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Seven aromatic glycosides (1-7), including four phenylethanol glycosides, one phenylmethanol glycoside, one phenylpropane glycoside and one benzoside, were isolated from the methanolic extract of Uighur Medicine Elaeagnus angustifolia flowers. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Compound 1 is a new compound, named as angustifol A. Six known compounds were identified as 2-phenylethyl-O-β-D-glucopyranoside(2), salidroside (3), vanillic acid 4-O-β-D-glucopyranoside(4), vanilloloside (5), (Z)-isoconiferin (6), 2-phenylethyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside (7). Compounds 2-7 were isolated from the genus Elaeagnus for the first time. In vitro anti-inflammatory assays revealed that none of these compounds showed good COX inhibitory activities.
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Uighur medicine compound, which created and used by Uighur nationality, is under the guidance of the Uighur medical theory system of herbal formula and dialectical use of minority nationality conventional medicines. In recent years, Uighur medicine attracted more and more attention of people which have used and were using it. Combining the history of Uighur medicine, this article summarizes the Uighur resources, medicinal materials, drugs preparation, ancient documents, and the establishment of the clinical evaluation system and so on, and then analyzes the status quo and the existing problems in Uighur medicine compound research and industry. On this basis, we put forward countermeasures and suggestions for the development of Uighur medicine.
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Two new lanostane triterpenoid acids, 12β, 15α-dihydroxy-24-methyl-3,23-dioxo-lanosta-7,9(11)-dien-26-oic acid (1), and 3α, 12β-dihydroxy-24-methyl-7,23-dioxo-lanosta-8-en-26-oic acid (2), were isolated from the methanolic extract of Uighur medicine Fomes officinalis. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Anti-inflammatory and cytotoxicity assays revealed that both compound 1 and 2 show no inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW264.7 cells, and no cytotoxicity activities against HepG2 cells.
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Objective To investigate the influence of long-term exposure to oil and gas toxicants on the peripheral blood T lym-phocyte subsets in Karamay Uygur and Han refining workers and the underlying mechanism.Methods 175 cases of Uighur and Han refinery workers who had long-term close contact with poison of oil and gas(112 cases of Han people and 63 cases of Uygur people)and 110 healthy people(70 cases of Han people,40 cases of Uighur)were selected as research subject.The peripheral blood T lymphocyte subsets of all cases were detected for comparative analysis.Results Compared with healthy control group,the median of CD4+in the uighur refinery workers was significantly reduced(P<0.05);the CD8+in Han ethnic refinery workers was signifi-cantly lower,while the ratio of CD4+/CD8+increased significantly(P<0.05).Compared with Han ethnic,the median of CD3+, CD8+in uighur significantly increased,while the ratio of CD4+/CD8+decreased significantly(P<0.05).Conclusion Long-term close contact(more than 5 years)of oil and gas poison will significantly reduce the function of peripheral blood T lymphocyte sub-sets of refinery workers,and the effect on Han ethnic oil refinery workers was significantly higher than that on Uighur,,so corre-sponding measures on effective occupational protection are necessary to carry out.
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Uihgur medicine is not only an important component of medicine for ethnic minorities in China,but an vital supplement to modern medicine.With the development of modern science,in recent years good progerss has been made in basic sciences and applied research of Uighur medicine.According to the property of Uighur materia medica,medicine can be divided into hot,cold,wet,dry,dry-hot,wet-hot,wet-cold,and dry-cold types,and according to strength of medicinal properties,this medicine is divided into four classes.Most of the drugs of levels 3 and 4 are credited with toxicity.This article summarizes the property and toxicity of medicines of levels 3 and 4 which are includel in Pharmaceutical Standards-Uighur Medicine (1998) edited by the former State Ministry of Health of the People's Republic of China.
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Objective To observe brain areas activated during verb generation in Uyghur and Chinese,and thus to explore the neural mechanism of speech formation and understanding and the language barriers after brain injury and during recovery.Methods The blood oxygen level dependent contrast functional magnetic resonance imaging (BOLD-fMRI) was used to scan activated brain areas of 31 cases of Uyghur and 28 cases of Chinese speakers as they completed a verb generation task.Results The mainareas activated in the brains of the Chinese group were the left caudate nucleus,the left inferior occipital gyrus,the left fusiformgyrus,bilateral supplementary motor areas (BA8/6),the left BA32 area,the left precuneus,the left superior parietal lobe (BA7),the left inferior parietal lobe,the left angular gyrus,the right precentral area (BA9),the pars triangularis of the left inferior frontal gyrus,the pars opercularis of the right inferior frontal gyrus and the bilateral cerebellum.The main activated areas of the Uyghur group were the left precentral area (BA9),the pars opercularis of the left inferior frontal gyrus,the pars triangularis of the left inferior frontal gyrus and the left cerebellum.Moreover,the Chinese group showed significantlygreater activation in left caudate body,the left orbital part of the middle frontal gyrus,the right caudate head and the bilateral anterior cingulate gyrus (BA32) compared to the Uyghur group.The Uyghur group,on the other hand,did not show activation significantly greater than that of the Chinese group in any area.Conclusions The brain areas activated when generating verbs in Uyghur and Chinese are not exactly the same-the processing of Uyghur mainly occursin the left hemisphere,while that of Chinese may need the participation of more brain areas in the right hemisphere.
