher in Wi-Fi + melatonin group than in Wi-Fi group. Conclusions: There are poor oxidative toxic eff ects of one hour of Wi-Fi exposure on the lens in the animals. However, melatonin supplementation in the lens seems to have protective eff ects on the oxidant system by modulation of GSH-Px activity.

Effectiveness analysis on management of antimicrobial agents within three years / 中国感染控制杂志

Objective To analyze antimicrobial use in the different grades of hospitals within 3 years after the car-rying out of rectification activities of antimicrobial use,and provide basis for making continuous improvement pro-gram of antimicrobial management.Methods Retrospective analysis was performed,outpatient and emergency pre-scriptions and medical records of discharged patients (100 were type Ⅰ incision surgery)were selected from 5 tertia-ry hospitals and 5 secondary hospitals within 3 months,antimicrobial use and management were investigated. Results 200 outpatient prescriptions,100 emergency prescriptions,and 200 medical records of discharged patients were selected from each hospital.In tertiary and secondary hospitals,antimicrobial usage rate in outpatient prescrip-tions was 17.40% and 18.00% respectively,emergency prescriptions was 31 .60% and 40.10% respectively;a-mong inpatients,antimicrobial usage density(AUD)was (28.13±8.04)and (49.67±11 .63)respectively,and anti-microbial usage rate was 41 .30% and 56.20% respectively;pathogenic detection rate of antimicrobial therapeutic cases was 45.70% and 22.70% respectively,therapeutic cases with limit level of antimicrobials was 61 .50% and 27.40% respectively;antimicrobial usage rate in type I incision surgery was 20.00% and 40.40% respectively;The rational rate of antimicrobial types was 94.60% and 59.20% respectively,rational rate of opportunity of antimicro-bial use was 95.20% and 48.20% respectively;combination rate was 8.80% and 36.60% respectively,and rational rate of treatment course was 84.00% and 52.80% respectively.Conclusion In tertiary hospitals,antimicrobial use after 3 years rectification of antimicrobial use conform to the antimicrobial management requirement of Ministry of Health,the overall quality index is better than secondary hospitals,management of antimicrobial in secondary hos-pitals use should be improved.

The value of plasma N terminal brain natriuretic peptide in dialysis adequacy assessment of maintenance hemodialysis / 中国医师进修杂志

Objective To investigate the value of plasma N terminal brain natriuretic peptide (NT-BNP) in dialysis adequacy assessment of maintenance hemodialysis (MHD).Methods One hundred and twelve MHD patients were divided into hemodialysis adequacy group (group A,63 patients,cardiothoracic ration ＜0.5) and hemodialysis inadequate group (group B,49 patients,cardiothoracic ration ≥ 0.5).The plasma NT-BNP levels of pre-dialysis,dialysis end,4th and 24th hour after dialysis were compared.Before and after dialysis the inferior vena cava diameter (VCD) was checked.The correlation between NT-BNP level at the end of dialysis,cardiothoracic ration and post dialysis VCD were analyzed.Results The levels of NT-BNP in group A,B before dialysis were(13 808 ± 7611) and (25 573 ± 8444)ng/L respectively,and there was significant difference (P ＜ 0.01).The levels of NT-BNP in two groups increased at the end of dialysis,but there was no significant difference (P ＞0.05).Then the levels of NT-BNP in two groups decreased significantly at 4th hour after dialysis (P ＜ 0.01).The levels of NT-BNP in two groups at 4th hour after dialysis were (8256 ±6611) and (21 320 ±6828) ng/L,and there was significant difference (P＜ 0.01).At 24th hour after dialysis,the level of NT-BNP in group A was still at a low level,but in group B,the level of NT-BNP increased again.Before dialysis,the levels of VCD between two groups had no significant difference (P ＞ 0.05).After dialysis,the level of VCD in group B decreased significantly(P ＜ 0.05).After dialysis,the level of VCD in group B was significantly higher than that in group A(P＜ 0.05).The level of NT-BNP had positive relationship with cardiothoracic ration and VCD (r =0.462,P＜ 0.01 ;r =0.513,P＜ 0.01).Conclusion The level of NT-BNP can reflect the volume overload and urea clearance index of MHD,which may be a more comprehensive evaluation index of the adequacy of dialysis.

