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1.
Osong Public Health and Research Perspectives ; (6): 362-362, 2018.
Article Dans Anglais | WPRIM | ID: wpr-718599

Résumé

The authors want to update the existing affiliation for one of the authors Keun-Dol Yook. Correct affiliation for the author should be Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, Daejeon, Korea.

2.
Osong Public Health and Research Perspectives ; (6): 255-260, 2018.
Article Dans Anglais | WPRIM | ID: wpr-717733

Résumé

OBJECTIVES: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. METHODS: We collected health insurance data between 2008 and 2012 from the Health Insurance Corporation and analyzed the data to determine the prevalence and treatment management of imported systemic mycoses. RESULTS: The prevalence of imported systemic mycoses between 2008 and 2012 increased slowly by 0.49/100,000 to 0.53/100,000 persons. The prevalence of coccidioidomycosis increased from 0.28/100,000 in 2008 to 0.36/100,000 persons in 2012. A mean of 229.6 cases occurred each year. Children and the elderly showed higher prevalence than adults in the 20- to 59-year-old age group. The rate of infection according to region ranged from 0.18/100,000 persons in Ulsan, to 0.59/100,000 persons in Gyeonggi. The prevalence in females was higher than that in males. Inpatient treatment was 3.3% (38 cases), with 96.7% treated as outpatients. Hospitalizations cost 272.7 million won and outpatient treatments cost 111.7 million won. The treatment cost for coccidioidomycosis from 2008 to 2012 was 330.9 million won, with personal charges of 79.2 million won and insurance charges of 251.7 million won. Most of the expenses for the coccidioidomycosis treatment were for inpatient treatment. CONCLUSION: The results in this study may be a useful resource for determining the changes in the trend of imported systemic mycoses.


Sujets)
Adulte , Sujet âgé , Enfant , Femelle , Humains , Mâle , Adulte d'âge moyen , Blastomycose , Coccidioïdomycose , Épidémiologie , Coûts des soins de santé , Histoplasmose , Hospitalisation , Patients hospitalisés , Assurance , Assurance maladie , Corée , Mycoses , Patients en consultation externe , Prévalence
3.
Osong Public Health and Research Perspectives ; (6): 325-331, 2017.
Article Dans Anglais | WPRIM | ID: wpr-644319

Résumé

OBJECTIVES: Studies on Clostridium difficile are rare in Korea. We investigated the epidemiological characteristics of C. difficile isolates from patients with C. difficile-associated disease (CDAD) in Korea. METHODS: Multiplex polymerase chain reaction was performed to detect the presence of tcdA and tcdB toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method. C. difficile strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR). RESULTS: Among patients with CDAD, 73 (25.8%), 32 (11.3%), 32 (11.3%), and 26 (9.2%) suffered from pneumonia, cancer or neoplasm, diabetes, and colitis, respectively. Of all stool samples, 43 samples (15.2%) were positive for C. difficile strains. We observed two expression patterns of toxin genes: tcdA+/tcdB+ (86% isolates) and tcdA−/tcdB+ (14% isolates), with all isolates expressing tcdB. Furthermore, some isolates were resistant to clindamycin (65%), ampicillin (56%), and cefazolin (40%), but all were susceptible to vancomycin and metronidazole. The tested samples were classified into diverse clusters using automated rep-PCR. CONCLUSION: Our findings revealed the characteristics and antibiotic resistance of C. difficile isolates from patients in Korea. The epidemiological data may provide valuable insight into development of treatment strategies for C. difficile infections in Korea.


Sujets)
Humains , Ampicilline , Céfazoline , Clindamycine , Clostridioides difficile , Clostridium , Colite , Résistance microbienne aux médicaments , Corée , Méthodes , Métronidazole , Réaction de polymérisation en chaine multiplex , Pneumopathie infectieuse , Réaction de polymérisation en chaîne , Vancomycine
4.
Annals of Laboratory Medicine ; : 60-63, 2016.
Article Dans Anglais | WPRIM | ID: wpr-37148

