Sustained-release solid dispersion of tripterin carried by colloidal silia dioxide / 中草药

Objective: To prepare the sustained-release solid dispersion of tripterin (SRSDT) with the intention of improving drug dissolution, meanwhile, the drug release was slowed down so as to make the toxicity diminished. Methods: SRSDT was prepared by the solvent method with colloidal silica dioxide (CSD) as carrier. The physical characteristics and in vitro release rate were further evaluated. Results: The ideal SRSDT was prepared by mixing tripterin and colloidal silica dioxide with the weight ratio of 1:12; The release rate of drug could keep moderate and controllable. In vitro cumulative release of SRSDT was up to more than 90% after 8 h. The results of differential scanning calorimetry, scanning electron microscopy, and X-ray powder diffraction could prove that the tripterin existed as amorphous form in the carrier. Conclusion: The SRSDT carried by CSD could control the release rate of drug and keep moderate and controllable, and the preparation process is simple, which has potential applications.

Study on solidifying volatile oil of cinnamon with colloidal silicon dioxide SYLOID244FP / 中国中药杂志

<p><b>OBJECTIVE</b>To evaluate the properties of solidifying volatile oil of cinnamon with colloidal silicon dioxide SYLOID244FP.</p><p><b>METHOD</b>Volatile oil of cinnamon was solidified by SYLOID244FP. The amount of SYLOID244FP was optimized with the cinnamaldehyde yield as criteria. Curing powder was characterized by scanning electron microscopy (SEM) and differential scanning calorimetry(DSC). The effects of SYLOID244FP on dissolution in vitro and thermal stability of cinnamaldehyde were studied.</p><p><b>RESULT</b>The optimum solidification ratio of SYLOID244FP to volatile oil of cinnamon was 1: 1. Dissolution rate of cinnamaldehyde increasesd and its thermal stability improved after volatile oil of cinnamon was solidified.</p><p><b>CONCLUSION</b>Solidifying herbal volatile oil with SYLOID244FP deserves studying further.</p>

Essence of material base in geoherbs: specificality of constituent structure / 中国中药杂志

Geoherbs, playing an indispensable role in the protection and the treatment of disease, has been demonstrated to be the treasure in Chinese medicine clinical. Geoherbs possessed the best quality and curative effect due to their distinctive inside chemical ingredients/components. In recent years, a lot of achievements were obtained in geoherbs research on chemistry; however, there was also much confusion in existence. More and more studies revealed that the better curative effect on geoherbs was attributed to its architectural feature with steady and well-organized in unique ingredients/components constituent, but not for the characteristic single chemical ingredient. The "constituent structure theory" suggested that the material base of geoherbs consist of different components of which compatibility proportion relationship was optimal. In addition, the single active ingredients had their unique three-dimensional structure. This paper explained the peculiarity of geoherbs material base based on constituent structure theory from there layers and multi-dimensional structure to geoherbs material base research in a new way.

Study on andrographolide solid dispersion vectored by hydroxyapatite / 中国中药杂志

<p><b>OBJECTIVE</b>To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution.</p><p><b>METHOD</b>Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to prepare andrographolide solid dispersion, in order to study its dissolution behavior, stability and physical characteristics.</p><p><b>RESULT</b>The solid dispersion prepared with andrographolide and hydroxyapatite with the proportion of 1:8 existed in the vector in an amorphous form, according to differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction. The in vitro dissolution of andrographolide solid dispersions was up to 93% at 45 min. After the accelerated stability test for three months, the drug dissolution and content in andrographolide solid dispersion showed no significant change.</p><p><b>CONCLUSION</b>The prepared solid dispersions with hydroxyapatite as the vector can effectively improve the stability and dissolution of water-insoluble drug andrographolide.</p>

Study on Xinyueshu spray drying assisted with copovidone and its effect on powder property / 中国中药杂志

To study the application characteristics of copovidone (PVP-S630) in Xinyueshu extracts during the spray drying process, and its effect on such pharmaceutical properties as micromeritics and drug release behavior. PVP-S630 was added into Xinyueshu extracts to study on the spray drying, the effect of different dosages of PVP-S630 against the wall sticking effect of the spray drying, as well as the power property of Xinyueshu spray drying power and the dissolution in vitro behavior of the effective component of hyperoside. The results showed that PVP-S630 revealed a significant anti-wall sticking effect, with no notable change in the grain size of the spray drying power, increase in the fluidity, improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior of hyperoside. It was worth further studying the application of PVP-S630 in spray drying power of traditional Chinese medicine.

Multi-dimensional structure quality control over Salvia miltiorrhiza injection based on component structure theory / 中国中药杂志

As the preparation process from Salvia miltiorrhiz herbs to S. miltiorrhiz injection involves complicated technology and has relatively more factors impacting quality safety, the overall quality control is required for its effectiveness and safety. On the basis of the component structure theory, and according to the material basis of S. miltiorrhiz injection, we discussed the multi-dimensional structure and process dynamic quality control technology system of the preparation, in order to achieve the quality control over the material basis with safety and effectiveness of S. miltiorrhiz injection, and provide new ideas and methods for production quality standardization of S. miltiorrhis injection.

Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid / 中国中药杂志

<p><b>OBJECTIVE</b>To prepare the sustained release solid dispersion of tripterine, using HPMC-stearic acid with the intention of improving drug dissolution and controlling drug releases moderate, so that the drug performances lower toxicity.</p><p><b>METHOD</b>Tripterine sustained release solid dispersions was prepared by the solvent method with different weight ratios of HPMC-stearic acid and tripterine, which were dissolved in 95% ethanol. And in vitro dissolution experiment was conducted. Differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction can prove the formation of solid dispersions.</p><p><b>RESULT</b>The ideal tripterine sustained release solid dispersions were prepared under the condition as follows, the weight ratio of tripterine and HPMC-stearic acid was 1: 10, and the release rate of drug can keep moderate and controllable. In vitro cumulative release of tripterine sustained release solid dispersion is up to more than 90% after 8 h, and the tripterine exist as amorphous in the solid dispersion.</p><p><b>CONCLUSION</b>The sustained release solid dispersion of tripterine, carried by HPMC-stearic acid, can improve the release of tripterine effectively and controls the release rate keep moderate and controllable, and the preparation process is simple, which has potential applications.</p>