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1.
Chinese Traditional and Herbal Drugs ; (24): 1992-1997, 2019.
Artículo en Chino | WPRIM | ID: wpr-851211

RESUMEN

After processing, the tuber of Typhonium giganteum was used as Typhonii Rhizoma in Chinese materia medica. It has effects such as dispelling wind phlegm, detoxifying, removing stasis, and relieving pain. However, due to its toxicity, it needs to be processed before using. In this paper, the toxicity, processing technology, changes of components and efficacy before and after processing, and pharmacological effects are analyzed and summarized, which will provide reference for further study of T. giganteum.

2.
Journal of Zhejiang University. Science. B ; (12): 701-706, 2008.
Artículo en Inglés | WPRIM | ID: wpr-359382

RESUMEN

<p><b>OBJECTIVE</b>To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis.</p><p><b>METHODS</b>NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry.</p><p><b>RESULTS</b>NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells.</p><p><b>CONCLUSION</b>NAT can inhibit apoptosis in HepG2 cells.</p>


Asunto(s)
Humanos , Apoptosis , Arilamina N-Acetiltransferasa , Metabolismo , Camptotecina , Células Cultivadas , Relación Dosis-Respuesta a Droga , Hepatocitos , Biología Celular
3.
China Journal of Chinese Materia Medica ; (24): 690-693, 2005.
Artículo en Chino | WPRIM | ID: wpr-358094

RESUMEN

<p><b>OBJECTIVE</b>To study the effects of two kinds of cactus polysaccharide on erythrocyte immune function in S180 mice.</p><p><b>METHOD</b>Classical pharmaceutical method and test kit.</p><p><b>RESULT</b>The cactus polysaccharide increased the content of RBC-CaR, RFER, decreased the content of RFIR, raised the content of sialic acid. And the effect of median dose group of medical cactus polysaccharide and high dose group of edible cactus polysaccharide is very remarkable (P < 0.01) compared with model group.</p><p><b>CONCLUSION</b>The cactus polysaccharide improved the erythrocyte function of tumor-mice, which may be one of anti-tumor mechanisms.</p>


Asunto(s)
Animales , Masculino , Ratones , Antineoplásicos Fitogénicos , Farmacología , Cactaceae , Química , Relación Dosis-Respuesta a Droga , Eritrocitos , Alergia e Inmunología , Metabolismo , Ácido N-Acetilneuramínico , Sangre , Trasplante de Neoplasias , Opuntia , Química , Plantas Comestibles , Plantas Medicinales , Química , Polisacáridos , Farmacología , Distribución Aleatoria , Receptores de Complemento 3b , Metabolismo , Formación de Roseta , Sarcoma 180 , Metabolismo , Patología
4.
China Journal of Chinese Materia Medica ; (24): 245-247, 2004.
Artículo en Chino | WPRIM | ID: wpr-256379

RESUMEN

<p><b>OBJECTIVE</b>To study mechanism of antitumor activity of Sargassum Fusiforme Polysaccharide (SFPS).</p><p><b>METHOD</b>The effect on cell cycle and apoptosis was studied with flow cytometry (FCM). Intracellular calcium concentration [Ca2+]i was marked with Fluo-3/AM and measured with laser scanner confocal microscope (LSCM).</p><p><b>RESULT</b>SFPS inhibited G0/G1 stage SGC-7901 from entering to S stage and increased APO%. The [Ca2+]i showed a transient rise and return to the original level. The concentration could be raised again by administering CaCl2.</p><p><b>CONCLUSION</b>The antitumor effect of SFPS seems to be accomplished through the apoptosis associated with the increase in intracellular calcium concentration. Intracellular stores release the calcium during its action.</p>


Asunto(s)
Humanos , Antineoplásicos , Farmacología , Apoptosis , Calcio , Metabolismo , Cloruro de Calcio , Farmacología , Ciclo Celular , Polisacáridos , Farmacología , Sargassum , Química , Neoplasias Gástricas , Metabolismo , Patología , Células Tumorales Cultivadas
5.
China Journal of Chinese Materia Medica ; (24): 967-970, 2004.
Artículo en Chino | WPRIM | ID: wpr-293660

RESUMEN

<p><b>OBJECTIVE</b>To study the effects of two kinds of cactus polysaccharide on Band 3 protein, cross-linking protein and lipid fluidity of erythrocyte membrane in S180 mice.</p><p><b>METHOD</b>The membrane protein content was analysed by SDS-PAGE. Lipid fluidity was measured by Skinitzky method.</p><p><b>RESULT</b>The two kinds of cactus polysaccharide increased the content of Band 3 protein and decreased the content of cross-linking protein, raised the lipid fluidity. While the effect of median dose group of medical cactus polysaccharide is very remarkable (P < 0.01), the effect of high dose group of edible cactus polysaccharide is very remarkable (P < 0.01).</p><p><b>CONCLUSION</b>By improving the erythrocyte membrane function of tumor-mice, they enhanced the immune function, which may be one of anti-tumor mechanisms.</p>


Asunto(s)
Animales , Masculino , Ratones , Proteína 1 de Intercambio de Anión de Eritrocito , Metabolismo , Antineoplásicos Fitogénicos , Farmacología , Relación Dosis-Respuesta a Droga , Membrana Eritrocítica , Metabolismo , Fisiología , Fluidez de la Membrana , Opuntia , Química , Plantas Medicinales , Química , Polisacáridos , Farmacología , Sarcoma 180 , Metabolismo
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