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<p><b>OBJECTIVE</b>To investigate the distribution of abnormal hilit syndromes in traditional Uighur medicine (TUM) among human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) patients, and to find out the clinical characteristics of abnormal savda syndrome type HIV/AIDS patients.</p><p><b>METHODS</b>Between June and July in 2012, 307 eligible HIV/AIDS patients from in-patient department and out-patient clinics of Xinjiang Uighur Autonomous Region the Sixth People's Hospital in Urumqi were investigated. TUM syndrome differentiation was performed by a senior TUM physician. Each participant completed a Sign and Symptom Check-List for Persons Living with HIV/AIDS (SSC-HIV) questionnaire. Depression was evaluated by using Hamilton Rating Scale for Depression Questionnaire. Blood specimen was collected from each participant to test the levels of blood chemicals.</p><p><b>RESULTS</b>Of 307 HIV/AIDS patients, 189 (61.6%) were abnormal savda syndrome type, 118 (38.4%) were non-abnormal-savda syndrome type. Mean CD4 counts of abnormal savda syndrome type patients was (227.61±192.93) cells/µL, and the prevalence of anemia, thrombocytopenia, and elevated cystatin C were 49.7%, 28.6%, and 44.7%, which were significantly higher than those in the non-abnormal-savda syndrome type patients (26.3%, 16.0% and 25.0%,P<0.05). In addition, depression (79.9%) and HIV/AIDS-related symptoms such as fatigue (42.3%), back aches (40.7%), lack of appetite (33.9%), night sweats (31.7%) were more common among abnormal savda syndrome patients (P<0.05).</p><p><b>CONCLUSION</b>Abnormal savda syndrome is the dominant syndrome among HIV/AIDS patients, and they present a more sever clinical manifestation.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Acquired Immunodeficiency Syndrome , Diagnosis , CD4 Lymphocyte Count , China , Ethnology , Cross-Sectional Studies , HIV Infections , Diagnosis , Medicine, Traditional , Surveys and QuestionnairesABSTRACT
Objective To investigate the relationship between the polymorphism of the tumor necrosis factor-αgene-308 promoter and bronchial asthma (BA)in Uighur and Kazakh population in Xinjiang.Methods PCR product sequencing method was used to detect the polymorphism distribution of TNF-αgene in 60 BA patients and 60 controls among Xinjiang Uighur and Kazakh population.Then we analyzed the association between different TNF-αgenotypes and BA in Uighur and Kazakh population.Results The distribution of GG,GA and AA genotype was significantly different between the two groups.Statistical analysis showed that BA group had a significantly higher TNF-αA allele frequency than that of the control one (P <0.05).After adjustment for sex and age,we found the A allele was a risk factor for BA pathogenesis (P <0.05).Conclusion The polymorphism of TNF-α gene-308 may be associated with the susceptibility to BA in Xinjiang Uighur and Kazakh population,so TNF-α gene-308 may be considered as a genetic marker for early identification of individuals at high risk for BA,which may play an important role in preventing the development of BA in clinical practice.
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Objective To investigate the clinical characteristics and differences among Uygur and Han patients with simple severe preeclampsia and their first-degree relatives. Methods To analysis the 100 cases with simple severe preeclampsia among Uygur and Han patients and their first-degree relatives. Results The age and gestational age between Uygur and Han group, there was no significant difference (P>0. 05). Average production time, women with preeclampsia history and BMI of Uygur group were higher than the Han group(P 0. 05). Conclusion During pregnancy, the Uygur should pay more attention to improve diet structure, control body weight, and strengthen their pregnancy health care, so that the disease can be early diagnosed and treated, reducing or avoiding therapeutic preterm labor.
