Risk factors and determinants of pulmonary function impairments in chronic respiratory diseases in Ethiopia: A hospital-based cross-sectional study

Introduction: Chronic respiratory diseases (CRDs) are diseases of the lung airways and parenchyma. Globally, they are the leading causes of morbidity and mortality. This study aimed to characterize the common CRDs, along with their lung function and possible determinants in symptomatic patients attending Bishoftu General Hospital, Ethiopia. Methods: A cross-sessional study was conducted at the outpatient of Bishoftu Hospital, Ethiopia from June 2019 to March 2020. Consecutive adult patients aged 18 and above with CRDs (≥8 weeks) were recruited. Questionnaires were used to collect data on demographics, symptoms, diagnoses, and putative risk factors. Lung function was measured by spirometry. Result: A total of 170 participants were recruited, the majority 102(60.0%) were female. The mean age was 49 years (SD=16). The most common symptoms were wheezing in the last twelve months 156 (91.8%), cough 138 (81.2%), and severe exertional breathlessness 137 (80.6%). Thirty-nine (22.9%) were either active or passive smokers. Half of the patients (50.3%) were exposed daily to vapors, dust, gases, or fumes and 58 (34.3%) were exposed to biomass smoke. In total, 138 (81.2%) had a positive allergen skin prick test. Chronic bronchitis (49.1%) and asthma (36.1%) were the most common clinical diagnoses. Classification of lung function revealed 23 (15%) normal, 29 (19%) obstructive, 36(23.5%) restrictive and 61(39.9%) mixed patterns. Airflow obstruction was independently associated with increasing age (p<0.05), exertional breathlessness (p<0.001), previous history of asthma (p<0.05), BMI (p<0.05), and doctor-diagnosed chronic obstructive pulmonary disease (p<0.001) and asthma (p<0.05). Conclusion: This study shows a high burden of abnormal lung function in patients attending clinics because of CRDs symptoms. These findings support the critical need for spirometry services to determine lung abnormality in patients with chronic respiratory symptoms.

Uncovering The Sociological Interpretation of Visual Impairment-Related Inequities and Their Social Determinants in India

Introduction: Determinants of health are divided into four types, such as “Biological-Psychological-Environmental-Social Determinants”. The social determinants of health include gender disparities, economic status, ethnicity, race, geographic isolation, or having a specific health condition. Moreover, the social deter-minants are interdependent and interrelated with one another. There can also be a primary determinant that affects the other determinants. For example, educational level of the patients is associated with knowledge and awareness of eye care and its conditions. However, education might have a different effect than income in should be access of eye care when needed. Methodology: The study is mainly dependent on secondary data analysis. Results: The primary objective of the study is to illustrate the sociological aspects of visual impairment-related inequities and to identify the social determinants of visual impairments and disparities in India. An-other aim of the paper is to present a deeper understanding of how inequities impact the incidence of visual impairment and blindness based on the social determinants of health. The present study adopts the ecological and Commission on Social Determinants of Health (CSDH) framework 2008. We reaffirm the fact that inequi-ties negatively affect the visual impairment and blindness conditions. The national health policies should take into account the social determinants of visual impairment in their policies relating to comprehensive eye care. Social and economic factors are connected with health and welfare; those socio-economic inequalities con-tribute to health inequalities. For reducing the health inequalities around the world, we need effective policy implementation and proper fund pools. Furthermore, committed action on societal determinants of health, sufficient human resources are also necessary to control the health disabilities, include visual impairment

Cidade saudável: o diagnóstico do território urbano por meio dos determinantes sociais de saúde: o caso Maracanaú / Healthy city: the diagnosis of the urban territory through the social determinants of health: Maracanaú case

To understand the urban territory through the analysis of Social Determinants of Health (SDOH) as a prerequisite for structuring a Healthy City Project. This research was characterized as a documentary survey through the Laws, Master Plan and Management Reports of the City of Maracanaú and in the Government Health Information Notebooks. The analysis took place through the reading and identification of what was about the SDOH, using Content Analysis. The results brought two categories of analysis that structured a diagnosis of the area, mapping the weaknesses found with regard to the SDOH analyzed, such as: population growth, mortality rate, urban violence, among others. It is believed that the diagnosis of the area carried out through the SDOH made it possible to identify the intervention points that can be used for the preparation of a Healthy City Project.

