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1.
Neuroscience Bulletin ; (6): 1411-1425, 2023.
Artículo en Inglés | WPRIM | ID: wpr-1010621

RESUMEN

L-dopa (l-3,4-dihydroxyphenylalanine)-induced dyskinesia (LID) is a debilitating complication of dopamine replacement therapy for Parkinson's disease. The potential contribution of striatal D2 receptor (D2R)-positive neurons and downstream circuits in the pathophysiology of LID remains unclear. In this study, we investigated the role of striatal D2R+ neurons and downstream globus pallidus externa (GPe) neurons in a rat model of LID. Intrastriatal administration of raclopride, a D2R antagonist, significantly inhibited dyskinetic behavior, while intrastriatal administration of pramipexole, a D2-like receptor agonist, yielded aggravation of dyskinesia in LID rats. Fiber photometry revealed the overinhibition of striatal D2R+ neurons and hyperactivity of downstream GPe neurons during the dyskinetic phase of LID rats. In contrast, the striatal D2R+ neurons showed intermittent synchronized overactivity in the decay phase of dyskinesia. Consistent with the above findings, optogenetic activation of striatal D2R+ neurons or their projections in the GPe was adequate to suppress most of the dyskinetic behaviors of LID rats. Our data demonstrate that the aberrant activity of striatal D2R+ neurons and downstream GPe neurons is a decisive mechanism mediating dyskinetic symptoms in LID rats.


Asunto(s)
Ratas , Animales , Levodopa/toxicidad , Dopamina , Trastornos Parkinsonianos/tratamiento farmacológico , Oxidopamina , Discinesia Inducida por Medicamentos , Cuerpo Estriado/metabolismo , Neuronas/metabolismo , Receptores de Dopamina D2/metabolismo , Antiparkinsonianos/toxicidad
2.
Neuroscience Bulletin ; (6): 576-588, 2023.
Artículo en Inglés | WPRIM | ID: wpr-982430

RESUMEN

Autapses selectively form in specific cell types in many brain regions. Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in the striatum. However, it remains unclear whether these neurons indeed form physiologically functional autapses. We applied whole-cell recording in striatal slices and identified autaptic cells by the occurrence of prolonged asynchronous release (AR) of neurotransmitters after bursts of high-frequency action potentials (APs). Surprisingly, we found no autaptic AR in SPNs, even in the presence of Sr2+. However, robust autaptic AR was recorded in parvalbumin (PV)-expressing neurons. The autaptic responses were mediated by GABAA receptors and their strength was dependent on AP frequency and number. Further computer simulations suggest that autapses regulate spiking activity in PV cells by providing self-inhibition and thus shape network oscillations. Together, our results indicate that PV neurons, but not SPNs, form functional autapses, which may play important roles in striatal functions.


Asunto(s)
Parvalbúminas/metabolismo , Cuerpo Estriado/metabolismo , Interneuronas/fisiología , Neuronas/metabolismo , Neostriado
3.
Arch. argent. pediatr ; 113(5): e260-e263, oct. 2015. ilus, tab
Artículo en Español | LILACS | ID: lil-757066

RESUMEN

El trauma ocular pediátrico es frecuente y es la principal causa de ceguera unilateral no congénita. La información en países en vías de desarrollo es escasa. El objetivo de esta serie de casos es describir las características clínicas y epidemiológicas del trauma ocular en niños menores de 14 años que consultaron al Hospital Dr. Rodolfo Robles Val verde en la Ciudad de Guatemala durante el año 2010. Se incluyeron 119 pacientes en el estudio. El género masculino en edad escolar (7-9 años) fue el más comprometido. El trauma más común fue el de globo cerrado. Los objetos más frecuentes causantes de la lesión fueron madera, juguetes y químicos. La vivienda fue el lugar donde más ocurrió el trauma. Se intervinieron 21 pacientes. Son necesarios programas de educación y prevención.


Pediatric ocular trauma is common and the leading cause of non congenital unilateral blindness. The information in developing countries is scarce. The objective of this case series is to describe clinical and epidemiological characteristics of ocular trauma in children under 14 years of age who visited Hospital Dr. Rodolfo Robles Valverde in Guatemala City in 2010. In this study 119 patients were included. School-aged (7-9 years) male gender was the most affected. Closed globe injury was the commonest. The most frequent objects causing the lesions were: wooden objects, toys and chemicals. Trauma occurred most frequently at home. Twenty one of the patients were surgically intervened. Education and prevention programs for pediatric ocular trauma are necessary.


