Meta-analysis on Jinlianqingre Effervescent Tablet for acute upper respiratory tract infection in children / 药物评价研究

Objective To systematically review the efficacy and safety of Jinlian Qingre Effervescent Tablet (JQET) compared to Ribavirin for acute upper respiratory tract infection in children.Methods CNKJ,CBM,WanFang Data,VIP,PubMed,EM base,Web of science,and Cochrane Library databases were searched from the date of establishment to December 2016 for all randomized controlled trials (RCTs) and quasi-RCT on the use of JQET in children with acute respiratory infections.Meta-analysis by using Rev Man 5.3.Results A total of seven RCTs involving 782 patients were included,while the group of JQET involving 392 patients,Ribavirin involving 390 patients.The results ofmeta-analysis indicated that the efficacy in Jinlianqingre group was superior to that of Ribavirin control group,such as clinical effectiveness [RR=l.26,95％CI=(1.18,1.34),P＜0.000 01],fever subsidence time [MD=-1.54,95％CI (-1.79,-1.30),P＜0.000 01],the time of subsided cough [MD=-1.53,95％CI (-1.79,-1.27),P＜0.000 01],the disappearance time of pharyngalgia [MD=-1.29,95％CI (-1.88,-0.70),P＜0.000 1],and Pharyngeal congestion disappearance time [MD=-2.80,95％CI(-3.11,-2.49),P＜0.000 01].The difference was statistically significant.There were three adverse reactions reported in JQET group.Conclusion JQET is superior to the Ribavirin control group in clinical effectiveness,fever subsidence time,time of subsided cough,disappearance time of pharyngalgia,and pharyngeal congestion disappearance time to treat acute upper respiratory tract infection in children.However,these results should be carefully interpreted,and this conclusion has to be further verified by high quality,large scale RCTs.

Clinical Observation of Fuyanxiao Effervescent Tablet in the Treatment of Damp-heat Pouring Downward Syndrome of Fungal Vaginitis / 中国药房

OBJECTIVE:To observe the efficacy and safety of Fuyanxiao effervescent tablet in the treatment of damp-heat pour-ing downward syndrome of fungal vaginitis. METHODS:80 patients with damp-heat pouring downward syndrome of fungal vagini-tis were randomly divided into control group and observation group. Control group was given one Nystatin vaginal suppository,and the drug was given in the third day after the menstrual period ending,once every night;observation group was given one Fuyanx-iao effervescent tablet,and the drug was given in the third day after the menstrual period ending,once every night. 2%-4% Sodi-um bicarbonate solution was used for vulva cleaning before taking the medicine at night,then patients kept lying flat to let the med-icine going into the vaginal depths. There were totally 3 treatment courses with 7 days each. During the treatment,sexual activities and antibiotics were prohibited. The clinical efficacy,TCM symptom scores,vaginal lactobacillus positive rate and recurrence rate before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:There were no significant dif-ferences in the total effective rate,recurrence rate and incidence of adverse reactions (P>0.05). Before treatment,there were no significant differences in the TCM symptoms and vaginal lactobacillus positive rate(P>0.05);after treatment,TCM symptoms in 2 groups were significantly lower than before,genital itching,leucorrhea color-quality and lower abdomen pain in observation group were significantly lower than control group,vaginal lactobacillus positive rate in observation group were significantly higher than before and control group,the differences were statistically significant (P0.05). CONCLUSIONS:Fuyanxiao effervescent tablet shows good efficacy in the treat-ment of damp-heat pouring downward syndrome of fungal vaginitis and improve clinical symptoms,with no recurrence rate and good safety.

Bactericidal Effect of the Aos Denti Germ for Denture Cleansing Effervescent Tablet against Oral Microorganisms

Human mouth environment is known to include a variety bacteria, including Streptococcus spp., Staphylococcus spp., Actinomyces spp., Lactobacillus spp., Candida spp., Enterobacteriaceae, et al. Human oral microorganisms can cause dental caries, gingivitis, periodontitis, respiratory tract infection, and cardiovascular disease. Thus, right denture cleaning is essential to oral and general human health. The aim of this study was to evaluate the bactericidal effect of a sodium dichloroisocyanurate-based effervescent tablet (Aos Denti Germ, Aos Company, Chungbuk, Korea) against oral microorganisms. A total of 5 species Streptococcus spp. (Streptococcus anginosus, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, and Streptococcus sobrinus), Actinomyces oris, Candida albicans, and Escherichia coli were used in this study. All strains were exposed to the distilled water prepared with effervescent tablet. After the exposure, the mixture of strains and effervescent tablet was inoculated onto blood agar or MacConkey agar plate and cultured at 36℃. All strains were killed immediately on exposure to effervescent tablet. The results suggested that effervescent tablet could be used as an effective denture cleanser for dental hygiene.

