ABSTRACT
The modernization of traditional Chinese medicine （TCM） theories is not only a prerequisite for the modernization of TCM but also a way to deal with the external environment and the difficulties of its development. The modernization of TCM is based on the premise of maintaining its own characteristics and advantages， and along with the progress of modern science and technology， the entire TCM has undergone new changes and improvements from theory to practice， and has become a scientific system with modern scientific level that adapts to the needs of the times. In the context of the unprecedented profound changes in contemporary TCM academics， this paper puts forward the definition of modernization of TCM theory and argues that the modernized theoretical system of TCM should maintain originality to build the foundation of TCM inheritance， clarify the frontier of the discipline and establish the conceptual system， form an open network to be compatible with multi-disciplinary interaction， incorporate the falsification and establish self-renewal system， creatively transform and innovatively develop， and modernize the interpretation and update the discourse system.
ABSTRACT
Aim To explore the effect of total salvianolic acid (TSA) combined with anti-PD-Ll on the development of breast cancer by inhibiting the infiltration of myelogenous macrophages into tumors. Methods E0771 breast cancer subeutaneous tumor model was constructed. Twenty-five mice were randomly divided into control group, model group, total salvianolic acid group (TSA 10 g • kg
ABSTRACT
In order to judge the future development trend of science and technology, plan ahead and lay out the frontier technology fields and directions, China Association of Chinese Medicine(CACM) has launched consultation projects for collecting "major scienti-fic issues and engineering technology difficulties in traditional Chinese medicine(TCM)" for the industry for three consecutive years since 2019. Up to now, 18 projects have been selected as major issues for research, and some experience and achievements have been made. These projects have been applied in important scientific and technological work such as scientific and technological planning and deployment at all levels of national, local, and scientific research institutions, the selection and cultivation of major national scientific and technological projects, and the construction of innovation bases, giving full play to the role of the think tank advisory committee of CACM. This study reviewed the selection of major issues for the first time, systematically combed its application in the national layout of science and technology, and put forward the existing problems and improvement suggestions, aiming to provide new ideas for further improving the selection of major issues and research direction, providing a theoretical basis and decision support for the national scientific and technological layout in the field of TCM, and promoting scientific and technological innovation to facilitate the high quality development of TCM.
Subject(s)
Medicine, Chinese Traditional , Inventions , China , Drugs, Chinese HerbalABSTRACT
Pharmaceutical products need to ensure the effectiveness, safety and quality controllability through scientific supervision, and as the broad masses of the people are full of new expectations for the supply of high-quality traditional Chinese medicine products, the reform and innovation of traditional Chinese medicine regulatory policies are also facing new opportunities and new challenges. National Medical Products Administration, National Administration of Traditional Chinese Medicine and other relevant departments have implemented the requirements of the Party Central Committee and the State Council, vigorously promoted the reform of the regulatory system in line with the characteristics of traditional Chinese medicine, introduced a series of innovative policies, and achieved phased results. Including the new registration classification standards in line with the characteristics of traditional Chinese medicine, encouraging the development of classical formulas and hospital preparations, encouraging the research and development of symptomatic Chinese medicines, and gra-dually improving the "three-combined " evidence system. However, in the face of the development problems of traditional Chinese medicine in the new era, it is still necessary to improve the scientific supervision system, further optimize the management measures for the registration of traditional Chinese medicines based on classical formulas, accelerate the improvement of the standard system for traditional Chinese medicine formula granules, and form management measures to encourage and support the secondary development of traditional Chinese medicines. In terms of scientific supervision of traditional Chinese medicine, it is necessary to follow the characteristics and development laws of traditional Chinese medicine itself, comprehensively consider the characteristics of epochal, scientific and systematic in regulatory policies, and serve the inheritance and innovative development of traditional Chinese medicine with scientific supervision.
Subject(s)
Humans , Medicine, Chinese Traditional , Drugs, Chinese Herbal/therapeutic use , Pharmaceutical Preparations , Reference StandardsABSTRACT
Tongue diagnosis is one of the diagnostic methods of Traditional Chinese Medicine (TCM), but its development has always been restricted by the lack of objective quantitative indicators. With the rapid development of computer technology and the advent of the algorithm era, the modernization of TCM tongue diagnosis has gradually become a hot research spot. This paper annalyses the literature and related patents of the modernization of tongue diagnosis and summarizes the R&D progress and application of tongue diagnosis as well as related instruments. It is found that domestic and foreign scholars focus on tongue diagnosis related research and attach importance to the formulation of relevant international standards. Tongue collection and analysis technology continues to develop; tongue diagnostic instruments are also gradually enriched. At present, their applications are extended to family self-use, but they are still mainly used in teaching, scientific research and other fields, involving the clinical efficacy evaluation of TCM, clinical case classification and health management, and there is still much room for development. In the future, we should strengthen the communication between multi-regional research centers, promote the communication among talents in different fields, constantly make up for the deficiencies and promote the development of tongue diagnosis research.