Compreender o território urbano por meio da análise dos Determinantes Sociais de Saúde (DSSs) como pressupostos para a estruturação de uma Agenda de Cidade Saudável. Esta pesquisa se caracterizou como um levantamento documental por meio das leis, plano diretor e relatórios de gestão da cidade de Maracanaú e nos cadernos de informação em saúde do governo. A análise se deu pela leitura e identificação do que versava sobre os DSSs, utilizando-se a análise de conteúdo. Os resultados trouxeram duas categorias de análise que estruturaram um diagnóstico do território, mapeando as fragilidades encontradas no que diz respeito aos DSSs analisados como crescimento demográfico, taxa de mortalidade, violência urbana, dentre outros. Acredita-se que o diagnóstico do território realizado por meio dos DSSs possibilitou identificar os pontos interventivos que possam ser utilizados para a preparação de uma agenda de cidade saudável.

Determinantes sociales y de salud en niños y adolescentes con quemaduras / Social and health determinants in children and adolescents with burns

Introducción: En Cuba, las quemaduras se han mantenido entre las 5 primeras causas de muerte por accidentes y en la población infantil constituyen un problema de salud. Objetivo: Describir algunos determinantes sociales de salud en niños y adolescentes con quemaduras. Método: Se realizó un estudio descriptivo y transversal de 60 pacientes, hasta los 18 años edad, atendidos en el Servicio de Caumatología del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba durante 2017. Para el procesamiento de la información se empleó el paquete estadístico SPSS, versión 11.5 para Windows, así como la frecuencia absoluta y el porcentaje para el análisis de los resultados. Resultados: En la serie predominaron los pacientes de 1-4 años de edad (41,6 %), los líquidos hirvientes como principal agente causal de las quemaduras (45,0 %), además de los problemas relacionados con el abasto de agua, con el sistema de depósito de residuales, el piso de tierra en las viviendas (18,3 %), el uso de la energía de alto riesgo para cocinar (53,9 %) y el hacinamiento (46,6 %). Conclusiones: Mediante la identificación de los determinantes sociales en la comunidad se pueden detectar posibles modos de enfermarse y trazar estrategias con vistas a prevenir enfermedades y lograr poblaciones sanas.

Introduction: In Cuba, burns have stayed among the first 5 causes of death due to accidents and constitute a health problem in the youth population. Objective: To describe some social health determinant in children and adolescents with burns. Method: A descriptive and cross-sectional study of 60 patients, up to 18 years was carried out. They were assisted in the Caumatology Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba during 2017. The SPSS statistical package, version 11.5 for Windows, was used to process the information, as well as the absolute frequency and the percentage for the analysis of the results. Results: In the series there was a prevalence of the 1-4 age group (41.6 %), boiling liquids as main causal agent of burns (45.0 %), besides the problems related to water supply, residual deposit system, houses with no tiled floor (18.3 %), use of high risk energy to cook (53.9 %) and overcrowding (46.6 %). Conclusions: By means of the identification of social determinants in the community possible ways of getting sick can be detected and draw up strategies aimed at preventing diseases and achieve healthy populations.

Evaluation of Revised Atlanta Classification and Determinant-based Classification for Acute Pancreatitis / 胃肠病学

Background: The revised Atlanta classification (RAC) and determinant-based classification (DBC) are widely used in assessing the severity of acute pancreatitis (AP). However, studies on comparison between RAC and DBC are scarce. Aims: To explore the accuracy of RAC and DBC in the assessment of AP severity. Methods: The clinical data of 481 AP patients from September 2015 to September 2019 at Taizhou People's Hospital were collected and severity were stratified according to RAC and DBC. The treatment and prognosis of each subgroup were compared. Results: On the basis of RAC, 269 (55.9%), 174 (36.2%) and 38 (7.9%) patients were classified as mild AP (MAP), moderate severe AP (MSAP) and severe AP (SAP), respectively. There were significant differences in mortality, ICU monitoring rate, ICU stay, operation rate and hospital stay among the above groups (P<0.05). On the basis of DBC, 319 (66.3%), 117 (24.3%), 34 (7.1%) and 11 (2.3%) patients were classified as MAP, MSAP, SAP and critical AP (CAP), respectively. There were significant differences in mortality, ICU monitoring rate, ICU stay, operation rate and hospital stay among the above groups (P<0.05). The ICU monitoring rate (100% vs. 63.2%, P=0.014), median ICU stay (35 days vs. 15 days, P=0.001), hospital stay [(50.36±21.54) days vs. (22.78±14.56) days, P=0.038] were significantly increased in CAP patients (classified by DBC) than those in SAP patients (classified by RAC), however, no significant differences in mortality and operation rate were found between the two groups (P=0.136; P=0.202). Conclusions: Both RAC and DBC can accurately stratify the severity of AP. SAP patients (classified by RAC) complicated with infected necrosis should be further classified into CAP.

