ABSTRACT
La infección por el Virus del Papiloma Humano es una afección altamente prevalente a nivel mundial y una de sus consecuencias es la verruga genital externa o condiloma genital. El tratamiento de estas lesiones ha sido tradicionalmente difícil, debido a la alta recurrencia de las lesiones. Se revisan los aspectos más novedosos del tratamiento de las verrugas genitales. Las sinecatequinas y una nueva formulación de Imiquimod al 3,75% resaltan como las terapéuticas más novedosas, mientras que la terapia fotodinámica carece de evidencia científica adecuada como para recomendar su uso rutinario. Las vacunas profilácticas y terapéuticas parecen poseer un gran potencial pero aún se encuentran en fases iniciales de investigación. Es deseable estudios con un mayor número de pacientes y un seguimiento más prolongado, que permita una comparación directa de la efectividad entre las diferentes técnicas terapéuticas a corto y largo plazo.
Human Papillomavirus infection is a highly prevalent condition worldwide whose frequent consequence is the external genital wart or genital condyloma. The treatment for this condition has been traditionally difficult due to the recurrence of the lesions. The most innovative aspects of the treatment of genital wart, are reviewed. The sinecatechins and a new formulation of Imiquimod 3.75% stand out as the most innovative therapeutic, while photodynamic therapy lacks adequate scientific evidence to recommend its routine use. The prophylactic and therapeutic vaccines seem to have great potential but are still in early stages of research. Studies should be conducted with larger patient samples and longer follow-ups to allow comparison of the effectiveness among the different therapeutic techniques in the short and long term.
Subject(s)
Humans , Male , Female , Condylomata Acuminata/therapy , Alphapapillomavirus , Genital Diseases, Female/therapy , Photochemotherapy , Podophyllin , Trichloroacetic Acid , Condylomata Acuminata/diagnosis , Catechin/therapeutic use , Vaccination , Cryotherapy , Papillomavirus Infections/therapy , Electrocoagulation , Imiquimod/therapeutic use , Genital Diseases, Male/therapyABSTRACT
BACKGROUND: Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts. OBJECTIVE: A prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent, sexually active men. METHODS: Over a period of 10 months, 48 patients were enrolled. They were randomly divided into two groups and selected on an alternative basis for either potassium hydroxide therapy or cryotherapy. While response to therapy did not differ substantially between both treatment modalities, side effects such as local pain and post-treatment hypopigmentation were considerably more prevalent in the groups treated using cryotherapy. Result: In our study, potassium hydroxide therapy proved to be at least as effective as cryotherapy and offered the benefit of a better safety profile. CONCLUSION: Topical 5% potassium hydroxide presents an effective, safe, and low-cost treatment modality for genital warts in men and should be included in the spectrum of therapies for genital warts. .
Subject(s)
Adolescent , Adult , Aged , Humans , Male , Middle Aged , Young Adult , Condylomata Acuminata/therapy , Cryotherapy/methods , Dermatologic Agents/administration & dosage , Genital Diseases, Male/therapy , Hydroxides/administration & dosage , Potassium Compounds/administration & dosage , Administration, Topical , Chi-Square Distribution , Dose-Response Relationship, Drug , Dermatologic Agents/therapeutic use , Follow-Up Studies , Hydroxides/therapeutic use , Prospective Studies , Potassium Compounds/therapeutic use , Reproducibility of Results , Treatment OutcomeABSTRACT
A feo-hifomicose subcutânea é uma doença causada por fungos demáceos que acomete principalmente indivíduos imunocomprometidos e geralmente cursa com lesões localizadas nos membros inferiores. Os autores relatam um caso de feo-hifomicose subcutânea em um paciente imunocompetente, com localização atípica - na hemibolsa escrotal esquerda -, tratado com sucesso com fluconazol sistêmico associado à excisão cirúrgica.
Subcutaneous phaeohyphomycosis is a disease caused by dematiaceous fungi that develops mainly in immunocompromised patients. Lesions are generally located on the lower limbs. The present report describes a case of phaeohyphomycosis in an immunocompetent patient in whom a subcutaneous abscess was located in an unusual site, on the left hemiscrotum. The abscess was treated successfully with oral fluconazole associated with surgical excision.
Subject(s)
Humans , Male , Middle Aged , Dermatomycoses/microbiology , Exophiala/isolation & purification , Genital Diseases, Male/microbiology , Scrotum/microbiology , Antifungal Agents/therapeutic use , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Fluconazole/therapeutic use , Genital Diseases, Male/diagnosis , Genital Diseases, Male/therapyABSTRACT
Cowper's syringocele is a rare but an under-diagnosed cystic dilation of the Cowper's ducts and is increasingly being recognized in the adult population. Recent literature suggests that syringoceles be classified based on the configuration of the duct's orifice to the urethra, either open or closed, as this also allows the clinical presentations of 2 syringoceles to be divided, albeit with some overlap. Usually post-void dribbling, hematuria, or urethral discharge indicate open syringocele, while obstructive symptoms are associated with closed syringoceles. As these symptoms are shared by many serious conditions, a working differential diagnosis is critical. Ultrasonography coupled with retro and ante grade urethrography usually suffices to diagnose syringocele, but supplementary procedures - such as cystourethroscopy, computed tomography scan, and magnetic resonance imaging - can prove useful. Conservative observation is first recommended, but persistent symptoms are usually treated with endoscopic marsupialization unless contraindicated. Upon reviewing the literature, this paper addresses the clinical anatomy, classification, presentation, diagnosis, and treatment of syringoceles in further detail.
