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1.
Braz. j. biol ; 83: e244123, 2023. tab
Article in English | LILACS, VETINDEX | ID: biblio-1278562

ABSTRACT

Abstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their association with clinical manifestation, particularly Jaccoud's arthropathy (JA). We analyzed DNA samples from 204 SLE patients, having a subgroup of them presenting JA (n=24). A control group (n=133) from the same city was also included. TLR9 single nucleotide polymorphisms (SNPs) (−1237 C>T and +2848 G>A) were identified by sequencing analysis. The TLR9 gene genotype frequency was similar both in SLE patients and the control group. In the whole SLE population, an association between the homozygosis of allele C at position −1237 with psychosis and anemia (p < 0.01) was found. Likewise, the homozygosis of allele G at position +2848 was associated with a discoid rash (p < 0.05). There was no association between JA and TLR9 polymorphisms. These data show that TLR9 polymorphisms do not seem to be a predisposing factor for SLE in the Brazilian population, and that SNPs are not associated with JA.


Resumo O receptor Toll-like 9 (TLR9) é um componente importante do sistema imunológico inato e tem sido associado a várias doenças autoimunes, como o Lúpus Eritematoso Sistêmico (LES). O objetivo deste estudo foi investigar polimorfismos no gene TLR9 em um grupo de pacientes brasileiros com LES e sua associação com a manifestação clínica, particularmente a artropatia de Jaccoud (JA). Foram analisadas amostras de DNA de 204 pacientes com LES, e um subgrupo com JA (n=24). Um grupo de controle (n=133) da mesma cidade também foi incluído. Os polimorfismos de nucleotídeos únicos TLR9 (SNPs) (−1237 C>T e +2848 G>A) foram identificados pela análise de sequenciamento. A frequência do genótipo genético TLR9 foi semelhante tanto em pacientes com LES quanto no grupo controle. Em toda a população de LES, foi encontrada associação entre a homozigose do alelo C na posição −1237 com psicose e anemia (p < 0,01). Da mesma forma, a homozigose do alelo G na posição +2848 foi associada a uma erupção cutânea discoide (p < 0,05). Não houve associação entre polimorfismos JA e TLR9. Esses dados mostram que os polimorfismos TLR9 não parecem ser um fator predisponível para o LES na população brasileira, e que os SNPs não estão associados ao JA.


Subject(s)
Humans , Toll-Like Receptor 9/genetics , Lupus Erythematosus, Systemic/genetics , Brazil , Pilot Projects , Genetic Predisposition to Disease/genetics , Gene Frequency/genetics
3.
Rev. chil. obstet. ginecol. (En línea) ; 87(3): 210-217, jun. 2022. ilus, tab
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1388728

ABSTRACT

INTRODUCCÍON: Los padres se han involucrado cada vez más en el embarazo y el nacimiento de sus hijos, pero aún se requieren intervenciones paternas que permitan reubicar al padre en su rol de corresponsabilidad en la crianza. OBJETIVO: Observar el comportamiento-actitud paterna hacia el/la hijo(a) y la cantidad de oxitocina (OT) secretada en el nacimiento, en padres preparados de un modo especial para el parto. Método: Estudio piloto de 8 meses, parte de una investigación mayor cuali-cuantitativa de dos fases. La fase cualitativa inicial desarrolló una intervención preparatoria de padres para el nacimiento, con énfasis en la vinculación padre-hijo(a). La fase cuantitativa correspondió al piloto de la intervención paterna antenatal. RESULTADOS: Los padres presenciaron activamente el momento del expulsivo y el encuentro madre-hijo(a). Posteriormente, todos optaron por el contacto físico piel-piel con su hijo(a). La OT paterna experimentó un aumento (no significativo) durante el contacto padre-hijo(a) en comparación con la OT basal (momento inmediato al nacimiento). CONCLUSIONES: Padres preparados, sensibilizados y vinculados con su hijo(a) desde el embarazo experimentarían variaciones de la cantidad de OT cuando realizan contacto piel-piel con su hijo(a) en el nacimiento. Se requiere investigación experimental con una muestra mayor de participantes para concluir de manera categórica.


INTRODUCTION: Fathers have been increasingly involved in the pregnancy and birth of their children, but paternal interventions are still required to relocate the father in his role of co-responsibility in parenting. OBJECTIVE: To observe the paternal behavior-attitude towards the child and the amount of oxytocin (OT) secreted at birth in parents prepared (in a special way) for childbirth. METHOD: Pilot study of 8 months, part of a larger qualitative-quantitative research of two phases. The initial qualitative phase developed a male preparatory intervention for the birth, with emphasis on the father-child bonding. The quantitative phase corresponded to the pilot of the antenatal paternal intervention. RESULTS: Fathers actively witnessed the moment of delivery and the mother-child attachment. Subsequently, all of them opted for physical skin-to-skin contact with their child. Paternal OT experienced a (non-significant) increase during father-child contact, compared to baseline OT (immediately after birth). CONCLUSIONS: Males prepared, sensitized and involved with their child since pregnancy would experience variations in the amount of OT when they make father-child skin-to-skin contact at childbirth. Experimental research with a larger sample of participants is required to categorically reach a conclusion.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Adult , Parent-Child Relations , Paternal Behavior/physiology , Oxytocin/physiology , Touch , Pilot Projects , Parturition , Object Attachment
4.
Rev. chil. ter. ocup ; 23(1): 27-35, jun. 2022. tab
Article in Spanish | LILACS | ID: biblio-1398783

ABSTRACT

Introducción: Los procesos de atención a personas mayores han presentado cambios debido al confinamiento sanitario causado por el COVID-19, por esta razón la telerehabilitación se impulsa como una estrategia para continuar los procesos de rehabilitación cognitiva a personas mayores. Objetivo: evaluar la percepción de la calidad de vida de personas mayores con deterioro cognitivo que se encuentran en telerehabilitación, comparado con la calidad de vida de personas mayores con deterioro cognitivo sin telerehabilitación. Método: se realizó un estudio descriptivo para identificar los cambios en la calidad de vida de personas mayores con procesos de telerehabilitación. Se emplearon los instrumentos Quality of Life in Alzheimer's Disease y la escala GENCAT. Resultados: el estudio descriptivo mostró cambios favorables en la calidad de vida de las personas mayores que estuvieron en el proceso de telerehabilitación, mientras que el grupo control presentó cambios negativos. Conclusiones: este estudio permite evidenciar los cambios en la calidad de vida de personas mayores con deterioro cognitivo que participa en un proceso de telerehabilitación durante el confinamiento sanitario. Estos cambios favorables se presentaron en las dimensiones de bienestar emocional, bienestar material, inclusión social y derechos.