Résumé

Mucormycosis, a fatal opportunistic infection in immunocompromised hosts, is caused by fungi belonging to the order Mucorales. Early diagnosis based on exact identification and multidisciplinary treatments is critical. However, identification of Mucorales fungi is difficult and often delayed, resulting in poor prognosis. This study aimed to compare the results of phenotypic and molecular identification of 12 Mucorales isolates collected from 4-yr-accumulated data. All isolates were identified on the basis of phenotypic characteristics such as growth rate, colony morphology, and reproductive structures. PCR and direct sequencing were performed to target internal transcribed spacer (ITS) and/or D1/D2 regions. Target DNA sequencing identified five Lichtheimia isolates, two Rhizopus microsporus isolates, two Rhizomucor pusillus isolates, one Cunninghamella bertholletiae isolate, one Mucor fragilis isolate, and one Syncephalastrum racemosum isolate. Five of the 12 (41.7%) isolates were incorrectly identified on the basis of phenotypic identification. DNA sequencing showed that of these five isolates, two were Lichtheimia isolates, one was Mucor isolate, one was Rhizomucor isolate, and one was Rhizopus microspores. All the isolates were identified at the species level by ITS and/or D1/D2 analyses. Phenotypic differentiation and identification of Mucorales is difficult because different Mucorales share similar morphology. Our results indicate that the molecular methods employed in this study are valuable for identifying Mucorales.


Sujets)
Humains , Génotype , Mucorales/classification , Mucormycose/microbiologie , Techniques de typage mycologique , Phénotype
5.
Korean Journal of Medicine ; : 444-448, 2016.
Article Dans Coréen | WPRIM | ID: wpr-101316

Résumé

Hyponatremia is the most common electrolyte abnormality in hospitalized patients and often presents no symptoms. The association between sinus node dysfunction and hyponatremia has rarely been reported. We describe a 77-year-old woman who developed reversible sinus node dysfunction accompanied by pulmonary edema that was associated with hyponatremia.


Sujets)
Sujet âgé , Femelle , Humains , Hyponatrémie , Oedème pulmonaire , Maladie du sinus , Noeud sinuatrial
6.
Korean Circulation Journal ; : 256-259, 2016.
Article Dans Anglais | WPRIM | ID: wpr-221720

Résumé

We describe a case of spontaneous bleeding from a branch of the right internal pudendal artery that resulted in massive scrotal swelling in a patient who had underwent primary percutaneous coronary intervention with the use of abciximab concurrent with conventional anticoagulation and dual antiplatelet therapies for the treatment of acute ST-segment elevation myocardial infarction. This unusual complication was promptly identified by percutaneous peripheral arteriography and successfully treated with gel-foam embolization.


Sujets)
Humains , Angiographie , Artères , Hémorragie , Infarctus du myocarde , Intervention coronarienne percutanée
7.
Korean Circulation Journal ; : 30-36, 2014.
Article Dans Anglais | WPRIM | ID: wpr-52948

Résumé

BACKGROUND AND OBJECTIVES: Metabolic syndrome and high sodium intake are associated with frequent cardiovascular events. Few studies have estimated sodium intake in subjects with metabolic syndrome by 24-hour urine sodium excretion. We evaluated sodium intake in individuals with metabolic syndrome. SUBJECTS AND METHODS: Participants were recruited by random selection and through advertisement. Twenty four-hour urine collection, ambulatory blood pressure measurements, and blood test were performed. Sodium intake was estimated by 24-hour urine sodium excretion. Participants receiving antihypertensive medications were excluded from analysis. RESULTS: Among the 463 participants recruited, subjects with metabolic syndrome had higher levels of 24-hour urine sodium excretion than subjects without metabolic syndrome (p=0.0001). There was a significant relationship between the number of metabolic syndrome factors and 24-hour urine sodium excretion (p=0.001). The proportion of subjects with metabolic syndrome was increased across the tertile groups of 24-hour urine sodium excretion (p<0.0001). The association of high sodium intake and metabolic syndrome was significant only among women. Among the factors related to metabolic syndrome, body mass index had an independent association with 24-hour urine sodium excretion (p<0.0001). CONCLUSION: Women with metabolic syndrome exhibited significantly higher sodium intake, suggesting that dietary education to reduce sodium consumption should be emphasized for women with metabolic syndrome.