Asunto(s)
Animales , Femenino , Masculino , Ratones , Cuerpo Estriado/efectos de los fármacos , Neuronas Dopaminérgicas/efectos de los fármacos , Endosulfano/toxicidad , Insecticidas/toxicidad , Sustancia Negra/efectos de los fármacos , Línea Celular Tumoral , Células Cultivadas , Supervivencia Celular/efectos de los fármacos , Cuerpo Estriado/metabolismo , Neuronas Dopaminérgicas/metabolismo , Intoxicación por MPTP , Neuroblastoma , Factores Sexuales , Sustancia Negra/metabolismo
4.
Braz. j. med. biol. res ; 48(9): 798-804, Sept. 2015. ilus
Artículo en Inglés | LILACS | ID: lil-756403

RESUMEN

Stroke is the third most common cause of death worldwide, and most stroke survivors present some functional impairment. We assessed the striatal oxidative balance and motor alterations resulting from stroke in a rat model to investigate the neuroprotective role of physical exercise. Forty male Wistar rats were assigned to 4 groups: a) control, b) ischemia, c) physical exercise, and d) physical exercise and ischemia. Physical exercise was conducted using a treadmill for 8 weeks. Ischemia-reperfusion surgery involved transient bilateral occlusion of the common carotid arteries for 30 min. Neuromotor performance (open-field and rotarod performance tests) and pain sensitivity were evaluated beginning at 24 h after the surgery. Rats were euthanized and the corpora striata was removed for assay of reactive oxygen species, lipoperoxidation activity, and antioxidant markers. Ischemia-reperfusion caused changes in motor activity. The ischemia-induced alterations observed in the open-field test were fully reversed, and those observed in the rotarod test were partially reversed, by physical exercise. Pain sensitivity was similar among all groups. Levels of reactive oxygen species and lipoperoxidation increased after ischemia; physical exercise decreased reactive oxygen species levels. None of the treatments altered the levels of antioxidant markers. In summary, ischemia-reperfusion resulted in motor impairment and altered striatal oxidative balance in this animal model, but those changes were moderated by physical exercise.


Asunto(s)
Animales , Masculino , Ratas , Isquemia Encefálica/complicaciones , Cuerpo Estriado/metabolismo , Trastornos Motores/prevención & control , Estrés Oxidativo/fisiología , Condicionamiento Físico Animal/fisiología , Daño por Reperfusión/complicaciones , Isquemia Encefálica/metabolismo , Catalasa/metabolismo , Modelos Animales de Enfermedad , Glutatión/metabolismo , Peroxidación de Lípido , Trastornos Motores/etiología , Oxidación-Reducción , Dolor/fisiopatología , Ratas Wistar , Especies Reactivas de Oxígeno/análisis , Superóxido Dismutasa/metabolismo
5.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 35(3): 262-266, Jul-Sep. 2013. graf
Artículo en Inglés | LILACS | ID: lil-687934

RESUMEN

Objective: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. Method: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. Results: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. Conclusion: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug. .


Asunto(s)
Animales , Masculino , Ratas , Anestésicos Disociativos/administración & dosificación , Factor Neurotrófico Derivado del Encéfalo/metabolismo , Encéfalo/efectos de los fármacos , Ketamina/administración & dosificación , Amígdala del Cerebelo/efectos de los fármacos , Amígdala del Cerebelo/metabolismo , Encéfalo/metabolismo , Cuerpo Estriado/efectos de los fármacos , Cuerpo Estriado/metabolismo , Modelos Animales de Enfermedad , Hipocampo/efectos de los fármacos , Hipocampo/metabolismo , Actividad Motora/efectos de los fármacos , Corteza Prefrontal/efectos de los fármacos , Corteza Prefrontal/metabolismo , Ratas Wistar , Natación , Factores de Tiempo
6.
Braz. j. med. biol. res ; 40(1): 89-96, Jan. 2007. ilus, graf
Artículo en Inglés | LILACS | ID: lil-439667

