Emerging therapeutic role of Prunella vulgaris in thyroid disease / 中草药·英文版

Thyroid disease is characterized by unusual levels of thyroid hormones, which results in either hyperthyroidism or hypothyroidism. The pathology of a particular type or stage of thyroid disease is very complicated, and always linked to a variety of biological functions. Although the mortality rate is not high, thyroid dysfunction could lead to metabolic and immunological disorders that can subsequently cause discomfort. To date, many drugs are suggested to have curative effects on thyroid disease, however, drug toxicity and long treatment periods encourage the search for more promising ones. Prunella vulgaris L. (Labiatae) is a popular herb that has shown great potential for improving human immunity and organ protection. It has been extensively used in the treatment of many diseases but its ability to treat specific diseases has not been fully reported. In this review, a literature search regarding herbs and herbal recipes for treating thyroid disease were carried out, organized, and summarized. In addition, this study conducted a literature search on the current situation and progress of P. vulgaris treatment for various diseases. Finally, this study discussed studies regarding P. vulgaris treatment of goiter, and the mechanism of treatment through the regulation of apoptosis. Accordingly, a combination therapy of herbs and Western medicine can provide significant therapeutic effects in the clinical treatment of thyroid disease. Furthermore, the association between P. vulgaris and various diseases suggests that P. vulgaris is rich in a variety of active substances that can fight oxidation and participate in the regulation of apoptosis, thus having a protective effect on the thyroid. Here, a comprehensive literature review regarding the application of herbs or herbal recipes in the treatment of thyroid disease was presented. It is concluded that there is strong evidence for further research regarding the use of P. vulgaris in the treatment of thyroid diseases.

Molecular docking study of "detoxification" mechanism of Chebulae fructus- Margarita intervention in stroke / 国际中医中药杂志

Objective:To analyze the material basis, target and pathway of Chebulae fructus and Margarita in Mongolian medicine Garidi-13 Pill on stroke with the method of network pharmacology and molecular docking technology, so as to better understand its "detoxification" mechanism. Methods:TCMIP and BATMAN-TCM were used to predict the target of Chebulae fructus and Margarita composition, and GeneCards were used to search for the target of stroke. The overlapping targets of the two platforms were imported into the Metascape software for GO biological analysis and KEGG pathway analysis. The molecular docking of key molecules and targets was carried out with LEDOCK. Results:A total of 22 active components were collected and 217 targets related to stroke were predicted. Among them, 1-O-galloyl-glucose, cuprum, ellagicacid, arjungenin and corilagin were the key substances playing the role of "detoxification" of the Chebulae fructus and Margarita; IL6, TNF, HSP90AA1, PTGS2, CASP3, NR1I2, VKORC1 and ATP1A1 were the key targets playing the role of "detoxification" . These targets were significantly enriched in cell response, humoral level regulation, hemostasis, response to steroid hormones, steroid metabolism, coagulation and other biological processes, as well as nitrogen metabolism, IL-17 signaling pathway and other pathways. Molecular docking verified the accuracy of previous prediction results from computer simulation level. Conclusion:The process of Chebulae fructus and Margarita intervening strok is closely related to the elimination of harmful metabolites and calmingthe inflammatory reaction, which was not only consistent with the modern medicine on the pathological process of stroke, but also consistent with the interpretation of "evil and poison" with Mongolian medicine theory.

Progresses of ultrasound elastography in endometrial lesions / 中国医学影像技术

Endometrial lesions are common gynecological diseases in women,including submucosal fibroids,endometrial polyps,endometrial hyperplasia and endometrial cancer,etc.Endometrial hyperplasia is one of the precancerous lesions,and early diagnosis can effectively reduce the rate of malignancy.Ultrasound elastography has been gradually used in gynecology.The classification,principles of ultrasound elastography and its application in diagnosis of endometrial lesions were reviewed in the article.

