ABSTRACT
Objective To analyze the factors that affecting peer review evaluation for National Science Foundation of China (NSFC) award application.Methods Base on the feedback of NSFC peer review experts,total 10 evaluation factors were extracted for analysis.The percentage of common problem and in application,and percentage of key criteriaconcerned by reviewers,and their effect on funding situation were analyzed.Results 10 evaluatiion factors were divided into 4 groups:core factors including research content and innovation;factors including hypothesis,budget and writing,basic factors including the significance of research and previous study,general factors including experience and capacity of applicants,research team and laboratory condition.Conclusions Analysis and evaluate of peer review factors from different angle may help applicants and administrators to improve the quality of NSFC application and evaluation.
ABSTRACT
Objective To investigate the correlation of hypoxia-inducible factor (HIF)-1? and va scular endothelial growth factor (VEGF) or micro-vessel density ( MVD). Methods The ovarian cancer cell line SKOV3 was transplanted into nude mice to form xenog eneic tumor. Mice were treated with rapamycin 4mg/kg,sulindac 100 mg/(kg.d) a nd saline 200 ?l respectively. Expression of HIF-1? and VEGF proteins and MV D were determined by immunohistochemistry. The mRNA of Glut1 and VEGF was studi ed by RT-PCR. Results The positive expression of HIF-1? and VEGF was moderate to strong, and MVD was high (31?8) in control group. In rapamycin treated group, the expression of H IF-1? was inhibited to weak positive or negative (P