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1.
Article in English | WPRIM | ID: wpr-921329

ABSTRACT

Objective@#This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease (CKD) in Shanghai community residents.@*Methods@#We used data from a cohort study of community residents who participated in three examinations in 2008, 2009, and 2013, respectively. Fasting plasma glucose (FPG) level, blood pressure (BP), and lipid levels were determined in 2,109 participants at all three visits, and CKD was evaluated between the second and the third visits. Visit-to-visit variabilities in metabolic factors were described by coefficients of variation (CV) at three visits. A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of CV. CKD was defined as the estimated glomerular filtration rate < 60 mL/min per 1.73 m @*Results@#A total of 200 (9.5%) participants had CKD at the third visit. Compared with the lowest quartile of CV, the highest quartile was associated with a 70% increased risk of CKD for FPG [odds ratio, @*Conclusion@#The visit-to-visit variabilities in metabolic factors were significantly associated with the risks of CKD in Shanghai community residents.


Subject(s)
Aged , Aged, 80 and over , China/epidemiology , Cohort Studies , Female , Glomerular Filtration Rate , Humans , Incidence , Male , Middle Aged , Renal Insufficiency, Chronic/physiopathology
2.
Gac. méd. Méx ; 156(5): 432-437, sep.-oct. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1249942

ABSTRACT

Resumen Introducción: La presión de pulso ampliada (PPA) se asocia a un filtrado glomerular calculado ≤ 60/mL/minuto/1.73 m2, por lo que puede ser útil como prueba diagnóstica para identificar a personas con insuficiencia renal crónica (IRC) estadio K/DOQI III-b. Objetivo: Determinar la utilidad de la PPA como prueba diagnóstica de IRC estadio K/DOQI III-b. Método: Estudio de prueba diagnóstica que incluyó a pacientes adultos sin comorbilidades, registrados en la Cohorte de Trabajadores de la Salud. Se utilizó la fórmula CKD-EPI para calcular la filtración glomerular. Se determinó la presión de pulso restando la presión arterial diastólica a la presión arterial sistólica. Se calculó sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo y prevalencia. Se elaboró una curva ROC para determinar el área bajo la curva. Resultados: Se incluyeron 6215 pacientes. Se observó que una PPA ≥ 50 mm Hg tuvo sensibilidad de 74 %, especificidad de 70 %, valor predictivo positivo de 1 %, valor predictivo negativo de 100 % y prevalencia de 1 %. El punto de inflexión en la curva ROC para identificar IRC K/DOQI III-b fue de 0.71. Conclusión: La PPA ≥ 50 mm Hg es útil como prueba diagnóstica para identificar a personas con IRC estadio K/DOQI III-b.


Abstract Introduction: Increased pulse pressure (IPP) is associated an estimated glomerular filtration ≤ 60/mL/min/1.73 m2; thus, it can be useful as a diagnostic test to identify people with K/DOQI stage III-b chronic kidney disease (CKD). Objective: To determine the usefulness of IPP as a diagnostic test for K/DOQI stage III-b CKD. Method: Diagnostic test study that included adult patients without comorbidities, registered in the Health Workers Cohort. The CKD-EPI formula was used to calculate glomerular filtration. Pulse pressure was determined by subtracting diastolic from systolic blood pressure. Sensitivity, specificity, positive predictive value, negative predictive value and prevalence were calculated using standard formulas. A ROC curve was generated to determine the area under the curve. Results: A total of 6,215 patients were included. An IPP ≥ 50 mmHg was observed to have a sensitivity of 74 %, specificity of 70 %, positive predictive value of 1 %, negative predictive value of 100 % and a prevalence of 1 %. The inflection point in the ROC curve to identify K/DOQI III-b CKD was 0.71. Conclusion: An IPP ≥ 50 mmHg is useful as a diagnostic test to identify people with K/DOQI stage III-b CKD.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Young Adult , Blood Pressure/physiology , Renal Insufficiency, Chronic/diagnosis , Blood Pressure Determination/methods , Predictive Value of Tests , ROC Curve , Sensitivity and Specificity , Area Under Curve , Renal Insufficiency, Chronic/physiopathology , Glomerular Filtration Rate/physiology
3.
Rev. chil. pediatr ; 91(3): 324-329, jun. 2020. graf
Article in Spanish | LILACS | ID: biblio-1126168

ABSTRACT

Resumen: El recién nacido prematuro se enfrenta a las condiciones extrauterinas con sistemas aún inmaduros, tanto anatómica como fisiológicamente. El riñón termina de desarrollarse a finales del tercer trimes tre del embarazo, por lo que está especialmente expuesto a alterar su desarrollo normal en caso de nacer en forma prematura. Esta situación puede condicionar, entre otras consecuencias, una menor masa renal funcional y cambios microvasculares que representan un riesgo elevado de hipertensión arterial y daño renal crónico en el largo plazo. En el presente artículo se analiza la evidencia existente actual sobre estos riesgos en los prematuros y se ofrece un esquema de seguimiento de estos niños desde el punto de vista nefrológico.


Abstract: The premature newborn faces extrauterine conditions with some systems still immature, both ana tomically and physiologically. The kidney finishes developing at the end of the third trimester of pregnancy, so it is especially exposed to alter its normal development if preterm birth occurs. This si tuation may condition, among other consequences, a lower functional renal mass and microvascular changes comprising a high risk of chronic kidney disease in the long term and arterial hypertension. This article analyzes the current evidence on these risks in premature infants and offers a nephrology follow-up scheme of these children.


