Salvadora persica protects mouse intestine from eimeriosis / Salvadora persica protege o intestino do rato da eimeriose

Abstract Eimeriosis is a global poultry health problem. In the current study, we investigated the role of Salvadora persica leaf extracts (SE) against murine eimeriosis induced by Eimeria papillata. The infection induced an oocyst output of 6242 ± 731 oocysts/g feces. After treatment with 300 mg⁄kg SE, the oocysts expelled in feces decreased by approximately 3-fold. In addition, the total number of E. papillata in the parasitic stage decreased in the jejunum of mice after treatment with SE. In addition, SE significantly reduced the number of apoptotic cells by approximately 2-fold in the infected jejunum. SE ameliorated the changes in glutathione, malondialdehyde, and catalase due to E. papillata infection. Finally, SE regulated the cytokine genes, interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α, and the apoptotic genes, B-cell lymphoma-2, Bax, and Caspase-3. SE protects the jejunum from E. papillata induced injury and may have potential therapeutic value as a food additive during eimeriosis.

Resumo A eimeriose é um problema global de saúde avícola. No presente estudo, investigou-se o papel dos extratos de folhas de Salvadora persica (SE) contra a eimeriose murina induzida por Eimeria papillata. A infecção induziu uma produção de oocistos de 6242 ± 731 oocistos/g de fezes. Após o tratamento com 300 mg⁄kg SE, os oocistos eliminados nas fezes diminuíram em aproximadamente 3 vezes. Além disso, o número total de E. papillata no estágio parasitário diminuiu nos jejunos de camundongos após o tratamento com SE. Da mesma forma, o SE reduziu significativamente o número de células apoptóticas em aproximadamente 2 vezes no jejuno infectado. O estudo mostrou que o SE melhorou as alterações na glutationa, malonaldeído e catalase devido à infecção por E. papillata. Finalmente, o SE regulou os genes das citocinas, interleucina (IL) -1β, IL-6, interferon-γ e fator de necrose tumoral α, e os genes apoptóticos, linfoma-2, Bax e Caspase-3. Assim, o SE protegeu os jejunos das lesões induzidas por E. papillata e pode ter potencial valor terapêutico como aditivo alimentar durante a eimeriose.

Effect of treatment with neem [azadirachta indica] compared with baycox drug on the caecum of chicken experimentally infected with eimeria tenella

The study evaluated the therapeutic efficacy of Neem herb in chicken experimentally infected with E. tenella compared to Baycox as a reference anticoccidial drug. 120 broiler chicks were enrolled, randomly divided to 4 groups, [A, B, C and D] non-infected non-treated [naive control], [B] infected with 10[4] E. tenella oocysts [infected control], [C] infected and treated with Baycox [7 mg/kg b.w. for 2 days] and [D] infected and treated with Neem leaves water extract [100 mg/kg b.w. for 9 days]. Evaluation was by clinical signs, performance data [gain weigh, food consumption oocyst shed/gram feaces [OPG]], in addition to histopathological changes in all chickens. The results revealed that chicks of GA had the best performance data compared to GB, GC and GD. In GC and GD there were a remarkable improvement in the data performance, clinical signs, gross and microscopically cecal lesions compared to GB. The efficacy of Baycox [GC] was shown to be superior to that of Neem [GD] compared to GB but an additive histopathological toxic effect besides those produced by E. tenella infection could be recorded. In contrast, Neem appeared to have a remarkable improvement on cecal integrity

Evaluacion comparativa de triancinolona en el control de coccidiosis en pollos de engorde / Comparative evaluation of triancinolone in coccidiosis control in chickens

La eficacia de Triancinolona en el control de coccidiosis en pollos de engorde fue evaluada en un experimento completamente aleatorizado utilizando pollos sexados Cobb x Cobb de un día de edad. Fueron asignados los tratamientos T1: no medicado - no inoculado; T2: no mediacado - inoculado; T3: Triancinolona - inoculado; T4: Monensina sódica - inoculado y T5: Salinomicina sódica - inoculado. Las aves fueron inoculadas con 10.000 ooquistes de Eimeria tenella y 40.000 de Eimerias intestinales. Los resultados del grado de lesiones mostraron que T3 (60,6 por ciento) y T4 (63,6 por ciento)ejercieron mayor control de la coccidiosis al comparados con T5 (96,9 por ciento) y T2 (100 por ciento). El contaje de ooquistes/g de heces mostró mayor eficacia para T3 (4.300) al comparada con T4 (126.900); T5 (98.100) y T2 (382.000); permitiendo destacar su efectivo mecanismo de acción para interferir el ciclo biológico de las coccidias. La conversión de alimento fue mejorada (P<0,05) en los grupos medicados (T3, T4 y T5) en ralación a T2 destacando el efecto adverso que sobre la respuesta productiva es ocasionado por las coccidias. Triancinolona tuvo mayor eficacia de acción en el control de esta parasitosis.

efficacy of ivermectin in treating rabbits experimentally infected with eimeria as indicated parasitologically and histologically

Ivermectin [Ivomec] was used as coccidiocidal drug against Eimeria in experimentally infected rabbits as indicated parasitologically and histologically. 20 Bosskat rabbits were divided into 5 groups, 3 groups were inoculated with 1000 sporulated oocysts and the other 2 groups were kept as negative controls with and without Ivermectin administration. Ivermectin [1: 10] was injected subcutaneously in a dose of 0.5 ml in animals of groups 1, 2 and 3. The treatment of group 1 was on the 4th day A.I. and on the 4th day and 7th day A.I. in group 2. The treated animals with one or two doses showed mild coccidiosis with very few numbers of oocysts deposition and rapid intestinal regeneration with degenerated eimerial developmental stages, especially the asexual ones