Iatrogenic Horner’s Syndrome Associated with Branchial Cleft Cyst Surgery.

Aim: To report a case of right-sided iatrogenic Horner's syndrome developed after branchial cleft cyst surgery. Presentation of the Scope: An 8 year-old boy presented with right-sided eyelid ptosis and enophthalmos, and diagnosed as having Horner’s syndrome. Discussion: Ophthalmic examination yielded miosis in the affected eye. Medical history revealed branchial cleft cyst surgery 4 years ago and mild ptosis was identified in the first postoperative day. Conclusion: Iatrogenic Horner syndrome may follow the cleft cyst surgery in on neck.

Sinusitis bacteriana simulando cefalea trigémino autonómica: discusión de caso / Bacterial sinusitis mimicking trigeminal autonomic cephalalgia: case discussion

De acuerdo a las recomendaciones de la IHS (Clasificación internacional de cefaleas) es mandatorio descartar origen sintomático en el estudio de las cefaleas trigémino autonómicas. Aunque este grupo no es frecuente, el no tratamiento puede representar una causa de muerte o convertirse en una razón de dolor de cabeza intratable. Discutimos en este artículo una paciente quien asiste al servicio de urgencias por un tipo de cefalea que inicialmente fue interpretada como cefalea primaria (Cefalea en salvas). Debido a la pobre respuesta al tratamiento instaurado, sumado a la ausencia de criterios diagnósticos de la clasificación internacional de cefaleas (IHS) se realizó un estudio diagnóstico más amplio encontrándose como diagnóstico final sinusitis bacteriana en las imágenes de resonancia magnética.

According to IHS (International Headache Association) recommendations, it is mandatory to rule out symptomatic origin in the work up of trigeminal autonomic cephalalgias. Although this group is uncommon, if untreated, it could represent a life threatening event or become a cause of intractable headache. We discuss a patient who was admitted to the emergency service suffering from a kind of headache that initially was diagnosed as a primary headache (Cluster headache). Taking into account the poor response with medications and the absence of full International headache criteria (IHS) was necessary to practice a broader work up finding a bacterial sinusitis in the magnetic resonance images.

Cefaleas primarias revisión de criterios diagnósticos y abordajes terapéuticos / Primary cephaleas: a revision of its diagnosis and therapeutic approach

Esta revisión aborda las cefaleas primarias, su diagnóstico y tratamiento. Para la IHS son: migraña, cefalea tensional, cluster y otros. Migraña: La segunda en prevalencia y la de mayor morbilidad, el aura diferencia la migraña con aura (Mca) de la sin aura (Msa). Epidemiología: prevalencia 10% con una relación 3: 1 mujer-hombre. Fisiopatología: es un trastorno nociceptivo central primario, con compromiso secundario vascular. Tratamiento: específico y no específico, tanto de las crisis como preventivo. Trastornos psiquiátricos y migraña: existe evidencia de correlación clínico patológica y farmacológica mayormente entre Mca y diversas patologías psiquiátricas. Migraña en el niño: se presenta con diferencias clínicas responde a otra farmacoterapia y es de gran importancia el enfoque familiar. Migraña y hormonas: el principal factor hormonal relacionado a la migraña es la caída hormonal. Migraña y epilepsia: comparte la hiperexcitabilidad cerebral y medicación. Migraña y enfermedad cerebrovascular: factores vasculares e isquémicos comunes. Medicina basada en la evidencia: supone un importante avance en la medición de la efectividad de los tratamientos. Cefalea tensional: la más frecuente de todas las cefaleas, subdiagnosticada. Diferencias entre episódica y crónica. Epidemiología: leve preponderancia femenina. Fisiopatología y factores influyentes: destaca el rol del sistema nociceptivo, el sedentarismo, el estrés y la tensión muscular. Tratamiento: farmacológico y no farmacológico. Cefalea en racimo: de menor prevalencia pero con clínica frondosa, muy invalidante pero con tratamiento efectivo. Otras cefaleas primarias: es importante desensibilizar de los factores desencadenantes. Conclusión: rescatamos conceptos sobre la tarea del médico de aliviar el sufrimiento del paciente, a través de un diagnóstico y un tratamiento adecuados.

This review focuses on primary headaches, its diagnosis and treatment. For the IHS specialists they are: migraine, tension-type headache (TTH), cluster and others. Migraine: the second in prevalence and the first in morbility, clinical features and differences between migraine with (Ma) and without aura (Mo). Epidemiology: 10% prevalence and 3: 1 women to men proportion. Patophysiology: primary central nociception disorder with secondary vascular involvement. Treatment: specific and non-specific, acute and preventive. Psychiatric disorders and migraine: there is evidence of clinical and pharmacologicallinks, mainly between Ma and several psychiatric disorders. Migraine in children’s: important clinical and therapeutic differences from adult, importance of family approach. Migraine and hormones: the importance of estrogens drops, as trigger factor, treatment. Migraine and epilepsy: both shares neuronal hyperexcitability pattern. Migraine and stroke: vascular and ischemic factors involved. Evidence-based medicine: improves treatment's results and studies outcome evaluation. TTH: first in prevalence, still highly sub diagnosed. Main clinical presentations: episodic and chronic. Epidemiology: slight female preponderance. Patophysiology and trigger factors: the role of limbic nociceptive system, sedentarism stress and muscular tension. Treatment: pharmacological and non-pharmacological. Cluster headache: low prevalence but high daily-living activities impact, effective treatment. Other primary headaches: variability of trigger factors and role of desensitization process. Conclusion: we remark the complexity of headache and the of physicians' role: to relief patients suffering, throughout a precise diagnosis and treatment.