Subject(s)
Humans , Infant, Newborn , Renal Insufficiency, Chronic/diagnosis , Renal Insufficiency, Chronic/etiology , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/therapy , Hypertension/diagnosis , Hypertension/etiology , Hypertension/physiopathology , Hypertension/therapy , Infant, Premature, Diseases/diagnosis , Infant, Premature, Diseases/etiology , Infant, Premature, Diseases/physiopathology , Infant, Premature, Diseases/therapy , Risk , Aftercare/methods , Kidney/growth & development , Kidney/embryology , Kidney/physiopathology , Nephrology/methods
4.
Braz. j. infect. dis ; 24(1): 25-29, Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1089328

ABSTRACT

ABSTRACT Background: To analyze the effectiveness and the safety of Sofosbuvir-based regimens to treat patients with chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD). Methods: A retrospective, observational study in patients with chronic HCV infection and CKD treated with Sofosbuvir-based regimens was performed. Liver fibrosis, comorbidities, HCV genotype and sustained virological resposnse (SVR) at 12th week post-treatment were evaluated. Kidney function was accessed by serum creatinine and glomerular filtration rate (GFR). The assumed level of significance was 5 %. Results: Thirty-five patients were treated. The mean age was 52.1 ± 10.9 years, 19 (54.3 %) were women, 32 (91.4 %) were already kidney transplanted and 3 (8.6 %) were on hemodialysis. The SVR by intention to treat was 88.6 %. The mean GFR was 65.8 ± 28.6 and 63.7 ± 28.3 ml/min pre- and post-treatment respectively (p > 0.05). Treatment was interrupted in 1 (2.85 %) patient due to anemia and in 2 (5.7 %) due to loss of kidney function. Conclusion: Sofosbuvir-based regimens are effective to treat HCV in patients with CKD. In patients with mild CKD this type of therapy seems to be safe.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Antiviral Agents/therapeutic use , Hepatitis C, Chronic/drug therapy , Renal Insufficiency, Chronic/physiopathology , Sofosbuvir/therapeutic use , Severity of Illness Index , Reproducibility of Results , Retrospective Studies , Analysis of Variance , Kidney Transplantation , Treatment Outcome , Statistics, Nonparametric , Creatinine/blood , Renal Insufficiency, Chronic/therapy , Sustained Virologic Response , Glomerular Filtration Rate , Imidazoles/therapeutic use , Immunosuppressive Agents/therapeutic use
5.
Salud bienestar colect ; 4(1): 59-68, ene.-abr. 2020. tab
Article in Spanish | LILACS | ID: biblio-1179925

ABSTRACT

INTRODUCCIÓN: la Insuficiencia Renal Crónica (IRC) es un síndrome progresivo e irreversible de las funciones renales que genera consecuencias físicas y daños psicológicos para el individuo. OBJETIVOS: evaluar los diferentes estados mentales y emocionales que podría padecer la persona con IRC. Conocer los diferentes trastornos involucrados con la insuficiencia renal. METODOLOGÍA: la investigación es de diseño transversal con análisis descriptivo no experimental. Lo que se utilizó para realizar la investigación fueron, fuentes de páginas científicas, al igual que documentos de revistas científicas confiables. RESULTADOS: las personas que padecen de esta enfermedad, tienden a poseer diversas alteraciones emocionales y mentales, dado por diferentes factores. Por lo que la depresión forma parte fundamental del contexto clínico emocional de la persona pareciente de esta patología. Dentro de todos los estudios realizados por autores distintos, se llegó a un análisis de que los hombres presentan una depresión leve mientras que las mujeres por otra parte presentan una depresión moderada. CONCLUSIÓN: este estudio indicó asociaciones entre las variables: depresión, ansiedad y etapas de la IRC. Las diferencias observadas son significativas para aquellos que están en las etapas inicial y final de la ERC, con más probabilidad de desarrollar trastornos del estado de ánimo y de ansiedad.


INTRODUCTION: Chronic Renal Failure (CRI) is a progressive and irreversible syndrome of renal functions that generates physical consequences and psychological damage to the individual. OBJECTIVES: to evaluate the different mental and emotional states that the person with CRF might suffer. Know the different disorders involved with kidney failure. METHODOLOGY: the research is cross-sectional with non-experimental descriptive analysis. What was used to conduct the research were, sources of scientific pages, as well as documents from reliable scientific journals. RESULTS: people who suffer from this disease tend to have various emotional and mental disorders, given by different factors. Therefore, depression is a fundamental part of the emotional clinical context of the similar person of this pathology. Among all the studies carried out by different authors, an analysis was reached that men have a mild depression while women on the other hand have a moderate depression. CONCLUSION: this study indicated associations between the variables: depression, anxiety and stages of CRF. The differences observed are significant for those who are in the initial and final stages of CKD, most likely to develop mood andanxiety disorders.


Subject(s)
Humans , Depressive Disorder/psychology , Renal Insufficiency, Chronic/physiopathology , Adaptation, Psychological , Renal Insufficiency, Chronic/psychology , Renal Insufficiency, Chronic/therapy , Cognitive Dysfunction , Conservative Treatment , Mental Disorders
6.
Rev. Assoc. Med. Bras. (1992) ; 66(supl.1): s03-s09, 2020. tab
Article in English | LILACS | ID: biblio-1057109

ABSTRACT

SUMMARY Chronic kidney disease is highly prevalent (10-13% of the population), irreversible, progressive, and associated with higher cardiovascular risk. Patients with this pathology remain asymptomatic most of the time, presenting the complications typical of renal dysfunction only in more advanced stages. Its treatment can be conservative (patients without indication for dialysis, usually those with glomerular filtration rate above 15 ml/minute) or replacement therapy (hemodialysis, peritoneal dialysis, and kidney transplantation). The objectives of the conservative treatment for chronic kidney disease are to slow down the progression of kidney dysfunction, treat complications (anemia, bone diseases, cardiovascular diseases), vaccination for hepatitis B, and preparation for kidney replacement therapy.


Subject(s)
Humans , Renal Insufficiency, Chronic , Prevalence , Risk Factors , Renal Dialysis , Renal Insufficiency/etiology , Renal Insufficiency/therapy , Renal Insufficiency, Chronic/classification , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/epidemiology , Kidney Failure, Chronic/physiopathology , Kidney Failure, Chronic/therapy , Kidney Failure, Chronic/epidemiology
7.
Säo Paulo med. j ; 137(6): 523-529, Nov.-Dec. 2019. tab
Article in English | LILACS | ID: biblio-1094520