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Objective To identify the genotype and allele distribution feature of cytochrome CYP2C19 in Chinese Uighur , Kazak and Han populations ,and by detecting the CYP2C19 genotype .Methods Finding out the differences of genotype distribution among the three Chinese nationalities .The 750 inpatients were selected from Second Department of Internal Medicine ,Cadres Ward of First Affiliated Hospital of Xinjiang Medical University .The CYP2C19 genotypes of the unrelated patients were assessed by pol‐ymerase chain reaction and restriction fragment length polymorphism .Results Six different CYP2C19 genotypes were determined in this study .There was a significant difference among the three Chinese nationalities (P< 0 .05) .The rate of fast metabolism type in Kazak is 93 .8% more than the rate of Han populations .The rate of slow metabolism type in Kazak is 6 .2% less than the rate of Han populations .The difference was statistically significant (P= 0 .006) .Conclusion Nationality has significant effect on genetic polymorphism of CYP2C19 in Chinese Uighur ,Kazakand and Han populations .
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BACKGROUND:The aid treatment of aphasia is mainly achieved through computer training system, and the applied software of the market at present is mainly Chinese aphasia training system software. The software for a native Uighur aphasia patient does not apply and no research of Uygur language aphasia training software has been reported. OBJECTIVE:To design a clinic oriented training software for Uighur aphasia, based on training specifications of rehabilitative therapist in the treatment of Uighur aphasia patients. METHODS:The experiment was conducted from January 2013 to December 2013 in South and North areas of Xinjiang Uygur Autonomous Region, deeply researching the common and familiar life material of the Uyghur’s and combining the life custom of the Uyghur’s, to screen the relevant materials of the speech rehabilitation training, preliminary build up the living language material database of the Uyghur’s. Basing on this database, we designed the computer-assisted application software which has the Uygur and Chinese double interface. The software is designed by the software research and development personnel in accordance with the requirements of the members of our group, with Uygur and Chinese double interface speech rehabilitation training software. 30 Uygur aphasiac patients after stroke in Xinjiang were screened for clinical trials and evaluation, the software after many corrections, detailed recorded the valuable dates and the problems existing in the experimental stage. And we constantly communicate with the software designers so as to repeatedly revise the wrong in the process of training, and eventualy developing a set of basic mature Uygur language aphasia and training software. RESULTS AND CONCLUSION:A set of basic mature Uygur aphasia training software was designed. With the research and development of the Uighur aphasia training software, speech therapists of Xinjiang get a fuly functional, easy operation, flexible extension training tool, which help to reduce the workload of speech therapists and improve the clinical efficiency.
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@#Objective To study the writing characteristics and related focuses in brain in patients with Uighur and Chinese agraphia.Methods Aphasia Battery of Chinese (ABC) and Uighur ABC were used to examine the characteristics of speaking and writing. The focues were observed with CT and MRI. Results 67 patients were with agraphia, in which 37 were Uigur and 30 were ethnic Han. Both groups mostly showed aphasic agraphia, the focuses were found in various areas in the brain, and mostly located on the left frontal, parietal, temporal lobes and basal ganglion. Conclusion The characteristics of writing were various with the types of agraphia, but similar between Uighur and Chinese cases with same writing characteristics.Writing behavior relies on the cooperation of the whole neuromechanism.
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Objective To investigate the relationships between the HPV infection and race susceptibility in the carcinogenesis of Uighur women with cervical cancer from the southern Xinjiang, one of the high risk region of cervical cancer in China. Methods To detect 21 subtypes of HPV and the 13 alleles of HLA from 200 cervical cancer cases and 200 normal tissues, by using flow-through hybridization and gene chip (HybriMax) method and polymerase chain reaction sequence-specific oligonucleotide method (PCRSSO). Results ( 1 )The proportion of HPV positive in cervical cancer and control group were 88.5% and 7.0% respecfively;HPV16 was the most common type in HPV positive cervical cancer patients with the rate of 90.96%, following were HPV18 (5.08%), HPV68(3.95% ),HPV45 (3.39%), HPV58 (3.39%),HPV39( 1.69% ), HPV31 ( 1.69% ), HPV56( 1.13% ). In cervical cancer and control group, the positive rate of HPV and HPV16 were significantly higher than that in control group. (2) In cervical cancer group the frequency of HLA-DRB1 * 15 in HPV positive cervical cancer cases was significantly higher than that among the HPV negative cases. While the frequency of HLA-DRB1 * 12 in HPV positive eervical caneer eases was significantly lower than that in the HPV negative e asea. Conclusion HPV16 was the most common type in both cervical cancer and control groups, the frequency of HPV16 in cervical carcinomas was very high, following HPV18 and HPV68, and HPV68 ranked third which was different from the results of other reports,this indicates that Uighur women are infected with this type more common. It appears that HLA-DRB1 * 15may be related to the susceptibility to cervical cancer and the HPV16 infection among the Uighur women,while the HLA-DRB1 * 12 the protective gene to HPV16 infection in Uighur women. The study of HLA alleles in the carcinogenesis of cervical carcinomas may play an important role in the gene intervention research of cervical cancer.
