Efficacy of piroxicam in osteoarthritis

To evaluate the therapeutic efficacy of this most important nonsteroidal anti-inflammatory drug by using series of 60 patients with osteoarthritis. Cross sectional study. The prospecting study was undertaken from amongst patients visiting the outpatient orthopedic department of District Head Quarter Hospital Charsadda of Khyber Pakhtunkhwa [KPK] for the period of six months from 1[st] January 2011 to 30[th] June 2011. This study was conducted on a mixed population of patients presenting with symptomatic osteoarthritis, which is relatively a common disease. Studies have shown that, the age of 40, 0% of all persons developed from mild clinical symptoms to degenerative changes in their weight bearing joints. indicates a significant therapeutic efficacy as compared to placebo, both at the 2[nd] and 4[th] week of treatment, table 3 represent the comparison of Piroxicam with placebo in the reduction of mean walking pain [hip] 2[nd] and 4[th] week of treatment on the basis of four point scale. The present study revealed sustained and significant improvement in the osteoarthritis of the knee or hip joint with Piroxicam treatment resulting in marked reduction in night-pain mean walking pain, and improved objective assessment in the functions of affected joints as compared to the findings emerging out of the use of the naproxen, aspirin and placebo

Circulating leukocytes; relation with acute mental stress and coronary artery disease

Evaluating circulating leukocytes in acute mental stress and relation with coronary artery disease. Descriptive study Muhammad Medical College Mirpurkhas, from March 2007 to August 2007. Two hundred young healthy adults were studied for stress experiment. Venous blood samples were drawn before and after stress for estimation of leukocyte counts. Values were presented as mean +/- standard error of mean [SEM]. The difference in Pre and during stress results of variables were TLC =-4630.85 +/- 140.65, N% =-11.8 +/- 0.36, L% =4.03 +/- 0.14, M% =5.48 +/- 0.37, E% = 1.18 +/- 0.07, B% = 1.11 +/- 0.022. Highly significant p-values [

Platelet screening tests in patients with hepatic cirrhosis

This is the largest report to investigate the importance of platelet screening tests in patients with hepatic cirrhosis. One hundred eighty seven patients were examined in this study. On an appropriate clinical historic back ground, biochemical results and biopsy - proven cirrhotic patients were investigated. An abnormal bleeding time was found in 78 patients. There were significant differences between the group of patients with an abnormal bleeding time and the group with a normal bleeding time with respect to platelet count, prothrombin time and serum bilirubin concentrations [all p < 0.05]. We recommend to measure the bleeding time in patients with raised bilirubin concentrations or poor hepatic function, even if platelet counts and prothrombin time are with in [safe limits], before making a decision about potentially dangerous therapeutic measures, such as surgery

Glucose tolerance and insulin response in myocardial infarction patients in type 2 diabetes mellitus

To investigate glucose tolerance and insulin response in myocardial infarction patients in type-2 diabetic population, normoglycemic FDRs or type-2 DM patients and MI with out DM and having no history of type-2 DM in family. Sixty five MI patients and twenty two healthy controls were selected for study. Subjects were divided in to four groups. The study was conducted for the period of 9 months in cardiology ward of various hospitals. Fasting plasma glucose levels in diabetic patients were abnormally higher as compared to other groups. Mean insulin level of FDRs and diabetic MI patients were significantly higher than controls and non diabetics. When viewed with higher fasting glucose level in groups, indicates considerable resistance. Higher insulin levels of FDRs may indicate start of insulin resistance at normoglycemic control. Finally we conclude that insulin resistance appears to be risk factors in diabetics and FDRs MI groups, while in non diabetics, non FDRs, MI patients these risk factors does not seem to play major role

HBV vaccination; status in health care workers

The study was conducted to determine the HBV vaccination status in health care workers of Muhammad Medical College Mirpurkhas. This was a descriptive study carried out at Muhammad Medical College Mirpurkhas, From December 2007 to February 2008. Total 480 health care workers were included; both male and female. Vaccination status and other data were filled on preformed Questionnaire proforma, if vaccinated or not. And if vaccinated either complete or incomplete. Total 480 health care workers were studied, including 300 [62.5%] male and 180 [37.5%] females. The mean age was 34 +/- 8.7 and 36 +/- 9.3 years in vaccinated and non-vaccinated subjects respectively. A total of 255 [53.15%] were vaccinated, including 215 males and 40 females. A 225 [44.875%] patients were non-vaccinated including 85 males and 140 females. The prevaccination HBsAg status was checked and found negative in all the subjects. The frequency of vaccination was highest among house officer 55 [91.66%] and lowest in the sanitary workers 3 [11.5%]. The most common reason of not being vaccinated was non-affordability [high cost of vaccine]. We conclude that a substantial number of health care workers are not vaccinated. So it demands a need for a more aggressive approach to be vaccinated and vaccine must be cost effective