ABSTRACT

ABSTRACT BACKGROUND: Findings regarding the effects of hyperuricemia on renal function and mortality have been inconsistent. OBJECTIVES: To investigate the effects of hyperuricemia on incident renal replacement therapy and all-cause mortality among patients with chronic kidney disease (CKD). DESIGN AND SETTING: Retrospective cohort study conducted in a medical center in Taiwan. METHODS: Patients with CKD in stages 3-5, without histories of renal replacement therapy, were consecutively recruited from 2007 to 2013. Their medical history, laboratory and medication data were collected from hospital records. The mean uric acid level in the first year of follow-up was used for analyses. Hyperuricemia was defined as mean uric acid level ≥ 7.0 mg/dl in men or ≥ 6.0 mg/dl in women. The primary outcomes were incident renal replacement therapy and all-cause mortality, and these data were retrospectively collected from hospital records until the end of 2015. RESULTS: A total of 4,381 patients were analyzed (mean age 71.0 ± 14.8 years; males 62.7%), and the median follow-up period was 2.5 years. Patients with hyperuricemia were at increased risk of incident renal replacement therapy and all-cause mortality, especially those with CKD in stages 4 or 5. Compared with patients with CKD in stage 3 and normouricemia, patients with CKD in stages 4 or 5 presented significantly higher risk of all-cause mortality only if they had hyperuricemia. CONCLUSIONS: In patients with CKD in stages 3-5, hyperuricemia was associated with higher risk of incident renal replacement therapy and all-cause mortality. Whether treatment with uric acid-lowering drugs in these patients would improve their outcomes merits further investigation.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Renal Replacement Therapy , Hyperuricemia/blood , Renal Insufficiency, Chronic/blood , Uric Acid/analysis , Severity of Illness Index , Proportional Hazards Models , Retrospective Studies , Risk Factors , Follow-Up Studies , Hyperuricemia/complications , Hyperuricemia/physiopathology , Hyperuricemia/mortality , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/mortality , Glomerular Filtration Rate
8.
Int. braz. j. urol ; 45(6): 1227-1237, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1056325

ABSTRACT

ABSTRACT Introduction: Children with a solitary post-nephrectomy kidney (SNK) are at potential risk of developing kidney disease later in life. In response to the global decline in the number of nephrons, adaptive mechanisms lead to renal injury. The aim of this study was to determine the prevalence and time of onset of high blood pressure (HBP), proteinuria, glomerular filtration rate (GFR) disruption and renal tubular acidosis (RTA) in children with SNK. Materials and methods: After obtaining the approval from our institution's ethics committee, we reviewed the medical records of patients under 18 years of age who underwent unilateral nephrectomy between January 2005 and December 2015 in three university hospitals. Results: We identified 43 patients, 35 (81.4%) cases of unilateral nephrectomy (UNP) were due to a non-oncologic pathology and Wilm's tumor was identified in 8 (18.6%) cases. In patients with non-oncologic disease, 9.3% developed de novo hypertension, with an average time of onset of 7.1 years, 25% developed proteinuria de novo, with an average time of onset of 2.2 years. For GFR, 21.8% presented deterioration of the GFR in an average time of 3.4 years. Ten (43.5%) patients developed some type of de novo renal injury after UNP. Patients with oncologic disease developed the conditions slowly and none of them developed proteinuria. Conclusions: Taking into account the high rate of long term postoperative renal injury, it can be considered that nephrectomy does not prevent this disease. The follow-up of children with SNK requires a multidisciplinary approach and long-term surveillance to detect renal injury.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Solitary Kidney/physiopathology , Solitary Kidney/epidemiology , Nephrectomy/adverse effects , Postoperative Period , Prognosis , Proteinuria/physiopathology , Proteinuria/epidemiology , Acidosis, Renal Tubular/physiopathology , Acidosis, Renal Tubular/epidemiology , Prevalence , Retrospective Studies , Risk Factors , Follow-Up Studies , Colombia/epidemiology , Age of Onset , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/epidemiology , Glomerular Filtration Rate/physiology , Hypertension/physiopathology , Hypertension/epidemiology
9.
Rev. méd. Chile ; 147(11): 1443-1448, nov. 2019.
Article in Spanish | LILACS | ID: biblio-1094174

ABSTRACT

Chronic kidney disease is associated with an increase in cardiovascular risk and mortality, and a decrease in the health-related quality of life. It is known that the physical capacity of patients with chronic kidney disease is lower than their healthy counterparts. It also decreases progressively after the start of hemodialysis, even leading to the loss of functional independence. There is a positive association between exercise and improvement of many targets in chronic kidney disease, especially in dialysis patients, such as cellular apoptosis, immune improvement and inflammation. In addition, several clinical studies and systematic reviews show an improvement in different clinical and laboratory variables and suggest a lower mortality, proving a reduction of health care economic costs. Exercise intervention in dialysis is safe. Although different guidelines promote exercise, it is necessary to work on its implementation on a large scale.


Subject(s)
Humans , Exercise/physiology , Renal Insufficiency, Chronic/therapy , Exercise Therapy , Quality of Life , Renal Dialysis , Evidence-Based Medicine , Renal Insufficiency, Chronic/physiopathology
10.
Int. braz. j. urol ; 45(5): 981-988, Sept.-Dec. 2019. tab
Article in English | LILACS | ID: biblio-1040089

ABSTRACT

ABSTRACT Objectives To compare and assess various outcomes and success of buccal mucosal graft urethroplasty (BMGU) in patients with CKD versus patients having normal renal function. Material and Methods This was a retrospective, single centre study, during period 2013 to 2017. Patients were grouped into two groups. Group 1 had patients with estimated Glomerular Filtration Rate (eGFR)>60mL/min/1.73m2 while group 2 had patients with eGFR <60mL/min/1.73m2. eGFR was calculated according to the MDRD equation. The two groups were compared with regard to various outcomes like length, location of stricture, technique of graft placement, intra-operative blood loss (haemoglobin drop), duration of hospital stay, post-operative complications and recurrence. Results A total of 223 patients were included in study with group 1 had 130 patients and group 2 had 93 patients. Mean age of patients with CKD were higher (47.49 years versus 29.13 years). The mean follow-up period was comparable between both groups (23.29 months and 22.54 months respectively). Patients with CKD had more post-operative Clavien Grade 2 or higher complications (p=0.01) and a greater recurrence rates (p<0.001) than in non-CKD patients. On multivariate analysis, age and CKD status was significant predictor of urethroplasty success (p=0.004) (OR= 14.98 (1.952-114.94, 95% CI). Conclusions CKD patients are more prone to post-operative complications in terms of wound infection, graft uptake and graft failure and higher recurrence rates following BMGU.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Urologic Surgical Procedures/methods , Urethra/surgery , Urethral Stricture/surgery , Renal Insufficiency, Chronic/physiopathology , Mouth Mucosa/transplantation , Postoperative Complications/etiology , Recurrence , Urologic Surgical Procedures/adverse effects , Multivariate Analysis , Retrospective Studies , Risk Factors , Treatment Outcome , Renal Insufficiency, Chronic/complications , Glomerular Filtration Rate , Middle Aged
11.
Int. braz. j. urol ; 45(4): 765-774, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1019890