Effectiveness and Determinant Variables of Augmentative and Alternative Communication Interventions in Cerebral Palsy Patients with Communication Deficit: a Systematic Review

ABSTRACT Purpose Assess the effectiveness of augmentative and alternative communication (AAC) interventions in patients with CP and to reveal determinant variables of main intervention outcomes: receptive and expressive language. Research strategies The search was performed in following databases: MEDLINE (Ovid); PubMed (NLM); Embase (Ovid); Cochrane Database of Systematic Reviews; Cumulative Index to Nursing and Allied Health Literature; Database of Abstracts of Reviews of Effects; Cochrane Central Register of Controlled Trials; Health Technology Assessment database and PEDro. Selection criteria Full-text and peer-reviewed studies in English studying the effectiveness of AAC in patients with cerebral palsy were included. Studies with patients (<18 years) diagnosed with CP were included. Data analysis A narrative analysis was conducted to evaluate the efficacy of AAC methods. A random-effects model meta-analysis was used to assess determinants of AAC intervention outcomes. Results The online database and manual reference search revealed 445 records. Nine studies investigating a total of 294 subjects with CP met predefined eligibility criteria: 4 studies with single subject, multiple baseline research designs, 3 longitudinal cohort studies, 1 case control study and 1 case series. Results revealed moderate-quality evidence that AAC interventions improve the receptive and expressive communication skills in patients with CP. The random-effects model meta-analysis revealed the power of identified determinant variables affecting the AAC intervention outcomes. Conclusion Diversity of CP patients requires proper analysis of determinant variables to ensure the efficacy of AAC assessment and intervention. More studies of high methodological and practical quality assessing the efficacy of AAC interventions are needed to clarify the evidence.

Current Anticoagulant Usage Patterns and Determinants in Korean Patients with Nonvalvular Atrial Fibrillation

Prevalence and Determinants of Suicidal Ideation among Patients Diagnosed With Depression at Mental Health hospital, Jeddah 2018

Introduction: In Saudi Arabia, depressive disorders areranked as the fifth of 10 top causes of death and it accounts for5 % of all deaths. Although there are a wide range of factorsassociated with suicidal ideation include social anddemographic factors and related health issues, depression isthe most important risk factor of suicidal behavior whichcharacterized by suicidal ideation, planning and attempts. Thisstudy aimed to identify prevalence and sociodemographicdeterminants of suicidal ideation among depressive patients.Methods: This is a cross-sectional study conducted in adultpatients diagnosed with depression and attended theoutpatient clinics located at Mental Health Hospital in Jeddahcity. A random sample of 213 patients was selected and thequestionnaires were distributed to collect data aboutdemographics and 21 depression items of Beck DepressionInventory-II. The scores of the depression items were summedto indicate the severity of the depression. The frequencies andpercentages were calculated for demographics and presentedin tables. Chi-square test, Spearman’s correlations, andregression analysis were conducted to identify significantassociations and predictors at 0.05 level of significance.Results: The prevalence of suicidal ideation amongthose depressive patients was 37.6%. The depression wassevere in about 47% of the patients and minimal inapproximately 20% of the patients. The associations betweensuicidal ideation and each of marital status, occupation,age, and depression severity were found statically significant(p<0.05), while association between gender and suicidalideation was not statistically significant (p= 0.311). The findingsof logistic regression show that age and depression severityare significant predictors for suicidal ideation. Patients whoaged > 44 years old have 2.3 less risk to develop suicidal ideasthan those aged ≤44 years old. The increase in depressionseverity by one degree, such as from mild to moderate, willincrease the risk of suicidal ideation by 4.1 times.Conclusions: A high prevalence of suicidal ideation wasdetected among Saudi depressive patients. The multivariateanalysis reveals that only age and depression severity wassignificant predictors for suicidal ideation.

