Epithelioid Cell Histiocytoma on the Palm Mimicking Pyogenic Granuloma / 대한피부과학회지

No abstract available.

A Case of Halo Phenomenon Induced by Molluscum Contagiosum / 대한피부과학회지

Halo nevi (HN), also known as Sutton's nevi or leukoderma acquisitum centrifugum, are nevomelanocytic nevi surrounded by a rim of depigmentation. A 9-year-old female presented with an asymptomatic solitary flesh-colored 0.75-cm-sized papule surrounded by depigmentation on the right cheek 1 month ago. The excisional biopsy demonstrated molluscum contagiosum and decreased basal layer pigmentation on Fontana-Masson stain. The halo phenomenon is often associated with an acquired nevus cell nevus, but has also been associated with a congenital nevus cell nevus, non-neuroectodermal lesions such as angiomas, seborrheic keratoses, lichen planus, sarcoid, psoriasis, involuting flat warts, and histiocytoma. Our patient had an unusual association of molluscum contagiosum with the halo phenomenon. We suppose that the halo phenomenon in this patient might have been provoked by the molluscum contagiosum virus. A halo nevus-like appearance suggests the possibility of disease other than nevus. In such cases, skin biopsy is required for confirmation.

Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma.

Deep benign fibrous histiocytoma in the oral cavity: a case report

Benign fibrous histiocytoma (FH) is a benign tumor composed of fibroblasts and histiocytes in varying proportions. This tumor is usually found in adult extremities but rarely occurs in deep soft tissues of the oral cavity. As it is difficult to diagnose with physical and radiologic exams, deep benign FH can only be diagnosed by histopathology. We report a case of a 36-year-old female patient who came to our department with painless swelling in the right buccal mucosa. This case report reviews the clinical, radiological, and histological aspects of this tumor.

Angiomatoid Fibrous Histiocytoma as a Second Tumor in a Young Adult with Testicular Cancer / Journal of the Korean Cancer Association, 대한암학회지

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor, with a low-grade malignant potential, occurring predominantly in children and young adults. Association between AFH and other malignancies has been rarely reported. A 27-year-old man who presented with a palpable abdominal mass was diagnosed as having testicular cancer with multiple liver and lung metastases. At 16 months after chemotherapy, a follow-up computed tomographic scan revealed a supraclavicular mass measuring 3 cm in size, which was suspected to be a recurrence. The patient underwent surgical excision, and the mass was pathologically diagnosed as a AFH. The patient has had no local recurrence and no distant metastasis for 12 months after resection. To the best of our knowledge, this is the first case report of AFH as a second tumor in a patient with testicular cancer.

Successful Management of a Recurrent Primary Malignant Fibrous Histiocytoma of the Lung: Report of a Case

We describe herein an extremely rare case of a recurrent primary pulmonary malignant fibrous histiocytoma 3 months after operation that occurred in a 55-year-old man who was treated with chemotherapy and radiotherapy successfully. Until now, 36 months later, the patient has shown no evidence of tumor recurrence. The clinical, radiographic, and pathologic features are reported here together with a brief review of the literature.

Surgical Treatment of Benign Fibrous Histiocytoma as a Form of Intraspinal Extradural Tumor at Lumbar Spine

A benign fibrous histiocytoma (BFH) is one of the fibrohistiocytic groups of soft-tissue tumors for which spinal involvement is extremely rare. To the best of our knowledge, most spine-originating BFHs are bone tumors. We report the first case of BFH occurring in the intraspinal extradural space on the lumbar spine. A 66-year-old female presented with severe claudication symptom. The preoperative magnetic resonance images showed a huge intraspinal, extradural, thecal-sac-compressing soft-tissue tumor that extended along the right L5 root to the neural foramen. The tumor was a relatively well-marginated, inhomogeneous soft-tissue mass with some fluid-containing cystic portions that were well enhanced by the gadolinium contrast dye. After a total facectectomy, the tumor was removed completely. The patient had a good neurological recovery without complications, and no recurrence was noted at the 6-month follow-up.

VATS Rib Resection in Benign Bone Tumor: A case report / 대한흉부외과학회지

A 42 year old male was admitted for a bony mass on the posterior arc of the left 6th rib, which was detected in a multiphasic health screening test. According to the chest computed tomography scan and bone scan, osteochondroma was suspected. He underwent VATS rib resection. There was no vessel or nerve injury. The patient was discharged without any complication on the 4th post operative day. The pathological diagnosis was benign fibrous histiocytoma. Generally, posterolateral thoracotomy is needed for rib resection, but we found that there was no difficulty in doing this kind of surgery under a thoracoscopic approach, which has the advantage of better cosmesis.