ABSTRACT

ABSTRACT Objectives To primarily evaluate the functional outcomes of PCNL for bilateral renal calculi/calculi in solitary functioning kidney with Chronic Kidney Disease(CKD). To identify factors affecting the renal replacement therapy following PCNL. Materials and Methods Patients with bilateral renal calculi/calculi in solitary kidney and CKD (eGFR<60/s.creatinine>2) and Good Performance Status [Eastern Cooperative Oncology Group (ECOG): 0-2] were included in the study. Results A total of 60 patients with CKD who had bilateral renal calculi/calculi in solitary functioning kidney underwent PCNL. At 6 months, eGFR improved or stabilized in 45 (75%) patients, while in 15 (25%) patients eGFR deteriorated. A total of 5 (14.28%) and 2 (25%) patients of CKD stage 4 and 5 respectively had improvement in eGFR as well as CKD stage. Fourteen (82.35%), 21 (60%), 3 (37.5%) patients of CKD stage 3, 4, 5 had improvement in eGFR but not significant enough to cause stage migration. Again 3 (17.65%) , 9 ( 40%) and 3 (37.5%) patients of CKD stage 3, 4, 5 had reduction in eGFR but not significant enough to cause stage migration. None of the patients had worsening of CKD stage. Preoperative CKD stage and eGFR were compared with measurements made at the final follow up visit (6 months). Conclusion Our results indicate that most patients of renal calculi with CKD show improvement or stabilization of renal function with aggressive stone removal. Improvement is more in patients who have mild to moderate CKD. Aggressive management of comorbidities, peri-operative UTI and complications may delay or avoid progression of CKD status in such patients.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Aged , Young Adult , Kidney Calculi/surgery , Renal Insufficiency, Chronic/surgery , Nephrolithotomy, Percutaneous/methods , Postoperative Complications/etiology , Time Factors , Severity of Illness Index , Kidney Calculi/physiopathology , Feasibility Studies , Prospective Studies , Reproducibility of Results , Risk Factors , Follow-Up Studies , Urinalysis , Treatment Outcome , Creatinine/blood , Renal Insufficiency, Chronic/physiopathology , ErbB Receptors/blood , Nephrolithotomy, Percutaneous/adverse effects , Glomerular Filtration Rate , Middle Aged
12.
Rev. Assoc. Med. Bras. (1992) ; 65(5): 657-662, May 2019. tab, graf
Article in English | LILACS | ID: biblio-1012955

ABSTRACT

SUMMARY BACKGROUND: To date, the therapeutic effects of exercise have not yet been evaluated regarding renal function parameters and quality of life specifically in patients with advanced chronic kidney disease. Thus, the study aim was to evaluate the effects of aerobic exercise in renal function and quality of life in patients with advanced chronic kidney disease. METHODS: A quasi-experimental prospective study [NCT03301987] was carried out. Nine patients with advanced chronic kidney disease were recruited from a hospital nephrology unit. Kidney function parameters such as creatinine, creatinine clearance, urea clearance, glomerular filtration rate, and creatinine/weight proportion, as well as the Kidney Disease Quality of Life SF-36 (KDQoL-SF36) were measured at baseline and after 1 month of aerobic exercise. RESULTS: Significant increases (P <.05) were observed for creatinine/weight proportion as well as symptoms, effects, charge, and physical domains of the KDQoL-SF36 after 1 month of therapeutic exercise. The other parameters did not show any statistically significant difference (P >.05). CONCLUSIONS: Aerobic exercise may cause improvements in renal function and quality of life of patients with advanced chronic kidney disease. Further studies about therapeutic exercise protocols specifically in patients with advanced stages of chronic kidney disease should be carried out in order to study their effectiveness and safety.


RESUMO OBJETIVO: Até o momento, os efeitos do exercício terapêutico ainda não tinham sido avaliados quanto aos parâmetros de função renal e qualidade de vida em pacientes com doença renal crônica avançada, especificamente. Assim, o objetivo do estudo foi avaliar os efeitos do exercício aeróbico na função renal e na qualidade de vida em pacientes com doença renal crônica avançada. MÉTODOS: Um estudo prospectivo quase experimental [NCT03301987] foi realizado. Nove pacientes com doença renal crônica avançada foram recrutados de uma unidade de nefrologia hospitalar. Parâmetros de função renal como creatinina, depuração de creatinina, liberação de ureia, taxa de filtração glomerular e creatinina/peso, bem como a qualidade de vida da doença renal SF-36 (KDQoL-SF36) foram medidos no início e após um mês de atividade aeróbica. RESULTADOS: Aumentos significativos (P<0,05) foram mostrados para a proporção de creatinina/peso, bem como sintomas, efeitos, carga e domínios físicos do KDQoL-SF36 após um mês de exercício terapêutico. Os demais parâmetros não apresentaram diferença estatisticamente significante (P>0,05). CONCLUSÕES: O exercício aeróbico pode produzir melhorias na função renal e na qualidade de vida de pacientes com doença renal crônica avançada. Especificamente, novos estudos sobre protocolos de exercícios terapêuticos em pacientes com estágios avançados de doença renal crônica devem ser realizados a fim de estudar sua eficácia e segurança.


Subject(s)
Humans , Male , Female , Aged , Quality of Life , Exercise/psychology , Renal Insufficiency, Chronic/therapy , Exercise Therapy/methods , Time Factors , Prospective Studies , Reproducibility of Results , Treatment Outcome , Statistics, Nonparametric , Creatinine/blood , Renal Insufficiency, Chronic/physiopathology , Glomerular Filtration Rate , Middle Aged
13.
J. bras. nefrol ; 41(1): 124-130, Jan.-Mar. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040238

ABSTRACT

Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-related nephrotoxicity. The main mechanism of NSAID action is cyclooxygenase (COX) enzyme inhibition, interfering on arachidonic acid conversion into E2 prostaglandins E2, prostacyclins and thromboxanes. Within the kidneys, prostaglandins act as vasodilators, increasing renal perfusion. This vasodilatation is a counter regulation of mechanisms, such as the renin-angiotensin-aldosterone system works and that of the sympathetic nervous system, culminating with compensation to ensure adequate flow to the organ. NSAIDs inhibit this mechanism and can lead to acute kidney injury (AKI). High doses of NSAIDs have been implicated as causes of AKI, especially in the elderly. The main form of AKI by NSAIDs is hemodynamically mediated. The second form of NSAID-induced AKI is acute interstitial nephritis, which may manifest as nephrotic proteinuria. Long-term NSAID use can lead to chronic kidney disease (CKD). In patients without renal diseases, young and without comorbidities, NSAIDs are not greatly harmful. However, because of its dose-dependent effect, caution should be exercised in chronic use, since it increases the risk of developing nephrotoxicity.