ABSTRACT
Single cell "omics" technology enables the capture of genome, transcriptome, proteome and other omics information in a high-throughput and unbiased manner at single-cell resolution, allowing the characterization of the functional state of individual cells to reveal their heterogeneity and differential responses to drug treatment. This technology has wide application in pharmacological research, facilitating drug screening, efficacy evaluation, and mechanistic studies. We envision that, in the field of traditional Chinese medicine (TCM), single cell omics technology can be applied in the identification of active ingredients and drug targets, and elucidation of drug mechanism of action. In this article, we briefly introduce the single cell omics technology - particularly single cell transcriptome sequencing, and review its application in the field of modern drug research. Based on that, we propose the concept of "single cell pharmacology" and articulate how it can be applied to transform the pharmacological research of TCM and promote TCM modernization.
ABSTRACT
At present, the 2019-novel coronavirus (2019-nCoV) is rampant all over the country, and controlling the spread of its epidemic has become a top priority. It is very difficult to control the epidemic spreading because there is no specific drug to fight against it. Therefore, it is urgent task for us to develop a specific drug as soon as possible, and attracting worldwide attention. The studies on anti-2019-nCoV drugs were generally carried out in three modes, as vaccine, chemical drugs and traditional Chinese medicine (TCM). Because the developing on vaccines and chemicals takes too long, it is hard to solve the urgent problem. Moreover, the RNA of coronavirus has been recombined so quickly that the vaccines and drugs studied with great efforts not only may miss the epidemic time, but also cannot be used in the next generation of new coronavirus treatment, as a result that the work of epidemic prevention is formidable. However, the prescriptions from traditional Chinese medicine theory can cure the epidemic disease, but how to develop it into a specific drug with clear chemical composition and clear pharmacologic mechanism, is also an urgent problem to be solved. In this paper, the new coronavirus and its drug development are reviewed, while the advantages and disadvantages are analyzed, and the drug dilemma research phenomenon is clarified by using the supramolecular “qi chromatography” theory. It is suggested that the strategy of anti-coronavirus drug developing should be put forward based on the impact of “qi chromatography” of biological supramolecular “imprinting template”, in order to develop new drugs against 2019-nCoV to control the spread of the epidemic as quick as we can, and establish a new research and development model of anti-coronavirus drug on integration of traditional Chinese and Western medicine, turning passive into active.
ABSTRACT
Lipidomics is a newly emerged discipline that systematically studies the types, functions and metabolic pathways of lipids in organisms, which can identify biomarkers and molecular mechanisms of diseases or drugs by analyzing changes in lipid metabolism networks from different physiological or pathological states. As an important component of systems biology, lipidomics has the research mentality which is similar to the overall concept as well as the system theory of traditional Chinese medicine (TCM). Therefore, lipidomics becomes a powerful tool to promote the modernization of TCM. Lipidomics technology is briefly described in this paper, and the application of lipidomics technology on research of TCM including pharmacodynamics, action mechanism and toxicity are summed up, and at the same time the experience of other disciplines in the research of Chinese materia medica property theory and quality control of TCM are combined to expand the application ideas of lipidomics in TCM research, as well as provide references for the organic integration between TCM theory and modern technology.
ABSTRACT
As an effective additive manufacturing technology, 3D printing technology has been widely used in aerospace, construction, machinery manufacturing and other fields, but it is rarely used in the pharmaceutical field, especially in the field of traditional Chinese medicine (TCM). In 2015, Spritam instant tablets produced by 3D printing technology greatly promoted the development and research of 3D printing technology in the pharmaceutical industry. In this paper, we reviewed three types of 3D printers (binder jet, material extrusion and inkjet printing) with high compatibility in the pharmaceutical industry, including the working principles, printing materials, product characteristics and others. In addition, the application prospects and existing problems of 3D printing technology in the production of innovative preparations of TCM, the development of innovative medical devices and the development of innovative functional foods were analyzed. The paper aimed to provide a reference for the development and preparation of innovative TCM by 3D printing technology.