Sujets)
Femelle , Humains , Pression sanguine , Indice de masse corporelle , Éducation , Tests hématologiques , Hypertension artérielle , Sodium , Sodium alimentaire , Prélèvement d'échantillon d'urine
8.
Korean Journal of Anesthesiology ; : S81-S82, 2014.
Article Dans Anglais | WPRIM | ID: wpr-185533

Résumé

No abstract available.


Sujets)
Dantrolène , Hyperthermie maligne
9.
Epidemiology and Health ; : e2014017-2014.
Article Dans Anglais | WPRIM | ID: wpr-721153

Résumé

OBJECTIVES: The symptoms of fungal infections vary from minor to severe. According to recent reports, fungal infection prevalence is increasing due to increases in the aging population and in patients with compromised immune systems. However, the total prevalence of fungal infections in South Korea is unknown. We investigated the recent 5-year prevalence of each type of fungal infection in South Korea across age, sex, and regional groups. METHODS: Nationwide data from the National Health Insurance of South Korea were used. The target population included patients who had received treatment for a fungal infection that was listed as the main disease. For each patient, multiple treatments were counted as one case per year in the data analysis. RESULTS: The annual prevalence of all-type mycoses increased from 6.9% in 2009 to 7.4% in 2013. Among the specific groups, the prevalence of dermatophytosis was highest (5.2%), followed by that of opportunistic mycoses (1.7%) and superficial mycoses (0.2%). The prevalence of subcutaneous mycoses and generalized mycoses was very low (8 cases per 100,000 persons and 3 cases per 1 million persons, respectively). CONCLUSIONS: Every year, approximately 7.1% of the Korean population receives treatment for fungal diseases. Cases of opportunistic mycoses are assumed to increase each year. Therefore, further research is needed to understand and monitor the prevalence of mycoses to establish management policies to reduce the burden of fungal diseases.


Sujets)
Humains , Vieillissement , Besoins et demandes de services de santé , Système immunitaire , Assurance maladie , Corée , Mycoses , Programmes nationaux de santé , Prévalence , Statistiques comme sujet , Teigne
10.
Soonchunhyang Medical Science ; : 158-159, 2013.
Article Dans Coréen | WPRIM | ID: wpr-147403

Résumé

Male chronic pelvic pain syndrome (MCPPS) is defined as chronic pain, pressure, or discomfort localized to the pelvis, perineum, or genitalia of males lasting more than 3 months that is not due to readily explainable causes. Other names for the disorder include prostatodynia and chronic nonbacterial (abacterial) prostatitis, although it is unclear how the symptoms relate to the prostate. And it appears to be extensive variability in clinical presentation and may result in chronic neuropathic pain and neuromuscular pain. Therefore patients with MCPPS should be cared by multimodal treatment including antihyperalgesics, antidepressants and pain intervention procedures such as caudal block. We report successful care in two men with MCPPS.


Sujets)
Humains , Mâle , Anesthésie caudale , Antidépresseurs , Douleur chronique , Association thérapeutique , Système génital , Névralgie , Douleur pelvienne , Pelvis , Périnée , Prostate , Prostatite
11.
Korean Journal of Anesthesiology ; : 363-366, 2013.
Article Dans Anglais | WPRIM | ID: wpr-24011

Résumé

Complete atrioventricular (AV) block is defined as a dissociation of atrial and ventricular activities. Complete AV block that occurs during the perioperative period is difficult to reverse and usually requires implantation of a pacemaker. Propofol does not affect a normal AV conduction system but may act as a trigger for AV block. It can also potentiate vagal stimulation factors and reduce sympathetic activity. We report a case of complete AV block that may have been related to administration of propofol.


Sujets)
Sujet âgé , Humains , Troubles du rythme cardiaque , Arthroplastie prothétique de genou , Bloc atrioventriculaire , Troubles dissociatifs , Période périopératoire , Propofol
12.
Korean Circulation Journal ; : 255-260, 2013.
Article Dans Anglais | WPRIM | ID: wpr-209907