Resumo Os anti-inflamatórios não esteroidais (AINEs) são medicamentos comumente utilizados, associados à nefrotoxicidade, sobretudo quando utilizados cronicamente. Fatores como idade avançada e comorbidades, que por si só já levam à diminuição da taxa de filtração glomerular, aumentam o risco de nefrotoxicidade dos AINEs. O principal mecanismo de ação dos AINEs é a inibição da enzima ciclooxigenase (COX), interferindo na conversão do ácido araquidônico em prostaglandinas E2, prostaciclinas e tromboxanos. Nos rins, as prostaglandinas atuam como vasodilatadoras, aumentando a perfusão renal. Essa vasodilatação atua como uma contrarregulação de mecanismos, como a atuação do sistema renina-angiotensina-aldosterona e do sistema nervoso simpático, culminando com uma compensação para assegurar o fluxo adequado ao órgão. O uso de AINEs inibe esse mecanismo, podendo causar lesão renal aguda (LRA). Altas doses de AINEs têm sido implicadas como causas de LRA, especialmente em idosos. A principal forma de LRA por AINEs é a hemodinamicamente mediada. A segunda forma de apresentação da LRA induzida por AINES é a nefrite intersticial aguda, que pode se manifestar com proteinúria nefrótica. O uso de AINEs em longo prazo pode ocasionar doença renal crônica (DRC). Nos pacientes sem doenças renais, jovens e sem comorbidades, os AINEs não apresentam grandes malefícios. Entretanto, por seu efeito dose-dependente, deve-se ter grande cautela no uso crônico, por aumentar risco de desenvolver nefrotoxicidade.


Subject(s)
Humans , Infant, Newborn , Aged , Aged, 80 and over , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Cyclooxygenase Inhibitors/adverse effects , Renal Insufficiency, Chronic/chemically induced , Acute Kidney Injury/chemically induced , Nephritis, Interstitial/chemically induced , Prostaglandins E/metabolism , Proteinuria/chemically induced , Anti-Inflammatory Agents, Non-Steroidal/metabolism , Risk Factors , Cyclooxygenase Inhibitors/metabolism , Renal Insufficiency, Chronic/physiopathology , Acute Kidney Injury/physiopathology , Nephritis, Interstitial/physiopathology
14.
Rev. bras. epidemiol ; 22(supl.2): E190010.SUPL.2, 2019. tab
Article in Portuguese | LILACS | ID: biblio-1042228

ABSTRACT

RESUMO: Objetivo: O presente estudo avaliou a função renal da população adulta brasileira, segundo critérios laboratoriais da Pesquisa Nacional de Saúde (PNS). Metodologia: Estudo descritivo realizado com os dados laboratoriais da PNS, coletados entre os anos de 2014 e 2015. Com base nos dados laboratoriais foram analisadas prevalências populacionais de creatinina sérica (CR) e estimativa da taxa de filtração glomerular (TFG), segundo variáveis sociodemográficas. Resultados: A amostra foi de 8.535 indivíduos com idade de 18 anos ou mais para o estudo da CR e de 7.457 indivíduos para o estudo de TFG. A prevalência TFG < 60 mL/min/1,73 m2 foi de 6,7% (IC95% 6,0 - 7,4), foi mais elevada em mulheres (8,2% IC95% 7,2 - 9,2) do que em homens (5,0% IC95% 4,2 - 6,0) p < 0,001 e em idosos ≥ 60 anos foi de 21,4%. Os valores de CR ≥ 1,3 mg/dL em homens foram 5,5% (IC95% 4,6 - 6,5) e em mulheres foram de CR ≥ 1,1 mg/dL, de 4,6% (IC95% 4,0- 5,4), sem diferença estatística significativa nos valores de CR entre sexo, p = 0,140. Conclusão: Resultados laboratoriais da PNS identificaram prevalências mais elevadas da doença renal crônica na população brasileira do que o estimado em estudos autorreferidos. ATFG < 60 mL/min/1,73 m2 é mais elevada em mulheres e atinge um quinto dos idosos. Esses exames podem ser úteis no propósito de identificar precocemente a doença e, dessa forma, prevenir a progressão da lesão renal e reduzir o risco de eventos cardiovasculares e de mortalidade.


ABSTRACT: Objective: To evaluate the renal function of the Brazilian adult population, according to laboratory criteria of the National Health Survey (Pesquisa Nacional de Saúde - PNS). Methodology: A descriptive study was carried out with laboratory data from the PNS, which was collected between the years 2014 and 2015. Population prevalence of the serum creatinine (CR) and estimated glomerular filtration rate (GFR) according to sociodemographic variables, were analyzed from the PNS laboratory data. Results: The sample consisted of 8,535 individuals aged 18 years old or older for the study of CR and 7,457 for the study of GFR. The GFR prevalence < 60 mL/min/1.73 m2 was 6.7% (95%CI 6.0 - 7.4), higher in women (8.2% 95%CI 7.2 - 9.2) than in men (5.0% 95%CI 4.2 - 6.0) p < 0.001, and in elderly > 60 years old it was 21.4%. For the values of CR ≥ 1.3 mg/dL in men were 5.5% (95%CI 4.6 - 6.5), and in women values of CR ≥ 1.1 mg/dL were 4.6% (95%CI 4.0 - 5.4), with no diference between the genders, p = 0.140. Conclusion: Results from the PNS laboratory identified a higher prevalence of chronic kidney disease in the Brazilian population than that estimated in self-reported studies, with higher GFR < 60 mL/min/1.73 m2 in women, and reaching one fifth of the elderly. These tests may be useful for the purpose of identifying the disease early on and thus preventing the progression of renal damage and reduce the risk of cardiovascular events and mortality.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Health Surveys/methods , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/epidemiology , Socioeconomic Factors , Brazil/epidemiology , Prevalence , Cross-Sectional Studies , Health Surveys/statistics & numerical data , Sex Distribution , Age Distribution , Creatinine/blood , Glomerular Filtration Rate , Middle Aged
15.
Acta bioquím. clín. latinoam ; 52(4): 489-500, dic. 2018. graf, tab
Article in Spanish | LILACS | ID: biblio-1001071

