Use Density of Carbapenems and Bacterial Drug Resistance in 5 Consecutive Years / 中国药房

OBJECTIVE:To investigate the effect of the correlation between the use density of carbapenems and the bacterial drug-resistance.METHODS:The data including the use density of carbapenems in the ICU ward of a hospital,the categories of the related pathogenic bacteria and monitoring results on drug resistances in 5 consecutive years were collected for an analysis of the quantitative change in a corresponding stage.RESULTS:Non-fermentative Gram-negative bacilli(NFGNB) were prone resistant to carbapenems and the resistant rate fluctuated in relation to the use density of carbapenems.The Enterobacter had low resistance to carbapenems and was independent of the use density of carbapenems.CONCLUSION:The use density of carbapenems has a positive correlation with the resistance of NFGNB.Reasonable drug use density may slow down or reduce bacterial drug-resistance.

Drug-resistance Monitoring and Medication Analysis:Survey of 148 Pseudomonas Aeruginosa Infection Cases / 中国药房

OBJECTIVE:To probe into the status quo of the drug resistance and the medication of pseudomonas aeruginosa so as to provide references for the clinic in the controlling of pseudomonas aeruginosa infection.METHODS:The susceptive rates of the susceptibility test performed on 148 pseudomonas areuginosa infection cases confirmed in 2004 in our hospital were collected statistically and a whole range tracking statistics were conducted on the use of antibacterials.RESULTS:Pseudomonas aeruginosa had a strong drug resistance,which had a different degree of drug resistance to all antibacterials;Antibiotics like piperacillin/tazobactam,ceftazidime and carbopenem took the lead in terms of their susceptive rates,which stood at 75.68%,73.65%and 70.27%,respectively;The cross resistances of the third generation cephalosporins and the compound agents of the third generation cephalosporins and their enzyme inhibitor were serious and which kept increasing rapidly;The adoption rates for the susceptive kinds were less than 50%before the susceptibility test.CONCLUSION:An effective way to control pseudomonas aeruginosa infection is to conduct strain culture and isolation and perform susceptibility test as early as possible.