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1.
Acta Paul. Enferm. (Online) ; 35: eAPE02291, 2022. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1364247

ABSTRACT

Resumo Objetivo Avaliar o conhecimento entre acadêmicos de enfermagem sobre a vacina contra o papilomavírus humano e comparar os resultados obtidos entre estudantes do primeiro e do último ano de graduação. Métodos Estudo descritivo, transversal, quantitativo, realizado entre maio e junho de 2019. Aplicado questionário a 179 estudantes do curso de Enfermagem de uma universidade pública do estado de São Paulo, contendo dados sociodemográficos e outro sobre o conhecimento do papilomavírus humano e a vacina contra o mesmo. Dados foram analisados através do programa Statistical Packcage for Social Science. Resultados 82,4% dos estudantes do primeiro ano e 95,5% do último responderam que sabiam o que é o papilomavírus humano, e afirmaram ser um vírus sexualmente transmissível. Lacunas de conhecimento foram identificadas, quanto à finalidade do exame citopatológico, aos fatores de risco relacionados à infecção e relacionados à vacina, como número de doses e possíveis riscos e benefícios da mesma. Conclusão Apesar de os acadêmicos demonstrarem conhecimento quanto ao papilomavírus humano, sua transmissibilidade e relação direta com o câncer do colo do útero, ainda apresentaram dúvidas importantes que devem ser sanadas, quanto à finalidade do exame citopatológico, aos fatores de risco para infecção pelo vírus e em relação à vacina contra o papilomavírus humano.


Resumen Objetivo Evaluar los conocimientos de académicos de enfermería sobre la vacuna contra el virus del papiloma humano y comparar los resultados obtenidos de estudiantes del primer y del último año de carrera. Métodos Estudio descriptivo, transversal, cuantitativo realizado entre mayo y junio de 2019. Cuestionario aplicado a 179 estudiantes de la carrera de Enfermería de una universidad pública del estado de São Paulo, que contenía datos sociodemográficos, y otro sobre conocimientos del virus del papiloma humano y su vacuna. Los datos fueron analizados a través del programa Statistical Packcage for Social Science. Resultados El 82,4 % de los estudiantes de primer año y el 95,5 % del último respondieron que sabían lo que es el virus del papiloma humano y afirmaron que es un virus sexualmente transmisible. Se identificaron vacíos de conocimiento respecto a la finalidad del estudio citológico, a los factores de riesgo relacionados con la infección y con la vacuna, como número de dosis y sus posibles riesgos y beneficios. Conclusión A pesar de que los académicos demostraron conocimientos respecto al virus del papiloma humano, su transmisión y relación directa con el cáncer de cuello uterino, también presentaron dudas importantes que deben ser aclaradas sobre la finalidad del estudio citológico, los factores de riesgo de la infección por el virus y sobre la vacuna contra el virus del papiloma humano.


Abstract Objective To assess nursing students' knowledge on the human papillomavirus vaccine and compare the results obtained among students of the first and last year of graduation. Methods This is a descriptive, cross-sectional, quantitative study, conducted between May and June 2019. A questionnaire was applied to 179 nursing students from a public university in the state of São Paulo, containing sociodemographic data and another on knowledge of human papillomavirus and the vaccine against it. Data were analyzed using the Statistical Packcage for Social Science. Results 82.4% of first-year students and 95.5% of last-year students answered that they knew what human papillomavirus is, claiming to be a sexually transmitted virus. Knowledge gaps were identified regarding the purpose of cytopathological examination, risk factors related to infection and related to the vaccine, such as number of doses and possible risks and benefits of it. Conclusion Although students demonstrated knowledge on human papillomavirus, its transmissibility and direct relationship with cervical cancer, they still presented important doubts that should be answered, regarding the purpose of the cytopathological examination, the risk factors for infection by the virus and in relation to the vaccine against the human papillomavirus.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Students, Nursing , Health Education , Knowledge , Papillomavirus Infections/transmission , Papillomavirus Vaccines/therapeutic use , Uterine Cervical Neoplasms/complications , Epidemiology, Descriptive , Cross-Sectional Studies , Surveys and Questionnaires , Papillomavirus Infections/etiology , Evaluation Studies as Topic
2.
Autops. Case Rep ; 12: e2021354, 2022. graf
Article in English | LILACS | ID: biblio-1360156

ABSTRACT

Peripheral neuropathy (PN) is characterized by the injury to the peripheral nervous system of varied etiology. Lymphoma is one of the etiologies of PN, presenting various neurological manifestations. Neuropathy associated with peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is unusual and fewer cases are documented in the literature. In addition, PTCL, NOS is extremely rare as primary in the female genital tract, especially uterine cervix, and exhibits aggressive clinical course with poor therapy response. We hereby describe a 47-year-old female who presented with fever and chills for 15 days. Clinical examination revealed left-sided lower motor neuron type of facial nerve palsy with Bell's phenomenon. Nerve conduction study of all four limbs illustrated asymmetrical axonal neuropathy (motor > sensory), suggesting mononeuritis multiplex. She developed vaginal bleeding during her hospital stay. Pelvic examination and imaging revealed a 4x3cm polypoidal mass on the posterior lip of the cervix, which was excised and diagnosed as extranodal primary PTCL, NOS based on morphology, immunohistochemistry, and in-situ hybridization findings. Besides, the cerebrospinal fluid (CSF) was infiltrated by the lymphoma cells, detected on cell block preparation. The patient succumbed to her illness within one week despite best efforts and the commencement of chemotherapy. No consent was obtainable for nerve biopsy and autopsy. Thus, we report an extremely rare case of primary extranodal PTCL, NOS of the uterine cervix with unusual presentation of mononeuritis multiplex. Further, we discussed the differentials of PTCL, NOS at this extranodal site.


Subject(s)
Humans , Female , Middle Aged , Uterine Cervical Neoplasms/complications , Lymphoma, T-Cell, Peripheral/complications , Mononeuropathies/etiology , Biopsy , Immunohistochemistry , Uterine Cervical Neoplasms/diagnosis , Lymphoma, T-Cell/diagnosis , In Situ Hybridization , Fatal Outcome
3.
Salud bienestar colect ; 5(1): 18-31, ene.-abr. 2021. ilus, tab, graf
Article in Spanish | LILACS | ID: biblio-1352345

ABSTRACT

INTRODUCCIÓN: Los problemas sanitarios en los pacientes que padecen cáncer cérvico-uterino influyen en la satisfacción personal y evitan una gran adherencia a la terapia médica, y además están relacionados con un número más notable de efectos secundarios y la estancia en la clínica de emergencia junto afecciones depresivas y problemas de ansiedad. OBJETIVO: Identificar la influencia del cáncer cérvico -uterino en las alteraciones en la salud mental de pacientes menores de 25 años en el Ecuador. METODOLOGÍA: La investigación fue de tipo cuantitativo, descriptivo, y de corte transversal. Se utilizaron encuestas de manera virtual dirigida a pacientes menores de 25 años que padecen de cáncer al cuello uterino en diversas Fundaciones que luchan contra el cáncer, contando con una muestra de 178 mujeres, estas se dividieron en 4 categorías: Salud mental, Estrés, Depresión y Total de escalas. RESULTADOS: El porcentaje que se obtuvo de manera general tuvo un rango variado, el 32,9% dio como resultado que la alteración que causa en la mujer es contundente, seguido del 30,6 que su afección en la salud mental es más baja. CONCLUSIÓN: Se concluye afirmando que el cáncer uterino es el segundo cáncer más prevalente en la mujer, el cual influye de manera progresiva en la salud mental, presentando reacciones negativas y percepciones, falta de control en las emociones, consecuentemente aquello debilita el sistema inmunológico previamente comprometido, generando alteraciones en el curso del tratamiento.