ABSTRACT

Antecedentes: La tasa de filtración glomerular estimada (TFGe) es ampliamente utilizada en la práctica clínica. El presente estudio evaluó la variación biológica intraindividual (CVI) de diferentes ecuaciones de TFGe en sujetos con enfermedad renal crónica (ERC) y sin ERC. Los objetivos de este estudio fueron (a) determinar los perfiles de variación biológica durante 24 horas de creatinina, cistatina C y TFGe y (b) determinar si el CVI de la creatinina, la cistatina C y la TFGe cambia el deterioro de la filtración glomerular. Métodos: Se analizaron muestras de sangre cada hora de 37 individuos (17 sin ERC, 20 con ERC) durante 24 h. La creatinina (método enzimático) y la cistatina C se midieron usando un Cobas 8000 (Roche Diagnostics). La TFGe se estimó utilizando la Modificación de la Dieta en la Enfermedad Renal y la Colaboración de Epidemiología de la Enfermedad Renal Crónica basada en creatinina y/o cistatina C. Las muestras de plasma se almacenaron a -80 °C antes del análisis. Se verificaron los análisis de valores atípicos y de homogeneidad antes de realizar un ANOVA anidado para determinar la variación biológica. Resultados: La CVI de creatinina fue más alta en sujetos sin ERC que en aquellos con ERC (6.4% frente a 2.5%) debido principalmente al efecto más marcado del consumo de carne sobre la variabilidad de creatinina en individuos con concentraciones iniciales de creatinina más bajas. A diferencia de la creatinina, las concentraciones de cistatina C no se vieron afectadas por el consumo de carne. La cistatina C mostró alguna variación rítmica diurna y menor en los sujetos con ERC. Los valores de referencia del cambio (VCR) de todas las ecuaciones de TFGe estuvieron dentro del 13% al 20% en ambos grupos de estudio. Conclusiones: A pesar de las diferencias en el CVI de la creatinina, el CVI y el VRC de las ecuaciones de TFGe fueron relativamente similares para los sujetos con o sin ERC.


Background: Estimated glomerular filtration rate (eGFR) is widely used in clinical practice. This study assessed the within-subject biological variation (CVI) of different eGFR equations in people with chronic kidney disease (CKD) and people without CKD. The aims of this study were (a) to determine the 24-h biological variation profiles of creatinine, cystatin C, and eGFR and (b) to determine whether CVI of creatinine, cystatin C, and eGFR changes on deterioration of glomerular filtration. Methods: Hourly blood samples were analyzed from 37 individuals (17 without CKD, 20 with CKD) during 24 h. Creatinine (enzymatic method) and cystatin C were measured using a Cobas 8000 (Roche Diagnostics). eGFR was estimated using the Modification of Diet in Renal Disease and the Chronic Kidney Disease Epidemiology Collaboration based on creatinine and/or cystatin C. Plasma samples were stored at -80 °C before analysis. Outlier and homogeneity analyses were checked before performing a nested ANOVA to determine biological variation. Results: CVI of creatinine was higher in people without CKD than in those with CKD (6.4% vs. 2.5%) owing primarily to the more profound effect of meat consumption on creatinine variability in individuals with lower baseline creatinine concentrations. Unlike creatinine, cystatin C concentrations were unaffected by meat consumption. Cystatin C showed some diurnal rhythmic variation and less in people with CKD. Reference change values (RCVs) of all eGFR equations were within 13% to 20% in both study groups. Conclusions: Despite differences in CVI of creatinine, the CVI and RCV of the eGFR equations were relatively similar for people with or without CKD.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Creatinine/blood , Renal Insufficiency, Chronic/physiopathology , Renal Insufficiency, Chronic/blood , Cystatin C/blood , Biological Variation, Individual , Glomerular Filtration Rate , Analysis of Variance
16.
Rev. méd. Chile ; 146(11): 1317-1324, nov. 2018.
Article in Spanish | LILACS | ID: biblio-985705

ABSTRACT

The 2017 Guidelines on hypertension of the American College of Cardiology and American Heart Association, which proposed values of 130/80 mmHg as the cutoff points for the onset of hypertension, aroused great interest. This recommendation is based in the SPRINT study (The Systolic Pressure Intervention Trial), which included hypertensive patients over 50 years of age, non-diabetic, without a history of stroke and with a low representation of subjects with a history of coronary artery disease (16%). A group with intensive anti-hypertensive therapy (pressure achieved 121.5 mmHg) achieved a significantly lower cardiovascular risk as compared with a group with standard therapy (pressure achieved 134.6 mmHg). The Guide proposes immediate pharmacological therapy in diabetic hypertensive patients, in those with stage 3 chronic kidney disease or with persistent albuminuria, and in patients with atherosclerotic disease. The Guideline does not include the management of isolated systolic hypertension of the elderly and did not consider studies that show an increased risk when pressure is reduced below 130/80 mmHg in patients with coronary disease, peripheral vascular disease, diabetes mellitus or chronic renal failure. The new classification of hypertension would increase the number of hypertensive patients in our country by more than one million, would increase the risk associated with diastolic pressure reductions in older adults and ignores the evidence indicating a risk associated with reductions below 130/80 mmHg in patients with diabetes, with chronic renal failure or with atherosclerotic disease. Therefore, it is advisable to maintain a threshold of 140/90 mmHg and perform a careful and gradual management of blood pressure in the latter group of hypertensive patients.


Subject(s)
Humans , Practice Guidelines as Topic/standards , Hypertension/physiopathology , Hypertension/therapy , Reference Values , Cardiovascular Diseases/physiopathology , Risk Factors , Coronary Disease/physiopathology , Diabetes Mellitus/physiopathology , Renal Insufficiency, Chronic/physiopathology , Hypertension/classification
17.
J. pediatr. (Rio J.) ; 94(5): 525-531, Sept.-Oct. 2018. tab, graf
Article in English | LILACS | ID: biblio-975998