Study on Clinical Characteristics and Traditional Chinese Medicine Syndrome of Severe Pneumonia Associated Sepsis / 世界科学技术-中医药现代化

This study was aimed to investigate therapies in combination of traditional Chinese medicine (TCM) and western medicine from the investigation of clinical characteristics and TCM syndromes of patients with severe pneumonia associated sepsis in ICU.A retrospective study was conducted to collect clinical data on 113 patients suffered from severe pneumonia associated sepsis.The basic information on hospital admission,TCM syndrome of deficiency of excess,APACHE Ⅱ score,CD3+ (％),CD4+ (％),and CD8+ (％) were analyzed.The total days of hospitalization and treatment outcome were recorded.A total of 113 patients who met the diagnostic criteria of severe pneumonia associated sepsis were divided into the survival group and the death group.There were 81 patients in the survival group while 32 patients in the death group.The total mortality rate was 28.32％.There was a statistical difference between two groups on the days of hospitalization,APACHE Ⅱ score,CD3+ (％),CD4+ (％),CD8+ (％) and CD4+/CD8+ (all P ＜ 0.05).The days of hospitalization of the death group was longer than that of the survival group,with higher APACHE Ⅱ score (P ＜ 0.05).The survival group showed a higher level of CD3+ (％),CD4+ (％),CD4+/CD8+ (％) than that of the death group (P ＜ 0.05).The survival group showed a lower level of CD8+ (％) than that of the death group (P ＜ 0.05).The deficiency syndrome group showed a higher mortality rate than that of the excess syndrome group (P ＜ 0.05).APACHE Ⅱ score,the days of hospitalization,deficiency syndrome,and CD3+ (％) were related to the death outcome of sepsis patients.It was concluded that severe pneumonia associated sepsis predicates a higher mortality rate.The clinical data collected at the beginning of hospital admission shows a certain prediction effects to the disease prognosis.There is a certain correlation between TCM syndrome and the disease severity.The mortality rate of deficiency syndrome is higher.

Progresses of translabial ultrasound in evaluation of postpartum anal sphincter complex / 中国介入影像与治疗学

The injury of anal sphincter complex during childbirth can result in long-term anal incontinence problems.Recently,several new techniques in ultrasound have been used to evaluate the function and injury of anal sphincter,such as tomographic ultrasound imaging,volume contrast imaging and speckle reduction imaging.The diagnosis rate of the injury of anal sphincter complex has been improved rapidly.The development of 2D and 3D ultrasound in evaluating function and injury of postpartum anal sphincter complex were reviewed in this article.

Enteral nutrition in pediatric Crohn's disease / 国际儿科学杂志

Crohn's disease (CD) is a major involvement terminal ileum and proximal colonic inflammatory bowel disease(IBD),by now it still cannot be cured.The main symptoms include abdominal pain,diarrhea,fever.With the progress of the disease,it can exhibit rectal bleeding,intestinal fistula intestinal obstruction,etc.Children with CD can display growth retardation and delayed puberty.The treatment of CD has been a hot spot that is being discussed by clinicians.The drug treatment has many side effects.The surgery has high recurrence rates and some complications.Enteral nutrition (EN) is a nuuitional way that we can mnsport nutriment into stomach or small intestine through oral or tube with few side effects.It can improve the poor nutrition of the patients,induction and maintenance conditions.EN has been widely used in clinical treatment of CD,especially in paediatric CD.This paper summarizes the importance of EN in treatment of CD,the main function,mechanisms,therapy and the factors of curative effect.

Relative determination approach to the metabolites of protoberberine alkaloids in rat urine by liquid chromatography tandem mass spectrometry for the comparative studies on rhizome coptidis and zuojinwan preparation

The lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. The present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. A liquid chromatography- electrospray ionization-mass spectrometry [LC-ESI-MS] method for the qualitative and quantitative determination of the metabolites after oral administration of Rhizome coptidis and Zuojinwan preparation in rat urine has been developed. Urine samples, extracted with a protein precipitation procedure were separated on a C[18] column using a mixture of water [containing 0.1% formic acid] and acetonitrile [30:70, v/v] as mobile phase. The detection was performed via MS with electrospray ionization interface in positive selected reaction monitoring [SRM] mode. One urine sample after administration was selected as ‹standard›. The method validation was carried out according to a conventional method which was calibrated by authentic standards. The fully validated method was applied to the pharmacokinetic study of 2,9-demethyljateorhizine-3-sulfate, 13-methoxyjateorhizine-3- glucoronide and 6-methyljateorhizine-5-glucoronide in rat urine. The results could provide evidence to explain the combination of Rhizome coptidis and Evodiae fructus in terms of elimination