Dehydropregnenolon acetat synthesized from 3 beta-acetoxy-pregn-5-en-17 beta-OL-20-YN

Researching synthetic method of Dehydropregnenolon acetat (DPA, 3β-acetoxy-pregn-5, 16-dien-20-on) from 3β- acetoxy-pregn-5-en 17β-ol-20-yn, a conclusion is given that using this method dicobalt hexacarbonyl was created in the first time in group acethylen, 3β- acetoxy-pregn-5-en 17β-ol-20-yn is synthesized with good output from equivalent 17β- hydroxy derivative. Respond not attach generates auxiliary products like known methods. Through two methods hydrating and hydrating in gentle conditions, dehydro pregnenolon acetat is synthesized with quite good output from 3β- acetoxy-pregn-5-en 17β-ol-20-yn. Intermediary compounds and final products characterized by melt point, infared spectrum, proton magnetic spectrum and weight spectrum

Study on synthesis on 7anpha-pregn-11beta, 17beta-diol-4-en-3-on-20-yne from 11beta-hydroxy-androstendion-3,17

From androst- 4,9(11)-dien-3,17-dion the synthesis of ethynylsteroid 17 alpha-pregn-11beta, 17-beta-diol-4-en-3-on20-yn was performed with a productivity of 68%. The 17 alpha-ethynylzition gave a productivity of 90%. The by product is 4% of 17 beta- ethynylization product. The product was identified by melting point, IR spectrum, proton magnetic resonance spectrum and mass spectrum