INTRODUCTION: Health problems in patients suffering from cervical-uterine cancer influence personal satisfaction and prevent a high adherence to medical therapy, and are also related to a more notable number of side effects and stay in the emergency clinic together depressive conditions and anxiety problems. OBJECTIVE: To identify the influence of cervical cancer -uterine in the alterations in the mental health of patients under 25 years in Ecuador. MATERIALS AND METHODS: The research was quantitative, descriptive, andcross-sectional. Surveys were used in a virtual way directed at patients under 25 years of age who suffer from cervical cancer in various Foundations that fight against cancer, with a sample of 178 women, these were divided into 4 categories: Mental health, Stress, Depression and Total stopovers. RESULTS: The percentage that was obtained in a general way had a varied range, 32.9% gave as a result that the alteration it causes in women is overwhelming, followed by 30.6 that their mental health condition is lower. CONCLUSION: It is concluded by stating that uterine cancer is the second most prevalent cancer in women, which progressively influences mental health, presenting negative reactions and perceptions, lack of control over emotions, consequently that weakens the previously compromised immune system, generating alterations in the course of treatment.


Subject(s)
Humans , Female , Young Adult , Uterine Cervical Neoplasms/psychology , Uterine Cervical Neoplasms/virology , Stress, Psychological/complications , Uterine Cervical Neoplasms/complications , Mental Health/statistics & numerical data , Disease , Epidemiology, Descriptive , Cross-Sectional Studies , Surveys and Questionnaires , Risk Factors , Depression , Alphapapillomavirus/genetics
4.
Rev. chil. obstet. ginecol. (En línea) ; 85(1): 74-98, feb. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1092778

ABSTRACT

El cáncer cérvico uterino (CaCu) corresponde al 10% de los cánceres femeninos, se describe prevenible y con viabilidad de curación, no obstante, con la optimización de las terapias las sobrevivientes superan los cinco años en el 70% de los casos, evidenciando efectos adversos producto principalmente del tratamiento que deterioran la calidad de vida e impactan sobre su sexualidad. OBJETIVO: Identificar efectos de la enfermedad y tratamiento que comprometen la calidad de vida sexual de la mujer con CaCu. METODOLOGÍA: Revisión de artículos originales entre los años 2010 y 2019 desde las bases de datos Pubmed, Scopus, Scielo, Google Académico, Science Direct, Elsevier, Redalyc, Springer Link, Wiley Online Library, Dialnet y Ovid, seleccionando 51 artículos de 90 en inglés, español y portugués a texto completo, que reportaran efectos físicos y psicosociales que comprometieran la calidad de vida sexual de mujeres con CaCu. RESULTADOS: La sexualidad de estas mujeres es impactada por efectos físicos, relacionadas con el estadio de la enfermedad y tratamiento como dispareunia, anorgasmia, alteraciones digestivas, urinarias, insomnio, inapetencia, linfedema y neuropatía periférica. Desde el ámbito psicosocial manifiestan efectos sobre su autoestima, depresión e inseguridad en la permanencia del vínculo de pareja. Emerge la comunicación sexual de pareja como condición categórica en el nivel de afectación de la calidad de vida sexual. CONCLUSIONES: la sexualidad de la mujer con CaCu está comprometida por efectos físicas y psicosociales secundarias principalmente al tratamiento recibido. La comunicación sexual de pareja surge como interviniente para superar estos efectos y debe considerarse en la atención profesional.


Cervical uterine cancer (CaCu) corresponds to 10% of female cancers, it is described as preventable and with viability of cure, however, with the optimization of therapies the survivors exceed five years in 70% of the cases, evidencing adverse effects mainly due to the treatment that deteriorates the quality of life and impact on their sexuality. OBJECTIVE: To identify the effects of the disease and treatment that compromises the quality of sexual life of women with CaCu. METHODOLOGY: Review of original articles between 2010 and 2019 from Pubmed, Scopus, Scielo, Google Scholar, Science Direct, Elsevier, Redalyc, Springer Link, Wiley Online Library, Dialnet, and Ovid databases, selecting 51 articles out of 90 in English, Spanish, and Portuguese in full text, which reported physical and psychosocial effects that compromises the quality of sexual life of women with CaCu. RESULTS: The sexuality of these women is impacted by physical effects, related to the stage of the disease and treatment, such as dyspareunia, anorgasmia, digestive and urinary disorders, insomnia, inappetence, lymphedema and peripheral neuropathy. From the psychosocial perspective, they show effects on their self-esteem, depression and insecurity in the permanence of the couple's relationship. Sexual communication between couples is emerging as a categorical condition in the level of affectation of the quality of sexual life. CONCLUSIONS: The sexuality of women with CaCu is compromised by physical and psychosocial effects mainly secondary to the treatment received. Couple's sexual communication emerges as an intervention to overcome these effects and should be considered in professional care.


Subject(s)
Humans , Female , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/psychology , Cervical Intraepithelial Neoplasia/complications , Cervical Intraepithelial Neoplasia/psychology , Sexuality , Quality of Life , Sexual Behavior , Uterine Cervical Neoplasms/therapy , Cervical Intraepithelial Neoplasia/therapy , Sexual Health
5.
An. bras. dermatol ; 93(4): 576-578, July-Aug. 2018. graf
Article in English | LILACS | ID: biblio-949934

ABSTRACT

Abstract: Sweet's syndrome is a rare dermatosis with little-known pathogenesis, associated with some clinical conditions such as infections, autoimmune diseases, inflammatory bowel diseases, vaccination, medications and neoplasms. Hematologic malignancies are the diseases most related to paraneoplastic Sweet's syndrome, but this clinical entity can also be found occasionally in some solid tumors, including genitourinary tract tumors. We report a rare case of paraneoplastic Sweet's syndrome associated with the diagnosis of cervical cancer.


