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1.
Biointerface Research in Applied Chemistry ; 12(2):1385-1396, 2022.
Article in English | Scopus | ID: covidwho-1328442

ABSTRACT

Currently, the entire globe is under the deadliest pandemic of Covid-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). At present, no specific treatment is available to combat COVID-19 infection. Euphorbia hirta (Euphorbiaceae) have been reported for a variety of biological activities, including antiviral. The present investigation aimed to identify potential phytoconstituents of the plant E. hirta from the category flavonoids and coumarins against the SARS-CoV-2 using in silico approach. The molecular docking studies were performed using two different targets of SARS-CoV-2, namely Main protease (Mpro;PDB ID: 6M2N) and RNA-dependent RNA polymerase (RdRp;PDB ID: 7BW4). Based on the molecular docking study in comparison with standard drug, four compounds, namely Euphrobianin, Quercetin, 3-o-alpha-rhamnoside, Isoquercitrin, and rutin, were screened against the target Mpro . Three phytoconstituents, euphorbianin, myricetin, and rutin, were screened against the target RdRp. In the in silico toxicity studies of screened phytoconstituents, except myrectin all were predicted safe. Results of euphorbianin and rutin were found more interesting as both compounds had high binding affinity against both targets. Finally, we want to conclude that euphrobianin, quercetin 3-o-alpha-rhamnoside, isoquercitrin, and rutin could be further explored rapidly as they may have the potential to fight against COVID-19. © 2021 by the authors.

2.
International Journal of Biological and Chemical Sciences ; 14(8):2941-2950, 2020.
Article in French | CAB Abstracts | ID: covidwho-1310167

ABSTRACT

As part of contributing to the symptomatic management of respiratory conditions that may manifest during Covid-19, the current study was undertaken to identify African medicinal plants active against these manifestations. A bibliographic study was carried out to identify the plant species used in the management of respiratory diseases in West Africa. The frequency of citation and a convergence score for the use of the species were also calculated. A total of 318 recipes from 145 plant species were inventoried through various publications. Guiera senegalensis, Sterculia setigera, Bridelia ferruginea, Euphorbia hirta and Terminalia avicennioides were the most cited plants with the best usage convergence scores. Leaves from these species were most cited while the cough was more indicated. The results of this study could serve as a database of plant species used in the management of respiratory tract diseases in West Africa.

3.
J. Phys. Conf. Ser. ; 1788, 2021.
Article in English | Scopus | ID: covidwho-1139901

ABSTRACT

Corona Virus Disease (COVID-19) is announced as pandemic by World Health Organization (WHO) since 11th March 2020. Riau Province has many herbal plants e.g. Cheilocostus specious, Euphorbia hirta l, Cassia torra, Bryophyllum pinnatum, Daniella ensifollia, and Ziziphus mauritiana that can cure many diseases and there is not report yet focusing on in-silico method using SARS-CoV-2 protease (PDB ID:6LU7). This study aims to reveal the potential of compounds contained in Riau Herbal Plants as anti SARS-CoV-2 through its binding to protein receptors. The study was conducted by molecular docking using Autodock Vina 1.5.6 and drug ability studies using Swiss ADME. The docking results of six active compounds including diosgenin, tannin, triterpenoid, chrysophanol, flavone and phytosterol were -8,3;-7,5;-7,5;-7,2;-6,9;-6,9 respectively against the affinity result for natural ligand of COVID-19 (-6,1). This result indicates the stronger bond between ACE2 and inhibitors because the affinity value of active compounds are higher than natural ligand of COVID-19. The SwissADME results show that triterpenoid and tannin violate some Lipinski Rules that make their drug-likeness is low. In general, all the active compounds were potential as candidates of SARS-CoV-2 antiviral but the most potential one is diosgenin in Cheilocostus specious. © Published under licence by IOP Publishing Ltd.

4.
Biomolecules ; 11(1)2020 Dec 30.
Article in English | MEDLINE | ID: covidwho-1006314

ABSTRACT

While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with Carica papaya and Euphorbia hirta were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.


Subject(s)
Carica/chemistry , Dengue Virus , Dengue/drug therapy , Euphorbia/chemistry , Phytochemicals , Plants, Medicinal/chemistry , SARS Virus , Severe Acute Respiratory Syndrome/drug therapy , Humans , Phytochemicals/chemistry , Phytochemicals/therapeutic use
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