Introduction: the processes of care for elderly have presented changes, due to the sanitary confinement caused by COVID-19 pandemic. For this reason, telerehabilitation is promoted as a strategy to continue the processes of cognitive rehabilitation for the elderly. Aim: To evaluate quality of life perceptions among older people with cognitive impairment, who received telerehabilitation, compared with quality of life of older people with cognitive impairment without Telerehabilitation. Method: a descriptive study to identify changes in quality of life of older people receiving tele-rehabilitation processes. Assessment instruments used were: Quality of Life in Alzheimer's Disease and the GENCAT scale. Results: this descriptive study showed favorable changes in quality of life of the elderly who were in the telerehabilitation process, while the control group presented negative changes. Conclusions: this study offers evidence on the changes in the quality of life for elderly people with cognitive impairment who participate in a telerehabilitation process during sanitary confinement. These favorable changes occurred in the dimensions of emotional well-being, material well-being, social inclusion and rights.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Quality of Life , Cognition , Cognitive Dysfunction , Telerehabilitation , Pilot Projects
5.
Int. braz. j. urol ; 48(2): 275-281, March-Apr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1364959

ABSTRACT

ABSTRACT Objectives: The purpose of our study was to assess the association between the winter season and desmopressin treatment failure in South Chinese children with monosymptomatic nocturnal enuresis (MNE). Materials and Methods: A retrospective study was conducted to analyze the clinical data of children with monosymptomatic nocturnal enuresis who have visited our urology clinic from January to December 2019. All patients received desmopressin treatment. Final treatment outcomes were categorized as successful (complete response) or failed (absent and partial response). The relationship between winter season and treatment response to desmopressin was evaluated. Additionally, associated risk factors were investigated with both univariate and multivariate regression analysis. Results: In total, 393 patients diagnosed with MNE were included in the present study. There were no statistically significant differences in pretreatment variables at first visit between patients who visited the clinic in winter and those who did so in other seasons. However, the treatment failure rate of MNE in the winter season was higher than that of other seasons (77.50% vs. 52.74%). Multivariate logistic regression analysis demonstrated that the severity of symptoms and an initial clinic visit in the winter season were significantly related to desmopressin treatment failure in MNE patients. Conclusion: Winter season and severity of symptoms are two risk factors associated with desmopressin treatment failure in MNE patients.


Subject(s)
Humans , Child , Enuresis , Nocturnal Enuresis/drug therapy , Seasons , Pilot Projects , Retrospective Studies , Deamino Arginine Vasopressin/therapeutic use
6.
Más Vita ; 4(1): 194-210, mar. 2022. tab, graf
Article in Spanish | LILACS, LIVECS | ID: biblio-1372269

ABSTRACT

La preeclampsia es una patología que surge de forma desconocida comprometiendo el estado de salud del binomio materno ­ neonatal, provocando daño multiorgánico. La característica principal es la relación con múltiples factores de riesgo tales como la hipertensión en familiares de primer grado, obesidad, alimentación, falta de controles obstétricos durante la gestación, entre otros; Objetivo: Validar el cuestionario diseñado para evaluar los factores que influyen en preclamsia, Determinar los factores de riesgo que influyen en su incidencia. Materiales y métodos: Se aplico una metodología cuanti cualitativa, corte transversal, exploratorio; la validación se efectuó a través del juicio de expertos, utilizando dos tipos de instrumentos uno para cada tipo de investigación, se valoran por separado, en el plan piloto se utiliza parte de la muestra seleccionada para la investigación macro. En el caso de la cualitativa se utiliza una técnica de entrevista a saturación, con una investigación de tipo fenomenológica, organizada por categorías. Resultados: El instrumento cuantitativo obtiene un puntaje 93% de confiabilidad, con un alfa de crombach de 0,7, el instrumento cualitativo 95%, dentro de los factores de riesgo se distingue los trastornos hipertensivos del embarazo, se asocia con un espectro de gravedad que va desde la hipertensión leve inducida por el embarazo hasta la eclampsia. Conclusión: Durante el estudio piloto se obtiene los datos con rapidez y efectividad, no existen conflictos en su comprensión, su confiabilidad garantiza el trabajo científico, la validación de instrumentos justifica el proceso, de inicio resultó conflictivo por la ausencia de instrumentos para medir los factores que influyen en esta patología, se encuentran los valores causales y en especial en las vivencias de cada uno de los actores e involucrados, La preeclampsia es un fenómeno frecuente cuya patología conlleva graves complicaciones para la madre y el feto con este tipos de estudio se aporta a su control y erradicación(AU)


