RESUMO
Yeasts can be enriched with microelements, including iron; however, special physicochemical conditions are required to formulate a culture media that promotes both yeast growth and iron uptake. Different iron sources do not affect biomass formation; however, considering efficacy, cost, stability, and compatibility with Saccharomyces cerevisiae metabolism, ferrous sulphate is recommended.
Assuntos
Compostos de Ferro/metabolismo , Saccharomyces cerevisiae/crescimento & desenvolvimento , Saccharomyces cerevisiae/metabolismo , Meios de Cultura/química , Sais/metabolismoRESUMO
Iron biokinetics of absorption and disposition were investigated following a single oral dose of 150 mg ferrous sulfate to 10 healthy female volunteers. The blood and serum samples collected at different time intervals were analyzed by atomic absorption spectrophotometer. Total iron in blood showed about 25% lower values than those given in literature. In blood, iron showed mean +/- SD value of Tmax 2.37 +/- 0.17 hours, Cmax 422 +/- 26.9 mcg.m/L t1/2mcg 0.54 +/- 0.03 hour, kabs 1.29 +/- 0.08/h, AUC 6923 +/- 1624 h.mg/L, CI 0.36 +/- 0.00 mL/h/Kg, Vd 5.36 +/- 0.02 mL/Kg and t1/2B 9.54 +/- 2.07 hour. In serum, iron showed mean ' SD values of Tmax 6.73 +/- 0.00 hour, Cmax 10.8 +/- 0.57 mcg.m/L, t1/2mcg 8.05 +/- 1.32 hour, kabs 0.09 +/- 0.01/h, AUC 412 +/- 91.8 h.mg/L, CI 6.80 +/- 0.07 mL/h/Kg, Vd 82.5 +/- 0.55 mL/Kg and t1/2B 8.59 +/- 0.96 hour