ABSTRACT
Decoction pieces are the main body of traditional Chinese medicine (TCM) clinical medication. With the modernization of TCM medication, TCM formula granules have gradually developed and begun to take shape. Although there are processing forms of TCM injection and oral liquid, they only account for a small part of TCM market and are mainly taken orally. However, when oral administration of lipid soluble ingredients is conducted, the dissolution is limited and the absorption is relatively small. In addition, it has side effects of stimulating gastrointestinal tract, resulting in low tolerance of patients. Although there are topical preparations made by water extraction and alcohol extraction, most of them are crude preparations with random dosage, which results in the waste of lipid soluble components to a certain extent. Most of the lipid soluble components of TCM have good biological activities, such as schisandrin b, tanshinone, methyl chlorogenic acid, etc., but there is no suitable medicinal form. To make the best use of "medicine", it is necessary to systematically study the lipid soluble components of TCM. On the basis of fairly mature extraction, separation and collection processes, a medicinal form with definite pharmacological effect and beneficial to its absorption is developed based on lipid soluble components. TCM essential oil has anti-aging, anti-dementia, anti-oxidation and other activities, which has been widely used in clinical, cosmeceuticals, health products and other fields. However, the effect of single essential oil is limited. Compatibility can not only enhance the efficacy and reduce toxicity, but also expand the application range of essential oil. Therefore, formula essential oil can be used as a new form of TCM, and mainly for external use, supplemented by internal use, to make up for the disadvantages of crude preparations and random dosing for external use of TCM, as well as the disadvantages of orally absorbed less and stimulated gastrointestinal tract, to meet the needs of clinical medication, faster, more accurate, better and stronger play the effect of lipid soluble components.
ABSTRACT
The five-flavor theory of Chinese materia medica (CMM) is the core content of traditional Chinese medicine (TCM), which characterizes the characteristic property of CMM components and is used for clinical guidance. However, it is still unclear how the five flavors are used to characterize the many groups of ingredients, the criteria for dividing the five flavors of herbs, and the scientific issues of the five flavors and the five internal organs. This paper analyzes and summarizes the historical evolution and research status of five-flavor theory of CMM. The supramolecular “imprint template” theory is used to analyze the five flavors of CMM: human and CMM are biological supramolecular bodies, and traditional Chinese medicine is used as a natural supramolecular “imprint template” aggregation. After the human body, it is inevitable to find self-recognition, self-organization, self-assembly and self-replication of the supramolecular body of the human organ that coincides with its own “imprint template”, so as to produce specific effects, and macroscopically show the five flavors of CMM with meridian tropism in five internal organs. Therefore, through the qualitative and quantitative study of the characteristics and action of the supramolecular “imprinting template” of various components of five flavors of CMM in vivo and in vitro and its network pharmacology, “Chinese herbal medicine group-taste bud supramolecular pore structure-meridian visceral cavity” correlation research method was established. From the macroscopic and microscopic aspects, the five flavors of CMM are studied. The combination of supramolecular chemistry theory and traditional Chinese medicine will certainly promote the development of TCM and realize the modernization of TCM.
ABSTRACT
Chinese materia medica (CMM) compound is the main form of clinical treatment of traditional Chinese medicine (TCM). The compatibility of CMM is one of the key scientific issues in the modernization of TCM. It has long been listed as a strategic issue. This article follows the natural attributes of TCM theory, and uses supramolecular chemistry to clarify the qualitative and quantitative effects of CMM compound and human body imprinting template: CMM and human body are giant and complex bio-molecular bodies, and there are corresponding groups of effective components of CMM and human diseases. The “imprinting template” produces a “gas evolution” according to the imprinting rule, and the compatibility of CMM can significantly change this effect, and it is preferable to study with supramolecular chemistry. Based on this, this paper first combs the historical evolution of CMM and the status quo of modern research, combined with supramolecular chemistry, puts forward seven key problems and research strategies to be solved, aiming at solving the key scientific problems of the modernization of TCM.
ABSTRACT
Sri Lanka and China enjoy profound traditional friendship and active bilateral friendly cooperation. With the deepening of bilateral FTA negotiations, service trade of traditional Chinese enters into Sri Lanka is also promising. Though the current policy and law exists insufficiency, leveraging the FTA negotiations, TCM-Center binding Confucius Institute, providing TCM features and developing tour routes of medical tourism can help to push service trade of traditional Chinese medicine into Sri Lanka. The development of overseas Chinese medicine health services is not only benefit to the local, but also contribute to the new pattern of Chinese economic reformation.
ABSTRACT
National health is the fundamental purpose of building a healthy China. This paper analyzes the development status and existing problems of informational TCM health care services for the elderly, and proposes development strategies for TCM health care services, including "Health Care Plus Intelligent Management, Platform Plus Tourism Support, Medical Network Integration, and Smoothening the Industry Chain" for the new era of "Internet Plus", with the purposes of realizing real-time disease detection and intelligent diagnoses, meeting the senior health care needs, responding proactively to the call of the aging population and promoting the development and revitalization of TCM in the field of senior care.