Optimation of extraction technology for Xinning Effervescent Tablet by central composite design/response surface method / 中草药

Objective: To optimize the extraction technology for Xinning Effervescent Tablet (XNET) by central composite design/ response surface method. Methods: Based on single-factor test, the independent variables were ethanol volume fraction, extracting time, and solvent ratio, while the dependent variables were extracting transfer rates of paeoniflorin, hesperidin, and schisandrin, with their weight calculation for a composite score. Multiple linear regression and multivariate binomial fit were used to estimate mathematic relationship between independent variables and dependent variables. Response surface description was based on optimal mathematical model, and then the optimal technical conditions were chosen. Results: The best multi-binomial model simulation was as follows: Y=-209.21 + 6.67 A + 39.68 B + 6.59 C + 0.077 AB-0.026 AC-0.59 BC-0.051 A2-8.37 B2-0.13 C2 (r=0.979 3, P < 0.01). Optimal extraction conditions were as follows: ethanol refluxing extraction, ethanol volume fraction of 65%, extraction time of 2 h, and solvent ratio of 12 (mL:g). Under these optimal conditions, the average extracting transfer rates of schisandrinthe, paeoniflorin, and hesperidin were 85.33%, 88.77%, and 93.18%, and the actual extracting rate of catalpol was 88.72%, matching with the predicted extraction rate of 89.22%. Conclusion: The established model can better reflect the relationship between the factors and indicators, with good and reliable predictability.

Oral rehydration salt powder II effervescent tablets: Preparation and quality control / 第二军医大学学报

Objective: To develop and prepare oral rehydration salt powder II (ORS II) effervescent tablets. Methods: Taking the mass/tablet, rigidity, disintegration time, and pressing status as the main indicators, we optimized the formulation and preparation process of the effervescent tablet by single factor test. The character, identification, disintegration time, acidity, and content determination of the tablets were also investigated. Results: It was found that the optimized preparation process of the effervescent tablets was to mix the acid part, which was granulated with ethanol, with the base part, and then compressed the mixture. The optimal formula was composed of: NaCl (11.5%), KCl (4.93%), C6H8O7 (6.21%), NaHCO3 (8.15%), C6 H12 O6 (65.7%), and PEG-6000 (3%). The rigidity of the prepared effervescent tablet was 4.5 kg and the disintegration time was 175 s. Conclusion: The formulation of the present product is consistent with the corresponding Chinese Pharmacopoeia monograph, requiting no additional effervescent; the preparation process is simple and the products are stable, and the product my be developed into a new oral rehydration salt formulation.

Preparation and Quality Control of Nifuratel Vaginal Effervescent Tablets / 中国药房

OBJECTIVE:To prepare nifuratel vaginal effervescent tablets(NVET)and establish a method for its quality control.METHODS:The NVET was prepared using acid or alkali effervescent by principal ingredient-separated granulation.The content of the principal ingredient was determined by UV spectrophotometry.RESULTS:The preparation was white or off-white colored tablet and its property was up to the standard stated in Chinese Pharmacopeia(2005 Edition)in identification and test.The linear concentration range of nifuratel was 100～400 ?g?mL-1(r=0.999 6)with an average recovery rate of 101.1%(RSD=0.62%,n=6).CONCLUSION:The preparation process for NVET is simple,and its quality is stable and controllable.

Determination of Amphotericin B in Vaginal Effervescent Tablets by RP-HPLC / 中国药房

OBJECTIVE: To establish a RP-HPLC method for the content determination of amphotericin B in amphotericin B vaginal effervescent tablets.METHODS: HPLC was performed on Kromasil C18 column with the mobile phase consisted of 0.01 mol ?L-1 potassium dihydrogen-acetonitrile(66∶34) at a flow rate of 1.0 mL?min-1.The detection wavelength was set at 408 nm;the sample size was 10 ?L,and the column temperature was set at room temperature.RESULTS: The linearity of amphotericin B was good in the range of 0.404～3.636 ?g(r=0.999 4) and the average recovery rate was 99.39%(RSD=0.22%,n=6).CONCLUSIONS: The method is simple,accurate,feasible,and it can be used for the determination of this tablets.

Study on preparation of the vagina effervescent tablet of Radix Arnebiae / 中成药

AIM: To extract the effective composition from Radix Arnebiae seu Lithospermi and make it into the vagina effervescent tablet. It would be convenient and effective to treat the disease for the patients. METHODS : To sift the technology of extracting the effective composition by experiment and find out the prescription of the vagina effervescent tablet,its time of disintegration and the quantity of producing foam can accord with the principle of the vagina effervescent tablet in Chinese pharmacopoeia. RESULTS : The technology of extracting the effective composition and the prescription of the vagina effervescent tablet by experiment are practical. CONCLUSION : It is convenience for patients to take vagina effervescent tablet of Radix Arnebiae to treat their diseases