Subject(s)
Humans , Female , Middle Aged , Paraneoplastic Syndromes/pathology , Uterine Cervical Neoplasms/pathology , Sweet Syndrome/pathology , Paraneoplastic Syndromes/complications , Uterine Cervical Neoplasms/complications , Sweet Syndrome/complications , Diagnosis, Differential , Neoplasm Recurrence, Local
6.
Rev. bras. ginecol. obstet ; 40(4): 196-202, Apr. 2018. tab
Article in English | LILACS | ID: biblio-958974

ABSTRACT

Abstract Objective To evaluate the association between hormonal contraception and the appearance of human papillomavirus HPV-induced lesions in the uterine cervix of patients assisted at a school outpatient clinic - ObGyn outpatient service of the Universidade do Sul de Santa Catarina. Methods A case-control study, with women in fertile age, performed between 2012 and 2015. A total of 101 patients with cervical lesions secondary to HPV were included in the case group, and 101 patients with normal oncotic colpocytology, in the control group. The data were analyzed through the Statistical Package for the Social Sciences (SPSS, IBM Corp. Armonk, NY, US) software, version 24.0, using the 95% confidence interval. To test the homogeneity of the proportions, the chi-square (χ2) test was used for the qualitative variables, and the Student t-test, for the quantitative variables. Results When comparing the occurrence of HPV lesions in users and non-users of combined oral contraceptives (COCs), the association with doses of 0.03 mg or higher of ethinylestradiol (EE) was observed. Thus, a higher probability of developing cervical lesions induced by HPV was identified (odds ratio [OR]: 1.9 p = 0.039); and when these cases were separated by the degree of the lesion, the probability of these patients presentingwith lowgrade squamous intraepithelial lesion was 2.1 times higher (p = 0.036), but with no impact on high-grade squamous intraepithelial lesions and the occurrence of invasive cancer. No significant differences were found in the other variables analyzed. Conclusion Although the results found in the present study suggest a higher probability of the users of combined hormonal contraceptives with a concentration higher than 0.03 mg of EE to develop low-grade intraepithelial lesions, more studies are needed to conclude causality.


Resumo Objetivo Avaliar a associação entre a contracepção hormonal e a presença de lesões induzidas pelo vírus do papiloma humano (HPV) no colo uterino de pacientes do serviço de ginecologia e obstetrícia do ambulatório de especialidade médicas da Universidadedo Sul de Santa Catarina - AME/UNISUL. Métodos Estudo observacional do tipo caso-controle, commulheres no menacme, no período compreendido entre 2012 e 2015. Foram incluídas 101 pacientes com lesões cervicais secundárias ao HPV, no grupo caso, e 101 pacientes com colpocitologia oncótica normal, no grupo controle. Os dados foram analisados por meio do programa SPSS 24.0, utilizando-se o intervalo de confiança de 95%. Para testar a homogeneidade de proporções foram utilizados o teste do qui-quadrado (χ2) para as variáveis qualitativas e o teste t de Student para as variáveis quantitativas. Resultados Ao comparar-se a ocorrência das lesões pelo HPV em usuárias de contraceptivos orais combinados (COCs) com a em não usuárias, observou-se a associação com doses de 0.03 mg ou superiores de etinilestradiol (EE), na qual se identificou 1.9 vezes mais probabilidade destas desenvolverem lesões cervicais induzidas pelo HPV (p = 0.039); ao separar-se esses casos pelo grau da lesão, a probabilidade destas pacientes apresentarem lesão cervical de baixo grau foi 2.1 vezes maior (p = 0.036), porémsemimpacto nas lesões cervicais de alto grau e na ocorrência de câncer invasor. Não foram encontradas diferenças significativas nas outras variáveis analisadas. Conclusão Embora os resultados encontrados no presente estudo sugiram maior probabilidade das usuárias de contraceptivo hormonal combinado, com concentração superior a 0.03 mg de EE, desenvolverem lesão cervical de baixo grau,mais estudos são necessários para concluir causalidade.


Subject(s)
Uterine Cervical Neoplasms/complications , Contraceptives, Oral, Hormonal/adverse effects , Papillomavirus Infections/complications , Case-Control Studies , Uterine Cervical Neoplasms/etiology , Retrospective Studies , Papillomavirus Infections/etiology
7.
Rev. chil. obstet. ginecol. (En línea) ; 83(2): 130-138, abr. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-959497

ABSTRACT

RESUMEN Fundamento: La persistencia del virus papiloma posterior a la conización del cuello uterino, se ha considerado un factor de riesgo para la persistencia de lesiones intra epiteliales (LIE) causadas por virus papiloma. Para determinar la asociación entre persistencia de lesión cervical y la presencia del virus papiloma posterior a la conización del cuello uterino, se realizó un estudio observacional prospectivo en un grupo de 123 pacientes portadoras de lesiones intraepiteliales de alto grado (LIEAG) tratadas con conización. Material y métodos: Se siguieron a 123 pacientes portadoras de LIEAG, ingresadas a la Unidad de Patología Cervical entre Abril de 2013 y Abril de 2014, las que fueron seguidas por 2 años hasta Abril de 2016. Se realizó genotipificación antes, y entre 4 a 6 meses posterior a la conización. Los datos se tabularon considerando la edad, paridad, tipo de virus, persistencia de LIE, reconización o requerimiento de histerectomía posterior. Resultados: La mediana de la edad fue de 37 años, el 91% fueron multíparas, y solo el 9% fueron nulíparas. El 56% ingresó por NIE III y el 44% por NIE II. Los virus más frecuentes fueron el 16, 31,58, 52 y 56. La persistencia de virus papiloma se constató en el 37% de las pacientes conizadas. La persistencia de LIE se observó en el 27% de las pacientes que fueron positivas para virus papiloma posterior a la conización, en comparación a sólo el 5% en las que fueron negativas. Del total de pacientes positivas para virus papiloma posterior a la conización, 12 de ellas presentaron persistencia de lesión confirmadas histológicamente por biopsia cervical, 8 pacientes requirieron recono por LIE de alto grado, 2 pacientes fueron a histerectomía y en 2 casos se realizó seguimiento estricto por NIE I. Cuando la tipificación post cono fue negativa solamente 3 pacientes requirieron conización y en sólo una se realizó seguimiento estricto por NIE I. Conclusión: La persistencia del virus papiloma posterior a la conización se asocia a mayor persistencia de LIEAG, mayor frecuencia de reconización o histerectomía posterior.