Estudio retrospectivo de masas cutáneas neoplásicas en caninos diagnosticadas histopatológicamente en la Universidad de la Salle (1999-2003) / Restrospective study of skin neoplasm in dogs diagnosed by histopathology at la Salle University (1999-2003)

El propósito del trabajo fue realizar un análisis retrospectivo de las neoplasias cutáneas en caninos diagnosticadas en la Universidad de la Salle, en Bogotá, en el período 1999-2003. El presente estudio se llevó a cabo con la información obtenida de los registros del área diagnóstica e histopatológica de la Universidad de La Salle. La información fue discriminada y analizada teniendo en cuenta las siguientes variables: diagnóstico, raza, sexo, edad, malignidad y localización del tumor. Los 192 casos de pacientes abordados en el estudio fueron agrupados de acuerdo con las neoplasias con el fin de determinar las características y el comportamiento de dichas patologías. La edad promedio de los pacientes fue de 6,5 años, la raza más afectada el Bóxer con el 91,1 por ciento (32 perros), seguido del labrador con un 13 por ciento (26 perros) y el caniche con un 10,5 por ciento (22 perros); los pacientes machos fueron los más afectados con un 58 por ciento (107 perros). Se reveló la gran incidencia del tumor de células de mast (26,2 por ciento en el 2003 y 10 por ciento en el año 2002). Entre otras neoplasias que se observaron de forma recurrente en el estudio se destacan el lipoma, tricoepitelioma, carcinoma de células escamosas y papilomatosis...

Generalized eruptive histiocytosis presenting with warty lesions on face

Generalized eruptive histiocytosis is a benign proliferative disorder of non-Langerhans cells. It is a very rare disease. The disease presents with soft to firm fleshy papules on face, neck and upper trunk. Biopsy is often needed to make the diagnosis because of its rarity and diverse presentation. There is tendency for the disease to regress spontaneously without treatment. Treatment, if any needed, suffices to topical modalities. We report here a case of generalized eruptive histiocytosis which presented with lesions of dual morphology. This is a very rare disease with diverse presentation being reported first ever in our country

Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma.

Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42 degrees C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSF1 DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at higher temperature (43 degrees C, 60 min) or incubation for longer time at 42 degrees C, exhibited necrosis characteristics; however,under mild heat shock (42 degrees C, 30 min) conditions cells showed activation of autophagy. Mild heat shock treatment induced proteolysis of HSF1, and under similar conditions we observed an increase in HSF2 expression followed by its enhanced DNA binding activity. Inhibiting HSF1 proteolysis by reversible proteasome inhibition failed to inhibit heat shock induced autophagy. Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy. We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells.

A Case of Epithelioid Cell Histiocytoma / 대한피부과학회지

Epithelioid cell histiocytoma (ECH), also known as epithelioid fibrous histiocytoma, is a rare variant of dermatofibroma, which can mimic melanocytic, vascular, epithelial, or other histiocytic lesions. Although the histogenesis of this condition remains unclear, a recent investigation suggested the possibility that ECH was an angioformative fibrous histiocytoma. There have been no reports of ECH in the Korean literature. Herein, we report a case of ECH in 45-year old man.

Malignant Fibrous Histiocytoma of Colon: A Case Report

Gastrointestinal malignant fibrous histiocytomas (MFH) are very rare and only about 30 cases have been reported in the English literature, among which 20 cases were from colorectal MFHs. A small bowel MFH with intussusception has been the only reported case in the Korean medical literature. A 52-year-old male presented with complaints of recently developed and aggravated right upper abdominal pain. We present the CT appearance and the clinico-pathologic findings of his primary inflammatory malignant fibrous histiocytoma, which arose from the subserosal layer of the ascending colon with tumor infiltration in all the layers. The colon showed extensive hemorrhagic necrosis and repetitive multifocal microperforations with resultant panperitonitis.

