Ketamine anaesthesia following premedication of rabbits with vitamin C

The effects of vitamin C on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were 6.0+/-0.5 and 36.0+/-0.9 min, respectively. Pre-treatment of rabbits with 30, 60 and 240 mg/kg, i.m. of vitamin C followed by ketamine 40 mg/ kg i.m. resulted in significant (p<0.05)decrease in the onset and increase in duration of ketamine anesthesia to 5.0 +/-0.06 and 37.0+/-0.7;4.0 +/-0.5 and 39.0*0.6;2.0+/-2.3 and 44.0+/-0.8 min, respectively. There was also significant (p<0.05)decrease in the heart rates in the animals treated with vitamin C and ketamine combinations. Serum analysis showed a significant (p<0.05)increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.

Intravenous propofol anaesthesia with xylazine and diazepam premedication in dogs

Three groups of dogs were used. In group I, dogs injected with 8 mg/kg I/V propofol without premedication. The mean duration of anesthesia was 12.3 +/- 1.19 minutes. In group II, dogs injected with 4 mg/kg propofol I/V after premedication with 0.05 mg/kg atropine and 1 mg/kg xylazine I/V. The mean duration of anesthesia was 28.3 +/- 1.55 minutes. In group III, dogs injected with 4 mg/kg propofol I/V after premedication with 0.05 mg atropine, 1 mg/kg xylazine and 0.2 mg/kg diazepam I/V. The mean duration of anesthesia was 41 +/- 1.27 minutes. It was noticed that premedication effectively increased the duration of anesthesia. Maintenance of anesthesia was carried out by injection of 2 mg/kg propofol I/V in groups II and III. The duration of anesthesia and recovery was increased. The mean recovery times were 17 +/- 0.72, 15 +/- 1.25 minutes, respectively. However, propofol anesthesia and maintenance showed significant decreases [P <0.05] in rectal temperature and respiratory rates, heart rates remained within physiologic limits. Hematologic values showed significant decrease [P <0.05] in PCV, RBCs and WBCs counts from the base line values. Satisfactory smooth induction of anesthesia, maintenance and recovery were obtained in dogs under various surgical procedures

Efeitos do midazolam sobre o sistema cardiovascular em cäes pré-medicados com levomepromazina / Cardiovascular effects of midazolan in levomepromazine premedicated dogs

Foram utilizados 10 cäes adultos, de ambos os sexos, sem raça definida, com peso corpóreo entre 10 e 18 kg. Os animais foram pré-medicados com 1,0 mg/kg de levomepromazina e 15 minutos após receberam 2,0 mg/kg de midazolam, ambos por via intravenosa. A freqüência respiratória mostrou um aumento moderado e a freqüência cardíaca reduçäo aos 15 minutos e elevaçäo aos 30 minutos. Houve reduçäo da pressäo arterial média e da pressäo sistólica com significado estatístico e näo clínico. Houve tendência de reduçäo da pressäo arterial diastólica. A hipnose durou aproximadamente 20 minutos e aos 30 muinutos os cäes estavam acordados e em tentativa de deambulaçäo