ABSTRACT Backgroud: The persistence of papilloma virus after conization of the cervix has been considered a risk factor for the persistence of cervical intra epithelial lesion (CIN) caused by papilloma virus. Aim: In order to determine the association between cervical lesion persistence and the presence of papilloma virus after conization, a prospective observational study was performed in a group of 123 patients with intraepithelial lesions treated with conization. Material and methods: We followed 123 patients with high grade CIN who were admitted to the Cervical Pathology Unit, between April 2013 and April 2014; they were followed for 2 years until April 2016. Viral genotyping was done before, and among the 4 to 6 months after the LEEP. Data were tabulated considering age, parity, type of virus, persistence of CIN, reconization or requirement of posterior hysterectomy. Results: The median age was 37 years, 91% were multiparous, and only 9% were nulliparous. 56% had NIE III and 44% NIE II. The most frequent viruses were 16, 31, 58, 52 and 56. The persistence of papillomavirus was present in 37% of patients. The persistence of CIN was observed in 27% of patients who were positive for papilloma virus after conization, compared to only 5% in those who were negative. Of the total number of patients positive for papilloma virus, in 12 of them had intra epitelial lesions were confirmed by cervical biopsy, 8 patients required recone for high grade CIN, 2 patients underwent hysterectomy, and 2 patients underwent follows up strictly by CIN I. When post cone typing was negative only 3 patients required conization and only one was followed strictly by CIN I.


Subject(s)
Humans , Female , Adult , Middle Aged , Young Adult , Uterine Cervical Neoplasms/surgery , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Conization , Papillomavirus Infections/pathology , Papillomaviridae/physiology , Biopsy , Uterine Cervical Neoplasms/complications , Prospective Studies , Follow-Up Studies , Cervical Intraepithelial Neoplasia/surgery , Cervical Intraepithelial Neoplasia/pathology , Colposcopy , Cytodiagnosis , Papillomavirus Infections/genetics , Observational Study
8.
Rev. bras. cancerol ; 64(4): 509-516, 2018.
Article in Portuguese | LILACS | ID: biblio-1025384

ABSTRACT

Introdução: O câncer do colo do útero apresenta elevada incidência em países de baixa e média rendas e provoca repercussões negativas sobre a funcionalidade das mulheres. O interesse na mensuração de medidas terapêuticas, que não se restrinjam às medidas do modelo biomédico, vem assumindo destaque no campo da oncologia. A Classificação Internacional de Funcionalidade (CIF) aparece no cenário mundial como ferramenta de orientação para construção da avaliação biopsicossocial. Objetivo: Exemplificar a metodologia para identificação dos componentes da funcionalidade em escalas específicas utilizadas no cuidado oncológico para mulheres com câncer do colo do útero. Método: Estudo realizado em três etapas: análise de revisões sistemáticas para identificação dos instrumentos específicos para avaliação de câncer do colo do útero; extração das medidas de avaliação; e ligação dos conceitos contidos nas medidas de desfecho com as categorias correspondentes da CIF por dois revisores independentes. Resultados: Na análise do Functional Assessment of Cancer Therapy-Cervix e da European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Cervical Cancer Module, identificaram-se 72 conteúdos principais ligados a 35 categorias da CIF. Destas, 23 referiam-se às funções corporais, oito às atividades e participação, três aos fatores ambientais e uma à estrutura corporal. Conclusão: Os dois instrumentos possuem ligação com a CIF, no entanto, exploram de forma insuficiente os fatores contextuais, o que demonstra a necessidade de orientação biopsicossocial nas avaliações em saúde para mulheres com câncer do colo do útero de maneira a contemplar, de forma equânime, os componentes da funcionalidade na aferição dos desfechos terapêuticos.


Introduction: Cervical cancer is highly prevalent in low- and middle-income countries and has a negative impact on women's functioning. The interest in the measurement of therapeutic measures that are not restricted to the biomedical model has been assuming prominence in the field of Oncology. The International Classification of Functioning (ICF) appears on the world stage as a guiding tool for the construction of the biopsychosocial evaluation. Objective: To exemplify methodology for identifying the components of functioning in documents used in oncology care in cervical cancer. Method: Three-step study - Analysis of systematic reviews to identify the specific instruments for cervical cancer; extraction of evaluation measures; and linking the concepts contained in the outcome measures with the corresponding categories of ICF by two independent reviewers. Results: In the analysis of the Functional Assessment of Cancer Therapy-Cervix and the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Cervical Cancer Module, we identified 72 main contents, related to 35 categories of ICF. Of these, 23 referred to bodily functions, eight to activities and participation, tree to environmental factors and an to a body structure. Conclusion: The two instruments have a link with the ICF; however, they exploit insufficiently the contextual factors, which demonstrates the need for biopsychosocial guidance in health assessments for women with cervical cancer, to contemplate the components of functioning in the measurement of therapeutic outcomes equitably.


Introducción: El cáncer de cuello de útero es altamente incidente en los países de baja y media renta y repercute negativamente en la funcionalidad de las mujeres. El interés en la medición de medidas terapéuticas que no se restrinjan a las medidas del modelo biomédico viene asumiendo destaque en el campo de la Oncología. La Clasificación Internacional de Funcionalidad (CIF) aparece en el escenario mundial como herramienta de orientación para la construcción de la evaluación biopsicosocial. Objetivo: Ejemplificar metodología para identificar los componentes de la funcionalidad en documentos utilizados en el cuidado oncológico en el cáncer del cuello del útero. Método: Estudio realizado en tres etapas: Análisis de revisiones sistemáticas para la identificación de los instrumentos específicos para el cáncer de cuello de útero; extracción de las medidas de evaluación; y conexión de los conceptos contenidos en las medidas de desenlace con las categorías correspondientes de la CIF por dos revisores independientes. Resultados: En el análisis del Functional Assessment del Cáncer Terapia-Cervix y de la European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Cervical Cancer Module se identificaron 72 contenidos principales, vinculados a 35 categorías de la CIF. De estas, 23 se referían a las funciones corporales, ocho a las actividades y participación, tres a los factores ambientales y una a la estructura corporal. Conclusión: Los dos instrumentos poseen conexión con la CIF, sin embargo, explotan de forma insuficiente los factores contextuales, lo que demuestra la necesidad de orientación biopsicosocial en las evaluaciones en salud para mujeres con cáncer del cuello del útero, para contemplar de forma ecuánime los componentes de la funcionalidad en la comparación de los resultados terapéuticos .


