RESUMO
Background: Ulcerative colitis (UC) is often accompanied by a variety of extraintestinal manifestations (EIM). EIM is important for the diagnosis and treatment of UC. Aims: To investigate the risk factors of EIM in patients with UC. Methods: The clinical data of patients with UC from Jan. 2013 to Dec. 2018 at the People's Hospital of Xinjiang Autonomous Region were retrospectively analyzed. Univariate and multivariate analysis were performed to investigate the risk factors of EIM in UC. Results: A total of 260 UC patients were enrolled, of them 120 (46.2%) had EIM. The main EIM were musculoskeletal manifestation, skin disease, eye disease, hepatobiliary disease. Univariate analysis showed that Uyghur (χ2=4.069, P=0.044), older (χ2=4.250, P=0.039), BMI≥24 kg/m2 (χ2=13.913, P=0.000), history of intestinal surgery (χ2=6.089, P=0.014) and disease activity (χ2=27.556, P=0.000) were associated with EIM in UC patients. Multivariate analysis showed that Uyghur (OR=1.802, P=0.042), BMI≥24 kg/m2 (OR=3.163, P=0.000), history of intestinal surgery (OR=4.089, P=0.042) and disease activity (OR=6.347, P=0.000) were risk factors of EIM in UC patients. Conclusions: Uyghur, BMI≥24 kg/m2, history of intestinal surgery and disease activity are important risk factors of EIM in UC patients.
RESUMO
Objective To analyze the extraintestinal manifestations and clinical characteristics of patients with ulcerative colitis (UC) and to improve the knowledge,diagnosis and treatment of UC with extraintestinal manifestations.Methods From January 2013 to December 2017,at the Department of Gastroenterology,People's Hospital of Xinjiang Uygur Autonomous Region,260 hospitalized patients diagnosed as UC were collected.The demographic characteristics,clinical phenotypes and extraintestinal manifestations were analyzed.Chi square test was used for statistical analysis.Results Among 260 UC patients,41.9％ (109/260) had extraintestinal manifestations,including fatty liver (17.3％,45/260),gallbladder stone (11.9％,31/260),type Ⅰ peripheral arthritis (8.1％,21/260),type Ⅱ peripheral arthritis (3.1％,8/260),oral ulcer (4.6 ％,12/260),erythema nodosum (3.8％,10/260),irireitis (1.9％,5/260),ankylosing spondylitis (1.5％,4/260),sacroiliitis (1.5％,4/260),pyoderma gangrenosum (0.4％,1/260) and primary sclerosing cholangitis (0.4％,1/260).Gender,ethnicity,age,history of intestinal surgery and body mass index (BMI) could affect the occurrence of extraintestinal manifestations in patients with UC (x2 =7.901,4.318,9.291,8.162 and 10.397,all P＜0.05).The incidence of joint lesions in Uygur UC patients was higher than that in Han UC patients (16.6 ％,24/145 vs.7.0％,8/115),and the difference was statistically significant (x2 =5.471,P=0.019).The incidence of extraintestinal manifestations in UC patients in the active phase was higher than that of UC patients in the inactive phase (52.9％,92/174 vs.19.8％,17/86),and the difference was statistically significant (x2 =25.908,P＜0.01).Conclusions UC is complicated with a variety of extraintestinal manifestations.The most commonly involved organs are liver and gallbladder,joint and oral cavity.The extraintestinal manifestations are more common in female,Uygur,patients with high BMI,youth,patients with a history of intestinal surgery and UC patients at the active phase.