ABSTRACT
In recent years ,pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine .Pharmacokinetics is an important means for connecting traditional Chinese medicine with west-ern medicine .Medications exert efficacy only when there is sufficient concentration at the target sites .The drug concentration is not only related to the dosage ,but is also closely correlated to the metabolic processes in human body .Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals ,which ignore significant changes of pharmacokinetic pa-rameters in the diseased state .In this paper ,the comparative pharmacokinetics of the traditional Chinese medicine based on ani-mal models in their diseased states was reviewed .Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed .
ABSTRACT
With the development of traditional Chinese medicine (TCM) modernization,the study of TCM is not only limited to clarify the chemical material basis in vitro,but also to further study the fate of active components contained in TCM in vivo as well as the interaction and effect among them.It is to say that the pharmacokinetic (PK) study of TCM is needed.The results of PK study of TCM are useful for investigating its mechanism of action,reasonable use of TCM in clinic and modernization of TCM.In this paper,some scientific issues,including the purpose and significance of PK study of TCM,its particularity,difficulty and commonly used research methods,were analyzed and summarized combining with research examples.The authors hoped that it would be helpful for the scholars and promote the development of PK study of TCM.
ABSTRACT
The modernization of traditional Chinese medicine (TCM) is a foundation of TCM to go abroad and get international recognition. It is the only way to revitalize the TCM industry. But in the process of it, we are facing various challenges: heavy metal contamination, low content of active ingredients, less innovation, the contradiction between resource utilization and protection, and so on. How to apply new technology and new theory of life science to solve these problems becomes an urgent matter. In recent years, the studies found that endophytic fungi played an irreplaceable positive role in the growth and development of herbal medicine, and had great impact on the quality of traditional Chinese medicine. Therefore this paper introduces the effect of endophytic fungi on genuine traditional Chinese medicines, cultivation of TCM, development and protection of TCM, et al, and explores its applicative prospect, providing new idea and new power for promoting the development of modernization of TCM.
ABSTRACT
Thefive elements theory provides us a system classification of all things so we can do the research in a much reasonable way. Further more, our bodies are full of complicated bio-chemical reactions and thefive elements theory should also be applicable to those reaction systems. This paper will try to make use of thefive elements theory to carry on an innovative classification of different types of bio-chemical reactions with the help of the former foundation of related researches, to make the complicated bio-chemical reactions easy to understand, and point out that this kind of lately academic thought is of great significance to the medicine researches as well as the integrated traditional Chinese and western medicine.
ABSTRACT
In this paper, the research work of Cell-broken Pieces of traditional Chinese Medicine was summarized;the preparation technology, quality standard, effectiveness and safety of typical Cell-broken Pieces were introduced;the attribute, connotation and orientation of Cell-broken Pieces were discussed. It can provide reference for the fur-ther research and development of Cell-broken Pieces of traditional Chinese Medicine.
ABSTRACT
Editor's Notes: The basic theory of traditional Chinese medicine is the theoretical foundation of Chinese medicine , modernization of Chinese medicine needs of the modern theory of Chinese medicine urgently . However , it is always the important issues about how modern Chinese medicine theory should be created , and what kind of theory should have been established concerned and explored by domestic and foreign counterparts in tradi-tional Chinese medicine . To lead the development of modern Chinese medicine theory , Modern Basic Theory of Traditional Chinese Medicine series of symposiums are set up specially in the current Review column, and discussed thoroughly and systematically using three consecutive pats respectively. Among them, part I contains 3 articles about new concepts, new theories, new disciplines; part II contains 5 articles about new ideas, new norms, how to clear concept, how to verify hypotheses, why to evaluate theory; part III contains 12 articles about concept of wholism updating, treatment based on syndrome differentiation development, viscera-state doc-trine innovation, pathogeny, etiology, pathogenesis, prevention, principle of treatment, knowledge structure, cogni-tion structure , monographic study , 5-year outlook . Published article on this issue is the first one belong to new concept of part I. In this paper, we want to describe the denotation and connotation of the new concept of the modern basic theory of traditional Chinese medicine from three aspects of a concept: a label , a theoretical definition , and an operational definition learning from the international academic understanding of scientific concepts, demonstrate the necessity of theoretical premise to the research and establishment of the modern basic theory of traditional Chinese medicine and the need to build on , illustrate the inevitable trend toward modern science . The whole article contains profound meaning and a certain breakthrough and innovation. We are expected to cause concerns and discusses of experts and scholars through this article .