Subject(s)
Humans , Female , Uterine Cervical Neoplasms/complications , International Classification of Functioning, Disability and Health , Uterine Cervical Neoplasms/physiopathology , Outcome Assessment, Health Care , Health Information Systems
9.
Rev. cuba. obstet. ginecol ; 43(3): 163-172, jul.-set. 2017.
Article in Spanish | LILACS, CUMED | ID: biblio-901324

ABSTRACT

Introducción: entre los factores de riesgo que favorecen la aparición de las lesiones cérvico uterinas, se encuentran la infección por virus de papiloma humano, la promiscuidad, el uso de anticonceptivos orales y el hábito de fumar. No obstante, varias investigaciones refieren que los polimorfismos genéticos podrían contribuir al desarrollo y progresión del cáncer cérvico uterino. Objetivo: identificar en la bibliografía revisada, la frecuencia de asociación de los polimorfismos de Glutation s - transferasa con el cáncer cérvico uterino y con factores de riesgo que inciden en la patología. Métodos: se realizó una extensa revisión de la literatura especializada a través de los buscadores en base de datos de PubMed, EBSCO, NCBI y BVS. Resultados: se constató la variabilidad en los reportes de las frecuencias alélicas de los genotipos GSTM1 y T1 en distintas poblaciones. Se corroboró en varios estudios revisados el hallazgo de asociación entre los genotipos GSTM1 y T1 nulos y cáncer cérvico uterino y, de igual forma con el consumo de tabaco y anticonceptivos orales por tiempo prolongado. Conclusiones: la bibliografía sobre el tema pone en evidencia que los genes que codifican la enzima Glutation s - transferasa intervienen en la protección celular contra los efectos citotóxicos, de manera que cuando éstos presentan alteración se afecta la actividad enzimática, lo que predispone a una mayor susceptibilidad al cáncer(AU)


Introduction: Among risk factors that lead to uterine cervix lesions we can find the human papilloma virus infection, promiscuity, use of oral contraceptive and smoking habit. However, several researches refer that genetic polymorphism could be related to the development and progression of the uterine cervix cancer. Objective: Identify the association of glutathione S- transferases polymorphism with uterine cervix cancer and risk factors relate with this disease, in the revise bibliography. Method: An extensive review was made of the specialized literature using web search in database PubMed, EBSCO, NCBI and BVS. Result: The variability of the allelic frequency of the GSTM1 and T1 genotypes in different populations was confirmed. Besides the association between null GSTM1 and T1 with uterine cervix cancer was corroborated. In addition, this association with smoking habit and the use of oral contraceptive for long time was corroborated. Conclusions: Consulted bibliography shows that genes encoding glutahione S- transferases enzyme contribute to the cellular protection against cytotoxic effects, therefore, alterations in these genes affect the enzymatic activity lead to a major susceptibility to suffer cancer(AU)


Subject(s)
Humans , Female , Polymorphism, Genetic , Uterine Cervical Neoplasms/complications , Glutathione Transferase , Papillomaviridae/genetics , Bibliography of Medicine , Environmental Exposure/adverse effects , Environmental Pollution
10.
Int. braz. j. urol ; 43(1): 104-111, Jan.-Feb. 2017. tab, graf
Article in English | LILACS | ID: biblio-840803

ABSTRACT

ABSTRACT Purpose Ureteral obstruction in cervical cancer occurs in up to 11% of patients, many of whom undergo ureteral stenting. Our aim was to describe the patient burden of chronic ureteral stenting in a population-based cohort by detailing two objectives: (1) the frequency of repeat procedures for ureteral obstruction; and, (2) the frequency of urinary adverse effects (UAEs) (e.g., lower urinary tract symptoms, flank pain). Materials and Methods From SEER-Medicare, we identified 202 women who underwent ureteral stent placement prior to or following cervical cancer treatment. The frequency of repeat procedures and rate ratios were compared between treatment modalities. The rates and rate ratios of UAEs were compared between our primary cohort (stent + cervical cancer) and the following groups: no stent + cervical cancer, stent + no cancer, and no stent + no cancer. The “no cancer” group was drawn from the 5% Medicare sample. Results 117/202 women (58%) underwent >1 stent procedure. The frequency of additional procedures was significantly higher in patients who received radiation as part of their treatment. UAEs were very common in women with stent + cancer. The rate of UTI was 190 (per 100 person-years), 67 for LUTS, 42 for stones, and 6 for flank pain. These rates were 3-10 fold higher than in the no stent + no cancer control group; rates were also higher than in the no stent + cancer and the stent + no cancer women. Conclusions The burden of disease associated with ureteral stents is higher than expected and urologists should be actively involved in stent management, screening for associated symptoms and offering definitive reconstruction when appropriate.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Ureteral Obstruction/etiology , Ureteral Obstruction/therapy , Stents/adverse effects , Uterine Cervical Neoplasms/complications , Time Factors , Ureter/surgery , Risk Factors , Cohort Studies , Treatment Outcome , Flank Pain/etiology , Lower Urinary Tract Symptoms/etiology
11.
Rev. Assoc. Med. Bras. (1992) ; 62(3): 255-261, May-June 2016. tab, graf
Article in English | LILACS | ID: lil-784320

ABSTRACT

SUMMARY Introduction: Obstructive nephropathy is a frequent complication in the course of advanced cervical cancer (CC), and ultrasonography-guided percutaneous nephrostomy (PCN) is a well established technique for fast ureteral desobstruction. Objective: To identify possible factors related to the survival and quality of life of patients with advanced CC presenting acute urinary obstructive complications that after desobstruction by PCN recovered urinary flux and renal function. Method: This is an analytical, descriptive, cross-sectional study that included 45 patients with CC who underwent PCN and were divided into 2 groups: “death” (DG) and “survival” (SG), in a public hospital that is reference for oncologic diseases in Northern Brazil. Results: The mean serum creatinine of the patients preceding PCN was >10 mg/dL, and after PCN <2 mg/dL. The cutoffs of 8.7 g/dL for Hb (p=0.0241) and 27% for Ht (p=0.0065) indicated the values that better discriminate the outcomes of the groups. The presence of low blood pressure was statistically correlated (p=0.0037) to the outcome “death”. Changes in glomerular filtration rate (already reduced in all cases) were not associated to the levels of Hb/Ht or to the outcome “death” during the nephrological follow-up. Conclusion: PCN was responsible for the recovery of renal function in 61.7% of the patients, leading to interruption of renal replacement therapy (RRT) in all of those patients. Hb levels >8.7g/dL and Ht >27% were associated to longer survival, and the presence of low blood pressure during follow-up was associated with progression to death.


RESUMO Introdução: a nefropatia obstrutiva é complicação frequente na evolução do câncer do colo uterino (CCU) avançado e a nefrostomia percutânea guiada por ultrassonografia (NFT) é uma técnica bem estabelecida para a rápida desobstrução ureteral. Objetivo: esclarecer os fatores relacionados à evolução ou não para óbito e qualidade de vida das pacientes com CCU avançado com complicações obstrutivas urinárias agudas e que, após desobstrução pela NFT, recuperaram fluxo urinário e função renal. Método: foi realizado estudo transversal analítico descritivo, que avaliou dois grupos de pacientes com CCU submetidas à NFT [óbito (GO) e sobrevida (GS)], em um hospital público, referência para doenças oncológicas da região Norte do país. Resultados: a creatinina sérica média inicial era >10 mg/dL pré-NFT e tornou-se <2 mg/dL após. Quanto à sobrevida, os pontos de corte de 8,7 g/dL de Hb e 27% de Ht melhor discriminaram a evolução dos grupos GO e GS (p=0,0241 e p=0,0065). Hipotensão se associou significantemente (p=0,0037) com a evolução para óbito. Variações na taxa de filtração glomerular, que já era reduzida em todos os casos, não se associaram aos níveis de Hb/Ht ou à evolução para óbito durante seguimento nefrológico. Conclusão: a NFT permitiu a recuperação da função renal em 61,7% das pacientes com CCU, dispensando terapia de substituição renal. Níveis de Hb >8,7 g/dL e Ht >27% estiveram associados a maior sobrevida, e a hipotensão durante o seguimento associou-se com evolução para óbito.