Résumé

BACKGROUND AND OBJECTIVES: Microalbuminuria (MAU) and decreased estimated glomerular filtration rate (eGFR) are risk factors for cardiovascular disease (CVD) in patients with hypertension. However, in hypertensive patients with normal or minimally reduced eGFR (> or =60 mL/min/1.73 m2) and with normo- or MAU, the value of combined estimation of eGFR and urine microalbumin for the risk assessment has not been widely reported. We evaluated the association between arterial stiffness and the combined estimation of eGFR and urine microalbumin. SUBJECTS AND METHODS: Subjects with never treated hypertension and normal or minimally reduced eGFR were evaluated (n=491, 50.1+/-10.4 years). eGFR was calculated by the simplified Modification of Diet in Renal Disease formula. Urinary albumin-to-creatinine ratio (UACR) was assessed with spot urine. Arterial stiffness was assessed with heart-femoral pulse wave velocity (hfPWV). All subjects were divided into four groups; group 1, eGFR > or =90 mL/min/1.73 m2 (normal eGFR) and normo-albuminuria (NAU); group 2, eGFR 89.9-60 mL/min/1.73 m2 (minimally reduced eGFR) and NAU; group 3, normal eGFR and MAU; group 4, minimally reduced eGFR and MAU. RESULTS: Group 1 had the lowest hfPWV (964.6+/-145.4; group 2, 1013.5+/-168.9; group 3, 1058.2+/-238.0; group 4, 1065.8+/-162.9 cm/sec). Analysis adjusting age, sex, body mass index, heart rate and mean arterial pressure showed significantly lower hfPWV of group 1 compared to group 2 (p=0.032) and 3 (p=0.007). Multiple regression analysis showed a significant association of hfPWV with logUACR {beta=0.096, 95% confidence interval (CI) 8.974-60.610, p=0.008} and eGFR (beta=-0.069, 95% CI -1.194 - -0.005, p=0.048). CONCLUSION: Minimally reduced eGFR or MAU is independently associated with increased arterial stiffness, indicating greater CVD risk.


Sujets)
Humains , Pression artérielle , Indice de masse corporelle , Maladies cardiovasculaires , Régime alimentaire , Débit de filtration glomérulaire , Rythme cardiaque , Hypertension artérielle , Analyse de l'onde de pouls , Insuffisance rénale , Appréciation des risques , Facteurs de risque , Rigidité vasculaire
13.
Journal of the Korean Society of Hypertension ; : 125-132, 2011.
Article Dans Coréen | WPRIM | ID: wpr-55997

Résumé

BACKGROUND: The value of metabolic syndrome (MetS) evaluation in predicting cardiovascular disease is recently criticized. We investigated, in hypertensive patients without diabetes mellitus, the influence of MetS on the target organ damage. METHODS: Data from the fourth Korean National Health and Nutrition Examination Survey performed in 2008 were analyzed. Metabolic syndrome is defined by the 2001 National Cholesterol Education Program-Third Adult Treatment Panel guideline. The category of hypertension is defined following the seventh report of the Joint National Commitee-7 guideline. RESULTS: The prevalence of target organ damage (TOD), defined as history of myocardial infarction/angina/stroke/chronic renal disease as well as the presence of macroalbuminuria, was increased according to blood pressure; 8.5% in the population of normal blood pressure, 12.5% in those of prehypertensive range, and 20.5% in hypertensive population. Hypertensive population associated with MetS showed greater prevalence of TOD than those without MetS even excluding diabetic population. The presence of MetS in hypertensive population showed 2.2 fold increased risk for TOD. Any single parameter of MetS diagnostic criteria as well as obesity did not show the comparable range of risk prediction as MetS. CONCLUSIONS: These results indicate a strong relationship of Mets with TOD in hypertensive population. Evaluating the metabolic components in hypertensive population is necessary in establishing management strategies for overall risk.


Sujets)
Adulte , Humains , Pression sanguine , Maladies cardiovasculaires , Cholestérol , Diabète , Hypertension artérielle , Articulations , Enquêtes nutritionnelles , Obésité , Prévalence
14.
Korean Journal of Medical Mycology ; : 86-89, 2011.
Article Dans Coréen | WPRIM | ID: wpr-99716