Benign Histiocytoma of the Lung: A Case Report

Histiocytomas have rarely been reported in the lungs. We report an unusual benign pulmonary histiocytoma in a 45-year-old man and discuss the differential diagnosis. Chest CT showed a well-defined solitary pulmonary nodule of approximately 3 cm in size in the posterobasal segment of the right lower lobe. Posterolateral thoracotomy and wedge resection was performed. Gross examination revealed a mass, measuring 2.2 x 2.1 cm that had a circumscribed margin within the lung parenchyma. Microscopically, the tumor was entirely composed of large polygonal to round cells with a few chronic inflammatory cells. These tumor cells contained abundant cytoplasm which was either granular, eosinophilic or foamy. Immunohistochemically, these cells were diffusely positive for CD68 and focally positive for 1-antitrypsin, but negative for cytokeratin, vimentin, and smooth muscle actin.

A Case of Fibrous Histiocytoma in Parotid Gland / 대한이비인후과학회지

Fibrous histiocytoma is a tumor of a biphasic cell population of fibroblasts and histiocytes. It usually occurs in the sun-exposed skin and orbital tissue but it has also been found in the upper aerodigestive tract, salivary gland, and deep layers of scalps and face. Fibrous histiocytoma in the parotid gland is extremely rare. It must be distinguished from other spindle cell tumors of parotid gland, particularly those of epithelial and myoepithelial origins. In immunohistochemical studies, antibody markers against vimentin and smooth muscle-specific actin lead to the diagnosis of fibrous histiocytoma. The malignant fibrous histiocytoma can be differentiated by its histopathology, since it consists of pleomorphism of cells, abundant mitotic figure, atypic mitotic figure and other tissue invasion. The clinical features such as rapid growth and distant organ metastasis allow a diagnosis of malignant variants. Treatment of benign fibrous histiocytoma can be made by a wide local excision without the sacrifice of near organs.

Clinical Experience of Malignant Fibrous Histiocytoma in Maxillary Sinus

Malignant fibrous histiocytoma is a connective tissue tumor containig fibroblast-like cells and histiocyte. It is one of the most common types of soft tissue sarcoma of late adult life but, the involvement of head and neck area is relatively rare. Although adequate modalities of treatment is performed, the prognosis of the tumor itself is not clear. Because of its highly malignant property and, as in cases of other regions of the body, devastating result would occur and aggressive treatment is required. Malignant fibrous histiocytoma shows variable histologic appearance, and may be classified into several subtypes(storiform- pleomorphic, myxoid, giant cell, inflammatory, angiomatoid) and the storiform-pleomorphic type is the most common type. The authors have recently experienced a case showing good clinical result to the present, after total maxillectomy and split thickness skin graft and postoperative radiotherapy(6400cGy) in the malignant fibrous histiocytoma involving the right maxillary sinus, so report this case with a review of literature.

A Case of Solitary Indeterminate Cell Histiocytoma / 대한피부과학회지

Indeterminate cell histiocytosis is a vary rare disease characterized by the proliferation of indeterminate histiocytes which morphologically and immunophenotypically resemble Langerhans cell but lack Birbeck granules. We report a case of solitary indeterminate cell histiocytoma in a 58-year-old woman. She presented with painless and nonprurituc solitary brownish papule on the left wrist, which had developed 10 years earlier. Histologic and immunohistochemical examination of the biopsy revealed a diffuse dermal infiltrate composed mainly of histiocytes which expressed Langerhans cell marker characteristics. Electron microscopic studies revealed no Birbeck granules within cytoplasm of the neoplastic cells, leading to a diagnosis of indeterminate cell histiocytosis.

A case of primary malignant fibrous histiocytoma of the lung / 대한내과학회지

Malignant fibrous histiocytoma(MFH) is a high grade soft tissue sarcoma, commonly occur in the retroperitoneum, extremities, head and neck in the patient with old ages. But it is very uncommon that MFH primarily occurs in the lung, and uncommon in young ages. We experienced a young male patient with primary MFH of the lung. The patient had huge masses on both lungs which were diagnosed as MFH by thoracoscopy-guided wedge resection of mass, so we could not perform operative management. And we tried 6 cycles of chemotherapy using ifosfamide, doxorubicin, dacarbazine. After chemotherapy, masses still remained in spite of decreasing sizes.

Hemosiderotic Histiocytoma

A 25 year old woman who presented a severely pruritic eruption of 1 month's duration on the lateral surface of her left shin is described. The histopathologic examination revealed dense cellularity consisting of hemosiderin laden macrophages and multinucleated giant cells of both the Touton type-like and the foreign body type, associated with many blood vessels, suggesting hemosiderotic histiocytoma. Given the additional finding of foamy cytoplasm, this case could be called xanthomatized hemosiderotic histiocytoma