RÉSUMÉ
Objective:To explore the therapeutic effect of Integration of Traditional Chinese and Western Medicine in the treatment of irritable bowel syndrome of diarrhea type of liver depression and spleen deficiency, and its influence on inflammatory factors and intestinal mucosal barrier function.Methods:From May 2017 to May 2019, 86 patients with diarrhea-predominant irritable bowel syndrome admitted to the Traditional Chinese Medicine Hospital of Wenling were randomly divided into observation group (43 cases) and control group (43 cases) according to random number table method.The patients in the control group were given trimetastatin tablets, while the patients in the observation group were given traditional Chinese medicine decoction on the basis of the control group.The two groups were treated for 6 weeks.The therapeutic effects, main symptom scores, inflammatory factors, intestinal mucosal barrier function and adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 93.02%(40/43), which was higher than 67.44%(29/43) of the control group(χ 2=8.871, P<0.05). The main symptom scores of the observation group were (0.52±0.16)points, (0.46±0.12)points, (0.58±0.15)points, (0.39±0.09)points and (0.41±0.10)points, repectively, which were lower than those of the control group[(1.28±0.25)points, (1.16±0.26)points, (1.34±0.27)points, (0.95±0.14)points and (0.93±0.17)points]( t=16.790, 16.030, 16.135, 22.064, 17.289, all P<0.05). The serum levels of IL-6[(8.27±1.38)μg/L] and IL-8[(2.63±0.43)μg/L] in the observation group were lower than those in the control group[(14.39±2.37)μg/L and (4.37±0.56)μg/L]( t=14.633, 16.160, all P<0.05). The levels of plasma endotoxin[(2.68±0.46)U/mL] and D-lactate[(4.87±0.79)μg/L] in the observation group were lower than those in the control group[(3.97±0.63)U/mL and (7.39±0.95)μg/L]( t=10.844, 13.374, all P<0.05). No serious adverse reactions occurred in both two groups. Conclusion:The combination of traditional Chinese and western medicine has good clinical effect in treating diarrhea-predominant irritable bowel syndrome, which can alleviate inflammation and improve intestinal mucosal barrier function, with fewer adverse reactions.
RÉSUMÉ
Objective:To explore the clinical effect of integrated traditional Chinese and western medicine in the treatment of functional dyspepsia of liver-stomach disharmony.Methods:From June 2018 to June 2019, 92 patients with functional dyspepsia admitted to Wenling Hospital of Traditional Chinese Medicine were divided into observation group(46 cases) and control group(46 cases) according to random number table method.The control group was treated with trimebutine maleate orally, while the observation group was treated with self-made traditional Chinese medicine decoction on the basis of the control group.Both two groups were treated for 4 weeks.The therapeutic effect, the changes of TCM symptom score, gastric motility index and adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group(93.48%) was higher than that of the control group(69.57%)(χ 2=8.731, P<0.05). After treatment, the scores of upper abdominal pain, abdominal distension and early saturated belch acid in the two groups were lower compared with those before treatment(all P<0.05). After treatment, the scores of upper abdominal pain, abdominal distension and early saturated belch acid in the observation group were lower than those in the control group( t=11.068, 22.320, 15.073, 14.369, all P<0.05). After treatment, the levels of serum MLT and LEP in the two groups were higher than those before treatment(all P<0.05), while the level of CRH were lower than those before treatment(all P<0.05). After treatment, the levels of serum MLT and LEP in the observation group were higher than those in the control group, while the level of CRH in the observation group was lower than that in the control group, the differences between the two groups were statistically significant( t=12.022, 15.884, 16.536, all P<0.05). The incidence of adverse reactions in the observation group(4.35%) was lower than that in the control group(23.91%)(χ 2=7.256, P<0.05). Conclusion:The combination of traditional Chinese and western medicine has good effect on functional dyspepsia of liver-stomach disharmony, it can improve gastric motility, and has few adverse reactions, which is worthy of clinical reference.
RÉSUMÉ
Objective To observe the therapeutic effects of exercise combined with tiotropium bromide and salmeterol/fluticasone inhaling on stable chronic obstructive pulmonary diseases (COPD).Methods Sixty COPD patients with pulmonary function Ⅲ-Ⅳ grade were randomly allocated into experiment group and control group (30 cases in each group).The patients in experiment group were treated with inhaled tiotropium bromide and salmeterol/fluticasone combined with excise,while the patients in control group were treated only with inhaled tiotropium bromide and salmeterol/ fluticasone.Respiratory training with shrinkage lip respiration and steps training was given to the patients in experiment group for 8 weeks.Main outcome measures included forced expiratory volume in one second (FEV1),FEV1,in the anticipation value (FEV1%),FEV1/forced vital capacity (FVC),Medical Research Council (MRC) score,activities of daily living (ADL) score and 6-minute walking distance (6MWD).Results MRC score in control group and experiment group was both lower than that of pre-treatment (P < 0.01).ADL score,6MWD and pulmonary functional parameters in both groups were improved than those of pre-treatment (P< 0.01).FEV1,FEV1%,FEV1/FVC,MRC score,ADL score and 6MWD were (1.41 ±0.25) L,(53.76 ±11.17)%,(62.12 ±10.78)%,(1.56 ± 1.16) scores,(5.51 ±0.18) scores and (342.7 ± 19.7) m after treatment in experimentgroup,and (1.28 ± 0.23) L,(46.27 ±8.85)%,(55.76 ±8.57)%,(2.29 ±1.13)scores,(4.47 ±0.13)scores and (280.6 ± 17.8)m after treatment in control group.There were significant differences between two groups (P<0.05).Conclusion Tiotropium bromide,salmeterol/ fluticasone inhaling can improve life quality and pulmonary functional parameters in patients with stable COPD,while exercise combined with that can significantly enhance the therapeutic effects.