Résumé

BACKGROUND: Dermatophytes (Trichophyton, Microsporum, and Epidermophyton) cause cutaneous mycoses called dermatophytosis. Forproper anti-dermatophytosis therapy, accurate and early diagnosis of dermatophytes is important. Laboratory diagnosis of dermatophytosis for dermatophytes still relies on microscopic and macroscopic examination of in vitro cultures and some physiological tests. These methods (conventional methods) are time-consuming (2~4 weeks) and yet, still have low sensitivity and specificity. Recently, in order to overcome such limitations of conventional methods, molecular-based methods have been developed to identify dermatophytes. The polymerase chain reaction-reverse blot hybridization assay (PCR-REBA) allows sensitive and specific identification of dermatophytes species. OBJECTIVE: This study was aimed to develop a new PCR-REBA with higher sensitivity using less amount of probe concentration, so the assay can be more practical in clinical settings. METHODS: For this, PCR primers and species-specific oligonucleotide probes were designed within the internal transcribed sequences 1 region between 5.8S and 18S rRNA. The species-specific probes designed in this study was to identify 6 species (T. rubrum, T. mentagrophytes, T. tonsurans, M. canis, M. gypseum, and E. floccosum) comprised 99% of dermatophytes isolatedin Korea. RESULTS: The detection efficiency of the PCR-REBA was compared with the microscopic method, and the results showed that the sensitivity of the PCR-REBA developed in this study is 100 times higher than previously developed one. Subsequently, the results of PCR-REBA were evaluated using clinical isolates. DNAs from a total of 68 clinical isolates were analyzed by PCR-REBA, and the inconsistent results between PCR-REBA and conventional microscopic identification results were confirmed by sequence analysis. CONCLUSION: In brief, the results showed that results of sequence analysis were identical with PCR-REBA implying newly developed PCR-REBA is very useful method for accurate and rapid identification of dermatophytes and would provide higher simplicity, specificity, sensitivity than conventional method.


Sujets)
Arthrodermataceae , Chimère , Techniques de laboratoire clinique , ADN , Diagnostic précoce , Microsporum , Mycoses , Sondes oligonucléotidiques , Réaction de polymérisation en chaîne , Sensibilité et spécificité , Analyse de séquence , Teigne
15.
Korean Circulation Journal ; : 314-320, 2010.
Article Dans Anglais | WPRIM | ID: wpr-196631

Résumé

BACKGROUND AND OBJECTIVES: Associations have been reported between the serum uric acid (SUA) level, metabolic syndrome (MS), and atherosclerosis. We have determined the relationship between the SUA level, MS, and arterial stiffness in Korean. SUBJECTS AND METHODS: Cross-sectional data from 1,276 adults who underwent routine laboratory tests and pulse wave velocity (PWV) measurements during a health check-up were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, diabetes, renal disease, or systemic disease, or were under treatment which would affect SUA levels, or taking medications for hypertension or dyslipidemia. RESULTS: After adjustment for age, smoking status, total cholesterol (TC), and creatinine, the odds ratios (ORs, 95% confidence interval) of gender-specific quartiles of SUA for MS were 1.0, 1.28 (0.66-2.47), 1.46 (0.76-2.82), and 2.21 (1.15-4.26) in females, and 1.0, 1.33 (0.82-2.17), 1.60 (0.96-2.66), and 2.03 (1.21-3.40) in males. However, after adjustment for waist circumference, there were no significant differences in the ORs among the SUA quartile groups in females and males (both, p=NS). The Pearson's correlation coefficients for the relationship between SUA levels and heart-femoral (hf) PWVs or brachial-ankle (ba) PWVs were not significant in females and males (r=0.054 and r=0.015, respectively, in females; r=-0.036 and r=-0.015, respectively, in males; all, p=NS). CONCLUSION: An elevated SUA level is associated with abdominal obesity among the MS components, but the SUA level is not associated with PWV in females or males.


Sujets)
Adulte , Femelle , Humains , Mâle , Athérosclérose , Maladies cardiovasculaires , Cholestérol , Créatinine , Dyslipidémies , Électrolytes , Hypertension artérielle , Obésité abdominale , Odds ratio , Analyse de l'onde de pouls , Fumée , Fumer , Acide urique , Rigidité vasculaire , Tour de taille
16.
Korean Journal of Medical Mycology ; : 133-144, 2009.
Article Dans Coréen | WPRIM | ID: wpr-137629

