RESUMEN
Objective To evaluate renal vascular damage (RVLs) and detect the expression of miR-145 in children with lupus nephritis (LN).Methods Clinical data of 41 cases of LN diagnosed by renal biopsy from the children with systemic lupus erythematosus (SLE) were collected. Glomerular damage score and RVLs were evaluated. The children were divided into groups according to RVLs score and pathological pattern. In situ hybridization was performed to detect the expression of miR-145 in kidney blood vessel. Differences in RVLs, miR-145 expression in the renal blood vessels and glomerular damage score were observed among the groups with different renal pathological pattern. Differences in clinical parameters, glomerular damage score and miR-145 expression in the renal blood vessels were investigated among groups with different RVLs. Results Among the groups with different pathological pattern, there was no difference in RVLs (P>?0.05) while signiifcant different were found in the expression of miR-145 and glomerular damage score (P??0.05) while a statistical different was found in the expression of miR-145 (P?
RESUMEN
In recent years,miR-145 is frequently reported as a key regulator of the phenotypic switch in vascular smooth muscle cells(VSMC),while the switch is the common pathological progress in many kinds of vascular diseases.Kidney is rich of vessels,and the regular function of its vessels has significance in the integral function of kidney.But,there is no article discussing about the relationship between miR-145 and kidney until now.This paper mainly discusses the possible mechanism of miR-145 in VSMC and present feasible experimental methods in a bid to provide a new perspective on kidney and related matters.
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Most chronic kidney diseases are complicated by tubulointerstitial inflammation and fibrosis,leading to progressive deterioration of renal function,and potentially ultimately resulting in irreversible end-stage kidney.And the advanced tubulointerstitial damage is often associated with the lose of peritubular capillaries.With the close relationship of the lose of peritubular capillaries and the progress of chronic kidney diseases,this review reprents the relationship of endothelium and the progress of chronic kidney diseases through three levels including endothelial injury,repairment,and relative intervention,in order to aid in the recognition,intervention and therapy of chronic kidney diseases.
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A survey was conducted to investigate the situation of English works reading activities among medical students and their attitude to the medical contents in English works.The result showed that medical students support the setting-up of literature and medicine course and it was believed that medicine in literature would be helpful to improve the quality of medical humanity education.