Preeclampsia is a pathology that arises in an unknown way, compromising the health status of the maternal-neonatal binomial, causing multi-organ damage. The main characteristic is the relationship with multiple risk factors such as hypertension in first degree relatives, obesity, diet, lack of obstetric controls during pregnancy, among others; Objective: to validate the questionnaire designed to evaluate the factors that influence preeclampsia, to determine the risk factors that influence its incidence. Materials and methods: A quantitative, qualitative, cross-sectional, exploratory methodology was applied; The validation was carried out through the judgment of experts, using two types of instruments, one for each type of research, they are valued separately, in the pilot plan part of the selected sample is used for the macro research. In the case of qualitative, a saturation interview technique is used, with a phenomenological type investigation, organized by categories. Results: The quantitative instrument obtains a 93% reliability score, with a crombach alpha of 0.7, the qualitative instrument 95%, within the risk factors distinguishes hypertensive disorders of pregnancy, it is associated with a spectrum of severity ranging from mild pregnancy-induced hypertension to eclampsia. Conclusion: During the pilot study the data is obtained quickly and effectively, there are no conflicts in its understanding, its reliability guarantees scientific work, the validation of instruments justifies the process, initially it was conflictive due to the absence of instruments to measure the factors that influence this pathology, are the causal values ​​and especially in the experiences of each of the actors and involved, Preeclampsia is a frequent phenomenon whose pathology entails serious complications for the mother and the fetus with this type of study is provided to its control and eradication(AU)


Subject(s)
Pre-Eclampsia/pathology , Risk Factors , Hypertension, Pregnancy-Induced , Eclampsia/pathology , Health Services Programming , Research , Pilot Projects , Incidence , Data Collection , Fetus
7.
Int. j. cardiovasc. sci. (Impr.) ; 35(2): 152-158, Mar.-Apr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1364987

ABSTRACT

Abstract Background: The implementation of Telecardiology in primary care in the city of Porto Alegre, Brazil, is a viable and promising strategy. It would decrease the distance between patient and specialized professional services by reducing unnecessary referrals and improving the quality of primary care and satisfaction of patients and health professionals. Objective: To implement a Telecardiology service and assess user satisfaction using the CARDIOSATIS scale. Methods: This was a pilot study developed by a partnership between the Institute of Cardiology and the Telehealth Center of Rio Grande do Sul. The study was carried out at Eri Flores-Vila Vargas health center in the city of Porto Alegre, from May to October 2019, and included 21 patients attending the health center. The descriptive analysis of data was performed using the SPSS program (Statistical Package for the Sciences) version 23. Data normality was checked using the Kolmogorov-Smirnov test. Statistical significance was set at 10%. Results: Mean age of participants was 43.8 ± 16.1 years. The most common risk factors in the sample were physical inactivity (81%) and smoking (43%). Most patients had normal electrocardiogram (ECG) readings. The time elapsed from the performance of the ECG test, transmission of the ECG traces to Telehealth, and return of the final ECG report to the health center was 0-7 days. The CARDIOSATIS scale revealed a high prevalence of "very satisfied" users for the general satisfaction domain, and only 14.3% of patients were dissatisfied with their health. Conclusions: Telecardiology reduced the distance between patient and the specialized professional, with a high level of patient and health professional satisfaction. Our study can serve as a basis for the implementation of a telecardiology network in the city of Porto Alegre in the future.


Subject(s)
Humans , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Remote Consultation/methods , Remote Consultation/trends , Remote Consultation/ethics , Telecardiology , Cardiovascular Diseases/nursing , Cardiovascular Diseases/diagnostic imaging , Pilot Projects , Telemedicine , Electrocardiography
8.
Psico USF ; 27(1): 157-167, jan.-mar. 2022. tab, graf
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1376039

ABSTRACT

Estudos mostram que o tabagismo é responsável por afetar algumas funções cognitivas. No entanto, a nicotina é apenas um dos componentes existentes no cigarro e existem evidências de que pode servir como agente neuroprotetivo e causar melhoras em algumas funções cognitivas. O objetivo desta pesquisa foi investigar como a nicotina interage com algumas funções cognitivas. Um ensaio clínico piloto com administração de gomas de nicotina contendo 2-mg ou 4-mg, ou gomas placebo contendo a mesma textura, sabor e aparência, foi realizado. Quarenta e dois participantes participaram da pesquisa e os resultados indicaram que a relação entre nicotina e o desempenho na tarefa Go/No-Go podem ser bidirecionais. Os resultados indicaram que participantes do grupo que utilizaram 4-mg de nicotina apresentaram menor desempenho, enquanto os participantes que fizeram uso de 2-mg de nicotina tiveram melhor desempenho do que os demais. Esta pesquisa tem aplicações biopsicossociais e podem ajudar na compreensão da relação entre tabagismo e nicotina, além de contribuir para estratégias que possam ajudar no abandono do cigarro ou na melhora de condições que afetem a cognição (AU).


Past findings in the literature indicated that smoking could affect given cognitive functions. However, nicotine is only one of the components in cigarettes and there is evidence that it may act as a neuroprotective agent and improve some cognitive functions. The purpose of this research was to investigate how nicotine interacts with certain cognitive functions. We conducted a pilot clinical trial using nicotine gum containing 2-mg or 4-mg, or placebo gum with the same texture, flavor, and appearance. Forty-two healthy nonsmokers were enrolled in this research. Our findings indicated that the relationship between nicotine and performance on the Go/No-Go task might be opposite. The results showed that participants in the 4-mg group performed worse, while participants who used 2-mg of nicotine performed better than the others. This research supports biopsychosocial applications and can help interpret the relationship between smoking and nicotine, and contribute to strategies that may support smoking cessation, or improve conditions that affect cognition (AU).


Estudios demuestran que el tabaquismo es responsable de afectar a algunas funciones cognitivas. Sin embargo, la nicotina es solo uno de los componentes de los cigarrillos, y existen evidencias de que la nicotina puede actuar como un agente neuroprotector y mejorar algunas funciones cognitivas. El objetivo de este estudio fue investigar cómo la nicotina interactúa con algunas funciones cognitivas. Se realizó un ensayo clínico piloto con la administración de chicles de nicotina de 2 mg o 4 mg, o chicles de placebo con la misma textura, sabor y apariencia. Cuarenta y dos participantes participaron en la investigación y los resultados indicaron que la relación entre la nicotina y el rendimiento en la tarea Go/No-go puede ser bidireccional. Los resultados indicaron que los participantes del grupo de 4 mg obtuvieron un menor rendimiento en las variables del Go/No-Go, mientras que los participantes que utilizaron 2 mg de nicotina obtuvieron un mejor rendimiento que los demás. Esta investigación respalda las aplicaciones biopsicosociales y puede ayudar a interpretar la relación entre el tabaquismo y la nicotina, además de contribuir a las estrategias que pueden ayudar a dejar de fumar o mejorar las condiciones que afectan la cognición (AU).