Résumé

Korean Institute of Tuberculosis (KIT) collected 129 strains of Aspergillus spp. from clinical specimens of patient suspected as pulmonary Aspergillosis. On the basis of morphological characteristics, these strains were identified as A. fumigatus (62 strains), A. niger (37), A. flavus (26), A. versicolor (1), A. nidulans (1), A. clavatus (1) and Neosartorya fennelliae (1). These strains were re-identified according to recent Aspergillus classification system which is mainly based on molecular characters. The strains were grouped by Randomly Amplified Polymorphic DNA (RAPD). The representative strains from each group were sequenced with partial betatubulin gene and compared with those of reference strains in the Aspergillus and were identified by the sequence. The identification was confirmed by morphological examination. As the results, they are reidentified as A. fumigatus (58), A. niger (11), A. tubingensis (26), A. flavus (27), A. sydowii (3), A. nidulans (1), A. clavatus (1), Neosartorya fennelliae (1), N. fischeri (1). This is also the first report of A. tubuingensis in clinical field in Korea.


Sujets)
Humains , Aspergillus , ADN , Corée , Neosartorya , Niger , Aspergillose pulmonaire , Tuberculose
17.
Korean Journal of Medical Mycology ; : 133-144, 2009.
Article Dans Coréen | WPRIM | ID: wpr-137628

Résumé

Korean Institute of Tuberculosis (KIT) collected 129 strains of Aspergillus spp. from clinical specimens of patient suspected as pulmonary Aspergillosis. On the basis of morphological characteristics, these strains were identified as A. fumigatus (62 strains), A. niger (37), A. flavus (26), A. versicolor (1), A. nidulans (1), A. clavatus (1) and Neosartorya fennelliae (1). These strains were re-identified according to recent Aspergillus classification system which is mainly based on molecular characters. The strains were grouped by Randomly Amplified Polymorphic DNA (RAPD). The representative strains from each group were sequenced with partial betatubulin gene and compared with those of reference strains in the Aspergillus and were identified by the sequence. The identification was confirmed by morphological examination. As the results, they are reidentified as A. fumigatus (58), A. niger (11), A. tubingensis (26), A. flavus (27), A. sydowii (3), A. nidulans (1), A. clavatus (1), Neosartorya fennelliae (1), N. fischeri (1). This is also the first report of A. tubuingensis in clinical field in Korea.


Sujets)
Humains , Aspergillus , ADN , Corée , Neosartorya , Niger , Aspergillose pulmonaire , Tuberculose
18.
Korean Circulation Journal ; : 52-56, 2009.
Article Dans Anglais | WPRIM | ID: wpr-161239

Résumé

BACKGROUND AND OBJECTIVES: High aerobic exercise capacity and sport-related physical activity are reported to be inversely associated with arterial stiffness in healthy young adults. However, it is unknown whether increased physical activity and/or high aerobic exercise capacity attenuate arterial stiffness in patients with untreated hypertension. SUBJECTS AND METHODS: We studied subjects with never-treated hypertension {n=84 (55 males); mean age+/-SD, 49+/-7 years; age range, 36-65 years}. We excluded subjects with a history of diabetes, angina, myocardial infarction, major arrhythmia, or cerebrovascular diseases and those who were taking any cardiovascular medications, including lipid-lowering agents. Carotid intima-media thickness (IMT) and heart-femoral pulse wave velocity (hfPWV) were measured before exercise testing was performed. Physical activity was estimated using a modified Baecke questionnaire. Aerobic exercise capacity was measured with maximal cardiopulmonary exercise testing (maximum oxygen uptake, Vo2max). RESULTS: Linear regression analysis showed a significant inverse correlation between sport-index and hfPWV (r=-0.404; p0.05). Carotid IMT was not associated with physical activity indices or Vo2max. CONCLUSION: In patients with untreated hypertension, increased sport activity was associated with lower aortic stiffness, but high aerobic exercise capacity was not. These results suggest that regular daily exercise, but not exercise capacity, is an important determinant of aortic stiffness in patients with untreated hypertension.