A Case of a Pulmonary Arteriovenous Malformation With Ebstein's Anomaly

A pulmonary arteriovenous malformation (PAVM) is a rare pulmonary vascular anomaly presenting as dyspnea or recurrent epistaxis. Ebstein's anomaly (EA), a congenital cardiac malformation, is also a rare condition. There have been no reports concerning the co-existence of PAVM with hereditary hemorrhagic telangiectasia (HHT) and EA. A 40-year-old woman was admitted with a 2-month history of increasing dyspnea and several years of recurrent epistaxis. On transthoracic echocardiography, she was diagnosed with EA and agreed to undergo surgical treatment. A chest CT angiography showed a 12-mm serpiginous vascular structure suspicious for a PAVM and a liver CT suggested HTT. Although it is unclear whether or not a concurrent PAVM and EA have an embryologic or genetic relationship, we report a case of a PAVM with EA. Further genetic and embryonic studies are needed to identify a possible relationship of the two medical conditions.

Juvenis de carpa capim alimentados com capim teosinto e suplementados com diferentes taxas de arraçoamento / Grass carp juveniles fed with teosinte grass and supplied with different feeding rates

Avaliou-se o desenvolvimento de juvenis de carpa capim (Ctenopharyngodon idella) alimentados com capim teosinto (Euchlaena mexicana) e suplementados com ração. Realizaram-se dois experimentos, de 45 dias, utilizando 240 juvenis em cada um (peso médio: 10,9±0,3g e 20,2±0,2g). No experimento 1, os peixes foram alimentados com capim teosinto mais ração, em 4 níveis de suplementação: 1, 2, 3 e 4 por cento do PV, denominados S1, S2, S3 e S4. No experimento 2, testou-se: C=Somente Capim Teosinto; SD=Capim Teosinto+ Suplementação diária (3 por centoPV); SA=Capim Teosinto + Suplementação a cada dois dias (3 por centoPV); R=Somente ração (3 por cento PV). No experimento 1, observou-se aumento linear positivo do peso em relação à suplementação com ração. A melhor taxa de crescimento específico foi obtida com o tratamento S4. O rendimento de filé foi maior nos tratamentos S3 e S4. No experimento 2, para a variável peso, o tratamento SD diferiu significativamente dos demais. Os tratamentos SD, SA e R não diferiram estatisticamente em relação ao rendimento de filé, porém, houve diferença entre o tratamento SD e o C. Conclui-se que a associação do capim teosinto com a ração (3 por centoPV) proporciona bom crescimento para juvenis de carpa capim.

This study was aimed at evaluating the growth of grass carp juveniles (Ctenopharyngodon idella) fed with teosinte grass (Euchlaena mexicana) and supplied with different feeding rates. Two experiments were done (45 days each), using 240 juveniles (weight=10.33 ± 0.33 and 20.15 ± 0.23g). In the first, four feeding rates (1, 2, 3 and 4 percent of body weight (BW), called S1, S2, S3 and S4 respectively) were tested. In the second, the treatments were: C = Only teosinte grass; SD = Teosinte grass + ration daily (3 percentBW); SA = Teosinte grass + ration each 2 days (3 percentBW); R = Only ration (3 percentBW). In the experiment 1, it was observed a weight increasing following the ration supply. The higher specific growth rate was obtained in S4. No differences among treatments was verify for carcass yield, however, the fillet yield was higher in S3 and S4. In the experiment 2, weight was higher in SD. The carcass yield (RC) did not present significant difference among the treatments in the experiment 2. Fillet yield was lower in fish fed only with teosinte grass (C). We concluded that the grass carp juveniles growing is positively affected by association of teosinte grass and ration supply, being necessary a minimum feeding rate (3 percentBW) daily for achieving good growth.