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Executive Function , Nicotine Chewing Gum , Nicotine/administration & dosage , Placebos/administration & dosage , Tobacco Use Disorder/psychology , Chi-Square Distribution , Pilot Projects , Double-Blind Method , Analysis of Variance
10.
Int. braz. j. urol ; 48(1): 131-156, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1356297

ABSTRACT

ABSTRACT Purpose: Sperm DNA fragmentation (SDF) and seminal oxidative stress are emerging measurable factors in male factor infertility, which interventions could potentially reduce. We evaluated (i) the impact of lifestyle changes combined with oral antioxidant intake on sperm DNA fragmentation index (DFI) and static oxidation-reduction potential (sORP), and (ii) the correlation between DFI and sORP. Materials and Methods: We conducted a prospective study involving 93 infertile males with a history of failed IVF/ICSI. Ten healthy male volunteers served as controls. Semen analysis was carried out according to 2010 WHO manual, whereas seminal sORP was measured using the MiOXSYS platform. SDF was assessed by sperm chromatin structure assay. Participants with DFI >15% underwent a three-month lifestyle intervention program, primarily based on diet and exercise, combined with oral antioxidant therapy using multivitamins, coenzyme Q10, omega-3, and oligo-elements. We assessed changes in semen parameters, DFI, and sORP, and compared DFI results to those of volunteers obtained two weeks apart. Spearman rank correlation tests were computed for sORP and DFI results. Results: Thirty-eight (40.8%) patients had DFI >15%, of whom 31 participated in the intervention program. A significant decrease in median DFI from 25.8% to 18.0% was seen after the intervention (P <0.0001). The mean DFI decrease was 7.2% (95% CI: 4.8-9.5%; P <0.0001), whereas it was 0.42% (95%CI; -4.8 to 5.6%) in volunteers (P <0.00001). No differences were observed in sperm parameters and sORP. Based on paired sORP and DFI data from 86 patients, no correlation was observed between sORP and DFI values (rho=0.03). Conclusion: A 3-month lifestyle intervention program combined with antioxidant therapy reduced DFI in infertile men with elevated SDF and a history of failed IVF/ICSI. A personalized lifestyle and antioxidant intervention could improve fertility of subfertile couples through a reduction in DFI, albeit controlled trials evaluating reproductive outcomes are needed before firm conclusions can be made. Trial registration number and date: clinicaltrials.gov NCT03898752, April 2, 2019.


Subject(s)
Humans , Male , Infertility, Male/drug therapy , Antioxidants/metabolism , Antioxidants/therapeutic use , Spermatozoa , Fertilization in Vitro , Pilot Projects , Prospective Studies , Oxidative Stress , DNA Fragmentation , Life Style
11.
Rev. SOBECC (Online) ; 27: 1-7, 01-01-2022.
Article in Portuguese | LILACS, BDENF | ID: biblio-1399716

ABSTRACT

Objetivo: Mensurar a taxa de precisão na autodemarcação da lateralidade realizada pelo paciente cirúrgico eletivo no período pré-operatório imediato e analisar a percepção do paciente e do médico-cirurgião diante dessa prática. Método: Estudo transversal desenvolvido de junho a dezembro de 2018, em um hospital privado do Sul do Brasil. A amostra foi composta por 105 pacientes submetidos a procedimentos cirúrgicos eletivos de órgãos ambíguos, que responderam a um questionário sobre a demarcação do sítio cirúrgico. Os dados foram avaliados por meio de análise descritiva. Resultados: Foram analisados 105 questionários, dos quais três foram excluídos por estar incompletos, dessa forma, a amostra foi composta por 102 documentos. Todos os pacientes realizaram a autodemarcação no local correto. Dentre os participantes, 93% dos pacientes e 99% dos cirurgiões relataram sentirem-se seguros quanto à autodemarcação. Conclusão: A autodemarcação pode constituir uma complementação na prática assistencial, consistindo em mais uma barreira de segurança e promovendo a participação do paciente como agente de cuidado, porém não substitui a confirmação pelo cirurgião no período pré-operatório.


Objective: To measure the accuracy rate in the self-demarcation of laterality performed by elective surgery patients in the immediate preoperative period and to analyze the perception of patients and surgeons regarding this practice. Method: Cross-sectional study developed from June to December 2018, in a private hospital in southern Brazil. The sample consisted of 105 patients undergoing elective surgical procedures for ambiguous organs, who answered a questionnaire about the demarcation of the surgical site. Data were evaluated using descriptive analysis. Results: 105 questionnaires were analyzed, of which three were excluded because they were incomplete, thus, the sample consisted of 102 documents. All patients performed the self-demarcation in the correct site. Among participants, 93% of patients and 99% of surgeons reported feeling confident about self-demarcation. Conclusion: Self-demarcation may complement care practice, consisting of another safety barrier and promoting the patient's participation as a care agent, but it does not replace confirmation by the surgeon in the preoperative period.