Sujets)
Humains , Jeune adulte , Troubles du rythme cardiaque , Pression artérielle , Glycémie , Indice de masse corporelle , Épaisseur intima-média carotidienne , Cholestérol , Exercice physique , Épreuve d'effort , Jeûne , Rythme cardiaque , Hypertension artérielle , Modèles linéaires , Activité motrice , Infarctus du myocarde , Oxygène , Analyse de l'onde de pouls , Sports , Rigidité vasculaire , Enquêtes et questionnaires
19.
Korean Journal of Medical Mycology ; : 156-167, 2008.
Article Dans Coréen | WPRIM | ID: wpr-93124

Résumé

In general, fungi including yeast and filamentous form, locate in soil, water, plant, animal and human. Fungi can be survived almost in every environmental conditions and be useful or harmful for humans. Some human pathogenic fungi may infection immunocompromised peoples and/or susceptible hosts causing hypersensitivity disease, mycotoxicoses, which can be induced by mycotoxins, and mycoses. Mycoses are classified into four classes, such as superficial and/or cutaneous mycoses, subcutaneous mycoses, opportunistic mycoses, and systemic or deep seated mycoses. Recently, due to the increasement of immune system defective patients which are usually caused by HIV infection, transplant and cancer, opportunistic systemic fungal infection has been dramatically elevated. Fast diagnose system and early antifungal treatments are required because the morbidity and mortality of these systemic infections are very high. Although these opportunistic infections caused by mainly Candida, Aspergillus and Cryptococcus spp. are getting higher, no culture collection and/or strain bank for the infectious fungal strains are operated in Korea. These situations allows us to establish a novel Korean collection of medical fungi (KCMF) for their genetic materials. KCMF will be a hub for human pathogenic fungal strains isolated in Korea and will serve to studies of clinical and basic mycological research as well as to maintain various mutants and varieties which could be useful for develop new antifungal agents and drug discovery. The successful Korean Collection of Medical Fungi (KCMF) will contribute to; 1. Create informative world-wide culture collection of clinically isolated fungal strains. 2. Obtain various medical mycological materials as well as antifungal agent resistant strains for studying fungi-related topics including novel antifungal agents. 3. Create world-wide network for the researchers who study medical mycology and provide workshop and various information for the fungal community. The purpose of establish a novel Korean collection of medical fungi(KCMF) is to isolate, classify, and collect human pathogenic fungal strains, isolated from human clinical specimens from superficial and systemic infections. Furthermore, maintaining a culture collection for Korean specific clinical isolates and resistant strains of antifungal agents.


Sujets)
Animaux , Humains , Antifongiques , Aspergillus , Candida , Cryptococcus , Champignons , Infections à VIH , Hypersensibilité , Système immunitaire , Corée , Mycologie , Mycoses , Mycotoxicose , Mycotoxines , Infections opportunistes , Plantes , Sol , Entorses et foulures , Transplants , Levures
20.
The Korean Journal of Internal Medicine ; : 109-115, 2006.
Article Dans Anglais | WPRIM | ID: wpr-30970

Résumé

BACKGROUND: Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and cardiovascular disease (CVD) risk. Although the individual components of the metabolic syndrome (MS) are well established cardiovascular risk factors, the impact of the MS and its components on PWV has not been well defined. METHODS: Using an automatic wave form analyzer, heart-femoral (hf) and brachial-ankle (ba) PWVs were measured simultaneously in 364 subjects (age, 44.8+/-9.3 years). None of the subjects had clinical atherosclerotic CVD, diabetes, or systemic disease. The association between PWVs and the features of the MS, individual and clustered, were analyzed. RESULTS: By univariate analysis, the individual components of the MS, except for a low HDL-cholesterol level, were associated with increased hfPWV and baPWV. Hypercholesterolemia was also associated with increase in both PWVs. A low HDL-cholesterol level was associated with an increased baPWV. However, by multivariate analysis, none of the components of the MS, except for an elevated blood pressure (BP), was an independent factor affecting hfPWV and baPWV. After controlling for age and gender, hfPWV and baPWV were increased according to the number of MS components present (p<0.001 for both). After controlling for age, gender and BP, the MS was associated with an increased baPWV (p<0.05). CONCLUSIONS: The clustering of MS components may interact to synergistically affect arterial stiffness, even though the individual MS components, except for an elevated BP, do not affect arterial stiffness independently.


Sujets)
Adulte d'âge moyen , Mâle , Humains , Femelle , Sujet âgé , Adulte , Écoulement pulsatoire/physiologie , Syndrome métabolique X/physiopathologie , Pression sanguine , Vitesse du flux sanguin , Artères/physiopathologie , Facteurs âges
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