Synthesis of 2-alkoxy-3cyano-4,6-diarylpyridines as antibacterial agents

Two facile synthetic methods were adopted for the preparation of new series of 2-alkoxy-3-cyano-4, 6-diarylpyridines VI-Xa-e. The first involved the reaction of substituted chalcones with malononitrile in sodium alkoxide-alcohol system. The second reacted the arylidene malononitrile XI, XII with the appropriate aryl methyl ketones XIII-XV in sodium alkoxide-alcohol system. The two methods gave good yields of the target compounds VI-Xa-e. Representative examples of the newly synthesized compounds were evaluated for antibacterial activity

Differential response of zea mays and corchorus olitorius to post-emergence application of fluroxypyr

Greenhouse and laboratory studies were conduct to evaluate the effect of Fluroxypyr [starane] at 200 cm[3] /feddan on one of the main crops in Egypt Zea mays and one of its associated weeds Corchorus olitorius. Single foliar treatment with the herbicide resulted in the death of the weeds 5 days after treatment, whereas the crop was non-significantly affected. Fluroxypyr treatment highly significantly decreased the fresh and dry weights of Corchorus weeds, markedly decreased the growth promoters contents [auxins, gibberellins and cytokinins], obviously increased the growth inhibitors and considerably reduced the total photosynthetic pigments by 18.3 percent as compared with the untreated Corchorus weeds. The results of the present work indicate that Fluroxypyr is an auxin-type herbicide since it stimulated the growth of Hordeum coleoptile sections at low concentrations and inhibited them at high concentrations. At 4 days after herbicide treatment, the electron micrograph showed that all the cells were disrupted and tonoplast, plasmalemma as well as chloroplast membrane were all burst. It was concluded after discussing the differential responses of the two plants, that Fluroxypyr at the recommended dose could be used to control Corchorus weed in Zea fields

Synthesis and antimicrobial activity of 3,5-bis- [1-3,4-oxadiazol-5-yl] -, [1,3-thiazolo] hydrazony1-and [7H] s-Triazolo- [3,4-b] -1,3,4 Thiadiazinyl] pyridine derivatives

Different 3, 5-bis [oxadiazolyl] pyridine derivatives 3-5 have been obtained from 1 depending on the reaction condition. Reaction of 5 with amines or alkylhalides afforded the corresponding Mannich bases 6 or s-alkyl derivatives 7. The latter derivatived were treated with ammonium acetate to give 9 and with hydrazine hydrate affording bis bicyclic pyridine derivatives 10. Preliminary antimicrobial tests showed products 6e and 8 to possess higher activity when compared with oxytetracycline

Synthesis of certain new pyridine derivatives of expected pharmacological activity

In this investigation, some new pyridyl-s-triazole, pyridyl oxadiazoline and pyridyl-s-triazole [3-4-b]-1,3,4-thiadiazole derivatives have been synthesize and characterized by elemental and spectral analyses

Synthesis of new pyridines and 1,2,4-triazolo [4,3-a] pyridines

Reaction of 3-cyano-4,6-disubstituted-2-oxo-1,2-dihydropyridine 1a with phosphorus pentasulfide gave the corresponding 2-thio-1,2-dihydropyridine 3. The reaction of compounds 1a,b with mixture of phosphorus oxychloride and phosphorus pentachloride afforded the 2-chloropyridine derivatives 4a,b. Treatment of 4a,b with hydrazine hydrate gave the corresponding 2-hydrazino derivatives 5a,b. Reaction of 5a,b with acid chlorides and carbon disulfide afforded the corresponding 1,2,4-triazolo [4,3-a] pyridines 7a,g and 8a,b, under the conditions of reacting compound 5a,b with the above-mentioned reagents, the cyano group was completely hydrolyzed to carboxylic acid. On the other hand, conversion of 5a,b into Schiff bases 6a,h followed by cyclization with bromine in acetic acid produced compounds 7a,g