Objetivos: Medir el índice de acierto en la autodemarcación de lateralidad realizada por el paciente quirúrgico electivo en el preoperatorio inmediato y analizar la percepción del paciente y del cirujano respecto a esta práctica. Método: Estudio transversal, desarrollado de junio a diciembre de 2018, en un hospital privado del sur de Brasil. La muestra estuvo conformada por 105 pacientes sometidos a procedimientos quirúrgicos electivos porórganos ambiguos, quienes respondieron un cuestionario sobre la demarcación del sitio quirúrgico. Los datos se evaluaron mediante análisis descriptivo. Resultados: se analizaron 105 cuestionarios, de los cuales se excluyeron tres por estar incompletos, por lo que la muestra estuvo conformada por 102 documentos. Todos los pacientes realizaron la autodemarcación en el lugar correcto. Entre los participantes, el 93% de los pacientes y el 99% de los cirujanos informaron sentirse seguros con la práctica de la autodemarcación. Conclusión: La autodemarcación puede ser un complemento a la práctica asistencial, siendo una barrera más de seguridad y promoviendo la participación del paciente como agente asistencial, pero no reemplaza la confirmación por parte del cirujano en el preoperatorio.


Subject(s)
Humans , Self Care , Surgicenters , Preoperative Period , Patients , Pilot Projects , Cross-Sectional Studies
12.
Rev. ABENO ; 22(2): 1876, jan. 2022. ilus, tab, graf
Article in English | LILACS, BBO | ID: biblio-1396745

ABSTRACT

This study investigated the prevalence of the coronavirus disease (COVID-19) and vaccination among dental students from public and private institutions, as well as verified the level of influence of the pandemic and vaccination on physical, mental health and academic performance. In this cross-sectional study an online questionnaire using Google Forms® was applied to dental students from a public and a private university on epidemiological data, COVID-19, vaccination and the impact of social distancing on health. The rate of COVID-19 infection in both groups was 36.8% (n=46), and when asked about the period of infection, 82.6% of these (n=38) contracted it before the first dose, but there were no statistically significant differences (χ2=2.667; p=0.102) between the groups. There was a difference between the groups tested, since 56.3% of the students from G1 were vaccinated with a second dose, compared to 29.6% from G2 (χ2= 16.554; p= 0.0009). Students were asked about the existence of risks in the dentistry course, and 76.8% considered that there are risks (n=96), with a statistically significant difference (χ2= 10.216; p= 0.001). Regarding the vaccine, 64% of the participants think it is safe (n=80), with a statistically significant difference between the groups (χ2= 4.374; p= 0.036). Most students contracted COVID-19 before the first dose, were vaccinated with the second dose by AstraZeneca and Pfizer immunizers. The academic performance and the physical and mental health of the students were significantly affected, with the students of advanced periods and those of public universities suffering more negative impacts (AU).


Este estudo investigou a prevalência da COVID-19 e vacinação entre estudantes de odontologia de instituições públicas e privadas, bem como verificar o nível de influência da pandemia e da vacinação na saúde física, mental e no desempenho acadêmico. Em um estudo transversal, foi aplicado um questionário online utilizando o Google Forms® a estudantes de odontologia de uma universidade pública e privada sobre dados epidemiológicos, COVID-19, vacinação e o impacto do distanciamento social na saúde. A taxa de infecção por COVID-19 em ambos os grupos foi de 36,8% (n=46), e quando questionados sobre o período de infecção, 82,6% destes (n=38) contraíram antes da primeira dose, mas não houve significância estatística diferenças (χ2=2,667; p=0,102) entre os grupos. Houve diferença entre os grupos testados, pois 56,3% dos escolares do G1 foram vacinados com uma segunda dose, comparado a 29,6% do G2 (χ2= 16,554; p= 0,0009). Os alunos foram questionados sobre a existência de riscos no curso de odontologia, e 76,8% consideraram que existem riscos (n=96), com diferença estatisticamente significativa (χ2= 10,216; p= 0,001). Em relação à vacina, 64% dos participantes a consideram segura (n=80), com diferença estatisticamente significativa entre os grupos (χ2= 4,374; p= 0,036). A maioria dos alunos contraiu COVID-19 antes da primeira dose, foram vacinados com a segunda dose pelos imunizadores AstraZeneca® e Pfizer®. O desempenho acadêmico e a saúde física e mental dos alunos foram significativamente afetados, com os alunos de períodos avançados e os de universidades públicas sofrendo mais impactos negativos (AU).


Subject(s)
Humans , Male , Female , Adult , Students, Dental , COVID-19 Vaccines , COVID-19/prevention & control , COVID-19/epidemiology , Pilot Projects , Mental Health , Cross-Sectional Studies/methods , Surveys and Questionnaires , Data Interpretation, Statistical
13.
Acta Paul. Enferm. (Online) ; 35: eAPE0381345, 2022. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1374041

ABSTRACT

Resumo Objetivo Avaliar a adesão de gestantes e acompanhantes à realização da massagem perineal digital durante a gestação e seu efeito na prevenção do trauma perineal no parto e na redução de morbidade associada nos 45 e 90 dias pós-parto. Métodos Estudo piloto de ensaio clínico randomizado com 153 gestantes de risco habitual, 78 mulheres no grupo de intervenção realizaram a massagem perineal digital e 75 mulheres do grupo controle receberam os cuidados habituais. Para a análise do desfecho principal (trauma perineal) e dos desfechos secundários, permaneceram em cada grupo 44 mulheres que tiveram parto vaginal. A intervenção foi realizada pela gestante ou acompanhante de sua escolha, diariamente, a partir de 34 semanas de gestação, por 5 a 10 minutos. Resultados A massagem perineal foi fator de proteção para edema nos primeiros 10 dias pós-parto (RR 0,64 IC95%0,41-0,99) e perda involuntária de gases nos 45 dias pós-parto (RR0,57 IC95%0,38-0,86). O ajuste residual ≥ 2 observado na análise das condições do períneo pós-parto mostrou uma tendência das mulheres do grupo intervenção terem períneo íntegro. As mulheres e os acompanhantes que realizaram a massagem perineal aceitaram bem a prática, recomendariam e fariam novamente em futura gestação. Conclusão A massagem perineal digital realizada diariamente, a partir de 34 semanas de gestação, foi uma prática bem aceita pelas mulheres e acompanhantes deste estudo. Apesar de não proteger a mulher de trauma perineal, esta prática reduziu o risco de edema 10 dias pós-parto e incontinência de gases 45 dias pós-parto. Registro Brasileiro de ensaio clínico: RBR-4MSYDX


