[ role of methyl prednisolon in facilitating and reducing the number of dilatation sessions esophageal in children with caustic burns]

To examine The benefit of high dose of high dose Methyl Prednisolon [1g/1,73m2/d] to facilitate and reduce the number of dilitation sessions in children with esophageal stenos caused by caustic burns. This Prospective study was carried out in Damascus Children hospital. 18 children with grade II and III esophageal caustic burns injuries were involved over a period of 2 years [1/6/2007-1/6/2009]. MP was given [1g/1,73m2/d] over 10 days]. These children had regular dilatation sessions once every 2-3 / weeks. This study involved 18 children with esophageal caustic injuries .The age was between [8m- 11y] and 50% were boys. Alkalines were the most cause 17[95%]. Only 2 children needed more sessions after the 2 year study, whilst in one of previous stdies [without the application of medical treatment],13 out of 26 children[50%] need dilation sessions beyond 2 year [p-value = 0,0043.]. Methyl Prednisolon has facilitated the dilatation and subsequently reduced the need for surgical intervention. [0,0146 = p-value].

benefit of high dose methyl prednisolon in the treatment of grade 2 caustic esophageal burn injuries in children

Background: To examine The benefit of high dose Methyl prednisolonM.P[1g/1, 73m2/d] in prevention of esophageal Stenosis due to grade II caustic burns. Materials and Methods: It is known that M.P has a systemic effects to reduce the esophageal inflammatory reactions after the caustic burns and subsequently prevents from the Stenosis. This Prospective study was carried out in Damascus Children hospital. 30 children with grade II esophageal caustic burns injuries were involved over a period of 2 years [1/6/2007-1/6/2009] M.Pwas given [1g/1, 73m2/d] over 10 days Then Pending on improvement with Endoscopy, the Treatment was extended to 15 or 20 days. Results: This study involved 30 children with caustic injuries. The age was between[8m-11y].. Boys were more affected as, 21[70%] were boys, 9[30%]were girls Alkalines were the most cause 19[63, 3%]. The recovery rate was 86, 6%. In One of our retrospective studies [without the application of M.P] the recovery rate was 53% [pvalue=0, 0035]. Conclusion: There was no significant complication, in this study. Key Words: burns, caustic, Methyl prednisolon, Stenosis, Endoscopy, Alkaline, esophageal inflammatory