Subject(s)
Humans , Male , Female , Adult , Aged , Nephrostomy, Percutaneous/mortality , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/mortality , Kidney Diseases/surgery , Kidney Diseases/etiology , Kidney Diseases/mortality , Quality of Life , Ureteral Obstruction/surgery , Ureteral Obstruction/etiology , Ureteral Obstruction/mortality , Sex Factors , Epidemiologic Methods , Age Factors , Treatment Outcome , Creatinine/blood , Glomerular Filtration Rate , Middle Aged
12.
Rev. Nac. (Itauguá) ; 8(1): 70-77, jun 2016.
Article in Spanish | LILACS, BDNPAR | ID: biblio-884716

ABSTRACT

La dermatomiositis es una enfermedad sistémica que se caracteriza fundamentalmente por la presencia de alteraciones inflamatorias de piel y músculo estriado. En ciertos casos constituye un síndrome paraneoplásico, por lo que su diagnóstico obliga a una exhaustiva búsqueda de la probable asociación con un cáncer. Presentamos tres casos de dermatomiositis asociados a neoplasias, dos mujeres con cáncer ginecológico y un varón con cáncer de estómago. Una de las mujeres también presentaba un síndrome mielodisplásico. En dos casos la dermatomiositis fue posterior al diagnóstico del cáncer y en uno los hallazgos fueron simultáneos.


Dermatomyositis is a systemic disease characterized primarily by the presence of inflammatory skin disorders and striated muscle. In some cases it constitutes a paraneoplastic syndrome, so diagnosis requires a thorough search of the likely association with cancer. We present three cases of dermatomyositis associated with malignancies, two women with gynecologic cancer and a man with stomach cancer. One of the women also had a myelodysplastic syndrome. In two cases dermatomyositis was after the diagnosis of cancer and in one, the findings were simultaneous.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Stomach Neoplasms/complications , Stomach Neoplasms/diagnosis , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/diagnosis , Dermatomyositis/complications , Dermatomyositis/diagnosis , Paraneoplastic Syndromes/diagnosis , Dermatomyositis/pathology
13.
Article in English | WPRIM | ID: wpr-213435

ABSTRACT

OBJECTIVE: To evaluate the relationship between type 2 diabetes mellitus (DM) and oncological outcomes in early stage cervical cancer patients who underwent radical surgical resection. METHODS: Patients with early stage cervical cancer diagnosed between 2001 and 2014 were retrospectively enrolled. We assessed the outcomes of 402 non-DM and 42 DM patients with cervical cancer. We tested the prognostic value of DM via Cox proportional hazard modeling. RESULTS: Patients with DM were more likely to be older and overweight. In the DM group, 20 and 22 patients were and were not taking metformin, respectively. The 5-year recurrence-free survival (RFS) and 5-year overall survival (OS) rate for the whole study population were 88.49% and 96.34%, respectively. In the DM group, there was no evidence that metformin affected the RFS (p=0.553) or the OS (p=0.429). In multivariate analysis, age (p=0.007), histology (p=0.006), and deep stromal invasion (p=0.007) were independent adverse prognostic factors for RFS. There was a borderline significant association of increased RFS with DM (p=0.051). However, a time-varying-effect Cox model revealed that the DM was associated with a worse RFS (hazard ratio, 11.15; 95% CI, 2.00 to 62.08, p=0.022) after 5 years. DM (p=0.008), age (p=0.009), and node status (p=0.001) were the only 3 independent prognostic factors for OS. CONCLUSION: Early stage cervical cancer patients with type 2 DM have a poorer oncological outcome than patients without DM.


Subject(s)
Adult , Age Factors , Diabetes Mellitus, Type 2/complications , Female , Humans , Hypoglycemic Agents/therapeutic use , Hysterectomy , Metformin/therapeutic use , Middle Aged , Prognosis , Proportional Hazards Models , Retrospective Studies , Survival Analysis , Uterine Cervical Neoplasms/complications
14.
Braz. j. infect. dis ; 19(6): 660-663, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769617

ABSTRACT

ABSTRACT Infections caused by emerging Cryptococcus non-neoformans species are being reported with increasingly frequency. Here, we present a case of fungaemia byCryptococcus laurentii in a woman receiving aggressive immunosuppressive therapy for cervical neoplasia. Three venous blood samples were aseptically collected on consecutive days and C. laurentiiwas isolated and identified through phenotypic and molecular methods. After central venous catheter removal and appropriate antifungal therapy, the patient showed significant improvement and blood culture became negative. Thus, patients following immunosuppressive therapies and using invasive medical devices are at risk of C. laurentii blood infections.


Subject(s)
Adult , Female , Humans , Cervical Intraepithelial Neoplasia/complications , Cryptococcosis/microbiology , Fungemia/microbiology , Immunocompromised Host/immunology , Uterine Cervical Neoplasms/complications , Cervical Intraepithelial Neoplasia/microbiology , Cryptococcosis/diagnosis , Cryptococcosis/immunology , Cryptococcus/genetics , Cryptococcus/isolation & purification , Fungemia/diagnosis , Fungemia/immunology , Uterine Cervical Neoplasms/microbiology
15.
Braz. j. infect. dis ; 19(6): 557-562, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769630

ABSTRACT

ABSTRACT OBJECTIVE: The goal of this study was to determine the prevalence of human papillomavirus infection infection and cervical lesions and its associated factors among HIV infected women attending an AIDS clinic in Amazonas state, Brazil. METHODS: Cross-sectional study. Women attending an AIDS clinic in the city of Manaus between March and December 2011 for gynecological examination were invited to participate. Enrolled patients answered a standardized interview including demographical, behavioral, and clinical data. Additionally, patients underwent a gynecological evaluation with collection of cervical samples for cytological analysis and high-risk human papillomavirus infection hybrid capture. A blood sample was also obtained to determine CD4 and viral load levels. RESULTS: A total of 310 (82.9%) women participated in the study. High-risk human papillomavirus infection was detected in 191 (61.6%) cases; 24 (13.5%) had low-grade squamous intraepithelial lesion (SIL) and 4 (2.2%) high-grade SIL. No invasive cervical cancer was diagnosed. Median age was 32 (interquartile range (IQR): 27-38) years and median of education was 8.5 (IQR 4-11) years of schooling and 56.1% had a monthly income up to US$180. In multivariate analysis, being less than 30 years old [OR = 1.7 (95% CI: 1.2-2.4,p = 0.005)], high-grade SIL [OR = 6.5 (95% CI: 1.6-23.0, p = 0.009)], and CD4 counts <200 cells/mm3 [OR = 1.6 (95% CI: 1.2-2.0, p < 0.001)] were associated with high risk human papillomavirus infection infection. CONCLUSIONS: In the present study high-risk human papillomavirus infection was frequent and it was associated to high-SIL. These results show the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.