ABSTRACT

Abstract Objective: To identify risk factors for chronic kidney disease progression in Brazilian children and to evaluate the interactions between factors. Methods: This was a multicenter prospective cohort in São Paulo, involving 209 children with CKD stages 3-4. The study outcome included: (a) death, (b) start of kidney replacement therapy, (c) eGFR decrease >50% during the followup. Thirteen risk factors were tested using univariate regression models, followed by multivariable Cox regression models. The terms of interaction between the variables showing significant association with the outcome were then introduced to the model. Results: After a median follow-up of 2.5 years (IQR = 1.4-3.0), the outcome occurred in 44 cases (21%): 22 started dialysis, 12 had >50% eGFR decrease, seven underwent transplantation, and three died. Advanced CKD stage at onset (HR = 2.16, CI = 1.14-4.09), nephrotic proteinuria (HR = 2.89, CI = 1.49-5.62), age (HR = 1.10, CI = 1.01-1.17), systolic blood pressure Z score (HR = 1.36, CI = 1.08-1.70), and anemia (HR = 2.60, CI = 1.41-4.77) were associated with the outcome. An interaction between anemia and nephrotic proteinuria at V1 (HR = 0.25, CI = 0.06-1.00) was detected. Conclusions: As the first CKD cohort in the southern hemisphere, this study supports the main factors reported in developed countries with regards to CKD progression, affirming the potential role of treatments to slow CKD evolution. The detected interaction suggests that anemia may be more deleterious for CKD progression in patients without proteinuria and should be further studied.


Resumo Objetivo: Identificar os fatores de risco para progressão da DRC em crianças do Brasil e avaliar as interações entre os fatores. Métodos: Coorte prospectiva multicêntrica em São Paulo, envolvendo 209 crianças com DRC em estágios 3-4. O desfecho do estudo incluiu: a) óbito, b) início da terapia de substituição renal, c) redução de > 50% na taxa estimada de filtração glomerular (eGFR) durante o acompanhamento. Foram testados 13 fatores de risco com o modelo de regressão univariada seguido do modelo de regressão multivariado de Cox. Os termos de interação entre as variáveis mostraram associação significativa e foram introduzidos ao modelo. Resultados: Após média de acompanhamento de 2,5 anos (IIQ = 1,4 a 3,0), 44 casos (21%) apresentaram desfecho: 22 iniciaram diálise, 12 apresentaram redução de > 50% na eGFR, sete foram submetidos a transplante e três morreram. Estágio avançado de DRC no acometimento (RR = 2,16, IC = 1,14-4,09), proteinúria nefrótica (RR = 2,89, IC = 1,49-5,62), idade (RR - 1,10, IC = 1,01-1,17), escore Z da pressão arterial sistólica (RR = 1,36, IC = 1,08-1,70) e anemia (RR = 2,60, IC - 1,41-4,77) foram associados ao resultado. Foi detectada interação entre anemia e proteinúria nefrótica na primeira visita (V1) (RR = 0,25, IC = 0,06-1,00). Conclusões: Como a primeira coorte de DRC no hemisfério sul, este estudo é concordante com os principais fatores relatados em países desenvolvidos com relação à progressão da DRC, afirmando o possível papel dos tratamentos para mostrar a evolução da DRC. A interação detectada sugere que a anemia pode ser mais nociva na progressão da DRC em pacientes sem proteinúria e deve ser ainda mais estudada.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Disease Progression , Renal Insufficiency, Chronic/physiopathology , Socioeconomic Factors , Prospective Studies , Risk Factors , Cohort Studies
18.
Ciênc. Saúde Colet ; 23(8): 2555-2564, Aug. 2018. tab
Article in Portuguese | LILACS | ID: biblio-952726

ABSTRACT

Resumo A doença renal crônica (DRC) é complexa, exigindo múltiplas abordagens em seu tratamento. O objetivo do presente estudo foi avaliar o impacto de um programa de intervenção nutricional sobre o estado nutricional e a qualidade de vida de idosos com DRC não dialítica. Foi realizada uma coorte prospectiva com 64 idosos, de ambos os sexos, com DRC estágio 3, atendidos em Unidade Básica de Saúde, em Diadema/SP. A intervenção nutricional consistiu em três encontros coletivos e um individual. O estado nutricional foi avaliado por antropometria, classificado pelo Índice de Massa Corporal (IMC) e o risco cardiovascular pela circunferência da cintura (CC). A qualidade de vida foi avaliada pelo WHOQOL-bref. Para as análises estatísticas, adotou-se nível de significância de 5%. A amostra apresentou idade média de 73,95 ± 7,84 anos, sendo a maioria do sexo feminino. Quanto ao estado nutricional, 21,9% apresentou baixo peso, 32,8% excesso de peso e 62,6% risco cardiovascular elevado ou muito elevado. O programa de intervenção proporcionou impacto positivo no estado nutricional, com redução do IMC e da CC, diminuindo o risco de desenvolvimento de doenças cardiovasculares e promoveu aumento da satisfação dos idosos em relação ao estado de saúde repercutindo na melhora da qualidade de vida.


Abstract Chronic kidney disease (CKD) is recognized as a complex disease that requires multiple approaches to its treatment. The aim of this study was to evaluate the impact of a nutritional intervention program on the nutritional status and quality of life of elderly pre-dialysis CKD patients. A prospective cohort study was carried out involving 64 elderly stage 3 CKD patients receiving treatment at a Primary Care Center in the Municipality of Diadema in the State of São Paulo, Brazil. The nutritional intervention consisted of one individual and three group meetings. Nutritional status was assessed using anthropometric variables and classified according to Body Mass Index (BMI). Cardiovascular risk was classified according to Waist Circumference (WC). Quality of life was assessed using the WHOQOL-BREF. The data was analyzed adopting a significance level of 5%. Mean age was 73.95 ± 7.84 years and the majority of the sample were women, had a low level of schooling, and low monthly income. With respect to nutritional status, 21.9% of the sample were underweight, 32.8% overweight, and 62.6% were at a high or very high risk of developing cardiovascular disease. The nutritional intervention program had a positive impact on nutritional status, leading to a decline in BMI and WC, reduction in risk of developing heart disease, increased satisfaction with current state of health, and improved quality of life.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Quality of Life , Nutritional Status , Renal Insufficiency, Chronic/physiopathology , Feeding Behavior , Thinness/epidemiology , Brazil/epidemiology , Cardiovascular Diseases/etiology , Cardiovascular Diseases/epidemiology , Body Mass Index , Nutrition Assessment , Health Status , Prospective Studies , Risk Factors , Cohort Studies , Patient Satisfaction , Overweight/epidemiology , Waist Circumference , Income , Middle Aged
19.
Säo Paulo med. j ; 136(3): 208-215, May-June 2018. tab
Article in English | LILACS | ID: biblio-962725