Resumen Objetivo Evaluar la participación de mujeres embarazadas y acompañantes en la realización del masaje digital perineal durante el embarazo y su efecto en la prevención del trauma perineal durante el parto y en la reducción de la morbilidad asociada con los 45 y 90 días post parto. Métodos Estudio piloto de ensayo clínico aleatorizado con 153 mujeres embarazadas con riesgo normal, 78 mujeres en el grupo de intervención realizaron el masaje digital perineal y 75 mujeres del grupo control recibieron los cuidados habituales. Para el análisis del desenlace principal (trauma perineal) y de los desenlaces secundarios, permanecieron en cada grupo 44 mujeres que tuvieron parto vaginal. La intervención la realizó la mujer embarazada o el acompañante por ella elegido, diariamente, a partir de las 34 semanas de embarazo, por 5 a 10 minutos. Resultados El masaje perineal fue factor de protección para el edema en los primeros 10 días postparto (RR 0,64 IC95%0,41-0,99) y la pérdida involuntaria de gases en los 45 días post parto (RR0,57 IC95%0,38-0,86). El ajuste residual ≥ 2 observado en el análisis de las condiciones del perineo postparto mostró una tendencia en las mujeres del grupo intervención a que tengan el perineo íntegro. Las mujeres y los acompañantes que realizaron el masaje perineal recibieron bien la práctica, la recomendarían y la harían nuevamente en un futuro embarazo. Conclusión El masaje digital perineal realizado diariamente, a partir de las 34 semanas de embarazo, fue una práctica bien recibida por las mujeres y acompañantes de este estudio. Pese a que no protege a la mujer de un trauma perineal, esta práctica redujo el riesgo de edema a los 10 días post parto y la incontinencia de gases 45 días post parto.


Abstract Objective To evaluate the adherence of pregnant women and companions to the performance of digital perineal massage during pregnancy and its effect on the prevention of perineal trauma during childbirth and on the reduction of associated morbidity at 45 and 90 days postpartum. Methods A pilot study of a randomized clinical trial with 153 normal risk pregnant women; 78 women in the intervention group underwent digital perineal massage and 75 women in the control group received usual care. For the analysis of the main outcome (perineal trauma) and secondary outcomes, 44 women who had vaginal delivery remained in each group. The intervention was performed daily by the pregnant woman or the companion of her choice from 34 weeks of gestation during 5-10 minutes. Results Perineal massage was a protective factor for edema in the first 10 days postpartum (RR 0.64 95%CI 0.41-0.99) and involuntary gas loss at 45 days postpartum (RR0.57 95%CI 0.38-0.86). The residual adjustment ≥ 2 observed in the analysis of perineal conditions postpartum showed a trend of women in the intervention group having an intact perineum. The women and companions who performed perineal massage accepted the practice well, recommended it and would do it again in a future pregnancy. Conclusion The digital perineal massage performed daily from 34 weeks of gestation was a practice well accepted by women of this study and their companions. Although not protecting women from perineal trauma, this practice reduced the risk of edema at 10 days postpartum and gas incontinence at 45 days postpartum. Brazilian Clinical Trial Registry: RBR-4MSYDX


Subject(s)
Humans , Female , Pregnancy , Adult , Perineum/injuries , Prenatal Care/methods , Pelvic Floor/injuries , Lacerations/prevention & control , Prenatal Education , Massage/methods , Quality of Life , Randomized Controlled Trials as Topic , Pilot Projects
14.
Dental press j. orthod. (Impr.) ; 27(1): e2219388, 2022. tab, graf
Article in English | LILACS, BBO | ID: biblio-1364782

ABSTRACT

ABSTRACT Introduction: Currently, no method is considered effective for the evaluation of digital models in the Certification Examination of the Brazilian Board of Orthodontics (BBO), considering the parameters of the currently used manual method. Objective: Thus, the aim of this study is to verify the reliability of an evaluation method for digital models that could be used in the BBO exam, compared to the gold standard. Methods: Measurements were performed by five previously calibrated examiners. Samples of ten sets of plaster models of the final phase of orthodontic treatment were measured using a manual method (Objective Grading System, OGS). These models were digitized using a 3D scanner and exported to Geomagic Qualify software, in which the measurements were made with the proposed digital method. These measurements were repeated using five models, after fifteen days. The intra-examiner performance with this method was analyzed with a paired t-test, whereas the inter-examiner analysis was carried out with analysis of variance and Tukey's test. To compare the manual and digital methods, a paired t-test and Pearson's correlation analysis were performed. Results: A statistically significant difference was found. The results showed that, when compared to the manual method, the digital method was effective in measuring the OGS in four of the seven variables studied: Marginal Ridge, Overjet, Occlusal Contact, and Interproximal Contact. The variables Alignment, BL inclination, and Occlusal Relationship showed a great amount of dispersion in the findings. Conclusion: Further studies are needed to develop an adequate digital methodology that can be used for all OGS variables.