RESUMEN

There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) rat models of Parkinson's disease. The bilateral infusion of MPTP (100 æg/side) or 6-OHDA (10 æg/side) into the substantia nigra pars compacta of adult male Wistar rats under thiopental anesthesia caused a modest (~67 percent) or severe (~91 percent) loss of tyrosine hydroxylase-immunostained cells, respectively. On the other hand, an apparent neuroprotective effect was observed when the rats were anesthetized with K/X, infused 5 min before surgery. This treatment caused loss of only 33 percent of the nigral tyrosine hydroxylase-immunostained cells due to the MPTP infusion and 51 percent due to the 6-OHDA infusion. This neuroprotective effect of K/X was also suggested by a less severe reduction of striatal dopamine levels in animals treated with these neurotoxins. In the working memory version of the Morris water maze task, both MPTP- and 6-OHDA-lesioned animals spent nearly 10 s longer to find the hidden platform in the groups where the neurotoxins were infused under thiopental anesthesia, compared to control animals. This amnestic effect was not observed in rats infused with the neurotoxins under K/X anesthesia. These results suggest that drugs with a pharmacological profile similar to that of K/X may be useful to delay the progression of Parkinson's disease.


Asunto(s)
Animales , Masculino , Ratas , Anestésicos Combinados/administración & dosificación , Ketamina/administración & dosificación , Fármacos Neuroprotectores/administración & dosificación , Enfermedad de Parkinson/tratamiento farmacológico , Sustancia Negra/efectos de los fármacos , Xilazina/administración & dosificación , Anestésicos Combinados/farmacología , Monoaminas Biogénicas/metabolismo , Cuerpo Estriado/metabolismo , Modelos Animales de Enfermedad , Inmunohistoquímica , Ketamina/farmacología , Aprendizaje por Laberinto/efectos de los fármacos , Aprendizaje por Laberinto/fisiología , Fármacos Neuroprotectores/farmacología , Oxidopamina , Enfermedad de Parkinson/metabolismo , Enfermedad de Parkinson/patología , Ratas Wistar , Sustancia Negra/metabolismo , Sustancia Negra/patología , Tiopental/administración & dosificación , Tiopental/farmacología , /metabolismo , Xilazina/farmacología
7.
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 107-8, 2005.
Artículo en Inglés | WPRIM | ID: wpr-634234

RESUMEN

The self-made high sensitivity and selectivity micro-biosensor was applied to monitor the change of dopamine in cerebral nucleus in rats in vivo. The micro-biosensor was prepared and used to detect dopamine level in vitro and monitor the dynamic change of dopamine in different cerebral nucleus in vivo. The results showed the lowest concentration of dopamine that could be detected by the biosensor was 32.5 nmol/L. Its positive peak was significantly different from that of AA, 5-HTP and E. The biosensor could keep working for monitoring the dopamine concentration in the cerebral tissue for more than 10 h. It was concluded that the microsensor has high sensitivity and selectivity to dopamine and can be used to dynamically monitor the change of dopamine in vivo.


Asunto(s)
Técnicas Biosensibles/instrumentación , Técnicas Biosensibles/métodos , Química Encefálica , Cuerpo Estriado/metabolismo , Dopamina/análisis , Microelectrodos , Monitoreo Fisiológico
8.
Braz. j. med. biol. res ; 37(12): 1839-1846, Dec. 2004. ilus, tab
Artículo en Inglés | LILACS | ID: lil-388052