Subject(s)
Adolescent , Adult , Female , Humans , Middle Aged , Young Adult , HIV Infections/complications , Papillomavirus Infections/epidemiology , Uterine Cervical Neoplasms/epidemiology , Brazil/epidemiology , Cross-Sectional Studies , DNA, Viral/analysis , Papanicolaou Test , Prevalence , Papillomavirus Infections/complications , Precancerous Conditions/epidemiology , Precancerous Conditions/pathology , Precancerous Conditions/virology , Risk Factors , Socioeconomic Factors , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Viral Load
16.
Rev. bras. ginecol. obstet ; 37(10): 480-485, out. 2015. tab
Article in Portuguese | LILACS | ID: lil-762027

ABSTRACT

OBJETIVO: Determinar a prevalência da lesão anal induzida por HPV em mulheres com neoplasia intraepitelial cervical grau 2/3 (NIC2/3).MÉTODOS: Estudo transversal, realizado no período de dezembro de 2008 a junho de 2009, no Estado de Pernambuco, nordeste do Brasil. Foram incluídas no estudo apenas mulheres com diagnóstico de NIC2/3 confirmado por biópsia e excluídas aquelas que não realizaram exame na primeira visita. As amostras para identificação do DNA de HPV anal por PCR e citologia anal foram coletadas com escovinha endocervical. A biópsia anal foi realizada nos casos de citologia anal anormal ou alterações maiores na anuscopia de alta resolução (AAR).RESULTADOS: Das AARs, 32,1% (n=37/115) foram normais e 63,5% (n=73/115) exibiram epitélio acetobranco. Vinte e dois por cento das citologias anais (n=26/115) foram anormais. Dentre elas, 12,2% (14/26) corresponderam à lesão intraepitelial anal de baixo grau e 3,4% (n=4/26), a lesão intraepitelial anal de alto grau. Foram realizadas 22 biópsias, das quais 13,7% (n=3/22) tiveram diagnóstico de neoplasia intraepitelial anal (NIA2) e 9% (n=2/22), NIA 3. Identificou-se 72,1% (n=83/115) de DNA do HPV nas amostras.CONCLUSÃO: Mulheres com NIC2/3 apresentam elevada prevalência de infecção por HPV e lesão HPV induzida em canal anal.


PURPOSE: To determine the prevalence of HPV-induced lesions in the anal canal of women with cervical intraepithelial neoplasia (CIN) grade 2/3.METHODS: A cross-sectional study was carried out from December 2008 to June 2009, in Pernambuco, northeastern Brazil. Only women with grade 2/3 CIN were included, and those who could not undergo anoscopy during their first visit were excluded. A cyttobrush was used for sample collection in order to identify HPV DNA through PCR and anal cytology. An anal biopsy was obtained in cases of abnormal anal cytology or major alterations in high resolution anoscopy (HRA).RESULTS: Thirty-two percent (n=37/115) of HRA were normal and 63.5% (n=73/115) showed acetowhite epithelium. Twenty-two percent (n=26/115) of anal cytologies were abnormal. Among the latter, 12.2% (n=14/26) were low-grade anal intraepithelial lesions and 3.4% (n=4/26) were high-grade anal intraepithelial lesions. Twenty-two anal biopsies were performed, 13.7% of which (n=3/22) were grade 2 anal intraepithelial neoplasia (AIN2) and 9% (n=2/22) were grade 3 AIN. Th HPV DNA was identified in 72.1% of cases (n=83/115).CONCLUSION: Women with CIN grade 2/3 showed a high prevalence of anal HPV infection and HPV-induced lesions.


Subject(s)
Humans , Female , Adolescent , Adult , Young Adult , Anus Diseases/complications , Anus Diseases/epidemiology , Cervical Intraepithelial Neoplasia/complications , Papillomavirus Infections/complications , Papillomavirus Infections/epidemiology , Uterine Cervical Neoplasms/complications , Anal Canal , Anus Diseases/virology , Brazil , Cross-Sectional Studies , Prevalence
17.
Rev. centroam. obstet. ginecol ; 20(4): 87-94, oct.-dic. 2015. ilus
Article in Spanish | LILACS | ID: biblio-835850

ABSTRACT

El Cáncer del Cuello Uterino, Ca-CU, es la principal causa de muerte en mujeres de 30 a 54 años de edad en países pobres. Se presenta una serie de imágenes de lesiones de Virus de Papiloma Humano, VPH,de alto y bajo riesgo para ilustrar a los lectores acerca de las mismas. Que han sido coleccionadas durante 45 años de ejercicio profesional en el Hospital Roosevelt de Guatemala.


The cervical cancer, Ca-CU, is the main cause of death in women of 30-54 years of age in poors countries. A serial collection of haig and low risk of Human Papillomavirus, HPV for reader´s ilustration. is present and colectionated for 45 years in the Rooservelt Hospital experience. The resposability of the state of Guatemala is evidenced in the combat to this cancer.


Subject(s)
Humans , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/prevention & control , /pathogenicity
18.
Rev. obstet. ginecol. Venezuela ; 74(3): 193-202, sep. 2014. tab
Article in Spanish | LILACS | ID: lil-740393

ABSTRACT

Objetivo: Evaluar las lesiones intraepiteliales cervicales en pacientes adolescentes que acuden a la consulta del Servicio de Ginecología de la Maternidad “Concepción Palacios”. Métodos: Estudio prospectivo, descriptivo, transversal. Se incluyeron 76 pacientes adolescentes en edades comprendidas entre los 10 y 19 años que hubiesen iniciado relaciones sexuales, con hallazgos citológicos y/o histológicos de patología cervical, a las cuales se les tomó muestra para determinar ácido desoxirribonucleico de virus de papiloma humano por reacción en cadena de polimerasa, se realizó colposcopia y de presentar cambios, se tomó biopsia. Se registraron factores de riesgo a partir de la historia clínica. Resultados: La edad promedio fue 17 ± 1 años, el inicio de las relaciones sexuales fue 15 ± 1 años, el número de parejas sexuales tuvo una mediana de 2. En 41 pacientes se encontró un solo tipo viral (53,9 %), el más frecuente fue el tipo 6 (43,1 %). El hallazgo citológico más frecuente fue lesión intraepitelial cervical de bajo grado con 52 pacientes. El epitelio acetoblanco plano se presentó en 32 pacientes, en 57 casos (75 %) las lesiones fueron exocervicales. El diagnóstico histológico más frecuente fue neoplasia intraepitelial 1 (77,6 %). Conclusiones: El tipo viral más frecuente fue el tipo 6, el alcohol fue el factor de riesgo con importancia estadística.