Alterations of HLA class I and II antigen expression in preinvasive, invasive and metastatic cervical cancers

HLA expression is altered in a large variety of human cancers. We performed immunohistochemical staining on tissues from normal, preinvasive, invasive and metastatic cervical cancer tissues using anti-HLA class I or class II antibody. In tissues from normal squamous epithelium, carcinoma in situ (CIS) and microinvasive carcinoma (MIC), the expressions of HLA-B, C heavy chains and class II heavy chain were significantly decreased as disease progressed. When the expression patterns were compared between primary and metastatic squamous cell carcinoma (SCC) lesions, statistically significant down-regulation of HLA class I and class II antigen in metastatic lesions was observed. The rates of HLA-B, C heavy chains and class II heavy chain expressions were all significantly down-regulated compared to the down-regulation rate of class I beta2-microglobulin (beta2m) in invasive squamous lesions, and the expressions of class II heavy chain in metastatic lesions was decreased further than that in primary lesions. Unlike SCC, the degree of HLA class I and class II loss was not evident as disease progressed in early stage of adenocarcinoma. In invasive adenocarcinoma lesions, only the expression of HLA-B, C heavy chains was decreased and no differences were seen in HLA-B, C heavy chain expression patterns between primary and metastatic lesions. These results suggest that alterations of HLA class I and II expressions seem to occur at a particular step in cervical cancer development and depend on tissue types: when the tumor becomes invasive and starts to metastasize.

Clinical Significance of Intrahepatic Biliary Stricture: The Impact on Efficacy of Hepatic Resection in Intrahepatic Stones

BACKGROUND: In the Far East, it is well known that hepatic resection is a best form of treatment for complicated intrahepatic stones (IHS). However, many investigators have reported that the associated intrahepatic biliary stricture is the main cause of treatment failure, requiring additional management because of recurrent cholangitis. PURPOSE: A retrospective comparative study was undertaken to clarify the long term efficacy of hepatic resection in IHS and to investigate the clinical significance of intrahepatic biliary stricture affected on treatment failure after hepatic resection. Patient and METHOD: The clinical records of 44 among 51 consecutive patients with symptomatic IHS who underwent hepatic segmentectomy or lobectomy between July 1986 and October 1996 were reviewed. We excluded 7 patients from study group because of postoperative death or incomplete follow- up. Patients were divided into two study groups: group A with intrahepatic biliary stricture (n=28) and group B without stricture (n=16). Residual or recurrent stones, recurrence of intrahepatic biliary stricture, late cholangitis, and final outcomes were analyzed and compared statistically between group A and B. Patients were followed up for a median duration of 65 months after hepatectomy. RESULTS: The overall incidence of residual or recurrent stones were 36% and 11%, respectively. The initial treatment failure rate was 50% in group A and 31% in group B. Intrahepatic biliary stricture was recurred in 46% of group A, but in none of group B (P=0.001). More than two thirds of restrictures were identified on the primary site. The incidence of late cholangitis was higher in group A (54%) than in group B (6%)(p=0.002). The late cholangitis was severe, recurrent and related to stones and strictures in 11 of the 15patients in group A. Twelve patients (ten in group A and two in group B) needed additional secondary multiple procedures at a median of 12 months after hepatectomy. These consisted of percutaneous fluoroscopic stone retrieval (n=6), postoperative cholangioscopy (POC) or percutaneous transhepatic cholangioscopy (PTCS) with electrohydraulic lithotripsy (EHL)(n=3), balloon dilatation (n=7)choledochotomy (n=3), S4 segmentectomy (n=1), Sphincteroplasty (n=1), drainage of the delayed subphrenic or liver abscess (n=2), and repair of prolonged biliary fistula (n=1). The final outcomes after hepatectomy with or without secondary management were good in 80%, fair in 16%, and poor in 4% of the cases. CONCLUSION: The majority of the recurrent cholangitis after hepatectomy in IHS were related to recurrent intrahepatic ductal strictures. Therefore, hepatic resection should be included the strictured duct. However, with hepatectomy alone, it is difficult to clean the IHS and relieve the ductal strictures completely, particularly in cases of bilateral IHS, so a perioperative team approaches, including both radiologic and cholangioscopic interventions, should be used for effective management of IHS.