RESUMO Introdução: Ainda não há um método considerado eficaz para análise dos modelos digitais no exame do Board Brasileiro de Ortodontia (BBO), considerando-se os parâmetros do método manual atual. Objetivo: Assim, o presente estudo objetiva verificar a confiabilidade de um método de avaliação em modelos digitais para o exame do BBO, comparando com o padrão-ouro. Métodos: As medições foram realizadas por 5 examinadores, previamente calibrados. A amostra de 10 pares de modelos de gesso da fase final do tratamento ortodôntico foi medida no método manual (Sistema Objetivo de Avaliação, SOA). Os modelos foram digitalizados por meio de um scanner 3D e exportados para o software Geomagic Qualify, onde foram feitas as medidas no método digital proposto. As medidas foram refeitas em 5 modelos após 15 dias. A análise intraexaminador desse método foi realizada por meio do teste t pareado; já a interexaminadores, feita com ANOVA e teste de Tukey, sendo encontrada diferença estatisticamente significativa. Para a comparação dos métodos manual e digital, foram utilizados o teste t pareado e a correlação de Pearson. Resultados: Uma diferença estatisticamente significativa foi encontrada. Os resultados mostraram que, comparada ao método manual, a metodologia digital mostrou-se eficaz para medição do SOA em quatro das sete variáveis estudadas: Margem interproximal, Sobressaliência, Contato oclusal e Contato interproximal. As variáveis Alinhamento, Inclinação V-L e Relação oclusal mostraram muita dispersão nos achados. Conclusão: Mais estudos são necessários para o desenvolvimento de uma metodologia digital adequada em todas as variáveis do SOA.


Subject(s)
Orthodontics , Software , Pilot Projects , Reproducibility of Results , Models, Dental
15.
J. bras. pneumol ; 48(1): e20210349, 2022. tab, graf
Article in English | LILACS | ID: biblio-1360534

ABSTRACT

ABSTRACT Objective: To assess the feasibility of using a new helmet interface for CPAP, designated ELMO, to treat COVID-19-related acute hypoxemic respiratory failure (AHRF) outside the ICU. Methods: This was a proof-of-concept study involving patients with moderate to severe AHRF secondary to COVID-19 admitted to the general ward of a public hospital. The intervention consisted of applying CPAP via the ELMO interface integrated with oxygen and compressed air flow meters (30 L/min each) and a PEEP valve (CPAP levels = 8-10 cmH2O), forming the ELMOcpap system. The patients were monitored for cardiorespiratory parameters, adverse events, and comfort. Results: Ten patients completed the study protocol. The ELMOcpap system was well tolerated, with no relevant adverse effects. Its use was feasible outside the ICU for a prolonged amount of time and was shown to be successful in 60% of the patients. A CPAP of 10 cmH2O with a total gas flow of 56-60 L/min improved oxygenation after 30-to 60-min ELMOcpap sessions, allowing a significant decrease in estimated FIO2 (p = 0.014) and an increase in estimated PaO2/FIO2 ratio (p = 0.008) within the first hour without CO2 rebreathing. Conclusions: The use of ELMOcpap has proven to be feasible and effective in delivering high-flow CPAP to patients with COVID-19-related AHRF outside the ICU. There were no major adverse effects, and ELMO was considered comfortable. ELMOcpap sessions significantly improved oxygenation, reducing FIO2 without CO2 rebreathing. The overall success rate was 60% in this pilot study, and further clinical trials should be carried out in the future. (ClinicalTrials.gov identifier: NCT04470258 [http://www.clinicaltrials.gov/])


RESUMO Objetivo: Avaliar a viabilidade do uso de uma nova interface do tipo capacete para CPAP, denominada ELMO, para o tratamento da insuficiência respiratória aguda (IRpA) hipoxêmica por COVID-19 fora da UTI. Métodos: Estudo de prova de conceito envolvendo pacientes com IRpA hipoxêmica moderada a grave secundária à COVID-19, internados na enfermaria geral de um hospital público. A intervenção consistiu na aplicação de CPAP por meio da interface ELMO integrada a fluxômetros de oxigênio e ar comprimido (30 L/min cada) e a uma válvula de PEEP (níveis de CPAP = 8-10 cmH2O), formando o sistema ELMOcpap. Os pacientes foram monitorados quanto a parâmetros cardiorrespiratórios, eventos adversos e conforto. Resultados: Dez pacientes completaram o protocolo do estudo. O sistema ELMOcpap foi bem tolerado, sem efeitos adversos relevantes. Seu uso foi viável fora da UTI por tempo prolongado e mostrou-se bem-sucedido em 60% dos pacientes. Uma CPAP de 10 cmH2O com fluxo total de gás de 56-60 L/min melhorou a oxigenação após sessões de ELMOcpap de 30-60 min, permitindo redução significativa da FIO2 estimada (p = 0,014) e aumento da PaO2/FIO2 estimada (p = 0,008) na primeira hora, sem reinalação de CO2. Conclusões: O uso do ELMOcpap mostrou-se viável e eficaz no fornecimento de CPAP de alto fluxo a pacientes com IRpA hipoxêmica por COVID-19 fora da UTI. Não houve nenhum efeito adverso importante, e o ELMO foi considerado confortável. As sessões de ELMOcpap melhoraram significativamente a oxigenação, reduzindo a FIO2 sem reinalação de CO2. A taxa global de sucesso foi de 60% neste estudo piloto, e novos ensaios clínicos devem ser realizados. (ClinicalTrials.gov identifier: NCT04470258 [http://www.clinicaltrials.gov/])


Subject(s)
Humans , Respiratory Insufficiency/therapy , COVID-19 , Pilot Projects , Feasibility Studies , Proof of Concept Study , SARS-CoV-2 , Intensive Care Units
17.
Article in Chinese | WPRIM | ID: wpr-928626

ABSTRACT

OBJECTIVES@#To study the significance of interleukin-6 (IL-6) and interleukin-27 (IL-27) in the differential diagnosis of acute respiratory distress syndrome (ARDS) and neonatal respiratory distress syndrome (NRDS) in preterm infants.@*METHODS@#The preterm infants with the manifestation of respiratory distress who were treated in the Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University, from March to November 2021, were enrolled in this prospective study. According to the diagnosis results, they were divided into two groups: ARDS group (n=18) and NRDS group (n=20). ELISA was used to measure the plasma levels of IL-6 and IL-27. The receiver operating characteristic (ROC) curve was used to analyze the value of each index in the diagnosis of ARDS.@*RESULTS@#The ARDS group had significantly higher plasma levels of IL-6 and IL-27 than the NRDS group (P<0.05). The ROC curve analysis showed that IL-6 had an area under the ROC curve (AUC) of 0.867 for the diagnosis of ARDS, with a sensitivity of 61.1% and a specificity of 95.0% at the cut-off value of 56.21 pg/mL. The ROC curve analysis also showed that IL-27 had an AUC of 0.881 for the diagnosis of ARDS, with a sensitivity of 83.3% and a specificity of 80.0% at the cut-off value of 135.8 pg/mL.@*CONCLUSIONS@#Plasma IL-6 and IL-27 can be used as biological indicators for early differential diagnosis of ARDS and NRDS in preterm infants.