Prevalence and Determinants of Pre-Hypertension among Undergraduate Preclinical Medical Students in Central Malaysia

@#Introduction: Pre-hypertension, a classification of blood pressure ranging from 120–139 mm Hg systolic and/ or 80–89 mm Hg diastolic, has been introduced to identify those high-risk group of developing hypertension to implement early intervention to halt disease progression. This study determines the prevalence of pre-hypertension and its determinants among undergraduate preclinical medical students in Malaysia. Materials & Methods: This was a cross-sectional study conducted among 158 registered second year medical students at one research university in central Malaysia from January to April 2018. Results: The prevalence of pre-hypertension was 20.6% among undergraduate preclinical medical students. The most respondent was female (69.9%), Malay ethnic (50.6%) who had normal body mass index (67.3%), no depression (79.5%), no anxiety (60.3%), no stress (68.6%), low physical activity level (44.9%), never smoked (95.5%), and never consumed alcohol (87.8%). Some respondents had positive family history of hypertension (43.6%) and diabetis mellitus (31.4%). After adjusted for all variables, gender (AOR=14.45, 95% CI 5.58-37.43) and depression status (AOR=6.37, 95% CI 1.29-31.49) were significantly associated with pre-hypertension. Conclusion: The prevalence of pre-hypertension among preclinical medical students was lower compared to other country, predicted by gender and depression status. However, further comprehensive multicentered studies in Malaysia with larger sample size is recommended to get more precise results in identifying determinants for pre-hypertension so that early intervention could be implemented nationwide.

Indonesian Children’s Quality Of Life: A Case Study Of Residents Relocation To Flats In Jakarta Province

@#Resident relocation to flats policy becomes a strategy of the Jakarta Provincial Government to overcome illegal settlements and slum areas. The relocation is also aimed to improve the quality of life, particularly of the children. This research analyses the determinant factors of the quality of life of children who are moved to the flats due to the relocation. This research uses the Kid-KINDLR questionnaire to collect data of children in the range of age 7-13 years and the Z-score method to process the data and to build an analysis. The Z-score > 0 indicates a good quality of life, while Z-score < 0 is otherwise. The result shows that 48% of the children have a good quality of life and 52% of the children have a poor quality of life (mean = 91.45 and SD = 9.559). There is a positive correlation between the quality of life of children and the pattern of nutrients intake of children (r = 0.053, p = 0.518), the education of the head of the family (r = 0.058, p = 0.478), and the household income (r = 0.070, p = 0.401). Whereas, the negative correlation between the quality of life of children and the number of family members (r = -0.088, p = 0.284). This research argues that to increase the quality of life of children, the facilities in the flats must be built properly for the growth of the children. In addition, family involvement must be improved to provide a high quality of nutrients intake for the children.

Advances in research on cell fate determinant Numb regulating liver cancer / 中华肝脏病杂志

Liver cancer is one of the most common malignant tumors in China, ranking fifth in malignant tumors and the third in tumor-related deaths. As a membrane-related protein, the asymmetric distribution of cell fate determinant Numb plays a key role in cell differentiation. Research reports that Numb may be closely associated to the occurrence and development of tumors. Recently, scholars have gradually valued its important role in liver cancer. This article briefly reviews the structure of Numb molecule, relationship between Numb and tumorigenesis, the molecular mechanism of Numb-regulated tumors, and the role of Numb in the development of liver cancer.