RESUMEN

We studied the effects of ethanol on concentrations of noradrenaline (NE), dopamine (DA) and serotonin (5-HT) and their metabolites in rat hippocampus and striatum. Ethanol (2 or 4 g/kg, po, from a 20 percent aqueous solution) was administered daily to male Wistar rats (4-13 per group) for 30 days and animals were sacrificed 30 min or 48 h after the last administration. Monoamines were measured by HPLC and considered significant at P < 0.05. A 47 percent increase in 5-HT levels was observed in the hippocampus with 4 g/kg ethanol in the 30-min protocol. Ethanol (2 and 4 g/kg) decreased DA (2114.5 ± 126.4 and 1785.1 ± 234.2 ng/g wet tissue, respectively) and 3,4-dihydroxyphenylacetic acid (DOPAC, 1477.6 ± 132.1 and 1218.8 ± 271.7 ng/g wet tissue, respectively) levels, while the higher dose also decreased NE (159.8 ± 13.5), 5-HT (228.0 ± 46.8) and 5-hydroxy-3-indoleacetic acid (5-HIAA, 304.4 ± 37.2 ng/g wet tissue), in the striatum after a 48-h withdrawal as compared to controls (DA: 3063.9 ± 321.3; DOPAC: 2379.6 ± 256.0; NE: 292.8 ± 50.2; 5-HT: 412.4 ± 36.2; 5-HIAA: 703.9 ± 61.4 ng/g wet tissue). In the 30-min protocol, ethanol (2 or 4 g/kg) decreased striatal NE (66 and 70 percent) and DA (50 and 36 percent) levels. On the other hand, increases were seen in 5-HIAA (146 and 153 percent) and 5-HT (59 and 86 percent) levels. Ethanol (2 g/kg, po) increased the homovanillic acid (HVA)/DA ratio (129 percent) in the striatum in the 30-min protocol, while at the higher dose it increased the HVA/DA ratio in the 48-h protocol (61 percent). These results indicate alterations in monoamines, mainly in the striatum, after chronic ethanol, which are influenced by dose and by the length of time after the last drug administration.


Asunto(s)
Animales , Masculino , Ratas , Catecolaminas/metabolismo , Depresores del Sistema Nervioso Central/farmacología , Cuerpo Estriado/efectos de los fármacos , Etanol/farmacología , Hipocampo/efectos de los fármacos , Depresores del Sistema Nervioso Central/administración & dosificación , Cuerpo Estriado/metabolismo , Dopamina/metabolismo , Etanol/administración & dosificación , Hipocampo/metabolismo , Norepinefrina/metabolismo , Ratas Wistar , Serotonina/metabolismo , Factores de Tiempo
9.
Braz. j. med. biol. res ; 30(5): 637-40, May 1997. tab
Artículo en Inglés | LILACS | ID: lil-196676

RESUMEN

Fencamfamine (FCF) is a central stimulant that facilitates central dopaminergic transmission through inhibition of dopamine uptake and enhanced release of the transmitter. We evaluated the changes in the inhibition of uptake and the release of striatal [3H]-dopamine at 9:00 and 21:00 h, times corresponding to maximal and minimal behavioral responses to FCF, respectively. Adult male Wistar rats (200-250 g) maintained on a 12-h light/12-h dark cycle (lights on at 7:00 h) were used. In the behavioral experiments the rats (N = 8 for each group) received FCF (3.5 mg/kg, ip) or saline at 9:00 or 21:00 h. Fifteen minutes after treatment the duration of activity (sniffing, rearing and locomotion) was recorded for 120 min. The basal motor activity was higher (28.6 + 4.2 vs 8.4 + 3.5 s) after saline administration at 21:00 h than at 9:00 h. FCF at a sigle dose significantly enhanced the basal motor activity (38.3 + 4.5 vs 8.4 + 3.5 s) and increased the duration of exploratory activity (38.3 + 4.5 vs 32.1 + 4.6 s) during the light, but not the dark phase. Two other groups of rats (N = 6 for each group) were decapitated at 9:00 and 21:00 h and striata were dissected for dopamine uptake and release assays. The inhibition of uptake and release of [3H]-dopamine were higher at 9:00 than at 21:00 h, suggesting that uptake inhibition and the release properties of FCF undergo daily variation. These data suggest that the circadian time-dependent effects of FCF might be related to a higher susceptibility of dopamine presynaptic terminals to the action of FCF during the light phase which corresponds to the rats' resting period.