Microalbuminuria and the prognosis of the serious patients / 国际外科学杂志

Microalbuminuria is regarded as a reflection of increased capillary permeability associated with the systemic inflammatory response syndrome. It is obversed that many medical diseases such as diabetes,kidney disease and cardiovascular disease may result in microalbuminuria and reported microalbuminuria with correlation of the prognosis of the serious patients. This article reviews ,microalbuminuria with correlation of the prognosis of the serious patients, the value of predicting illness severity in the serious patients.

Influence of tethered cord syndrome on the upper urinary tract and its etiology / 中华泌尿外科杂志

Objective To investigate the influence of tethered cord syndrome (TCS) on the up-per urinary tract and its etiology. Methods Forty patients with TCS diagnosed by spinal MRI were enrolled in this study. There were 21 males and 19 females with mean age of 23 years old. The course of disease ranged from 1 to 40 years. Urinalysis, mid-stream urine culture, serum creatinine(SCr), urinary system ultrasound, IVU, eystography and urodynamic study were carried out on all patients. Results Urinary tract infection was found in 17 patients and increased level of SCr was found in 6 pa-tients (251.64±98.5μmol/L). Of the 29 patients who underwent urinary system ultrasound examina-tion, 12 cases had hydronephroais and dilated upper ureter. Of the 30 patients who underwent IVU, 10(33.3%) had ureterectasia and hydronephrosis, 22 cases had bladder turriform or Christmas tree like deformity with diverticulum and trabeculum. Of the 22 patients accepted cystography, 17 cases had vesieoureteral reflux on 27 sides. Post-void residual (PVR) was evaluated in 35 patients and found increased in 31 cases. Cystometry had been done in 33 patients. The mean value of maximal detrusor pressure (Pdetmax) during filling phase was 41.2±20.9 cm H2O. The detrusor compliance was 22.35±18.8 ml/cm H2O. During voiding phase, detrusor-sphincter dyssynergia(DSD)was observed in 16 patients, detrusor areflexia was observed in 16 patients and detrusor underactivity was observed in 13 patients. Resting urethral pressure profilemetry was measured in 16 patients. Maximal urethral closure pressure (MUCP) was 76.1±33.1 cm H2O. The upper urinary tract deterioration was de-fined as increased SCr, hydronephrosis or vesicoureteral reflux. There were 20 patients diagnosed as upper urinary tract deterioration. The compliance of the upper urinary tract deteriorating group and the no-deteriorating group was 9.4±7.8 vs 19.3±15.8 ml/cm H2O, Pdetmax was 43.1±21.2 vs 24.0±11.9 cm H2O, PVR 189.0±138.0 vs 47.8±36.8 ml, MUCP 86.2±32.4 vs 46.8 5±20.8 cm H2O, incidence of damaged detrusor 100.0% vs 69.2% and DSD 65.0% vs 23.1%, respectively. There were significant differences between the 2 groups(P<0.05). And when comparing the VUR group with no VUR group, the incidence of urinary tract infection was 94.1%(16/17) vs 20.0%(1/ 5) (P=0.003). And when comparing urinary tract infection group with no infection group, the inci-dence of upper urinary tract deterioration was 88.2% (15/17) vs 21.7%(5/23)(P=0.000). Condn-sion Low compliance bladder, high Pdetmax during filling phase, increased PVR, high MUCP, damage of detrusor contractive function and DSD are the risk factors for upper urinary tract deteriora-tion in the TCS patients.

The Isolation,Culturing and Differentiation of Neural Stem Cells Originated from Rat Embryonic Brain / 医学研究杂志

Objective To investigate the met ho ds of isolation,culturing and passaging of neural stem cells originated from ra t embryonic brains.Methods The neural stem cells were obtained from the brain tissue of rat embryos.They were cultured and passaged with serum-free medium.T hey were identified with Nestin and stained with NF68,GFAP,and GalC after diff erentiation.Results We cultured the neural stem cells through several passages .With the help of serum,they differentiated to neurons,astrocytes and oligode ndrocytes.Conclusion The neural stem cells derived from rat embryonic brains a re able to proliferate and multiplepotent for differentiation.