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Objective: To identify the differential expression of human leukocyte antigen I (HLA-I) between patients of Uighur and Han ethnic groups with cervical diseases. Methods: The expression levels of HLA-I protein in chronic cervicitis, cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (CSCC) tissues from female patients of Uighur and Han ethnic groups were examined by immunohistochemistry method. Results: The expressions of HLA-I protein in chronic cervicitis, CIN and CSCC tissues were normal, partial-lost and negative, respectively. The total loss rates of HLA-I protein expression were 2% (1/49), 26% (29/113) and 49% (34/70) in chronic cervicitis, CIN and CSCC tissues, respectively (P<0.05). The increasing tendency of total loss rate of HLA-I protein expression accompanied by the enhancement of cervical disease severity in the Uighur ethnic group was similar to that of the Han ethnic group. The total loss rates of HLA-I protein expression in CIN and CSCC tissues were both higher in Uighur women (27% and 53%, respectively) than those in Han women (18% and 37%, respectively). Conclusion: The loss of HLA-I protein expression may predict the progression of cervical cancer. The differential expression of HLA I between Uighur and Han ethnic groups may reflect the different genetic pathways of carcinogenesis.
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Objective To establish differential protein expression profile specific for serum proteome of cervical carcinoma in Uighur women by protein 2-dimensional liquid phase chromatogra-phy. Methods We collected and prepared sera of cervical carcinoma from Uighur women, and sepa-rated and processed data using 2-dimensional liquid phase chromatography system specific for protein (ProteomeLabTM PF-2D ). Results A differential expression profile of serum proteome based on characteristics of protein isoelectrie point and hydrophobic features was successfully established. Fifty-six differentially expressed protein spots were found, among which there was an obvious difference in 12 peaks. Conclusion Two-dimensional liquid phase chromatography is an effective and feasible method to establish differential expression profile of serum proteome and to offer a new way for the screening of serum protein markers of Uighur women with cervical carcinoma.
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Objective To study the effect of Abnormal Savda Munziq (ASMq) on MDR and expression of mRNA of Bel/Fu cell line. Methods Several genes expression including MDR1, MRP, TOPOII? and GST-? were analyzed by RT-PCR. Results ASMq has been found to down-regulate MDR1 gene and simultaneously up-regulate TopoⅡ?mRNA. Conclusion ASMq can reverse the drug resistance against 5-Fu in Bel/Fu cells. Inhibition of MDR1 mRNA and up-regulate TopoⅡ? mRNA may contribute to the mechanisms.
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Objective:To observe the clinic effect of wild apricot in Xinjiang Uighur nationality on fatty liver.Methods:With a western medicine group as the control group,the treatment courses of both two groups were 12 weeks.The trial group was given wild apricot decoction orally,the control group was given vitamin B,C and Glucurolactone tables.Results:Wild apricot exerted a significant effect in lowering the fat and treating the fatty liver without any toxic and side-effects.Conclusion:Wild apricot in Xinjiang Uighur nationality served as a vital treatment to fatty livers,which was worth being further promoted in the clinical therapy.
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Objective To study the Secretor gene (FUT2) molecular structure of Uighur population in Xinjiang area,China. Methods DNA was extracted from 40 Uygur unrelated donors' blood and sequence analysis of FUT2 genes was performed. Results Four mutations in the FUT2 genes of Uighur donors have been identified. The frequencies of mutations were 71.25% for 357T, 28.75% for 357C,77.50% for 385A,22.50% for 385T,70% for 428G,30% for 428A,72.50% for 739G and 27.50% for 739A. Conclusion Based on the characteristics of FUT2 gene structure of Xinjiang Uighur,it cauld be thought that there are some relationships between Xinjiang Uighur, Taiwanese of China and Caucasiany.
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AIM: To study the molecular mechanisms of Abnormal Savda Munziq responsible for its anticancer property. METHODS: Anti-proliferative effect of Abnormal Savda Munziq ethanol extract was determined by MTT assay;DNA fragmentation was determined by gel electrophoresis assay,cell cycle analysis was detected by flow cytometer;apoptosis related gene expression was detected by RT-PCR assay;Caspase-3 activity was determined by Caspase-3 assay kit. RESULTS: Abnormal Savda Munziq ethanol extract possessed inhibition effect on HepG2 cells proliferation(P