Determinantes biológicos de mortalidad neonatal, en una población de mujeres adolescentes y adultas de un hospital en Colombia / Biological determinants of neonatal mortality, in a population of adolescent and adult women of a hospital in Colombia

INTRODUCTION. La muerte neonatal está asociada a determinantes maternos, obstétricos, fetales, neonatales y los cuidados de la salud. OBJETIVO Establecer los determinantes asociados a mortalidad neonatal en una unidad de cuidados intensivos de Colombia. Métodos. Estudio de casos y controles anidado en una cohorte, donde se incluyeron 5567 neonatos vivos, de los cuales fallecieron 125. Con Stata 11.0® se construyeron las estadísticas descriptivas y mediante odds ratio (intervalo de confianza 95%) se establecieron las asociaciones. La regresión logística fue empleada en el análisis multivariado. Se consideró un valor de p<0,05 como significativo. RESULTADOS. La mortalidad se presentó en 2,25% de los neonatos, ocurriendo 76,80% de las muertes entre 0-7 días. Los determinantes maternos y obstétricos asociados de manera independiente a mortalidad neonatal incluyeron número de visitas en el control prenatal menor a 6, trabajo de parto prematuro espontáneo, sangrados del tercer trimestre e hipertensión arterial crónica. Entre los determinantes neonatales, la necesidad de reanimación cardiorrespiratoria, prematuridad o bajo peso al nacer, infecciones bacterianas graves, enfermedad de membrana hialina, hipertensión pulmonar, malformaciones congénitas y anomalías cromosómicas y cardiomiopatía hipertrófica, se asociaron independientemente a mortalidad neonatal. Para las complicaciones y eventos adversos hubo asociación independiente y estadísticamente significativa para infecciones asociadas a la atención en salud, hemorragia intraventricular grados III y IV de Papille y hemorragia pulmonar. CONCLUSIONES. La mortalidad neonatal obedeces a determinantes maternos, obstétricos y feto-neonatales, por lo cual el mejoramiento de los cuidados de estos, reduciría la mortalidad neonatal.

INTRODUCTION. Neonatal death is associated with maternal, obstetric, fetal, neonatal, and health determinants. Objective. To establish the determinants associated with neonatal mortality in a Colombian intensive care unit. METHODS. Case-control study nested in a cohort, where 5567 live infants were included, of which 125 died. Stata 11.0® descriptive statistics were constructed and associations were established using odds ratio (95% confidence interval). Logistic regression was used in the multivariate analysis. A value of p <0.05 was considered significant. RESULTS. Mortality occurred in 2.25% of neonates, with 76.80% of deaths occurring between 0-7 days. Maternal and obstetric determinants independently associated with neonatal mortality included numbers of visits in prenatal control less than 6, spontaneous preterm labor, third trimester bleeding, and chronic hypertension. Among neonatal determinants, the need for cardiorespiratory resuscitation, prematurity or low birth weight, severe bacterial infections, hyaline membrane disease, pulmonary hypertension, congenital malformations and chromosomal abnormalities, and hypertrophic cardiomyopathy were independently associated with neonatal mortality. For complications and adverse events, there was an independent and statistically significant association for infections associated with health care, intravenous haemorrhage degrees III and IV of Papille, and pulmonary hemorrhage. CONCLUSIONS. Neonatal mortality is due to maternal, obstetric and fetal-neonatal determinants, so improving neonatal care will reduce neonatal mortality.

Determinant Factors Of Depression: A Survey Among University Students

@#We compared the determinant factors of depression; among faculties in university, among junior and senior students, and gender differences among representative samples of faculties in university. Centre for Epidemiological Studies Depression (CES-D) consisting for 20 questions was used to assess the status of well-being of students. A total of 240 students participated and completed the assessment forms. The results were then compared and analyzed using the IBM SPSS Statistics version 21. There was no effect of faculty on depression (p=0.854). The association between year of study and depression was not statistically significant (p≥0.05). Likewise, the association between gender and depression was statistically not significant (p≥0.05). The study revealed absence of statistically significant effect of faculty on depression. It was also found that gender and depression as well as year of study and depression were not statistically significant.

