Study on inclusion process of decomposed volatile oil from Atractylodes macrocephala with hydroxypropyl-β-cyclodextrin / 中草药

Objective: To optimize the inclusion process of decomposed volatile oil from Atractylodes macrocephala (DVOA) with hydroxypropyl-β-cyclodextrin (HP-β-CD). Methods: The inclusion complex was prepared by the freeze drying method. The preparation process was evaluated using fluorescence spectrophotometry. The inclusion process conditions were screened by the orthogonal test, with the inclusion ratio and oil ratio as indexes, and mass ratio between HP-β-CD and DVOA, inclusion temperature and inclusion time as the impacting factors. The inclusion complex was characterized through ultraviolet-visible spectra (UV-vis), fluorescence spectra (FL) and microscopic imaging, and the stability test was performed. Simultaneously, the chemical composition in DVOA before and after inclusion was analyzed by GC-MS technique. Results: The DVOA and HP-β-CD had formed inclusion complex, the optimal inclusion conditions were as follows: The mass ratio of HP-β-CD to DVOA was 10:1, the inclusion temperature was 30℃, the inclusion time was 2.0 h, and the ratios of average inclusion and oil were 73.32% and 10.43%, respectively. The chemical composition of DVOA was consistent before and after inclusion, the inclusion just had the slight effects on proportion of each component. Conclusion: The preparation process of DVOA/HP-β-CD inclusion complex under the optimal conditions is reasonable, stable, and feasible, and can provide the reliable experimental basis for the anti-tumor new drug research and development of DVOA.

Study on the inclusion actions of diclofenac sodium and β-cyclodextinr in aqueous solution / 中国药学杂志

OBJECTIVE：Probe into the feasibility of preparation of diclofenac sodium with β-cyclodextrins in 1∶1 and 2∶1 inclusion compounds ,and find out the affection in solubility of diclofenac sodium. METHODS:The 1∶1 and 2∶1 melusion compounds were prepared by liquid-phase an alysis the content and determination them solubility.RESULT:The 1 ∶1 and 2∶1 inclusion compounds were prepared by different ratio of reactants and etermined them mp were 299～300.5℃ and 302～303℃ respectively. CONCLUSION：Of us is that solubilits of the 1∶1 and 2∶1 inclusion compounds increase 0.65 and 1 times respetively comparing with declofenac sodium.

Inclusion of ginsenoside Rg_3 with hydroxypropyl-?-cyclodextrin / 中草药

Objective To investigate the inclusion of ginsenoside Rg_3 with hydroxylpropyl-?-cyclodextrin (HP-?-CD) in aqueous solutions, inclusion molar ratio of host and guest molecules, and change of thermodynamic parameters during the inclusion process. Methods The measurements of the inclusion mechanism, inclusion molar of the host and guest molecules, and change of thermodynamic parameters were carried out by the following methods: phase solubility, IR, NMR, and TLC methods, respectively. Results The results indicated that the inclusion compound of ginsenoside Rg_3-HP-?-CD was formed. The content analysis of the inclusion compound showed that the inclusion ratio of ginsenoside Rg_3-HP-?-CD was 1∶1. The change in the thermodynamic parameters suggested that the inclusion could proceed (△G