ABSTRACT

ABSTRACT BACKGROUND: Despite evidence that diet is very important in relation to chronic kidney disease (CKD) progression, studies in this field are scarce and have focused only on some specific nutrients. We evaluated the energy, macronutrient and micronutrient intakes and dietary patterns of non-dialysis CKD participants in the PROGREDIR study. DESIGN AND SETTING: Cross-sectional study; CKD cohort, São Paulo, Brazil. METHODS: Baseline data on 454 participants in the PROGREDIR study were analyzed. Dietary intake was evaluated through a food frequency questionnaire. Dietary patterns were derived through principal component analysis. Energy and protein intakes were compared with National Kidney Foundation recommendations. Linear regression analysis was performed between energy and nutrient intakes and estimated glomerular filtration rate (eGFR), and between sociodemographic and clinical variables and dietary patterns. RESULTS: Median energy and protein intakes were 25.0 kcal/kg and 1.1 g/kg, respectively. In linear regression, protein intake (β = -3.67; P = 0.07) was related to eGFR. Three dietary patterns (snack, mixed and traditional) were retained. The snack pattern was directly associated with male gender (β = 0.27; P = 0.006) and inversely with diabetes (β = -0.23; P = 0.02). The traditional pattern was directly associated with male gender (β = 0.27; P = 0.007) and schooling (β = 0.40; P < 0.001) and inversely with age (β = -0.01; P = 0.001) and hypertension (β = -0.34; P = 0.05). CONCLUSIONS: We identified low energy and high protein intake in this population. Protein intake was inversely related to eGFR. Dietary patterns were associated with age, gender, schooling level, hypertension and diabetes.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Energy Intake , Nutritional Status/physiology , Eating , Renal Insufficiency, Chronic/physiopathology , Socioeconomic Factors , Dietary Proteins/administration & dosage , Diet Records , Linear Models , Sex Factors , Cross-Sectional Studies , Age Factors , Diabetes Complications/complications , Educational Status , Snacks , Glomerular Filtration Rate/physiology , Hypertension/complications
20.
Rev. Assoc. Med. Bras. (1992) ; 64(4): 346-353, Apr. 2018. tab
Article in English | LILACS | ID: biblio-956457

ABSTRACT

SUMMARY The objective was to evaluate the association between nutritional status and the glomerular filtration rate (GFR) in remaining quilombolas. Cross-sectional study carried out on 32 remaining quilombola communities in the municipality of Alcântara-MA. The nutritional indicators (IN) used were: body mass index (BMI); Waist circumference (WC); Waist-to-hip ratio (WHR); Waist-to-height ratio (WHtR); conicity index (CI) and estimated visceral adipose tissue (VAT). GFR was estimated from the CKD-EPI creatinine-cystatin C formula. The Shapiro Wilk test was used to evaluate the normality of the quantitative variables. In order to compare the second IN sex, the chi-square test was applied. The Anova or Kruskal-Wallis tests were used to verify the association between IN and GFR. Of the 1,526 remaining quilombolas studied, 89.5% were black or brown, 51.2% were women, 88.6% belonged to economic classes D and E and 61.2% were farmers or fishermen. Clinical investigation revealed 29.2% of hypertensive patients, 8.5% of diabetics and 3.1% with reduced GFR. The BMI revealed 45.6% of the remaining quilombolas with excess weight. When compared to men, women presented a higher prevalence of overweight by BMI (56.6% vs 33.8%, p <0.001) and abdominal obesity CC (52.3% vs 4.3%), WHR (76,5% vs 5.8%), WHtR (82.3% vs 48.9%) and VAT (27.1% vs 14.5%) (p <0.001). Comparing the means of IN according to the GFR, it was observed that the higher the mean value of the IN lower the GFR (p <0.05). The GFR reduced with increasing mean values of nutritional indicators of abdominal obesity, regardless of sex.


RESUMO O objetivo foi avaliar a associação entre o estado nutricional e a taxa de filtração glomerular (TFG) em remanescentes quilombolas. Estudo transversal, realizado em 32 comunidades remanescentes de quilombolas, no município de Alcântara - MA. Os indicadores nutricionais (IN) utilizados foram: índice de massa corporal (IMC); circunferência da cintura (CC); relação cintura-quadril (RCQ); relação cintura-estatura (RCEst); índice de conicidade (Índice C) e tecido adiposo visceral estimado (TAVe). A TFG foi estimada a partir da fórmula do CKD-EPI creatinina-cistatina C. O teste Shapiro Wilk foi utilizado para avaliar a normalidade das variáveis quantitativas. Para comparar os IN segundo sexo foi aplicado o teste qui-quadrado. Os testes Anova ou Kruskal-Wallis foram usados para verificar a associação entre os IN e a TFG. Dos 1.526 remanescentes quilombolas estudados, 89,5% eram da cor preta ou parda, 51,2% eram mulheres, 88,6% pertenciam às classes econômicas D e E e 61,2% eram lavradores ou pescadores. A investigação clínica revelou 29,2% de hipertensos, 8,5% de diabéticos e 3,1% com TFG reduzida. O IMC revelou 45,6% dos remanescentes quilombolas com excesso de peso. Quando comparadas aos homens, as mulheres apresentaram maior prevalência de excesso de peso pelo IMC (56,6% vs. 33,8%; p <0,001) e obesidade abdominal CC (52,3% vs. 4,3%), RCQ (76,5% vs. 5,8%), RCEst (82,3% vs. 48,9%) e TAVe (27,1% vs. 14,5%) (p<0,001). Comparando as médias dos IN segundo a TFG observou-se que, quanto maior o valor médio dos IN, menor a TFG (p<0,05). A TFG foi reduzida com o aumento dos valores médios dos indicadores nutricionais de obesidade abdominal, independentemente do sexo.


Subject(s)
Humans , Male , Female , Adult , Obesity, Abdominal/physiopathology , Glomerular Filtration Rate/physiology , Reference Values , Triglycerides/blood , Uric Acid/blood , Brazil/ethnology , Logistic Models , Sex Factors , Anthropometry , Cholesterol/blood , Nutritional Status/physiology , Cross-Sectional Studies , Risk Factors , Analysis of Variance , Statistics, Nonparametric , Creatinine/blood , African Continental Ancestry Group , Diabetes Mellitus/physiopathology , Renal Insufficiency, Chronic/etiology , Renal Insufficiency, Chronic/physiopathology , Cystatin C/blood , Obesity, Abdominal/complications , Obesity, Abdominal/ethnology , Hypertension/physiopathology , Middle Aged
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