RESUMO
This study was designed to examine the effects of intracerebroventricular [ICV] injection of ketanserin [5-HT[2a] receptor antagonist] and SB242084 [5-HT[2c] receptor antagonist] on harmaline induced feeding and drinking response in 24-h food-deprived [FD24] broiler cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were injected intracerebroventriculary with 0, 25, 50 and 100 microg of harmaline. In experiment 2, chickens received 10 microg ketanserin prior to the injection of harmaline. In experiment 3, birds were administered with harmaline after 3 microg SB242084 and the cumulative food and water intake was determined at 3 h post injection. The results of this study showed that harmaline decreases food consumption and increases water intake in FD24 broiler cockerels [P
RESUMO
Foeniculum vulgare [fennel] has been widely used in traditional medicine for treatment of various diseases including pediatric colic. This study was designed to assess the antinociceptive effects of aqueous extract of F. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic and histaminergic systems
The results of this study showed that aqueous extract of F. vulgare [50, 100 and 200 mg/kg, IP] induces antinociceptive effects [P<0.001] and that the pretreatment with chlorpheniramine and cimetidine significantly attenuate this effect [from 71.9% to 21.6%, P<0.001 and from 71.4% to 35.9%, P=0.003, respectively]
Furthermore, chlorpheniramine and cimetidine significantly decreased onset of first abdominal writhing [latency] in comparison with extract [P<0.05], however naloxone, cyproheptadine and phentolamine had no effect on antinociception and the latency induced by F. vulgare. The ED[50] value for antinociceptive effects of extract was 87.6 mg/kg. These results suggest that antinociceptive effects of F. vulgare are partially mediated by histamine H[1] and H[2] receptors?