Subject(s)
Adult , Child , Humans , Male , Bulbourethral Glands , Cysts/diagnosis , Genital Diseases, Male/diagnosis , Cysts/therapy , Dilatation, Pathologic/classification , Dilatation, Pathologic/diagnosis , Dilatation, Pathologic/therapy , Genital Diseases, Male/therapyABSTRACT
La infección genital por virus papiloma humano constituye la infección de transmisión sexual más frecuente en la actualidad. Las verrugas genitales externas se presentan en cuatro formas clínicas diferentes: condilomas acuminados, verrugas queratóticas, verrugas papulares y verrugas planas. Las diversas alternativas terapéuticas para verrugas genitales externas se pueden clasificar en dos grandes grupos: aquellas autoaplicadas por el paciente y las aplicadas por el médico. Entre las alternativas autoaplicadas destacan Imiquimod, con tasas de curación entre 37 por ciento y 85 por ciento y recurrencias entre 5 por ciento y 19 por ciento, y la Podofilotoxina, con tasas de curación entre 45 por ciento y 88 por ciento y recurrencias entre 0 por ciento y 91 por ciento. Entre las alternativas aplicadas por el médico, tenemos métodos químicos y métodos de remoción. Entre los métodos químicos destaca Podofilina, con tasas de curación entre 19 por ciento y 80 por ciento y recurrencia entre 23 por ciento y 70 por ciento; entre los métodos de remoción destaca la crioterapia, con tasas de curación entre 60 por ciento y 97 por ciento y recurrencias de 80 por ciento.
The human papilloma virus genital infection constitutes the most frequent sexual transmission infection of our time. The clinical manifestations of external genital warts vary in four different types: acuminated condyloma, keratolic warts, papular warts and flat genital warts. The diverse therapeutic alternatives for external genitals warts can be classified in two large groups: those applied by the patient, and those applied by the physician. Among the alternatives applied by the patient, both Imiquimod, with clearance rates between 37 percent - 85 percent and recurrence between 5 percent - 19 percent; and Podofillotoxin 0.5 percent solution, with clearance rates between 45 percent - 88 percent, and recurrence between 0 percent-91 percent stand out. Among the alternatives applied by physicians, we have chemical methods and removal methods. In chemical methods Podofillin stands out with clearance rates between 19 percent - 80 percent and recurrence between 23 percent - 70 percent; among removal methods, cryotherapy is the most important, with clearance rates between 60 percent - 97 percent, and recurrence of 80 percent.
Subject(s)
Humans , Male , Female , Condylomata Acuminata/diagnosis , Condylomata Acuminata/therapy , Genital Diseases, Female/diagnosis , Genital Diseases, Female/therapy , Genital Diseases, Male/diagnosis , Genital Diseases, Male/therapy , Condylomata Acuminata/classification , Diagnosis, DifferentialABSTRACT
Las urgencias en pediatría siempre han constituido un problema frecuente y, muchas veces, difícil de resolver, ya sea por la poca historia aportada por los padres -lo que es propio de la preocupación y ansiedad de la situación-, como también por la falta de información en relación a algunas maniobras simples que pueden ser realizadas por cualquier médico. Las lesiones genitourinarias suelen desestimarse en una evaluación de urgencia, a pesar de la trascendencia que éstas pudieran tener a futuro, por lo que suelen pesquisarse en una evaluación secundaria, o luego de la aparición de complicaciones. El presente artículo tiene como objetivo dar a conocer los conceptos que componen el manejo de urgencias genitourinarias en cirugía pediátrica, haciendo énfasis en aquellas que ocurren con mayor frecuencia y que implican un riesgo de complicaciones deletéreas, así como también en las que, por simplicidad de maniobras, pueden ser realizadas en cualquier servicio de atención de urgencia. Los temas expuestos son: torsión testicular, torsión de hidátide testicular, parafimosis, lesiones del tracto urinario y atrapamiento de prepucio en cremallera del pantalón.
Subject(s)
Humans , Male , Child , Genital Diseases, Male/diagnosis , Genital Diseases, Male/therapy , Varicocele/diagnosis , Varicocele/therapy , Emergencies , Paraphimosis/therapy , Pediatrics/methods , Penis/injuries , Testis/injuries , Spermatic Cord Torsion/diagnosis , Spermatic Cord Torsion/therapy , Urinary Tract/injuriesABSTRACT
An experience in treatment of perineal and genital gangrenes with natural honey at CHU-TOKOIN [Lom-Togo] with success is reported; 14 patients all are male with average age 48.6 years were concerned by this experience; as the high prices of modern pharmaceutical products and because of the increasing frequence of patients with this affection, so the autors find out the antibiotic and cicatrising value of natural honey
Subject(s)
Humans , Male , Honey , Perineum/pathology , Genitalia, Male/pathology , Genital Diseases, Male/therapyABSTRACT
Foram analisados, retrospectivamente, os prontuários de 48 pacientes com síndrome de Forunier atendidos no Serviço de Cirurgia de Emergência do Hospital das Clínicas da Faculdade de Medicina da Universidade de Säo Paulo, no período de 1982 a 1991. Foram analisados os dados clínicos e laboratoriais à admissäo. Os seguintes fatores, associados a um mau prognóstico, foram considerados estatísticamente significativos: elevaçäo da creatinina sérica, hipoxemia, alcalose ou acidose metabólica, diabete e idade maior que 50 anos. Baseados nestes critérios, os pacientes foram divididos em dois grupos: grupo I, forma leve (32 casos) e grupo II, forma grave (16 casos). Acreditamos que esta classficaçäo permita um melhor planejamento da terapêutica. Nos casos classificados como graves, o tratamento deve incluir debridamento amplo, com ressecçäo de todos os tecidos necróticos, reoperaçöes programadas, transversocolostomia, antibioticoterapia de amplo espectro e nutriçäo parenteral total. Nas formas leves, os pacients podem ser tratados com debridamento e antibioticoterapia