Asunto(s)
Ratas , Animales , Masculino , Conducta/efectos de los fármacos , Estimulantes del Sistema Nervioso Central/farmacología , Ritmo Circadiano/efectos de los fármacos , Cuerpo Estriado/metabolismo , Dopamina/biosíntesis , Dopamina/metabolismo , Norbornanos/farmacología , Ratas Wistar
10.
Medicina (B.Aires) ; 56(2): 169-72, 1996. tab, graf
Artículo en Inglés | LILACS | ID: lil-172301

RESUMEN

Neuropathological mechanisms triggered by excitatory aminoacids are Known to involve nitric oxide (NO). Neurons containing NO are histochemically reactive to nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), which labels NO synthase in CNS, Sprague-Dawley male rats subjected to perinatal asphyxia (PA) at 37 degreese Celsius, and PA plus 15 degreese Celsius hypothermia were evaluted when 6 months old by NADPH-d histochemical reaction. Computarized image analysis was used for quantification of stained sections. NADPH-d neurons in striatum from subsevere and severe PA showed a significant increment in soma size and dendritic process length versus control and hypothermic treated rats. Post-ischemic damage reurons are therefore involved in NO changes induced by PA that may be prevented by hypothermia treatment.


Asunto(s)
Animales , Masculino , Recién Nacido , Ratas , Asfixia Neonatal/metabolismo , Cuerpo Estriado/metabolismo , NADPH Deshidrogenasa/metabolismo , Neuronas/metabolismo , Óxido Nítrico/metabolismo , Análisis de Varianza , Animales Recién Nacidos , Hipotermia Inducida , Ratas Sprague-Dawley , Factores de Tiempo
11.
Rev. chil. neuro-psiquiatr ; 32(2): 213-21, abr.-jun. 1994. tab, ilus
Artículo en Español | LILACS | ID: lil-148415

RESUMEN

Este trabajo presenta la metodología experimental de un modelo de hipoxia cerebral in vitro. El modelo fue empleado para evaluar la liberación de un análogo no metabolizable de glutamato en condiciones de hipoxia, como un reflejo del estado funcional de los terminales nerviosos glutamatérgicos en condiciones de hipoxia, observándose una significativa liberación del marcador tritiado en relación a la hipoxia, lo cual concuerda con hallazgos previos tanto en animales de experimentación como en seres humanos. La metodología presentada es simple y permite manejar a voluntad del investigador una serie de parámetros relevantes desde el punto de vista fisiopatológico de la injuria neuronal por hipoxia, de un modo que es imposible de lograr en los estudios in vivo


Asunto(s)
Animales , Ratas , Ácido Glutámico/análogos & derivados , Cuerpo Estriado/metabolismo , Hipoxia Encefálica , Técnicas In Vitro , Aminoácidos Excitadores , Daño por Reperfusión Miocárdica , Perfusión , Terminales Presinápticos/fisiología
12.
Braz. j. med. biol. res ; 27(3): 737-41, Mar. 1994. graf
Artículo en Inglés | LILACS | ID: lil-148948

RESUMEN

Fencamfamine (FCF) is a psychostimulant drug classified as an indirect dopamine agonist. In the present study we evaluated the daily variation in plasma FCF concentration and in striatal dopamine receptors. Adult male Wistar rats (250-300 g) maintained on a 12-h light/12-h dark cycle (lights on at 07:00 h) were used. Rats received FCF (10.0 mg/kg, ip) at 09:00, 15:00, 21:00 or 03:00 h and blood samples were collected 30 (N = 6) or 60 (N = 6) min after the injections. Plasma FCF was measured by gas chromatography using an electron capture detector. Two-way ANOVA showed significant differences in FCF concentration when blood samples were collected 30 min after the injection, and the highest value was obtained following injection at 21:00 h. Moreover, at 15:00, 21:00 and 03:00 h, plasma FCF levels were significantly lower 60 min after injection when compared to the 30-min interval. Two other groups of rats (N = 6) were decapitated at 09:00 or 21:00 h and the striata were dissected for the binding assays. The Bmax for [3H]-spiroperidol binding to striatal membranes was higher at 21:00 h, without changes in affinity constant (Kd). In conclusion, plasma FCF levels and dopamine receptors undergo daily variation, a phenomenon that should be considered to explain the circadian time-dependent effects of FCF


Asunto(s)
Animales , Masculino , Ratas , Ritmo Circadiano , Norbornanos/sangre , Receptores Dopaminérgicos/metabolismo , Ácido Homovanílico/metabolismo , Cromatografía de Gases , Ritmo Circadiano/efectos de los fármacos , Cuerpo Estriado/efectos de los fármacos , Cuerpo Estriado/metabolismo , Inyecciones Intraperitoneales , Norbornanos/administración & dosificación , Norbornanos/farmacología , Ratas Wistar , Espiperona/metabolismo , Factores de Tiempo
13.
Braz. j. med. biol. res ; 24(6): 591-4, 1991. tab
Artículo en Inglés | LILACS | ID: lil-99494

