[Coincidence of congenital infiltrative facial lipoma and lingual myxoma in a newborn Holstein calf]

A one-day-old male Holstein calf was presented with a palpable subcutaneous mass, extending from the parotid to the orbital region, involving the entire right side of the face and a large flabby mass without any evidence of inflammation or edema on the tongue. Macroscopically, the cut surface of the lingual mass appeared slightly lobulated, pink, with a mucoid appearance and gelatinous consistency. Histopathological examination confirmed the infiltrative subcutaneous lipoma and lingual myxoma

evidenced by low cellularity and abundant basophilic, mucinous stroma. In this report, clinical and detailed histhopathological findings of congenital infiltrative myxoma and its coincidence with infiltrative facial lipoma is reported in a newborn calf.

effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration

A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone [CoQ10] on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups [n=20]. Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group [P<0.05]. Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group [P<0.05] Intraperitoneal administration of CoQ10 [10 mg/kg/day] in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration

Effect of a static magnetic field on bone healing in the dog: radiographic and histopathological studies

Although the promotional effects on bone healing of pulsed electromagnetic fields [PEMF] have been well demonstrated, the effects of static magnetic fields [SMF] remained unclear. In this study, effects of a custom-made magnetic wrap on radiographic and histopathological aspects of bone healing using a canine unstable osteotomy gap model were investigated. After an osteotomy of the midshaft radius, bone healing was evaluated over an 8-week-period in the control dogs [n = 5] and dogs exposed to SMF [1000 gauss] [n = 5]. Bone healing was evaluated by qualitative and quantitative evaluation of serial radiographs every 2 weeks. Histopathological study was also performed on osteotomized radii upon completion of the experimental period. Dogs exposed to SMF had more advanced radiographic healing of osteotomy sites. Cellular morphology scores of the SMF group was significantly greater as compared with the control group [P<0.05]. These results suggested that using the osteotomy gap model, SMF enhanced the radiographic and histopathological aspects of bone healing in dogs. Dogs at risk for delayed healing of fractures may benefit from treatment with SMF

Elastic cartilage grafting in canine radial fracture

Bone has a capability to repair itself when it is fractured. Repair involves the generation of intermediate tissues, such as fibrous connective tissue, cartilage and woven bone, before final bone healing can occur. The process of cartilage-to-bone transition [CBT] is a key for the achievement of rigid bone healing during fracture repair. We tested this potential for elastic cartilage using a long bone defect model in dog. Eight sexually intact female mongrel dogs, 4.57 +/- 0.53 years old and weighing 11.48 +/- 0.63 kg, were studied. After an ostectomy of the midshaft radius, bone healing was evaluated over an 8-week period in control dogs [n = 4] and dogs in which autologous grafts of auricular cartilage were inserted into the bone defects [n = 4]. Quantitative radiographic assessment was conducted every 2 weeks. Eight weeks post-operative, qualitative histopathologic analysis was performed on the operated radii. Furthermore, histological grading was done using the Ulutas et al., scoring system. Experiment dogs had more advanced radiographic healing of ostectomy sites. The defects with elastic cartilage implants were bridged completely with new bony spicules originated from the implants. Transformation of elastic cartilage clusters to mesenchymal connective tissue and bony spicules was obvious in the experiment group. Significant differences were observed for cellular morphology [3 +/- 0.82 [experiment] vs. 1.75 +/- 0.5 [control]] and cartilage integration [2 [experiment] vs. 1 [control]] at ostectomy sites between the studied groups. This study demonstrated that by using the ostectomy gap model, autologous auricular cartilage enhanced the radiographic and histopathologic aspects of bone healing in dogs

Antiapoptotic effect of deprenyl in sensory neurons of rat dorsal root ganglion after sciatic nerve transection

Study on antiapoptotic effect of Deprenyl insensory neurons of dorsal root ganglion of rat. White Sprague-Dawley rats. The regions ofoperation were sciatic nerve in midthigh and L dorsal rootganglion. New born rats [3rd days] were divided intofive groups and their left side sciatic nerves weretransected at midthigh region.Five test groups wereadministered by deprenyl in different doses of: 0.1, 1, 10,25 and50 mg/Kg and the antiapoptotic effect of drug werecompared with control group.Statistical analysis: The values obtained from each testgroups were compared with control group by t-test andoneway ANOVA. The results showed that treatment of animal withdeprenyl prevented reduction in neurons number, in dosedependent manner. The group treated with dose 25mg/Kgshowed the better results. Deprenyl is able to prevent the induction ofapoptosis in axotomized and nonaxotomizedneurons