Taguchi's loss function applied in the breeding of Tilapia, Oreochromis niloticus fed with different levels of proteins of yeast in tank-nets / Função perda de taguchi aplicada na criação de tilápia, oreochromis niloticus alimentadas com diferentes níveis de proteínas de levedura em tanques-rede / Función pérdida de taguchi aplicada en la creación de tilapia, oreochromis niloticus alimentadas con diferentes niveles de proteínas de levadura en estanques-red

The experiment was based on observations of 120 juveniles of tilapias of Nile, Oreochromis niloticus, sexually reverted, with an initial medium weight of 116.65 0.85 g, distributed in a completely randomized design for 168 days. The objective of this work was to evaluate the effect of introducing tank-nets on the function Taguchi's loss fed with 0% (control), 20%, 40% and 60% (tests) of yeast distillery protein in substitution of traditional source of protein. The test of Tukey was accomplished showing that there were not statistical differences (p > 0.05) among the effi ciency, the length and the weight of the fi sh. With relationship to the survival, it was observed that the treatments (T2, T3, T4) were statistically superior (p < 0.01) to the treatment T1. Taguchi's loss for the cost of production and for the dead fi shes in tank-nets in the treatment T2 = 20%, T3 = 40% and T4 = 60% (tests) were lower the group control (T1 = 0%). This result confi rm the direction of yeast distillery protein in substitution of traditional source of protein.

Foram utilizados 120 juvenis de tilápia do Nilo, Oreochromis niloticus, sexualmente revertidos, com peso médio inicial de 116,65 ± 0,85 g, distribuídos num delineamento inteiramente casualizado, durante 168 dias. O objetivo foi avaliar o efeito da introdução de tanques-rede com cultivo de peixes alimentados com 0% (grupo padrão), 20%, 40% e 60% (grupos testes) de proteína oriunda de levedura de destilaria em substituição à proteína de fontes tradicionais sobre a função perda de Taguchi. O teste de Tukey foi realizado mostrando que não houve diferenças estatísticas (p > 0,05) entre a efi ciência, o comprimento e o peso dos peixes. Com relação à sobrevivência, foi observado que os tratamentos (T2 , T3 , T4 ) foram estatisticamente superiores (p < 0,01) ao tratamento T1 . As perdas de Taguchi para o custo de produção e para os peixes mortos nos tanques para os tratamentos T2 = 20%, T3 = 40% e T4 = 60% , foram inferiores ao grupo controle (T1 = 0%). Este resultado confi rma o direcionamento da proteína oriunda de levedura de destilaria em substituição à proteína de fontes tradicionais.

Fueron utilizados 120 joveniles de tilapia del Nilo (Oreochromis niloticus), sexualmente revertidas con peso mediano inicial de 116,65 mas o menos 0,85g distribuido en un diseno totalmente seleccionado al azar por 168 dias. El objetivo de este trabajo fue evaluar el efecto de la sustitución de 0% (control), 20%, 40% y 60% (grupo teste) de proteína oriunda de levadura de destilería en sustitución a la proteína de fuentes tradicionales sobre la función pérdida de Taguchi. La prueba de Tukey era demonstración lograda que no había diferencias estadísticas (p>0,05) entre la eficacia, la longitud y el peso de los pescados. Con relación a la supervivencia, fue observado que los tratamientos (T2, T3, T4) eran estatisticamente superior (p<0,01) ao T1 del tratamiento. Las pérdidas de Taguchi para el coste de producción y para los peces muertos en los estanques-red para los tratamientos T2 = 20%, T3 = 40% y T4=60%, fueron inferiores al grupo control (T1 = 0%). Este resultado confirma el direccionameiento de la proteína oriunda de la levadura de destilería en sustitución a la proteína de fuentes tradicionales.