RESUMEN

We investigated the effect of hyperprolactinemia by long-term domperidone treatment (10.0 mg/kg, single daily dose, ip) on striatal dopamine (DA) receptor sensitivity in male Wistar rats weighing 250-300 g(N=8). Domperidone treatment for days continued to produce an increased in serum concentration of prolactin (PRL) form 17.3 ñ 2.2 to 33.1 ñ 7.3 and from 16.8 ñ 2.3 to 21.9 ñ 2.1, 2 and 72 h after domperidone withdrawal, respectively. Hyperprolactinemia induced by long-term domperidone treatment did not change binding sites (B max) and dissociation constant (Kd) of [3***H]-spiroperidol binding when compared to controls. These results show that byperprolactinemia induced by long-term domperidone treatment does not effect the sensitivity of striatal DA receptors presumably because the effect of neuroleptic drugs is due to their interaction with the receptors and not to the concomitant hyperprolactinemia


Asunto(s)
Animales , Ratas , Masculino , Cuerpo Estriado/metabolismo , Domperidona , Hiperprolactinemia/metabolismo , Receptores Dopaminérgicos/metabolismo , Sitios de Unión , Hiperprolactinemia/inducido químicamente , Prolactina/sangre , Ratas Wistar
14.
Braz. j. med. biol. res ; 22(6): 741-3, June 1989. tab
Artículo en Inglés | LILACS | ID: lil-75215

RESUMEN

Dopamine (DA) receptor sensitivity was studied after long-term treatment with haloperidol (0.5 ad 3.0 mg/Kg, ip, single daily dose) or saline in hypophysectomized and infact rats. Haloperidol treatment for seven days produced a 25 to 125% increase in [3H]-spiroperidol binding to strial DA receptors in a dose-dependent fashion. The increase in binding sits (Bmax) was ximilar in both hypophysectomized and intact rats when compared to controls. The present results show that haloperidol treatment


Asunto(s)
Ratas , Animales , Masculino , Cuerpo Estriado/metabolismo , Haloperidol/farmacología , Hipofisectomía , Receptores Dopaminérgicos/metabolismo
15.
Braz. j. med. biol. res ; 21(3): 645-7, Mar. 1988. tab
Artículo en Inglés | LILACS | ID: lil-60271

RESUMEN

The effects of icv administration of ß-endorphin on secretory activity of dopaminergic neurons is described. Homovanillic and dihydroxyphenyl acetic acid levels in cerebrospinal fluid and extracts of brain tissue were determined after administration of ß-endorphin to animals pretreated or not with saloxone. The results suggest that ß-endorphin interferes with formation of dopaminergic metabolites by acting on opioid receptors


Asunto(s)
Ratas , Animales , Ácido 3,4-Dihidroxifenilacético/líquido cefalorraquídeo , betaendorfina/fisiología , Cuerpo Estriado/metabolismo , Ácido Homovanílico/líquido cefalorraquídeo , Sustancia Negra/metabolismo , Dopamina/metabolismo , Naloxona/uso terapéutico , Neuronas/fisiología
17.
Yonsei Medical Journal ; : 62-65, 1988.
Artículo en Inglés | WPRIM | ID: wpr-20076

RESUMEN

Sulpiride, a selective antagonist for adenylate cyclase-independent dopamine receptors, was administrated to 25 patients with blepharospasm and oromandibular dystonia(Meige's syndrome). Of the 25, 7 patients (28%) exhibited marked and lasting improvement with sulpiride and 12 patients (48%) showed mild or transient improvement. This favorable therapeutic response to sulpiride suggests that striatal glutamate underactivity may play a role in the pathophysiology of Meige's syndrome as a primary or secondary defect.


Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Enfermedades de los Ganglios Basales/tratamiento farmacológico , Cuerpo Estriado/metabolismo , Dopamina/metabolismo , Glutamatos/metabolismo , Ácido Glutámico , Síndrome de Meige/tratamiento farmacológico , Persona de Mediana Edad , Sulpirida/uso terapéutico
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