Assessment of the therapeutic efficacy of praziquantel on the colonic lesion in experimentally infected mice with schistosoma mansoni

Therapeutic efficacy of praziquantel on colonic schistosomiasis was assessed in this study. Sixty swiss albino mice were infected by 80-100 Schistosoma mansoni cercariae and classified into four groups these first group received a single oral dose of 6.24 mg praziquantel/mouse, the second group was treated by the same dose daily in two successive days, the third group was treated also by the same dose in three successive days and the fourth group was left untreated as a control group. It was found that the third group which was treated by the triple doses give a higher cure rate [98%] than the other two treated groups [64.7% and 82.7% respectively]. Histopathological examination of the colon showed no definite pathological changes in the third group in comparison with the other groups. These data indicate that treatment by the triple doses of praziquantel on three successive days gives a high cure rate of the patients with less side effects

Effect of schistosoma mansoni infection on kidney sodium potassium adenosine triphosphatase activity in experimental

Schistosoma mansoni is a common parasite in Egypt. Disturbance in renal function is a striking complication of bilharzial infection. ATPase enzyme is considered to be responsible for the generation of energy supply for the extrusion of Na[+] exchange for K[+] and maintence of water and electrolyte balance. In this study Na [+] K[+] ATPase activities have been assayed in kindeys of healthy and Schistosoma mansoni - infected mice before and after treatment with praziquantel. Schistosoma mansoni infection caused significant decrease of the kidney Na[+] - K[+] ATPase activities which were reversed by treatment of mice with praziquantel [200 mg/kg B. Wt. for three doses in 24 hours]. Possible explanations of these findings are clarified