Subject(s)
Diagnosis, Differential , Humans , Infant, Newborn , Infant, Premature , Interleukin-27/blood , Interleukin-6/blood , Pilot Projects , Prognosis , Prospective Studies , ROC Curve , Respiratory Distress Syndrome, Newborn/diagnosis , Respiratory Distress Syndrome, Newborn/diagnosis
18.
Article in Chinese | WPRIM | ID: wpr-928139

ABSTRACT

Chinese medicine dispensing granules, the result of the efforts to transform Chinese medicinal decoction pieces in China, features portability and ease of storage. Thus, it is destined to be an indispensible dosage form in the modernization drive of Chinese medicine. The Announcement on Ending the Pilot Project of Chinese Medicine Dispensing Granules was released in February 2021 and relevant regulations went into force in November 2021, which marks the a new journey for the development of Chinese medicine dispensing granules and the beginning of the "post-pilot era". However, it faces the challenges in quality and standard. This study reviewed the history of Chinese medicine dispensing granules, analyzed the technical progress, market, and main problems in development, and proposed suggestions and prospects for its development in the "post-pilot era", which is expected to serve as a reference for its industry development and rational use.


Subject(s)
China , Drugs, Chinese Herbal/therapeutic use , Industrial Development , Medicine, Chinese Traditional , Pilot Projects
19.
Singapore medical journal ; : 203-208, 2022.
Article in English | WPRIM | ID: wpr-927278

ABSTRACT

INTRODUCTION@#This study aimed to evaluate the potential of non-contrast-enhanced magnetic resonance (MR) imaging as an imaging surveillance tool for detection of hepatocellular carcinoma (HCC) in at-risk patients and to compare the performance of non-contrast MR imaging with ultrasonography (US) as a screening modality for the same.@*METHODS@#In this retrospective study, patients diagnosed with HCC between 1 January 2010 and 31 December 2015 were selected from our institution's cancer registry. Patients who underwent MR imaging and had US performed within three months of the MR imaging were included. For each MR imaging, two non-contrast MR imaging sequences - T2-weighted fat-saturated (T2-W FS) sequence and diffusion-weighted imaging (DWI) - were reviewed for the presence of suspicious lesions. A non-contrast MR image was considered positive if the lesion was seen on both sequences. The performance of non-contrast MR imaging was compared to that of hepatobiliary US for the detection of HCC.@*RESULTS@#A total of 73 patients with 108 HCCs were evaluated. Sensitivity of non-contrast MR imaging for the detection of HCC using T2-W FS and DWI was 93.2%, which was significantly higher than that of US, which was 79.5% (p = 0.02). In a subgroup of 55 patients with imaging features of liver cirrhosis, the sensitivity of non-contrast MR imaging was 90.9%, which was also significantly higher than that of US, which was 74.5% (p = 0.02).@*CONCLUSION@#Our pilot study showed that non-contrast MR imaging, using a combination of T2-W FS and DWI, is a potential alternative to US as a screening tool for surveillance of patients at risk for HCC.


Subject(s)
Carcinoma, Hepatocellular/pathology , Contrast Media , Diffusion Magnetic Resonance Imaging/methods , Gadolinium DTPA , Humans , Liver Neoplasms/pathology , Magnetic Resonance Imaging/methods , Pilot Projects , Retrospective Studies , Sensitivity and Specificity
20.
Article in English | WPRIM | ID: wpr-927269

ABSTRACT

INTRODUCTION@#Linkage to care among individuals with substance misuse remains a barrier to the elimination of the hepatitis C virus (HCV). We aimed to determine whether point-of-care (PoC) education, screening and staging for liver disease with direct access to hospitals would improve linkage to care among this group. @*METHODS@#All participants were offered PoC education and HCV screening. HCV-positive participants were randomised to standard care (controls) or direct access, which provided a direct pathway to hospitals. Linkage to care was determined by reviewing electronic medical records. Linkage of care cascade was defined as attendance at the specialist clinic, confirmation of viraemia by HCV RNA testing, discussion about HCV treatment and initiation of treatment. @*RESULTS@#351 halfway house residents were screened. The overall HCV prevalence was 30.5% (n = 107), with 69 residents in the control group and 38 in the direct access group. The direct access group had a significantly higher percentage of cases linked to specialist review for confirmatory RNA testing (63.2% vs. 40.6%, p = 0.025), HCV treatment discussion (p = 0.009) and treatment initiation (p = 0.01) compared to the controls. Overall, only 12.6% (n = 13) had treatment initiation during follow-up. PoC HCV screening with direct access referral had significantly higher linkage to HCV treatment initiation (adjusted odds ratio 9.13, p = 0.005) in multivariate analysis. @*CONCLUSION@#PoC HCV screening with direct access improves linkage to care and simplifies the HCV care cascade, leading to improved treatment uptake. PoC education, screening, diagnosis and treatment may be an effective strategy to achieving HCV micro-elimination in this population.


Subject(s)
Antiviral Agents/therapeutic use , Halfway Houses , Hepacivirus/genetics , Hepatitis C/epidemiology , Humans , Pilot Projects , Point-of-Care Systems , RNA , Referral and Consultation , Substance Abuse, Intravenous/epidemiology
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