Novel indium-111 labeled gastrin peptide analogues [MG-CL1-4]: synthesis and quality control

Radiolabeled neuropeptides are widely investigated to diagnose and therapy of tumors. These peptides get internalization after binding with particular receptors at the surface of cells and finally move to lysosome. Internalization into tumor cells helps in mapping the infected site. Minigastrin peptide analogues [MG-CL1-4] were synthesised and labeled with 111-In radioisotope under different sets of conditions for imaging CCk-2 receptor bearing tumors. Different parameters such as temperature [80-100[degree]C], pH [4-12], incubation time [5-30 minutes] and dilution effect were investigated to get the maximum labeling yield and stability. The results indicated that MG-CL1-4 is successfully labeled with indium-111 at pH 4.5 with heating at 98[degree]C for 15 minute. At these conditions i.e. heating, pH and incubation minimum oxidized and maximum labeling yield, more than 94 %, was obtained. The labeling stability was studied by incubating the radiolabeled complex for predefined time points in PBSA and blood serum. Results show that more than 90% radiolabeled MG-CL1-4 remained intact

Critical care at PNS shifa - a statistical review for the year 1999

Various systems of patient sorting are operational around the globe in different way in order to prioritize the patient care. In Pak Armed Forces patients are placed on VSIL/SIL according to severity of their condition so that critical care can be offered to them on priority basis. Analysis of hospital statistics of PNS Shifa has revealed that major causes for admission to critical care centres are almost universal with minor variations. This study has also highlighted the significance of hospital statistics

Evaluation of family welfare services of Pakistan navy - preliminary report - 1998

Population of Pakistan is growing at a very fast rate and we have doubled our population twice since independence. This tends to neutralize the socio-economic gains made in various sectors. Population welfare Programme of the country is trying hard to contain the population but have not been able to achieve the desired goals. The family welfare services of Pakistan Navy are providing coverage to its dependent population. An evaluation study comprising 6000 clients has been undertaken. Initial findings have shown some very encouraging results. It has been found that demographic indicators of our dependent population are far better than the national statistics. This can be attributed to a very well organised family welfare service in Pak Navy besides other factors