RESUMEN
Rhemannie Radix Preparata (RRP) has been previously employed in traditional oriental medicine as a treatment for diabetic thirst and improving blood flow. The aim of this study was to evaluate its hypoglycemic control by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-(STZ)-induced diabetic rats. Further, RRP extracts were prepared in water (RRPW), in 50% ethanol (RRP50), and in 100% ethanol (RRP100), respectively, and compared for their actions in diabetic rats. The oral treatment of RRP (5 mg/kg b.w./d) to diabetic rats for 21 days resulted in a significant decline in blood glucose by 67% compared to diabetic control rats (P < 0.05). The altered activities of glucokinase, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and acetyl CoA carboxylase (ACC) in the livers of diabetic rats were reversed significantly to near-normal levels by the administration of RRP (P < 0.05). Among the three RRP extracts, RRP100 was the most effective in terms of hypoglycemic action. However, the administration of RRP to diabetic rats did not improve insulin production. The modulatory effects of RRP100 on the attenuation of carbohydrate enzyme activities appear to hold promise for widespread use for the treatment of diabetes in the future.
Asunto(s)
Animales , Ratas , Acetil-CoA Carboxilasa , Glucemia , Metabolismo de los Hidratos de Carbono , Etanol , Glucoquinasa , Gluconatos , Glucosafosfato Deshidrogenasa , Hipoglucemiantes , Insulina , Hígado , Medicina Tradicional de Asia Oriental , Fosfogluconato Deshidrogenasa , Sed , AguaRESUMEN
AIM: To observe the therapeutic effect of glucomanan on diabetic mice. METHODS: The diabetic mice induced by alloxan model was established. The mices were randomly divided into the control and treated group to test level of blood glucose respectively. RESULTS: At doses of 100, 200 mg·kg-1 ig 1 and 4 h ahead of time, Glucomanan markedly reduced blood glucose level; At doses of 100, 200 mg·kg-1 ig, it markedly reduced blood glucose level of diabetic mice induced by alloxan; Useing glucomanan 100 mg·kg-1 ig bid x 3 d constantly reduced amount of water-drinking. CONCLUSION: Glucomanan may have significant effect on diabetic mice induced by alloxan.
RESUMEN
Kangjixiaoke Granules was composed Red Radix Ginseng,Rhizoma Coptidis,Radix Rehmannia and Rhizoma Polygonati Odorati.The experimental result showed that it pos- sessed obvious hypoglycemic action on normal mice,alloxan diabetes mice and hyper- glycemia mice induced by adrenaline.No toxic response and side-effect were observed in acute toxic test.
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AIM To observe the anti hyperglycemic effect of sodium orthovanadate on type 2 diabetes rats. METHODS Rats were fed by highly fatted food to grow into obesity. Then values of plasma free fatty acid (FFA) were tested. Glucose disposal was measured with the hyperinsulinemic euglycemic clamp technique to assess insulin resistance in vivo. Small dose of streptozocin was injected ip with insulin resistance. Those with plasma glucose over 11 1 mmol?L -1 were assigned to type 2 diabetes model group, continually fed with sodium orthovanadate for 3 days and assayed the values of plasma glucose in fasting state. RESULTS ①Rats fed with fatted food needed more insulin to maintain normal plasma glucose, ie (0 54?0 02) U?min -1 , higher than that of normal control ( P
RESUMEN
AIM To observe the therapeutic effect of glucomanan on diabetic mice. METHODS The diabetic mice induced by alloxan model was established. The mices were randomly divided into the control and treated group to test level of blood glucose respectively. RESULTS At doses of 100,200 mg?kg -1 ig 1 and 4 h ahead of time,Glucomanan markedly reduced blood glucose level;At doses of 100, 200 mg?kg -1 ig,it markedly reduced blood glucose level of diabetic mice induced by alloxan;Useing glucomanan 100 mg?kg -1 ig bid?3 d constantly reduced amount of water-drinking. CONCLUSION Glucomanan may have significant effect on diabetic mice induced by alloxan.