Analysis on status and determinants of outpatient service utilization of rural floating population in Beijing at different residence time / 北京大学学报(医学版)

Objective: To study the status and identify the determinants of outpatient service utilization of rural floating population in Beijing who have different accumulated residence time.Methods: The survey data of rural floating population health and health care services in Beijing in 2014 were used, and the migrant population aged 18 years and above were taken as the research object.Whether to use outpatient service within two weeks was taken as dependent variable, gender, age, education level, self-assessment score of socioeconomic status, accumulated residence time in Beijing, health insurance, average household income, suffering from high blood pressure or diabetes as independent variables.Logistic regression model was used to analyze the influencing factors.Results: The average age of the research object was 36.7 years, with mostly secondary education.The average accumulated residence time in Beijing was 8.4 years.The two-week prevalence rate was 10.3%, the two-week visiting rate calculated by person-time was 6.0%.The Logistic regression model suggested that, socioeconomic status, accumulated residence time and suffering from high blood pressure or diabetes were statistically significant determinants of outpatient service utilization.Conclusion: The research object is a younger and less educated population, their health status is better and outpatient service utilization is lower.It is found that people who have longer accumulated residence time in Beijing have lower outpatient service utilization.This is because people with longer residence time have lower age-adjusted two-week prevalence rate.This is also because people with longer residence time have larger proportion of taking continuous measures under doctor's advice.It does not mean people with longer residence time have lower utilization of medical service.The residence time variable plays the role of proxy variable.It can solve the problem of variables' endoge-neity.At the same time, it can reflect the influence to outpatient services utilization of some determinants,which are not included in the model but varies with residence time.

The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents

Due to the increased frequency of interspecies transmission of avian influenza viruses, studies designed to identify the molecular determinants that could lead to an expansion of the host range have been increased. A variety of mouse-based mammalian-adaptation studies of avian influenza viruses have provided insight into the genetic alterations of various avian influenza subtypes that may contribute to the generation of a pandemic virus. To date, the studies have focused on avian influenza subtypes H5, H6, H7, H9, and H10 which have recently caused human infection. Although mice cannot fully reflect the course of human infection with avian influenza, these mouse studies can be a useful method for investigating potential mammalian adaptive markers against newly emerging avian influenza viruses. In addition, due to the lack of appropriate vaccines against the diverse emerging influenza viruses, the generation of mouse-adapted lethal variants could contribute to the development of effective vaccines or therapeutic agents. Within this review, we will summarize studies that have demonstrated adaptations of avian influenza viruses that result in an altered pathogenicity in mice which may suggest the potential application of mouse-lethal strains in the development of influenza vaccines and/or therapeutics in preclinical studies.

The Impact of the Financial Crisis on Lifestyle Health Determinants Among Older Adults Living in the Mediterranean Region: The Multinational MEDIS Study (2005-2015) / 예방의학회지

OBJECTIVES: By the end of the 2000s, the economic situation in many European countries started to deteriorate, generating financial uncertainty, social insecurity and worse health status. The aim of the present study was to investigate how the recent financial crisis has affected the lifestyle health determinants and behaviours of older adults living in the Mediterranean islands. METHODS: From 2005 to 2015, a population-based, multi-stage convenience sampling method was used to voluntarily enrol 2749 older adults (50% men) from 20 Mediterranean islands and the rural area of the Mani peninsula. Lifestyle status was evaluated as the cumulative score of four components (range, 0 to 6), that is, smoking habits, diet quality (MedDietScore), depression status (Geriatric Depression Scale) and physical activity. RESULTS: Older Mediterranean people enrolled in the study from 2009 onwards showed social isolation and increased smoking, were more prone to depressive symptoms, and adopted less healthy dietary habits, as compared to their counterparts participating earlier in the study (p<0.05), irrespective of age, gender, several clinical characteristics, or socioeconomic status of the participants (an almost 50% adjusted increase in the lifestyle score from before 2009 to after 2009, p<0.001). CONCLUSIONS: A shift towards less healthy behaviours was noticeable after the economic crisis had commenced. Public health interventions should focus on older adults, particularly of lower socioeconomic levels, in order to effectively reduce the burden of cardiometabolic disease at the population level.

A comparison between the revision of Atlanta classification and determinant-based classification in acute pancreatitis / 中华内科杂志