Objective: To evaluate cervical intraepithelial lesions in adolescent patients attending the Gynecology Service Consultation to the Concepción Palacios Maternity Hospital. Methods: Prospective, descriptive, transversal. 76 patients were included, adolescents aged between 10 and 19 who had initiated sex with cytologic findings and/or histological cervical pathology, to which sample was taken to determine deoxyribonucleic acid from human papilloma virus by reaction polymerase chain. We practice colposcopy and biopsy was taken, when it was necessary. The risk factors were registration for the medical history. Results: The mean age was 17 ± 1 years, the onset of sexual intercourse was 15 ± 1 years, the number of sexual partners had a median of 2. In 41 patients there was a single viral type (53.9 %), the most frequent was type 6 (43.1 %). The most common cytologic finding was cervical intraepithelial lesion low grade with 52 patients. Flat acetowhite epithelium occurred in 32 patients, 57 cases (75 %) were ectocervical lesions. The most frequent histological diagnosis was intraepithelial neoplasia I (77.6 %). Conclusions: The most frequent viral type was type 6, the alcohol was the risk factor with statistical significance.


Subject(s)
Humans , Female , Child , Adolescent , Young Adult , DNA , Cervical Intraepithelial Neoplasia/complications , Uterine Cervical Neoplasms/complications , Polymerase Chain Reaction , Papillomaviridae/pathogenicity , Reproductive Health , Sexually Transmitted Diseases , Cross-Sectional Studies , Epidemiology, Descriptive , Pathology , Prospective Studies , Risk Factors
19.
West Indian med. j ; 62(4): 313-317, 2013. graf, tab
Article in English | LILACS | ID: biblio-1045650

ABSTRACT

OBJECTIVE: To determine the rate of recurrence of cervical intraepithelial neoplasia (CIN) in HIVpositive women evaluated at the University H ospital of the West Indies (UHWI). METHOD: A chart review of all non-pregnant HIV-positive women who attended the gynaecologic and colposcopic clinics between January 1994 and December 2004 identified 21 such women. Fifteen of these patients who had CIN and had at least one follow-up Pap smear were the main subjects of this study. These patients were compared to 21 HIV-negative controls who were seen during the same period and who also had at least one follow-up Pap smear. Treatment modalities for the groups included cold coagulation and large loop excision of the transformation zone (LLETZ). Cox proportional hazards analysis was used to determine the effect of HIV status on the time to first recurrence of CIN. RESULTS: The mean ages of the subjects were 32.7 ± 8.0 and 33.2 ± 8.1 years, respectively. With a mean follow-up period of 1.7 years, the rate of recurrence of CIN in patients with and without HIV was 66.24 (95% CI 27.6, 159.1) and 3.0 (95% CI 1.3, 7.3) per 100 person years. The hazards rate ratio for recurrence in subjects with HIV after adjusting for age and CIN stage was 19.1 (95% CI 4.4, 82.1). CONCLUSION: HIV increases the risk of recurrence of CIN.


OBJETIVO: Determinar la tasa de recurrencia de la neoplasia intraepitelial cervical (NIC) en las mujeres VIH-positivas evaluadas en el Hospital Universitario de West Indies (HUWI). MÉTODO: Una revisión de las historias clínicas de todas las mujeres VIH-positivas no embarazadas que asistieron a la clínica ginecológica y la clínica colposcópica entre enero de 1994 y diciembre de 2004, identificó 21 de estas mujeres. Quince de estas pacientes que tenían NIC y habían tenido al menos una prueba de Papanicolaou de seguimiento, fueron los sujetos principales de este estudio. Estas pacientes fueron comparadas con 21 controles de VIH-negativos que fueron vistos durante el mismo período y que también tuvieron al menos una prueba de Papanicolaou de seguimiento. Las modalidades de tratamiento para los grupos incluyeron coagulación fría y escisión con asa grande de la zona de transformación (LLETZ). El modelo de análisis de riesgos proporcionales de Cox fue utilizado para determinar el efecto del estatus de VIH al momento de la primera recurrencia de CIN. RESULTADOS: Las edades promedios de los sujetos fueron 32.7 ± 8.0 y 33.2 ± 8.1 años, respectivamente. Con un período de seguimiento promedio de 1.7 años, la tasa de recurrencia de NIC en pacientes con y sin VIH fue 66.24 (95% IC 27.6, 159.1) y 3.0 (95% IC 1.3, 7.3) por 100 persona/años. El cociente de tasas de riesgo de recurrencia en pacientes con VIH después de ajustar por edad y etapa de CIN fue 19.1 (95% IC 4.4, 82.1). CONCLUSIÓN: El VIH aumenta el riesgo de recurrencia de la NIC.


Subject(s)
Humans , Female , Adult , Young Adult , HIV Infections/complications , Uterine Cervical Neoplasms/therapy , Cervical Intraepithelial Neoplasia/therapy , Neoplasm Recurrence, Local , Time Factors , Vaginal Smears , Case-Control Studies , Proportional Hazards Models , Uterine Cervical Neoplasms/complications , Cohort Studies , Treatment Outcome , Cervical Intraepithelial Neoplasia/complications , Colposcopy , Ablation Techniques , Papanicolaou Test , Hospitals, University , Jamaica
20.
Rev. méd. Chile ; 140(12): 1580-1584, dic. 2012. ilus
Article in Spanish | LILACS | ID: lil-674030

ABSTRACT

Nephrotic syndrome secondary to paraneoplastic glomerulopathies is exceptional. We are aware of only three cases reported of cervical carcinomas associated with nephrotic syndrome. Two women, aged 40 and 79 years, presented with nephrotic syndrome. The first had a membranous nephropathy and the second was not biopsied. The first women had a metrorrhagia after 8 months of unsuccessful therapy with corticosteroids and immunosuppressive drugs. An advanced cervical carcinoma with lymph node metastases was found. In the second patient, a cervical carcinoma and hematometra was discovered two months after diagnosis ofa nephrotic syndrome. The syndrome subsided completely, nine months after radiotherapy and chemotherapy in the first patient and 10 months after hysterectomy in the second patient.


Subject(s)
Adult , Aged , Female , Humans , Carcinoma/therapy , Nephrotic Syndrome/therapy , Uterine Cervical Neoplasms/therapy , Carcinoma/complications , Glomerulonephritis, Membranous/etiology , Nephrotic Syndrome/etiology , Paraneoplastic Syndromes/etiology , Remission Induction/methods , Uterine Cervical Neoplasms/complications
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