Objective To compare the performance of the revision of Atlanta classification (RAC) and determinant-based classification (DBC) in acute pancreatitis. Methods Consecutive patients with acute pancreatitis admitted to a single center from January 2001 to January 2015 were retrospectively analyzed. Patients were classified into mild, moderately severe and severe categories based on RAC and were simultaneously classified into mild, moderate, severe and critical grades according to DBC. Disease severity and clinical outcomes were compared between subgroups. The receiver operating curve (ROC) was used to compare the utility of RAC and DBC by calculating the area under curve (AUC). Results Among 1120 patients enrolled, organ failure occurred in 343 patients (30.6%) and infected necrosis in 74 patients (6.6%). A total of 63 patients (5.6%) died. Statistically significant difference of disease severity and outcomes was observed between all the subgroups in RAC and DBC (P<0.001). The category of critical acute pancreatitis (with both persistent organ failure and infected necrosis) had the most severe clinical course and the highest mortality (19/31, 61.3%). DBC had a larger AUC (0.73, 95%CI 0.69-0.78) than RAC (0.68, 95%CI 0.65-0.73) in classifying ICU admissions (P=0.031), but both were similar in predicting mortality(P=0.372) and prolonged ICU stay (P=0.266). Conclusions DBC and RAC perform comparably well in categorizing patients with acute pancreatitis regarding disease severity and clinical outcome. DBC is slightly better than RAC in predicting prolonged hospital stay. Persistent organ failure and infected necrosis are risk factors for poor prognosis and presence of both is associated with the most dismal outcome.

The determinants of the patient readiness for hospital discharge / 中国实用护理杂志

As the development of fast-tracking, the patient perception of readiness for hospital discharge is becoming more and more popular in discharge decision making. A lot of research indicates that the patient readiness of discharge can predict the satisfaction, the safety, readmission, death and compliance of the patients. This study is about to review the conception, research significances, measurements, and determinants of the discharge readiness. The primary objective was to analyze the determinants of hospital discharge, according to three aspects of patient factors, hospital factors and social support. This study is expected to offer theoretical support for the improvement of discharge readiness.

The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China

ABSTRACT This study highlights the prevalence of aminoglycoside-modifying enzyme genes and virulence determinants among clinical enterococci with high-level aminoglycoside resistance in Inner Mongolia, China. Screening for high-level aminoglycoside resistance against 117 enterococcal clinical isolates was performed using the agar-screening method. Out of the 117 enterococcal isolates, 46 were selected for further detection and determination of the distribution of aminoglycoside-modifying enzyme-encoding genes and virulence determinants using polymerase chain reaction -based methods. Enterococcus faecium and Enterococcus faecalis were identified as the species of greatest clinical importance. The aac(6')-Ie-aph(2")-Ia and ant(6')-Ia genes were found to be the most common aminoglycoside-modifying enzyme genes among high-level gentamicin resistance and high-level streptomycin resistance isolates, respectively. Moreover, gelE was the most common virulence gene among high-level aminoglycoside resistance isolates. Compared to Enterococcus faecium, Enterococcus faecalis harbored multiple virulence determinants. The results further indicated no correlation between aminoglycoside-modifying enzyme gene profiles and the distribution of virulence genes among the enterococcal isolates with high-level gentamicin resistance or high-level streptomycin resistance evaluated in our study.

Epidemiología de la prematuridad, sus determinantes y prevención del parto prematuro / Epidemiology of prematurity, its determinants and prevention of preterm birth

La prematuridad es un grave de problema de salud pública por la gran morbilidad y mortalidad que generan, además, de los elevados costos económicos y sociales que ocasiona su atención. A nivel mundial, aproximadamente uno de cada diez neonatos nacen prematuros. Sus determinantes son múltiples. En el parto prematuro están involucrados además de los determinantes biológicos, los que son responsabilidad del sector salud y los que son responsabilidad del estado, como son los determinantes políticos, ambientales, sociales y económicos. Es por ello que la prevención y el tratamiento de la prematuridad debe ser una política pública obligada para todas las naciones, e involucra a muchos actores. Las estrategias empleadas para prevenir y tratar al parto prematuro son amplias y van desde los cuidados preconcepcionales, hasta la atención del parto y del neonato en el periodo postnatal.

Prematurity is a serious public health problem by the high morbidity and mortality also generated high economic and social costs caused by its staff. Globally, about one in ten infants born prematurely. Its determinants are numerous. In preterm birth are involved in addition to biological determinants, which are the responsibility of the health sector and which are the responsibility of the state, such as political, environmental, social and economic determinants. That is why prevention and treatment of prematurity should be a public policy required for all nations, and involves many actors. The strategies used to prevent and treat premature birth are spacious and range from preconception care, to care delivery and newborn in the postnatal period.